Ana Maria Cuervo

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Full Name
Ana Maria Cuervo
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Cuervo_Ana_Maria_2x.jpg
Type
Faculty
Expert
First Name
Ana Maria
Last Name
Cuervo
Faculty ID
8784
Patient Type
Adult
Department
einstein-dept-developmental-molecular-biology
einstein-dept-medicine
Email
ana-maria.cuervo@einsteinmed.edu
Phone
718-430-2689
Titles
Type
Academic
Department
Department of Developmental & Molecular Biology
Department Link
Rank
Distinguished Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Distinguished Professor
Division
Hepatology
Type
Administrative
Title
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Chanin Building
Room
504
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Cuervo is co-director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. In October 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders.</p>
<p>Dr. Cuervo&rsquo;s group is interested in understanding how altered proteins can be eliminated from the cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy)&nbsp;with different neurodegenerative diseases including Parkinson&rsquo;s, Alzheimer&rsquo;s and Huntington&rsquo;s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pionered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity.</p>
<p>Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director&rsquo;s, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdoxk, the Gerry Aurbach, the SEBBM L&rsquo;Oreal-UNESCO for Women in Science, the&nbsp;C. Ronald Kahn Distinguished Lecture&nbsp;and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell.</p>
<p>Dr. Cuervo has served in NIH advisory panels, special emphasis panels, and study sections, the NIA Scientific Council and the NIH Council of Councils and &nbsp;has been recently elected member of the NIA Board of Scientific Counselors and member of the of the Advisory Committee to the NIH Deputy Director.. She has received numerous awards for the pioneerign work of her team such as &nbsp;the 2005 P. Benson Award in Cell Biology, the 2005/8 Keith Porter Fellow in Cell Biology, the 2006 Nathan Shock Memorial Lecture Award, the 2008 Vincent Cristofalo Rising Start in Aging Award, the 2010 Bennett J. Cohen Award in Aging Biology, the 2012 Marshall S. Horwitz, MD Faculty Prize for Research Excellence and the 2015 Saul Korey Prize in Translational Medicine Science. She has also received twice the LaDonne Schulman Teaching Award. In 2015 she was elected International Academic of the Royal Academy of Medicine of the Valencia Community and in 2017, she was elected member of the Real Academia de Ciencias Exactas, Fisicas y Naturales. She was elected member of the American Academy of Arts and Sciences in 2018 and member of the National Academy of Science in 2019.</p>

Research Areas
Understanding the molecular basis of malfunctioning of autophagy (cellular quality control system) with age and the contribution of defects on this cellular pathway to age-related disorders such as neurodegeneration, metabolic disorders and cancer.
Specialties
Areas of Expertise
Cancer
Cell biology
Huntington’s disease
Metabolism
Parkinson’s disease
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is considered a leader in the field of autophagy&mdash; the process by which cells remove and recycle their waste. The Barcelona, Spain native is also an expert on the cellular biology of aging. Dr. Cuervo has been quoted in numerous publications, including <em>The New York Times</em>, <em>Nature, Science</em>, <em>Scientific American</em>, and <em>The Scientist</em>.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is co-editor-in-chief of <em>Aging Cell</em> and has served on various National Institutes of Health (NIH) advisory panels and study sections, the National Institute on Aging&rsquo;s Council, and the NIH Council of Councils. She is currently a member of the Advisory Committee to the NIH deputy director, and chair of the NIA Board of Scientific Counselors. She is an elected member of the National Academy of Sciences and of the American Academy of Arts and Sciences.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo&rsquo;s work focuses on the causes of age-related diseases including degenerative disorders such as Alzheimer&rsquo;s disease and Parkinson&rsquo;s disease, metabolic conditions such as diabetes, and cardiovascular disorders. Her goal is to develop therapies that will restore normal cellular housekeeping and thus prevent the accumulation of toxic protein byproducts and the death of affected cells in age-related disorders. Dr. Cuervo was named to the Highly Cited Researchers List (ranking of top 1% cited researchers) since 2018.</p>

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Professional Title
M.D.
Ph.D.
Selected Publications

<p>(selected from &gt;200 per review publications)</p>
<ol>
<li>Cuervo, A.M.*; Stephanis, L.; Freundberg, R.; Lansbury, P.; Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Science</span></em>305, 1292-1295, 2004</li>
<li>Kaushik, S.; Massey, A.C.; Kiffin, R., Cuervo, A.M*. Role of lysosomal lipid microdomains in the regulation of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">EMBO J.</span> </em>25, 3921-33, 2006</li>
<li>Zhang, C., Cuervo, AM*. Restoration of chaperone-mediated autophagy in aging improves cellular maintenance and organ function. <em><span style="text-decoration: underline;">Nat. Med.</span> </em>14: 959-65, 2008</li>
<li>Singh, R.; Kaushik, S.; Wang, Y.; Xiang, Y.; Novak, I; Komatsu, M.; Tanaka, K.; Cuervo, A.M*.; Czaja, M.J*.&nbsp; Autophagy regulates lipid metabolism. <em><span style="text-decoration: underline;">Nature</span></em> 458:1131-5, 2009</li>
<li>Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, de Vries R, Kaushik S, Arias E, Harris S, Sulzer D, Cuervo AM*&nbsp; Cargo recognition failure is responsible for inefficient autophagy in Huntington&rsquo;s Disease. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>13:567-76, 2010</li>
<li>Bandyopadhyay U, Shridar S, Kaushik S, Kiffin R, Cuervo AM*, Identification of regulators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol Cell</span> </em>39: 535-47, 2010.</li>
<li>Koga H., Kaushik S., Macian F. Verkushka, V. Cuervo AM* A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat Comm</span></em>&nbsp;2: 386, 2011</li>
<li>Kon, M, Koga, Hl, Kiffin, R., Chapochnick, J. Macian, F, Vartikovski L., Cuervo AM*. Chaperone-mediated autophagy is required for turmor growth. <em><span style="text-decoration: underline;">Science TM</span> </em>3:109ra117, 2011</li>
<li>Wong E, Bejarano E, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM*. Molecular determinants of selective clearance of protein inclusions by autophagy. <em><span style="text-decoration: underline;">Nat Comm</span> </em>3:1240, 2012</li>
<li>Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes, E., Honig, L.S., Dauer, W., Consiglio A, Raya A, Sulzer, D, Cuervo AM. Interplay of LRRK2 with chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>16:394-406, 2013</li>
<li>Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Chemical modulation of Chaperone-mediated autophagy by novel retinoic acid derivatives. <em><span style="text-decoration: underline;">Nat. Chem. Biol.</span> 9:374-82</em>, 2013</li>
<li>Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM Functional interaction between autophagy and ciliogenesis. <em><span style="text-decoration: underline;">Nature</span> 502:194-200, 2013 </em></li>
<li>Bejarano, E, Yuste, A, Patel B, Stout, RJ, Spary, D Cuervo AM. <em>Connexins modulate autophagosome biogenesis. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 16:401-14, 2014</em></li>
<li>Schneider JL, Suh Y, Cuervo AM*.&nbsp; Deficient chaperone-mediated autophagy in liver leads to metabolic disregulation. <em><span style="text-decoration: underline;">Cell Metab</span>.</em> 20:417-432, 2014</li>
<li>Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM*. Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging. <em><span style="text-decoration: underline;">Aging Cell,</span></em> 14:249-64, 2015</li>
<li>Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming ER, Bellen H, Cuervo AM*, Zhang S*. Huntingtin functions as a scaffold for selective macroautophagy. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 17: 262-75, 2015</li>
<li>Park C, Shu Y, Cuervo AM*.Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. <em><span style="text-decoration: underline;">Nat. Commun.</span> </em>6:6823 doi: 10.1038/ncomms7823, 2015</li>
<li>Kaushik, S. Cuervo AM*. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. <em><span style="text-decoration: underline;">Nat. Cell. Biol. </span></em>17: 759-70, 2015</li>
<li>Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM*. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol. Cell</span> </em>59, 270-84, 2015</li>
<li>Kaushik, S. Cuervo AM*. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. <span style="text-decoration: underline;"><em>Autophagy.</em> </span>12(2):432-438, 2016</li>
<li>Maus M, Cuk M, Patel B, Lian J, Qimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do H-T, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.<span style="text-decoration: underline;"><em>Cell Metab</em></span> 25: 698-712, 2017</li>
<li>Beckerman P, Karchin JB, Park ASD , Dummer P, Soomro I, Boustany-Kari C, Pullen S Qiu C, Miner JH, Hu C-A, Rohacs T, Inoue K, Shuta I, Saleem M, Palmer M, Cuervo AM, Kopp J, Susztak K. Transgenic Expression of Human APOL1 Risk Variants in Podocytes Induces Kidney Disease in Mice. <span style="text-decoration: underline;"><em>Nat Med</em></span> 23: 429-438, 2017</li>
<li>&nbsp;Gomes LR, Menck, CFM, Cuervo AM*, Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. <em><span style="text-decoration: underline;">Autophagy</span></em> 13: 928-940, 2017</li>
<li>Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-, Mandelkow E, Cuervo AM*. Interplay of pathogenic forms of human tau with different autophagic pathways. <em><span style="text-decoration: underline;">Aging Cell</span> </em>17(1): doi: 10.2222/acel.12692, 2017 PMID: 29024336</li>
<li>Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM*, Muzumdar R. Humanin is an endogenous activators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">J Cell Biol</span> </em>&nbsp;&nbsp;217:635-647, 2018 PMID:2918752</li>
<li>Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. <em><span style="text-decoration: underline;">Autophagy</span> </em>doi: 10.1080/15548627.2018.1474992, 2018</li>
<li>Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. <em><span style="text-decoration: underline;">Aging Cell</span> </em>&nbsp;doi: 10.1111/acel.12777, 2018</li>
<li>Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS Farnesyl Transferase Inhibition for the Treatment of Tauopathies.<em><span style="text-decoration: underline;"> Science TM. </span></em>2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed. aat3005.</li>
<li>Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. <em><span style="text-decoration: underline;">PLOs Biology</span></em>, 17(5):e3000301. doi: 10.1371/journal.pbio.3000301, 2019</li>
<li>Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo. <span style="text-decoration: underline;"><em>Nature Comm.</em></span>&nbsp;11(1):645. doi: 10.1038/s41467-019-14164-4, 2020</li>
<li>Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D&rsquo;Alessandro A, Will B, Cuervo AM. Chaperone-mediated autophagy sustains hematopoietic stems cell function. <span style="text-decoration: underline;"><em>Nature</em> </span>591:117-123, 2021&nbsp;</li>
<li>Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate A, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Inhibition of chaperone-mediated autophagy by acetylated tau promotes disease propagation. <span style="text-decoration: underline;"><em>Nat. Comm.</em></span> 12(1):2238 doi: 10.1038/s41467-021-22501-9, 2021</li>
<li>Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. <span style="text-decoration: underline;"><em>Cell</em> </span>184: 1-19&nbsp; doi: 10.1016/j.cell.2021.03.048, 2021</li>
<li>Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu Vincent, Krause GJ, Jafari M, Singh R, Mu&ntilde;<span lang="EN-GB" style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">oz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated </span><span style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">autophagy and the circadian clock. <em><u>Nat. Cell Biol.</u> 23(12):1255-1270 10.1038/s41556-021-00800-z. 2021, 2022</em></span></li>
<li>Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernald DF, Diaz A, Tasset I, Mart&iacute;n-Segura A, Gijbel MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker A, Jin H, Sibinga N, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berb&eacute;e JFP, Pasterkamp G, Sluimerc JC, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">.</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">&nbsp;</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Protective role of chaperone-mediated autophagy against atherosclerosis. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Proc. Nat. Acad. Sci.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> Inaugural Paper, 2022</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">119(14):e2121133119. doi: 10.1073/pnas.2121133119, 2022</span></li>
<li>Barbaro JM, Sidoli S, Cuervo AM, Berman JW. <span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis.</span> <em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u>B</u></em><em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u><span style="font-size: 11pt; line-height: 115%;">iomedicines</span></u></em><span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">. 10(6):1257., 2022</span></li>
<li>Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fern&aacute;ndez O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Aging Cell.</u> </em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">e13713. doi: 10.1111/acel.13713, 2022</span></li>
<li>Rovira M, Sereda R, Pladevall-Morera D, Ramponi V, Marin I, Maus M, Madrigal-Matute J, D&iacute;az A, Garc&iacute;a F, Mu&ntilde;oz J, Cuervo AM, Serrano M. The lysosomal proteome of senescent cells contributes to the senescence secretome. <em><u>Aging Cell.</u></em><span style="font-size: 11pt; line-height: 115%;"> e13707. doi: 10.1111/acel.13707, 2022</span></li>
<li>Gomez-Sintes R Xin Q, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, McCabe M, Dong S, Reynolds CA, Patel B de la Villa P, Macian F, Boya P, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Targeting NCoR-RAR interaction activates chaperone-mediated autophagy and protects against retinal degeneration. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Nat. Comm</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. 13(1): 4220, doi: 10.1038/s41467-022-31869-1, 2022</span></li>
<li>Kaushik S, Juste YR, Lindenau K, Dong S, Macho-Gonzales A, Santiago-Fernandez O, McCabe M, Singh R, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Chaperone-mediated autophagy regulates adipocyte differentiation. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Sci. Adv.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> 8 (46) DOI: 10.1126/sciadv.abq2733 , 2022</span></li>
</ol>
<p><em>RECENT REVIEWS</em></p>
<ol>
<li>Kaushik S, Cuervo AM. Proteostasis and aging. <span style="text-decoration: underline;"><em>Nat Med.</em></span> 21:1406-15, 2015</li>
<li>Tekirdag KA, Cuervo AM. Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. <em><span style="text-decoration: underline;">J. Biol. Chem</span>. </em>&nbsp;293:5414-5424, 2018</li>
<li>Kaushik K, Cuervo AM. The coming of age of Chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Rev. Cell. Mol. Biol.</span></em> Doi: doi.org/10.1038/s41580-018-0001-6, 2018</li>
<li>Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Selective autophagy as a potential therapeutic target for neurodegenerative disorders. <em><span style="text-decoration: underline;">Lancet Neuro</span></em><span style="text-decoration: underline;">l</span> 17(9):802-815, 2018</li>
<li>Arias E, Cuervo AM. Pros and cons of chaperone-mediated autophagy in cancer. <span style="text-decoration: underline;"><em>Trends. Endocrinol Metab</em></span>. S1043-2760(19)30208-5. doi: 10.1016/j.tem.2019.09.007, 2019</li>
<li>Krause GJ, Cuervo AM. Assessment of mammalian endosomal microautophagy. <span style="text-decoration: underline;"><em>Methods Cell Bio</em></span><em>l</em> 164:167-185, 2021</li>
<li><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span><span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Autophagy and the Hallmarks of Aging. <em><u>Ageing Res Rev.</u></em></span> <span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;doi: 10.1016/j.arr.2021.101468, 2022</span></li>
<li>Jafari, M., McCabe, M, <strong>Cuervo AM</strong>. <span style="text-align: justify; text-indent: -22.5pt; font-family: Arial, sans-serif; font-size: 11pt;">Chaperone-mediated autophagy: mechanisms and physiological relevance &nbsp;<em><u>Current. Opin. Physiol</u>. </em>Available online 26 September 2022. doi: doi.org/10.1016/j.cophys.2022.100597</span></li>
</ol>

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Charles B. Hall

Submitted by Anonymous (not verified) on
Full Name
Charles B. Hall
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/6913-charles-hall.jpg
Type
Faculty
Expert
First Name
Charles
Last Name
Hall
Faculty ID
6913
Patient Type
Adult
Department
einstein-dept-epidemiology-population-health
einstein-dept-neurology
Email
charles.hall@einsteinmed.edu
Phone
718-430-3724
Titles
Type
Academic
Department
Department of Epidemiology & Population Health
Department Link
Rank
Professor
Tags
me-patientcare-cancer-research-epidemiology
Division
Biostatistics
Type
Academic
Department
The Saul R. Korey Department of Neurology
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Professor
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312
Address Line 1
Albert Einstein College of Medicine
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Jack and Pearl Resnick Campus
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1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Charles Hall has been a senior biostatistician for the Einstein Aging Study (EAS) since 2001. The EAS, a longitudinal research study that focuses on the aging brain, is one of the longest running of its kind in the United States. A biostatistician by training, Dr. Hall investigates the connection between cognitive activities and the onset of age-related diseases such as Alzheimer&rsquo;s and dementia. His long-term observational research have shown that brain-stimulating activities have a positive correlation with delayed dementia onset and progression. Such findings support the hypothesis that education along with brain exercise&mdash;through endeavors such as reading, writing, group discussions and crossword puzzles&mdash;can help the brain build up extra defenses to fight off neuronal damage caused by age-related diseases.</p>
<p>In recent years Dr. Hall's main work has been as lead statistician for the World Trade Center (WTC) Health Program at the Fire Department of the City of New York. Dr. Hall has been Principal Investigator on four Cooperative Agreements funded by the National Institute of Occupational Safety and Health that examine respiratory disease, cancer, and mortality in WTC rescue/recovery workers and has contributed to other research on the health effects of the exposure.&nbsp;</p>

Specialties
Areas of Expertise
Change-point models
Cognitive reserve
Longitudinal data analysis
Survival analysis
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hall is a biostatistician recognized for leading important long-term studies of aging and dementia. His research has shown, for example, that brain-stimulating activities delay the onset of dementia. He is the longtime director of the statistical core of the Einstein Aging Study, one of the longest-running prospective studies of aging in the country. He is also the lead statistician for the data coordinating center of the federally funded World Trade Center (WTC) Medical Monitoring &amp; Treatment Program, which provides free health monitoring and treatment for workers and volunteers involved in the rescue, recovery and clean-up activities at the WTC site in New York City.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In his aging studies, Dr. Hall has pioneered the use of change-point models &ndash; powerful statistical tools for detecting subtle but meaningful changes in data. He has used these models to show that having more years of formal education or engaging in cognitively stimulating leisure activities appear to protect against developing clinical dementia symptoms.</span></p>

CHAM Provider
Off
Professional Title
Ph.D.
Selected Publications

<p>&nbsp;</p>
<p>A complete list of publications can be found at <a href="http://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">NCBI</a… /><br /></p>

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Jan Vijg

Submitted by Anonymous (not verified) on
Full Name
Jan Vijg
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Vijg_Jan_2x.jpg
Type
Faculty
Expert
First Name
Jan
Last Name
Vijg
Faculty ID
11318
Patient Type
Adult
Department
einstein-dept-genetics
einstein-dept-ophthalmology-visual-sciences
Email
jan.vijg@einsteinmed.edu
Phone
718-678-1151
Titles
Type
Academic
Department
Department of Genetics
Department Link
Rank
Professor
Type
Academic
Department
Department of Ophthalmology & Visual Sciences
Department Link
Rank
Professor
Type
Administrative
Title
Chair, Department of Genetics
Type
Administrative
Title
Lola and Saul Kramer Chair in Molecular Genetics
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845838 40.8516937)
Room
450
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Michael F. Price Center
Address Line 3
1301 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p><strong>Genome Instability in Aging and Disease</strong></p>
<p>Genome instability, i.e., the tendency of the genome to acquire mutations and epimutations, underlies human genetic disease, causally contributes to cancer and has also been implicated in aging and age-related, degenerative conditions other than cancer. Little is known about the mechanisms that give rise to spontaneous changes in the genome or epigenome and how this may lead, in somatic cells, to increased cancer risk and loss of organ and tissue function with age. We study genome and epigenome instability as a function of age in various model organisms, including mouse and fruit fly, and its consequences in terms of alterations in tissue-specific patterns of gene regulation.</p>
<p>In the past we developed transgenic reporter systems in mouse and fruit fly, which allowed us to determine tissue-specific frequencies of various forms of genome instability, e.g., point mutations, deletions, translocations. By crossing the mutational reporter animals with mutants harboring specific defects in various genome maintenance pathways, the relevance of these pathways for the accumulation of specific forms of genome instability is assessed, in relation to the pathophysiology of aging. Similarly, by using knockdown approaches we assess the effect of specific genes implicated in longevity and healthy aging, e.g., SOD, FOXO, SIR2, on genome integrity.</p>
<p>We are currently focused on single-cell genomics to assess mutation frequencies and spectra in human tissues during aging. To gain insight into the possible functional consequences of random somatic mutations we use single-cell multiomics assays to link specific mutations to transcriptional and translational end point.&nbsp;</p>
<p><strong>Projects</strong></p>
<p><a href="http://einstein.yu.edu/departments/genetics/research/aging-program-proj… Program Project</a></p>
<p><strong> People</strong></p>
<ul>
<li>Yolanne Blake</li>
<li>Shixiang Sun</li>
<li>Moonsook Lee</li>
<li>Zhenqiu Huang</li>
<li>Alex Maslov</li>
<li>Johanna Heid</li>
<li>Yujue Wang</li>
<li>Julian Gingold</li>
<li>Olivia Albert</li>
<li>Ronald Cutler</li>
</ul>

Research Areas
Areas of Research: Genome instability as a possible cause of aging; genome maintenance and its role as a longevity assurance system; epigenetics of aging and cancer; single-cell genomics and epigenomics
Specialties
Expert Tags
Areas of Expertise
DNA mutation analysis
DNA repair
Ultra-high-throughput genomics and epigenomics
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Vijg studies the molecular genetic changes associated with aging. Instability of genome and epigenome &ndash; the entire set of an organism&rsquo;s genes and the switches that control their activity &ndash;&nbsp; has long been implicated as the main cause of cancer and of the loss of organ and tissue function associated with aging.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Vijg&rsquo;s research team was the first to develop a transgenic animal model for studying how mutations in human genes affect aging in a living organism. Since then, he has developed new versions of this mouse model that aid researchers in monitoring ongoing changes in DNA in different tissues or during various developmental stages over the course of the lifespan. Currently, Dr. Vijg uses next-generation sequencing to directly quantify and characterize mutations and epimutations in cells and tissues of aging organisms. An important component of these studies is the development of new methods for analyzing genome and epigenome in single cells to better understand intra-tissue heterogeneity during aging and in relation to cancer.</span></p>

CHAM Provider
Off
Professional Title
Ph.D.
Selected Publications

<p><strong>Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dollé MET, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J.</strong> Increased cell-to-cell variation in gene expression in aging mouse heart. <em>Nature</em> 2006;441:1011-1014.</p>
<p><strong>Vijg J, Campisi J.</strong> Puzzles, promises and a cure for ageing. <em>Nature</em> 2008;454: 1065.<br>
<strong>White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J. </strong>Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing. Nat Commun. 2015;6:6790.</p>
<p><strong>Gravina S, Dong X, Yu B, Vijg J.</strong> Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome. Genome Biol. 2016;17:150.</p>
<p><strong>Dong X, Milholland B, Vijg J.</strong> Evidence for a limit to human lifespan. Nature 2016; 538:257–259. PMID:27706136.</p>
<p><strong>Dong X, Zhang L, Milholland B, Lee M, Maslov AY, Wang T, Vijg J.</strong> Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nat Methods 2017;14:491-493. PMC5408311</p>
<p><strong>Zhang L, Dong X, Lee M, Maslov AY, Wang T, Vijg J.</strong> Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. Proc Natl Acad Sci USA 2019;116:9014-9019. PMC650011</p>
<p><strong>Brazhnik K, Sun S, Alani O, Kinkhabwala M, Wolkoff AW, Maslov AY, Dong X, Vijg J.</strong> Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver. Sci Adv. 2020;6:eaax2659. PMC6994209</p>
<p><strong>Vijg J, Dong X</strong>. Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging. Cell 2020;18:12-23.</p>
<p><strong>Zhang L, Dong X, Tian X, Lee M, Ablaeva J, Firsanov D, Lee S-G, Maslov AY, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J.</strong> Maintenance of genome sequence integrity in long- and short-lived rodent species. Sci Adv 2021;7:eabj3284. PMC8550225</p>
<p><strong>Huang Z, Sun S, Lee M, Maslov AY, Shi M, Waldman S, Marsh A, Siddiqui T, Dong X, Peter Y, Sadoughi A, Shah C, Ye K, Spivack SD, Vijg J.</strong> Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. Nat. Genet. 2022;54:492-498. </p>
<p> </p>

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Joe Verghese

Submitted by Anonymous (not verified) on
Full Name
Joe Verghese
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Verghese_Joe_MB_BS_MS_2x.jpg
Type
Faculty
First Name
Joe
Last Name
Verghese
NPI
1235214545
Faculty ID
5323
CMO Specialties
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-neurology
einstein-dept-medicine
Languages
Hindi
Gender
Male
Email
joe.verghese@stonybrookmedicine.edu
Phone
631-444-2599
Titles
Type
Academic
Department
The Saul R. Korey Department of Neurology
Department Link
Rank
Adjunct Clinical Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Adjunct Clinical Professor
Division
Geriatrics
Type
Clinical
Title
Chief, Divisions of Cognitive & Motor Aging (Neurology) and Geriatrics (Medicine)
Type
Clinical
Type
Clinical
Title
Professor, The Saul R. Korey Department of Neurology
Type
Clinical
Title
Division Chief, Department of Medicine Geriatrics
Type
Clinical
Title
Director, Jack and Pearl Resnick Gerontology Center
Type
Clinical
Title
Director, The Saul R. Korey Department of Neurology Division of Cognitive & Motor Aging
Type
Clinical
Title
Murray D. Gross Memorial Faculty Scholar in Gerontology
Type
Clinical
Title
Professor, Department of Medicine (Geriatrics)
Type
Administrative
Type
Administrative
Type
Administrative
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87923 40.97199)
Address Line 1
6 Executive Plaza
City
Yonkers
State
NY
Zip
10701-6832
Location Title
Montefiore at 6 Executive Plaza
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.1151419 40.9086776)
Address Line 1
Stony Brook University
Address Line 2
101 Nicolls Road
City
Stony Brook
State
NY
Zip
11794
Location Title
Stony Brook University
Education and Trainings
Education Type Label
Fellowship
Education Institution
Albert Einstein College of Medicine
Education Type Label
Residency
Education Institution
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Joe Verghese graduated from St. Johns Medical College, Bangalore, India in 1989. He did his postgraduate training in Internal Medicine and Neurology in United Kingdom. He completed his Neurology residency at the Albert Einstein College of Medicine, Bronx, NY in 1998. He did his fellowship training in Neurophysiology as well as Aging &amp; Dementia in 1999 at the same institution. He received a Master of Science degree in Clinical Research Methods with Distinction in 2001. Dr Verghese is board-Certified in Neurology.</p>
<p>Dr. Verghese is Professor of Neurology and Medicine, Murray D. Gross Memorial Faculty Scholar in Gerontology, and Director, Resnick Gerontology Center at Einstein. He is the Chief of the Division of Cognitive and Motor Aging (Neurology), and former Chief of Geriatrics (Medicine 2012-2023).</p>
<p>Dr. Verghese is a recipient of the Beeson award from the National institute on Aging as well as national awards from the American Geriatrics Society and the Gerontological Society of America. His research interest is the effects of disease and aging on mobility and cognition in older adults. He has over 300 peer-reviewed publications, and several current and past federally funded grants in this area. His current projects include non-pharmacological interventions to prevent dementia, the role of divided attention tasks such as walking while talking in predicting outcomes such as disability and cognitive decline, pre-dementia syndromes (Motoric Cognitive Risk syndrome), and global health studies.</p>

Research Areas
Effects of disease and aging on gait and cognition in older adults. Influence of cognitively stimulating activities on reducing risk of dementia and mobility loss, cognitive control of mobility, and global health
Specialties
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Joe Verghese is a board-certified neurologist and expert on aging who assesses how diseases and aging affect cognitive ability and mobility in older adults. Among his current projects, he is evaluating the effectiveness of a non-invasive brain stimulation technique intended to alleviate symptoms of Alzheimer&rsquo;s disease and improve brain function. He is also conducting studies across the world to identify the causes of cognitive impairment and risk factors for Alzheimer&rsquo;s disease and dementia.</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. is a recipient of the Beeson award from the National Institute on Aging and the Outstanding Scientific Achievement for Clinical Investigation Award from the American Geriatrics Society. He has over 250 publications in his areas of expertise.</p>

CHAM Provider
Off
Professional Title
M.B.,B.S.
M.S.
Clinical Focus

Dr. Verghese focuses on the care of older adults with cognitive concerns.&nbsp;

Research Focus

Dr. Verghese&rsquo;s research focus is the effects of disease and aging on mobility and cognition in older adults, and he leads several federally funded projects in these areas.

Selected Publications

<p>Verghese J, Lipton RB, Katz MJ, Hall CB, Kuslansky G, Buschke H. Abnormality of Gait As A Predictor Of Non-Alzheimer Dementia. N Engl J Med 2002 ; 347: 1760-1767. Verghese J, Lipton RB, Katz MJ, Hall CB, Kuslansky G, Derby CA, Ambrose AF, Sliwinski M, Buschke H. Leisure activities and the risk of dementia in the elderly. N Engl J Med 2003; 348: 2508-2516. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ. Low blood pressure and the risk of dementia in very old individuals. Neurology 2003; 61: 1667-1672. Verghese J, Levalley A, Hall CB, Katz M, Ambrose AF, Lipton RB. Epidemiology of gait disorders in community residing elderly. J Am Geriatr Soc 2006, 54(2):255-61. Holtzer R, Verghese J, Xue X, Lipton R. Cognitive processes related to gait velocity: Results from the Einstein Aging Study. Neuropsychology 2006; 20(2):215-23. Verghese J, LeValley A, Derby C, Kuslansky G, Katz M, Hall C, Buschke H, Lipton RB. Leisure Activities And The Risk of Amnestic Mild Cognitive Impairment In The Elderly. Neurology 2006; 66(6):821-7. Verghese J, Holtzer R, Lipton R, Wang C. Quantitative Gait Markers And Risk of Incident Falls in Older Adults. <em>J Gerontol Med Sci</em> 2009; 64: 896-901.&nbsp; Rolita L, Holtzer R, Wang C, Lipton RB, Derby CA, Verghese J.&nbsp; Homocysteine and Mobility in Older Adults.&nbsp; <em>J Am Geriatr Soc. 2010; 58:545-50.V</em>erghese J<strong>, </strong>Holtzer R.&nbsp; Walking the Walk While Talking: Cognitive Therapy for Mobility in Dementia? <em>Neurology 2010; 74:1938-9; </em>Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. <em>Journal of Gerontology: Medical Sciences </em>2012<em><strong>; </strong></em>Verghese J, Noone ML, Johnson, B,<sup>&nbsp; </sup>Ambrose AF, Wang C, Buschke H, Pradeep VG, Salam KA, Shaji KS, Mathuranath PS. Picture Based Memory Impairment Screen For Dementia.<em> Journal of the American Geriatrics Society</em>, 2012; 60(11):2116-20.&nbsp;</p>
<p><em>&nbsp;</em></p>

EMR ID
4090
Biography

<p>Joe Verghese, MBBS, MS, is Chief, Division of Cognitive and Motor Aging and Chief, Division of Geriatrics at Montefiore. He is the founding Director of the Montefiore-Einstein Center for the Aging Brain, an interdisciplinary cognitive assessment center. He is also Professor of Neurology and Medicine at our Albert Einstein College of Medicine. Dr. Verghese&rsquo;s clinical focus is dementia and cognitive impairment.</p><p>In 1989, Dr. Verghese received his Bachelor of Medicine, Bachelor of Surgery at St. John&rsquo;s Medical College in India. Dr. Verghese obtained his Membership in the Royal College of Physicians of Ireland (M.R.C.P.I) in 1994. From 1995 to 1999, Dr. Verghese trained at Albert Einstein College of Medicine. During this time, he completed a residency in neurology, becoming Chief Resident in his final year, as well as two fellowships---one in aging and dementia and one in neurophysiology.He then attended Albert Einstein College of Medicine, where he received his Master of Science with distinction in clinical research methods in 2001.</p><p>Expanding on his clinical specialties, Dr. Verghese&rsquo;s research focuses on the effects of disease and aging on mobility and cognition in older adults. His work has been published in over 200 peer-reviewed journals, books and medical articles.</p><p>In 2010 and 2018, Dr. Verghese was named Mentor of the Year in the Clinical Research Training Program at Albert Einstein College of Medicine.</p><p>Dr. Verghese is board certified by the American Board of Neurology and Psychiatry. He is a member of numerous professional societies including the International Society to Advance Alzheimer&rsquo;s Research and Treatment, the American Neurological Association, American Geriatrics Society and the National Clinical Research Forum.</p>

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Richard B. Lipton

Submitted by Anonymous (not verified) on
Full Name
Richard B. Lipton
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/b07d5c20-c947-11ed-8462-993dfb204153.jpg
Type
Provider
Faculty
Expert
First Name
Richard
Last Name
Lipton
NPI
1407931728
Faculty ID
7405
CMO Specialties
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-neurology
einstein-dept-psychiatry-behavioral-sciences
einstein-dept-epidemiology-population-health
Gender
Male
Email
richard.lipton@einsteinmed.edu
Phone
718-430-3886
Titles
Type
Academic
Department
The Saul R. Korey Department of Neurology
Department Link
Rank
Professor
Tags
me-patientcare-neurology-about-team
me-patientcare-neurology-programs-headachecenter
me-patientcare-neurology-programs-centerfortheagingbrainteam
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Professor
Type
Academic
Department
Department of Epidemiology & Population Health
Department Link
Rank
Professor
Division
Epidemiology
Type
Administrative
Title
Edwin S. Lowe Chair in Neurology
Type
Administrative
Title
Vice Chair, The Saul R. Korey Department of Neurology
Type
Administrative
Title
Director, Montefiore Headache Center
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8444 40.85103)
Address Line 1
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461-1900
Location Title
Montefiore at AECOM
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Van Etten
Room
3C12C
Address Line 1
Albert Einstein College of Medicine
Address Line 3
1225 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Chicago Pritzker School of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
Professional Interests

<p>Richard B. Lipton, M.D., is the Edwin S. Lowe Professor and Vice Chair of Neurology, Professor of Epidemiology and Population Health and Professor of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine.&nbsp;Dr. Lipton earned his medical degree at the University of Chicago Pritzker School of Medicine. After a medical internship at Northwestern Memorial Hospital, he completed his neurology residency and clinical neurophysiology fellowship at the Albert Einstein College of Medicine. He also completed a fellowship in neuroepidemiology at Columbia University. He is a diplomate of the American Board of Psychiatry and Neurology and a fellow of the American Academy of Neurology.</p>
<p>His research focuses on cognitive aging, Alzheimer&rsquo;s disease and migraine headaches. He is the Principal Investigator of the Einstein Aging Study, an NIH funded Program Project, and collaborates on several R01s.&nbsp; His research focuses on risk factors and biomarkers of cognitive decline and Alzheimer&rsquo;s disease. His recent studies examine cognitive aging across the lifespan with an emphasis on the effects of pain and stress on brain function.</p>
<p>His headache research focuses on the epidemiology of migraine and on clinical trials.&nbsp; His epidemiologic studies have evaluated trigger factors for headache attacks and risk factors for headache progression.&nbsp;Dr. Lipton has published more than 800 original articles, many with trainees.&nbsp; He is a&nbsp;5 time winner of the H.G. Wolff Award for excellence in headache research from the American Headache Society and a two time winner of the Enrico Greppi award from the European Headache Federation.&nbsp; Dr. Lipton is Director of the Montefiore Headache Center, an interdisciplinary subspecialty center focused on headache, patient care,&nbsp;research and education.</p>
<p>Dr. Lipton holds leadership positions in several professional societies. He is a Past-President of the American Headache Society (AHS).&nbsp; He serves on the editorial boards of several journals, including Neurology. He has written 11 books. Dr. Lipton enjoys mentoring medical students, residents, PhD students and fellows.&nbsp; Over the last decade he has mentored 7 CRTP students and&nbsp;10 K-award recipients. He has received both the CRTP Mentor of the Year Award and the Einstein Faculty Mentoring Award.&nbsp;</p>
<p>Dr. Richard Lipton was a speaker at the inaugural Migraine World Summit in 2016. <a id="mb1" title="Lipton at Migraine World Summit 2016" href="http://einstein.yu.edu/departments/neurology/video.asp?videourl=/depart…; target="_blank" rel="noopener videos">Click here for the video.</a></p>

Research Areas
I study migraine headaches, cognitive aging and dementia. My work includes longitudinal population studies that link stress, pain and cognitive performance to genetics, biomarkers and neuroimaging.
Specialties
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A noted authority on headaches and migraine, Dr. Lipton is director of the Montefiore Headache Center, recognized internationally for its leadership in the diagnosis, classification and treatment of headache disorders. Dr. Lipton is also director of the Einstein Aging Study, which has been examining both normal brain aging and the special challenges of Alzheimer&rsquo;s disease and other dementias since 1980.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A prolific researcher and writer, Dr. Lipton has published eight books and more than 600 original articles and reviews. He is a recipient of the Medical Book Award from the British Medical Association for his text<span>&nbsp;</span><em>Headache in Clinical Practice</em>. He is also an associate editor of<span>&nbsp;</span><em>Cephalalgia: An International Journal of Headache</em><span>&nbsp;</span>(the journal of the International Headache Society) and sits on the editorial boards of several journals, including<span>&nbsp;</span><em>Neurology</em>. He is a three-time recipient of the H.G. Wolff Award for excellence in research from the American Headache Society (AHS).&nbsp; Dr. Lipton serves on the advisory council of the International Headache Society and is a former president of the AHS. He is also professor of psychiatry and behavioral sciences and of epidemiology &amp; population health at Einstein.</span></p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

Dr. Lipton&rsquo;s clinical work focuses on headache medicine, particularly chronic migraine.&nbsp; He is interested in integrative approaches that combine pharmacologic and behavioral treatments with neuromodulatory devices in a patient-centered fashion.&nbsp; The Montefiore Headache Center has a large full-time faculty and trains two fellows in headache medicine annually.

Research Focus

Dr. Lipton's research interests include clinical trials on headache disorders, Alzheimer's disease, and other dementias. I also conduct epidemiologic studies and develop outcome measures in both areas.<quillbot-extension-portal></quillbot-extension-portal>

Selected Publications

<p class="MsoNormal" style="text-autospace: ideograph-numeric ideograph-other;"><strong style="mso-bidi-font-weight: normal;"><u><a href="https://www.ncbi.nlm.nih.gov/myncbi/1dWheFdF_r05E/bibliography/public/"… style="color: windowtext;">https://www.ncbi.nlm.nih.gov/myncbi/1dWheFdF_r05E/bibliography/public/<…;

EMR ID
3377
Is Open Scheduling
Off

Gary J. Kennedy

Submitted by Anonymous (not verified) on
Full Name
Gary J. Kennedy
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Kennedy_Gary_J_MD_3697.jpg
Type
Provider
Faculty
Expert
First Name
Gary
Last Name
Kennedy
NPI
1669543047
Faculty ID
7739
CMO Specialties
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-psychiatry-behavioral-sciences
Gender
Male
Email
gkennedy@montefiore.org
Phone
718-920-6270
Titles
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Professor
Tags
me-neuroscience-psychiatry-team
Type
Administrative
Title
Vice Chair for Education, Department of Psychiatry and Behavioral Sciences
Type
Administrative
Title
Director, Division of Geriatric Psychiatry, Montefiore Medical Center
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Building
Klau
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Texas, San Antonio
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
University of Texas, San Antonio
Professional Interests

<p>Dr. Gary Kennedy is the Vice Chair for Education and Professor of Psychiatry and Behavioral Sciences and Director of the Division of Geriatric Psychiatry and Fellowship Training Program at Montefiore Medical Center and Albert Einstein College of Medicine. More than sixty psychiatrists with subspecialty training in geriatrics have graduated from this program.</p>
<p>Dr. Kennedy&rsquo;s research has focused on cardiac arrhythmias, the epidemiology of depression and dementia, mental health care in nursing homes, primary care sites and in the community, and novel communications approaches between health care providers. He has authored numerous publications on late-life mental health and has given numerous invited presentations to educational, scientific, and public policy organizations in the United States and abroad.</p>
<p>Dr. Kennedy's numerous professional awards and achievements include the following:</p>
<ul>
<li>He has served as a consultant to the New York State Commission on Life and the Law regarding physician-assisted suicide and to the Law Revision Commission regarding guardianship procedures in New York State mental health law.</li>
<li>He was a member of the New York State Department of Health Advisory Work Group on Human Subject Research Involving Protected Classes.</li>
<li>He has been a member of the American Psychiatric Association Council on Aging.</li>
<li>He was a member of the Mental Disorders of Aging Initial Review Group and Chairperson of the Small Business Innovative Research Program Contract Reviews for the National Institute of Mental Health.</li>
<li>He has appeared on National Public Radio and the Today Show with Katie Couric.</li>
<li>He has received a New Investigator Award from the National Institute of Health, a travel study fellowship to the United Kingdom and Israel from the United States World Health Organization, and an Archstone Award for Program Innovation from the American Public Health Association.</li>
<li>He is a Fellow of the Brookdale Center on Aging of Hunter College and of the New York Academy of Medicine.</li>
<li>He was a member of the Group for the Advancement of Psychiatry.</li>
<li>He was the 2005-2007 chair of the Geriatric Mental Health Foundation, a Washington based 501c3 group advocating for the mental health and well being of senior Americans.</li>
<li>In 2006, he was asked by The Atlantic Philanthropies to design a Bermuda-specific mental health training program for older adults with mental illness.</li>
<li>In 2005, he was a Visiting Professor for the Geriatric Fellowship Training Program of the National Health Research Institute of Taiwan.</li>
<li>In 2003, he received an Annual Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill.</li>
<li>In 2003, he was invited to testify before the President's New Freedom Commission on Mental Health.</li>
<li>He was the 2002 President of the American Association for Geriatric Psychiatry.</li>
<li>The American Journal of Nursing cited his Geriatric Mental Health Care, published in 2000, as one of the best books of the year in gerontology.</li>
<li><span style="font-family: Arial;"><span style="font-size: medium;">In 2009&nbsp;he was member of&nbsp;the six person Professional Exchange Program sponsored by the Caring Commission of the United Jewish </span></span><span style="font-family: Arial;"><span style="font-size: medium;">Appeal-Federation of New York and JDC-ESHEL, The Association for the Planning and </span></span><span style="font-family: Arial;"><span style="font-size: medium;">Development of Services for the Aged in Israel</span></span></li>
<li><span style="font-family: Arial; font-size: medium;">He is a&nbsp;Life Fellow, American Psychiatric Association</span></li>
<li>In 2014&nbsp;he received the&nbsp;Julia and Leo Forchheimer Lifetime Achievement Award, New York Foundation for Elder Care</li>
<li>Since 1992, he has been listed as one of The Best Doctors in America.</li>
</ul>
<p>Dr. Kennedy's work has been supported by the National Heart, Lung and Blood Institute; the National Institute on Aging; the Forchheimer Foundation; the Resnick Gerontology Center; the New York State Department of Health; United Jewish Appeal-Federation; the JE &amp; ZB Butler Foundation; The University Place Foundation; the Irving Weinstein Foundation; The Goldstein Foundation; The United Hospital Fund; The New York Community Trust; the Robert Wood Johnson Foundation; The New York Foundation for Elder Care; and The Atlantic Philanthropies. He has also received unrestricted educational grants form Janssen Pharmaceutica, Pfizer Incorporated, and Forest Laboratories, as well as clinical research grants from Janssen Pharmaceutica, AstraZeneca, and Forest Laboratories.</p>
<p>Born in Dallas, Dr. Kennedy is an alumnus of the University of Texas in Austin and the University of Texas Health Science Center in San Antonio.</p>

Specialties
Areas of Expertise
Alzheimer’s and dementia
Prevention of cognitive impairment
Research for aging population
Depression in declining health
Expert Summary

<p>Dr. Kennedy is a nationally recognized expert on Alzheimer’s disease and dementia. He has been widely interviewed on network television on caregiving issues in dealing with loved ones with Alzheimer’s, and on maintaining cognitive abilities.</p>

CHAM Provider
Off
Professional Title
M.D.
Selected Publications

<p>Kennedy GJ, Hofer M, Cohen D, et al: Significance of depression and cognitive impairment in patients undergoing programmed stimulation of cardiac arrhythmias. Psychosom Med 49:410-421, 1987</p>
<p>Kennedy, GJ, Kelman HR, Thomas C, et al: Hierarchy of characteristics associated with depressive symptoms in an urban elderly sample. Am J Psychiatry 146:220-225, 1989&nbsp;</p>
<p>Kennedy, GJ, Kelman HR, Thomas C: Emergence of depressive symptoms in late life; the importance of declining health and increasing disability. J Community Health, 15:93-104, 1990</p>
<p>Kennedy GJ, Kelman HR, Thomas C: Persistence and remission of depressive symptoms in late life. Am J Psychiatry 148:174-178, 1991</p>
<p>Thomas C, Kelman HR, Kennedy GJ, Ahn C, Yang C-Y: Depressive symptoms and mortality in the elderly. J Gerontology: Social Sciences 47:S80-87, 1992</p>
<p>Kelman HR, Thomas C, Kennedy GJ, Chen J: Cognitive impairment and mortality among older community residents. J Amer Pub Health 84:1255-1260, 1994</p>
<p>Kennedy GJ, Katsnelson N, Laitman L, Alvarez E: Psychogeriatric services in certified home health agencies; case reports and guidelines for the psychiatric consultant. Am J Geriatric Psychiatry 3:339-347, 1995</p>
<p>Kelman HR, Thomas C, Kennedy GJ, Chen J: Cognitive impairment and the quality of life of elderly urban community residents. Proceedings of the 25th Public Health Conference on Records and Statistics and the National Committee on Vital and Health Statistics DHHS Pub No. (PHS) 96-1214, 181-186, 1995</p>
<p>Suicide and Depression in Late Life; Critical Issues in Treatment, Research and Public Policy. GJ Kennedy ed., Einstein Monograph Series in Clinical and Experimental Psychiatry, Wiley &amp; Sons Inc, NY 1996</p>
<p>Kennedy GJ, Kelman HR, Thomas C, Chen J: The relation of religious preference and practice to depressive symptoms among 1855 older adults. J Gerontology; Psychological Science 51B:P301-P308, 1996</p>
<p>Lindenmayer JP, Negron AE, Shah S, Lowinger R, Kennedy G, Bark N, Hyman R: Cognitive deficits and psychopathology in elderly schizophrenic patients. Am J Geriatric Psychiatry 5:31-42, 1997</p>
<p>Colenda CC, Greenwald BS, Crosset JHW, Husain MM, Kennedy GJ: Provider barriers to effective psychiatric services for the elderly. Psychiatric Services 48:321-325, 1997</p>
<p>Kennedy GJ, Frazier A: Medical comorbidity and mental disorders in the elderly. Current Opin Psychiatry 12:451-455, 1999</p>
<p>Kennedy GJ, Goldstein MZ, Northcott C, et al: Evolution of the geriatric curriculum in general residency training: recommendations for the coming decade. Academic Psychiatry 23:1-11, 1999</p>
<p>Magai C, Kennedy GJ, Cohen C, Gomberg D: A controlled clinical trial of sertraline in the treatment of depression in nursing home residents. Am J Geriatric Psychiatry 8:66-75, 2000</p>
<p>Kennedy GJ, Tanenbaum, S: Suicide and Aging: International Perspectives. Psychiatric Quart 71:345-362, 2000</p>
<p>Kennedy GJ, Geriatric Mental Health Care; A Treatment Guide for Health Professionals,Guilford Publications, Inc. New York 2000</p>
<p>Kennedy GJ, Scalmati A: The interface of depression and dementia. Curr Opin Psychiatry 14:367-369, 2001</p>
<p>Kennedy GJ. Telephone-facilitated treatment of depression in primary care using the PHQ-9. Primary Psychiatry 11(6): 18-21, 2004</p>
<p>Cooney LM, Kennedy GJ, Hawkins KA, Hurme SB. Who can stay at home: Assessing the capacity to choose to live in the community. Archives of Internal Medicine 164:357-360, 2004</p>
<p>Kennedy GJ. Will more antidepressants mean fewer suicides in late life? Primary Psychiatry 12(1): 26-29 2005</p>
<p>Horowitz A, Reinhardt AP, Kennedy GJ. Major and subthreshold depression among older adults seeking vision rehabilitation services. American Journal of Geriatric Psychiatry 13:180-187, 2005</p>
<p>Kennedy GJ, Marcus P. Use of antidepressants in older patients with co-morbid medical conditions: Guidance from studies of depression in somatic illness. Drugs &amp; Aging 2005;22:273-87</p>
<p>Sakuaye K, Blank K, Cohen CI, Cohen GD, Kennedy GJ, Liptzin B, Schillerstorm J, Schultz S. Medicare managed mental health care: A looming crisis. Psychiatric Services 2005;56:795-798</p>
<p>Milstein G, Kennedy GJ, Bruce ML, et al. The clergy,s role in reducing stigma: A bi-lingual study of elder patients views. World Psychiatry 2005;4S1:28-34</p>
<p>Naturally occurring retirement communities: An expanding opportunity for health promotion and disease prevention. Primary Psychiatry 2006:13:33-35</p>
<p>Marcus P, Kennedy GJ, Wetherbee C, Korenblatt J, Dorta H. Training Professional Home Care Staff to Help Reduce Depression Among Elderly Home Care Patients. Clinical Geriatrics 2006;14:13-16 .</p>
<p>Milstein G, Kennedy GJ, Bruce ML, Flannelly KJ, Chelchowski N, Bone L. The clergy&rsquo;s role in reducing stigma: A bi-lingual study of elder patients&rsquo; views. World Psychiatry 2005;4S1:28-34</p>
<p>Sakuaye K, Blank K, Cohen CI, Cohen GD, Kennedy GJ, Liptzin B, Schillerstorm J, Schultz S. Medicare managed mental health care: A looming crisis. Psychiatric Services 2005;56:795-798</p>
<h1 align="left">Kennedy GJ. Pharmacologic Treatment of Dementia and Mild Cognitive Impairment: Critical Appraisal. Primary Psychiatry 2005;12:19-21</h1>
<p>Kennedy GJ. Editorial. Should primary care be the primary site of geriatric mental health care? Am J Geriatr Psychiatry 2005;13:745-747</p>
<p>Kennedy GJ. Caution vs. closure: The use of atypical antipsychotics for the treatment of behavioral disturbances in dementia. Primary Psychiatry 2005;12:16-19</p>
<p>Kennedy GJ. Psychotherapies and other psychosocial interventions for depression in late life: Innovation through hybridization. Primary Psychiatry 2005;12:16-20</p>
<p>Quam H, Kennedy GJ. Schizoaffective Disorder; Challenges of diagnosis and treatment in late life. Clinical Geriatrics 2006;14:13-16</p>
<p>Marcus P, Kennedy GJ, Wetherbee C, Korenblatt J, Dorta H. Training Professional Home Care Staff to Help Reduce Depression Among Elderly Home Care Patients. Clinical Geriatrics 2006;14:13-16</p>
<p>Kennedy GJ. Addressing the unmet promise of antidepressant trials in older adults. Primary Psychiatry 2006;13:24-27,36</p>
<p>Kennedy GJ, Herlands T. Missing elements in the treatment of depression and dementia. Primary Psychiatry 2006;13:24-26</p>
<p>Kennedy GJ. Naturally occurring retirement communities: An expanding opportunity for health promotion and disease prevention. Primary Psychiatry 2006:13:33-35</p>
<p>Kennedy GJ. The Sequenced Treatment Alternatives to Relive Depression (STAR*D) studies: How applicable are the results for older adults? Primary Psychiatry 2006:13:</p>
<p>Kennedy GJ, Golde TE, Tariot PN, Cummings JL. Amyloid-based interventions in Alzheimer&rsquo;s disease. CNS Spectrums 2007;12:1 (suppl 1) 1-16</p>
<p>Kennedy GJ. Reducing the Risk of Late-Life Suicide Through Improved Depression Care. Primary Psychiatry. 2007;14(1):26-28,31-34</p>
<p>Kennedy GJ. Exercise, aging and mental health. Primary Psychiatry 2007;14(4):23-28</p>
<p class="Default">Kennedy GJ. Insomnia in Late Life: New Perspectives on an Old Problem. Primary Psychiatry. 2007;14(7):29-36</p>
<p>Kennedy GJ. From Symptom Palliation to Disease Modification: Implications for Dementia Care. Primary Psychiatry. 2007;14(11):30-34</p>
<p>Kennedy GJ, Feldman BL. Prevention of Depression: Immediate Need But Distant Horizon. Primary Psychiatry 2007;14(9):28-34</p>
<p>Kennedy GJ. Bipolar Disorder in Late Life: Depression. Primary Psychiatry. 2008;15 (3):30-34</p>
<p>Kennedy GJ. Bipolar Disorder in Late Life: Mania. Primary Psychiatry. 2008;15(1):28-33</p>
<p>Kennedy GJ. Targets for Telephone-Based Behavioral Health Interventions. Primary Psychiatry. 2008;15(5):35-39</p>
<p>Kennedy GJ. Advances in the Treatment of Late-Life Psychotic Depression. Primary Psychiatry. 2008;15(7):</p>
<p>Kennedy GJ, Leon LA. Recent Advances in Dementia Research. Primary Psychiatry. 2008;15(11):27-30</p>
<p>Kennedy GJ. Geriatric Psychiatry and Cardiology: New perspectives on heart, brain, mood and cognition. Primary Psychiatry 2008;15(9):35-38</p>
<h2><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… E</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… C</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… M</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… T</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… S</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… A</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… LG</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… G</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… A</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;Cmd=Search&amp;T… RB</a>. Neuropsychological strategies for detecting early dementia. J Int Neuropsychol Soc. 2008 Jan;14(1):130-42</h2>
<p>Kennedy GJ, Smyth CA. Screening older adults for executive dysfunction: An essential refinement in the assessment of cognitive impairment. American Journal of Nursing 2008;108(12):60-69 (demonstration interview available at <a href="http://links.lww.com/A326">http://links.lww.com/A326</a&gt;)</p>
<p>Kennedy GJ, &nbsp;Smyth CA. Challenges of Screening for Executive Dysfunction&nbsp; Online-only content for &ldquo;Screening Older Adults for Executive Dysfunction,&rdquo; American Journal of Nursing, December. 2008, p. TK-TK at <a href="http://links.lww.com/TKTK">http://links.lww.com/TKTK</a></p&gt;
<p>Kennedy GJ,&nbsp; Smyth CA. More on the Validity of Brief Tests of Executive Function</p>
<p>Online-only content for &ldquo;Screening Older Adults for Executive Dysfunction,&rdquo; American Journal of Nursing, December. 2008, p. TK-TK. at <a href="http://links.lww.com/TKTK">http://links.lww.com/TKTK</a></p&gt;
<p>Kennedy GJ, Scalmati A. Notes from the 13th Annual Einstein Symposium on</p>
<p>The Comprehensive Approach to Dementia. Primary Psychiatry 2009;16(6):19-23</p>
<p>Kennedy GJ, Olson TR. &ldquo;Cadaver conference day&rdquo;: A psychiatrist in the gross anatomy course. Primary Psychiatry 2009;16(1):26-30</p>
<p>Friedman MB, Kennedy GJ, Williams KA. Cognitive camouflage &ndash; How Alzheimer&rsquo;s can mask mental illness. Aging Well 2009; 2(2):16</p>
<p>Kennedy GJ. Parkinson&rsquo;s disease and dementia. Primary Psychiatry 2009;16(4):19-23</p>
<p>Scalmati A, Kennedy GJ. Psychotherapy as end of life care: Special considerations for the older patient. Psychiatric Annals 2009;39(9):833-837</p>
<p>Kennedy GJ. Advanced Age, Dementia, and Driving: Guidance for the Patient, Family and Physician. Primary Psychiatry. 2009;16(8):</p>
<p>Kennedy GJ, George C, Lui YW. Dementia or Depression? Diagnostic Bias in Geriatric Practice. Primary Psychiatry. 2009;16(9):19-23</p>
<p>Sakauye K, Streim J, Kennedy GJ, Kerwin P, Llorente M, Schultz SK, Srinivasan S. Disaster preparedness for older Americans: Critical issues for the preservation of mental health. American Journal of Geriatric Psychiatry 2009; 17(12):916&ndash;924</p>
<p>Kennedy GJ, Kover E, Scalmati A. Mental Health Services for Holocaust Survivors</p>
<p>Notes from the 2009 Professional Exchange to Israel. Primary Psychiatry 2009;16(12): 2009</p>
<p>Kennedy GJ, Martinez MM, Garo N. Sex and mental health in old age. Primary Psychiatry. 2010;17(1):26-34</p>
<p>Kennedy GJ. Do the Longevity Genes Prevent Dementia? Primary Psychiatry. 2010;17(3):20-22</p>
<p>Kennedy GJ. Proposed Revisions for the Diagnostic Categories of Dementia in the DSM-5. Primary Psychiatry. 2010;17(5):26-28</p>
<p>Kennedy GJ, Kastenschmidt E. Prevention of dementia and cognitive decline: notes from the NIH-State-of-the- Science Conference. Primary Psychiatry. 2010;17(7):</p>
<p>Koh S, Blank K, Cohen C, Cohen G, Faison W, Kennedy G, Kyomen H, Liptzin B, Meador K, Rohrbaugh R, Busch B, Sakauye K, Schultz S, Streim J. Public&rsquo;s view of mental health services for the elderly: Responses to Dear Abby. Psychiatric Services 2010;61:1146&ndash;1149</p>
<p>Kastenschmidt EK, Kennedy GJ. Depression and anxiety in late life: diagnostic insights and therapeutic options. Mt Sinai Journal of Medicine 2011;78:527-545</p>
<p><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Roane%20DM%5BAuthor%5D&amp;caut… DM</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Tucker%20J%5BAuthor%5D&amp;caut… J</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Eisenstadt%20E%5BAuthor%5D&amp;… E</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Gomez%20M%5BAuthor%5D&amp;cauth… M</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Kennedy%20GJ%5BAuthor%5D&amp;ca… GJ</a>. Assessing the benefits of a geropsychiatric home-visit program for medical students.<a title="Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry." href="http://www.ncbi.nlm.nih.gov/pubmed?term=2012%5Bpdat%5D+AND+Roane+D%5Bau… Psychiatry.</a> 2012 May 1;36(3):216-8. doi: 10.1176/appi.ap.09090156.</p>
<p>Kennedy GJ, Scalmati A, Greenberg D. An Alliance for the Mental Health of Holocaust Survivors: Towards the Integration of Mental Health Services and Social Programs for Holocaust Survivors in New York City. <em>Kavod -</em> <em>Honoring Aging Survivors: A Professional Journal for Care Providers and Families </em>Issue 2, Winter, 2012&nbsp; http://kavod.claimscon.org/</p&gt;
<p>Pickett YR, Ghosh S, Rohs A, Kennedy GJ, Bruce ML, Lyness JM. Healthcare use among older primary care patients with minor depression. American Journal of Geriatric Psychiatry 2014;22(2):207-210.</p>
<p>Pickett YR, Kennedy GJ, Freeman K, Cummings J, William Woolis W. The Effect of Telephone-Facilitated Depression Care on Older, Medically Ill Patients. Journal of Behavioral Health Services &amp; Research 2014;41(1):90-96 PMID23572444</p>
<p>Kennedy GJ, Gardner L. The silver lining in the graying of American: Healthy aging is the new norm. Psychiatric Times 2013, October, vol. XXX, No. 10;20C-D &nbsp; &nbsp;&nbsp;</p>
<p>Ce&iuml;de, M E. Kennedy GJ. Psychosomatic Medicine. Addressing Psychosomatic Illness in the Elderly: Integrated Care. Psychiatric Times 2014: 36-37 Nov. 31(11):36-37</p>
<p class="desc">Kennedy GJ, Castro J, Chang M, Chauhan-James J, Fishman M <a href="https://www.ncbi.nlm.nih.gov/pubmed/27222136">Psychiatric and Medical Comorbidity in the Primary Care Geriatric Patient-An Update.</a> Curr Psychiatry Rep.&nbsp;2016&nbsp;Jul;18(7):62. doi: 10.1007/s11920-016-0700-7.</p>
<p class="desc">Kennedy GJ. <a href="https://www.ncbi.nlm.nih.gov/pubmed/27660195">Behavioral Interventions for Patients with Major Depression and Severe COPD.</a> Am J Geriatr Psychiatry.&nbsp;2016&nbsp;Aug 26. pii: S1064-7481(16)30219-6. doi: 10.1016/j.jagp.2016.08.012</p>
<p><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Mooney%20SJ%5BAuthor%5D&amp;c… SJ</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Joshi%20S%5BAuthor%5D&amp;cau… S</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Cerd%C3%A1%20M%5BAuthor%5D&am…; M</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kennedy%20GJ%5BAuthor%5D&amp;… GJ</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Beard%20JR%5BAuthor%5D&amp;ca… JR</a>,&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Rundle%20AG%5BAuthor%5D&amp;c… AG</a>. Neighborhood Disorder and Physical Activity among Older Adults: A Longitudinal Study. <a title="Journal of urban health : bulletin of the New York Academy of Medicine." href="https://www.ncbi.nlm.nih.gov/pubmed/28108872">J Urban Health.</a>&nbsp;2017&nbsp;Jan 20. doi: 10.1007/s11524-016-0125-y PMID: 28108872</p>
<p class="Title2">Mooney SJ, Joshi S, Cerd&aacute; M, Kennedy GJ, Beard JR, Rundle AG. <a href="https://www.ncbi.nlm.nih.gov/pubmed/28154108">Contextual Correlates of Physical Activity among Older Adults: A Neighborhood Environment-Wide Association Study (NE-WAS).</a> Cancer Epidemiol Biomarkers Prev.&nbsp;2017&nbsp;Apr;26(4):495-504. doi: 10.1158/1055-9965.EPI-16-0827. Epub&nbsp;2017&nbsp;Feb 2.</p>
<p>Mooney SJ, Joshi S, Cerd&aacute; M, Quinn JW, Beard J, Kennedy GJ, Benjamin EO, Ompad DC, Rundle AG. Patterns of Physical Activity among Older Adults in New York City: A Latent Class Approach. American Journal of Preventive Medicine (in press)</p>
<p><strong>BOOKS</strong></p>
<p><em>Selected Models of Practice in Geriatric Psychiatry</em>. The American Psychiatric Association Task Force on Models of Practice in Geriatric Psychiatry; MZ Goldstein, CC Colenda, GJ Kennedy, H Van Dooren, W Van Stone, DP Hay, J Sadovoy, American Psychiatric Association, Washington, D.C., 1993</p>
<p><em>Suicide and Depression in Late Life; Critical Issues in Treatment, Research and Public Policy. </em>Edited by GJ Kennedy, Einstein/Montefiore Monograph Series in Clinical and Experimental Psychiatry, John Wiley &amp; Sons, Inc.,New York, 1996</p>
<p><em>Geriatric Psychiatry Self-Assessment Program</em>, Editor-in-chief, GJ Kennedy, Kendal Hunt, Inc, 1999</p>
<p><em>Geriatric Mental Health Care; A Treatment Guide for Health Professionals </em>GJ Kennedy, Guilford Publications, Inc. New York 2000</p>
<p>Geriatric Depression: A Clinical Guide, Gary Kennedy, Guilford Publications, Inc. New York, 2015</p>

EMR ID
3344
Biography

<p>Gary J. Kennedy, MD, is Director, Geriatric Psychiatry and Geriatric Psychiatry Fellowship Training Program and Vice Chair for Education and Professor of Psychiatry and Behavioral Sciences at Montefiore Einstein. His clinical focus centers on depression and dementia, caregiver support and holocaust survivors. He also teaches nursing homes and collaborates with community-based agencies.</p><p>After obtaining his Bachelor of Arts in biology from the University of Texas at Austin in 1970, Dr. Kennedy earned his Doctor of Medicine at the University of Texas Health Science Center at San Antonio in 1975. He remained there to complete a psychiatry residency in 1979 before moving to Montefiore to complete a psychobiology research fellowship in psychosomatic medicine in 1981. Following this, Dr. Kennedy completed a geriatric psychiatry fellowship at Montefiore in 1983.</p><p>Building on his clinical focus, Dr. Kennedy&rsquo;s research is focused on cardiac arrhythmias, the epidemiology of depression and dementia, mental health care in nursing homes and primary care sites and in the community. He has a longstanding interest in improving communication between healthcare providers, especially around issues of depression and dementia care for both patients and their families. Dr. Kennedy&rsquo;s work has been published in numerous peer-reviewed citations, and he has considerable experience in the evaluation of research applications as well as mentoring new investigators.</p><p>Dr. Kennedy has won many awards for his work, including the Leo and Julia Forchheimer Foundation Lifetime Achievement Award in 2014. In 2023, he was named in America&rsquo;s Most Honored Doctors by The American Registry and in Castle Connolly&rsquo;s Top Doctors.</p>

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Nir Barzilai

Submitted by Anonymous (not verified) on
Full Name
Nir Barzilai
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https://assets.montefioreeinstein.org/profiles/images/nir-barzilai.jpg
Type
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Expert
First Name
Nir
Last Name
Barzilai
NPI
1235228727
Faculty ID
484
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-genetics
Languages
Hebrew
Gender
Male
Email
nir.barzilai@einsteinmed.edu
Phone
718-430-3144
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Endocrinology
Type
Academic
Department
Department of Genetics
Department Link
Rank
Professor
Type
Administrative
Title
Ingeborg and Ira Leon Rennert Chair in Aging Research
Type
Administrative
Title
Director, Institute for Aging Research
Locations
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POINT (-73.84563 40.84596)
Address Line 1
1575 Blondell Avenue
City
Bronx
State
NY
Zip
10461-2601
Location Title
Montefiore Medical Park at 1575 Blondell
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3444 Kossuth Avenue
City
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State
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Zip
10467-2241
Location Title
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POINT (-73.8459022 40.8504961)
Building
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Room
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Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
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Location Title
Albert Einstein College of Medicine
Education and Trainings
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Education Institution
Israel Institute of Technology
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Fellowship
Education Institution
Memorial Sloan Kettering Cancer Center
Education Type Label
Residency
Education Institution
Memorial Sloan Kettering Cancer Center
Education Type Label
Residency
Education Institution
Hadassah University Hospital
Education Type Label
Residency
Education Institution
Yale - New Haven Hospital
Professional Interests

<p>Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health&rsquo;s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology &amp; Diabetes and Geriatrics.</p>
<p>Dr. Barzilai&rsquo;s research interests are in the biology and genetics of aging. One focuses on the genetic of exceptional longevity, where we hypothesize and demonstrated that centenarians have protective genes, which allows the delay of aging or for the protection against age-related diseases. In a Program he is leading we take full advantage of phenotypes, DNA, and cells from the Ashkenazi Jewish families with exceptional longevity and the appropriate controls and his group have established at Einstein (over 2600 samples of which ~670 are centenarians) and discovered underling genomic differences associated with longevity. Longevity Genes Project (LGP) is a cross-sectional, on-going collection of blood and phenotype from families with centenarian proband. LonGenity is a longitudinal study of 1400 subjects, half offspring of parents with exceptional longevity, validating and following their aging in relationship to their genome. The second direction, for which Dr. Barzilai is holding an NIH Merit award that focuses on the metabolic decline of aging, and his team hypothesize that the brain leads this decline. His lab has identified several central pathways that specifically alter body fat distribution and insulin action and secretion by intraventricular or hypothalamic administration of several peptides that are modulated by aging including: Leptin, IGF-1, IGFBP3 and resveratrol.</p>
<p>He has received numerous grants, among them ones from the National Institute on Aging (NIA), American Federation for Aging Research, the Ellison Medical Foundation and The Glenn Medical foundation. He has published over 280 peer-reviewed papers, reviews, and textbook chapters. He is an advisor to the NIH on several projects and serves on several editorial boards and is a reviewer for numerous other journals. Dr. Barzilai is in the Scientific Director and on the board of the American Federation for Aging Research, is its co-scientific director, and has served on several NIA study section. He is also a founder of CohBar Inc., a biotech that develops mitochondrial derived peptides as therapy for aging and its diseases and of Lifebioscince biotech. Dr. Barzilai has been the recipient of numerous prestigious awards, including the Beeson Fellow for Aging Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Paul F. Glenn Foundation Award, the NIA Nathan Shock Award, the 2010 Irving S. Wright Award of Distinction in Aging Research and the IPSEN&nbsp;Longevity Prize (2016).</p>
<p>He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.</p>
<p>Born in Israel, Dr. Barzilai served as chief medic and physician in the Israel Defense Forces. He graduated from The Ruth and Bruce Rappaport Faculty of Medicine at the Technion-Israel Institute of Technology in Haifa and completed his residency in internal medicine at Hadassah Medical Center in Jerusalem. He served in a refugee camp during the war in Cambodia (1979-1980) and built a nutritional village in the homeland of the Zulu (1983 &ndash; Kwazulu). He has completed 2 fellowships at Yale (metabolism) and Corenell (Endocrinoology and molecular Medicine). He was an invited speaker to the 4th Israeli President Conference (2012) and a Vatican conference on efforts to enhance cures (2013, 2016). He has also taken part in Global initiatives and spoke at The Milken Global Institute, Asian Megatrends and is an advisor for the Prime Minister of Singapore on Aging. Dr. Barzilai has been on the &lsquo;Forward 50, top 50 influence Jews in the US (2011). His work has been profiled by major outlets, including the New York Times, the BBC and PBS' NOVA science now, TEDMED and several TEDx talk is the leading feature on the Ron Howard/Jonathan Silberberg/National Geographic film about the Age of Aging. He authored Age Later (2019)</p>

Research Areas
We study the genetic of longevity, hypothesizing that centenarians have protective genes that allows the delay of aging and protect against age-related diseases.
Specialties
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Barzilai discovered the first &ldquo;longevity gene&rdquo; in humans. His research established that the gene variant that leads to high HDL, or &ldquo;good cholesterol,&rdquo; is linked to healthy aging and extreme longevity. Dr. Barzilai has been profiled by major outlets, including<span>&nbsp;</span><em>The</em><span>&nbsp;</span><em>New York Times,&nbsp;</em>PBS&rsquo; &ldquo;NOVA scienceNow&rdquo; and National Geographic.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Treatments for age-related diseases like type 2 diabetes are being developed based on Dr. Barzilai&rsquo;s work and are currently in clinical trials. In addition to his &ldquo;longevity gene&rdquo; research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. Dr. Barzilai is professor of medicine (endocrinology) and of genetics, a member of the Diabetes Research Center and director of the Diabetes Research and Training Center&rsquo;s Animal Physiology core.</span></p>

CHAM Provider
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Professional Title
M.D.
Selected Publications

<ol>
<li><strong>Genomic of Exceptional Longevity in humans.</strong>
<ol style="list-style-type: lower-alpha;">
<li><strong>Barzilai N</strong>, Atzmon G, Schechter C, Schaefer E, Lipton R, Cheng S, Shuldiner AR. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA. 2003. 290:2030-40</li>
<li>Atzmon G, &hellip; <strong>Barzilai N</strong>: Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol. 2006 Apr;4(4):e113. PMC1413567.</li>
<li>Atzmon G, &hellip; , <strong>Barzilai N</strong>, Govindaraju DR, Suh Y. Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A. 2009 Dec 4 PMC2868292</li>
</ol>
</li>
<li><strong>The resiliency to cognitive decline with Exceptional Longevity.</strong>
<ol style="list-style-type: lower-alpha;">
<li>Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, <strong>Barzilai N</strong>, Milman S. Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity. J Am Geriatr Soc. 2016 Aug;64(8):1583-91. doi: 10.1111/jgs.14222. Epub 2016 Jul 5. PMID: 27377170 PMC4988893</li>
<li>Perice L, <strong>Barzilai N</strong>, Verghese J, Weiss EF, Holtzer R, Cohen P, Milman S. Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging (Albany NY). 2016 Oct 14;8(10):2414-2424. doi: 10.18632/aging.101063. PMID: 27744417 PMC5115897c)</li>
<li>N. Barzilai, G. Atzmon, C.A. Derby, and R.B. Lipton, A genotype of exceptional longevity is associated with preservation of cognitive function (2006). Neurology; 67: 2170 PMID: 17190939 PMC3347321</li>
<li>Sanders AE, Wang C, Katz M, Derby CA, <strong>Barzilai N</strong>, Ozelius L, Lipton RB. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA. 2010 Jan 13;303(2):150-8.PMID: 20068209, PMC3047443</li>
</ol>
</li>
<li><strong>Metabolism and mammalian aging.</strong> Muzumdar R, &hellip; <strong>Barzilai N</strong>. Visceral Adipose Tissue Modulates Mammalian Longevity. Aging Cell. 2008 Mar 18. PMCID: PMC2504027.
<ol style="list-style-type: lower-alpha;">
<li>Cobb LJ, &hellip; <strong>Barzilai N</strong>, Cohen P. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 Apr 10. PMCID: PMC4925829.</li>
<li>Heo HJ, Tozour JN, Delahaye F, Zhao Y, Cui L, <strong>Barzilai N</strong>, Einstein FH. Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition. Aging Cell. 2016 Jul 29. PMCID: PMC5013021</li>
</ol>
</li>
<li><strong>GH/IGF-1 axis and mammalian aging.</strong> Muzumdar RH, &hellip;, <strong>Barzilai N</strong>Central and opposing effects of IGF-I and IGF-Binding Protein-3 on systemic insulin action. Diabetes 2006;55(10):2788-96.
<ol style="list-style-type: lower-alpha;">
<li>Huffman DM, &hellip; <strong>Barzilai N</strong>. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell. 2015 Nov 4. PMCID: PMC4717281</li>
<li>Milman S,&hellip;<strong>Barzilai N</strong>. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell, 2014 Mar12. PMCID: PMC4116456.</li>
<li>Suh Y, &hellip;, <strong>Barzilai N</strong>, Cohen P. Functionally-significant insulin-like growth factor-I receptor mutations in centenarian. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42. PMCID: PMC2265137</li>
<li>Ben-Avraham &hellip; P, <strong>Barzilai N</strong>, Atzmon G. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017 Jun 16;3(6):e1602025. doi: 10.1126/sciadv.1602025. eCollection 2017 Jun. PMID:28630896</li>
</ol>
</li>
</ol>

EMR ID
3869
Is Open Scheduling
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