Julia K. Gittler

Submitted by Anonymous (not verified) on
Full Name
Julia K. Gittler
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Gittler_Julia_MD_420x504.jpg
Type
Provider
Faculty
First Name
Julia
Last Name
Gittler
NPI
1427492081
Faculty ID
16099
Clinical Terms
Employment Status
part-time
Patient Type
Pediatric
Department
einstein-dept-medicine
einstein-dept-pediatrics
Gender
Female
Email
jgittler@montefiore.org
Phone
718-920-2680
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Dermatology
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Assistant Professor
Type
Clinical
Title
Pediatric Dermatologist
Type
Clinical
Title
Assistant Professor of Dermatology and Pediatrics
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84534 40.845)
Address Line 1
1628 Eastchester Road
City
Bronx
State
NY
Zip
10461-2663
Location Title
Montefiore at 1628 Eastchester
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Columbia University Medical Center
Education Type Label
Residency
Education Institution
New York University Medical Center
Professional Interests

<p class="MsoNormal" style="mso-pagination: widow-orphan;">Julia K. Gittler, MD, is an attending physician and Assistant Professor at Montefiore-Einstein. Dr. Gittler&rsquo;s clinical areas of focus include all areas of pediatric dermatology, including eczema, vascular and other birthmarks, acne, genetic skin disorders and other pediatric dermatologic conditions.</p>
<p class="MsoNormal">Dr. Gittler earned her Bachelor of Arts at the University of Pennsylvania College of Arts and Sciences in 2008 and graduated summa cum laude. From 2008 to 2013, she attended the Albert Einstein College of Medicine, receiving her Doctor of Medicine and earning distinction in dermatology research through a research fellowship at the Rockefeller University. Her training also includes completion of a yearlong pediatrics internship at Cohen Children&rsquo;s Medical Center in 2014, a three-year dermatology residency at New York University in 2017 and a yearlong pediatric dermatology fellowship at Columbia University in 2018.</p>
<p class="MsoNormal" style="mso-pagination: widow-orphan;">Following her clinical interests, Dr. Gittler&rsquo;s research focus is on pediatric dermatology. Her work has been published in many peer-reviewed journals. She has also shared her research through poster presentations and lectures at regional and national conferences.</p>
<p class="MsoNormal" style="mso-pagination: widow-orphan;">Dr. Gittler is certified in pediatric dermatology by the American Board of Dermatology. She is a member of the American Academy of Dermatology and the Society of Pediatric Dermatology.</p>

Research Areas
Pediatric Dermatology
CHAM Provider
Off
Professional Title
M.D.
EMR ID
102886
Is Open Scheduling
On

Jose Moonjely Davis

Submitted by Anonymous (not verified) on
Full Name
Jose Moonjely Davis
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/17613-jose-moonjely-davis.jpg
Type
Provider
Faculty
First Name
Jose
Last Name
Moonjely Davis
NPI
1972983336
Faculty ID
17613
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
josedavis@montefiore.org
Phone
866-633-8255
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Pulmonary Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.839137 40.8526781)
Building
Tower 2
Address Line 1
Montefiore Medical Center
Address Line 3
1250 Waters Place
City
Bronx
State
NY
Zip
10461
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Rajiv Gandhi University of Health and Science
Education Type Label
Fellowship
Education Institution
Baylor College of Med
Education Type Label
Residency
Education Institution
Western Reserve Health Education- NEOMED
Education Type Label
Residency
Education Institution
San Antony's Mission Hospital
Education Type Label
Residency
Education Institution
Kristu Jayanti Hospital
CHAM Provider
Off
Professional Title
M.B.,B.S.
EMR ID
180097
Visit Type ID
2542
Is Open Scheduling
On

Heyi Li

Submitted by Anonymous (not verified) on
Full Name
Heyi Li
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/cbc2d3f0-3eb1-11ed-a405-bd68d3fd2c32.jpg
Type
Provider
Faculty
First Name
Heyi
Last Name
Li
NPI
1265986178
Faculty ID
17368
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
heli@montefiore.org
Phone
718-920-6054
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Pulmonary Medicine
Type
Clinical
Title
Attending Physician
Type
Clinical
Title
Assistant Professor
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87862 40.88032)
Address Line 1
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-240
Location Title
Montefiore Greene Medical Arts Pavilion
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Zhejiang Medical University
Education Type Label
Fellowship
Education Institution
Mayo Medical School
Education Type Label
Residency
Education Institution
Cook County Hospital
CHAM Provider
Off
Professional Title
M.D.
EMR ID
173372
Biography

<p>Heyi Li, MD, is an attending physician and Assistant Professor, Pulmonary and Critical Care Medicine at Montefiore Einstein. Her clinical focus is on the management of acute and chronic disorders of the lung and breathing, such as chronic obstructive lung diseases, asthma, interstitial lung diseases, infectious lung diseases and lung nodules. She performs airway and chest procedures including bronchoscopies and thoracentesis, and also provides consultations on smoking cessation and respiratory rehabilitation.</p><p>After earning her Bachelor of Engineering degree at Zhejiang University, Hangzhou, China in 2011, she continued her education with the institution&rsquo;s School of Medicine, earning her Doctor of Medicine in 2015. Dr Li&rsquo;s postdoctoral training brought her to the United States, completing a three-year residency in internal medicine at John H. Stroger Jr. Hospital of Cook County in 2019 and a pulmonary and critical care fellowship at Mayo Clinic at Rochester, Minnesota in 2022.</p><p>Dr. Li&rsquo;s clinical research focuses on care delivery research and implementation science. Her goal is to develop a mature line of inquiry in implementation science, focused on both conceptual frameworks and pragmatic implementation strategies. She has shared her work through peer-reviewed journals and has presented it at regional and national conferences. Dr. Li has also been a periodic reviewer for <em>Critical Care Medicine</em> and the <em>American Journal of Respiratory and Critical Care Medicine</em>.</p><p>Dr. Li is board certified in Internal Medicine and Pulmonary Medicine by the American Board of Internal Medicine. She is a member of the American College of Chest Physicians, the American Thoracic Society and the Society of Critical Care Medicine.</p>

Visit Type ID
2542
Is Open Scheduling
On

Benedict C. Wu

Submitted by Anonymous (not verified) on
Full Name
Benedict C. Wu
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/41dd1920-3372-11ec-868d-89cf3c4ab01c.jpg
Type
Provider
Faculty
First Name
Benedict
Last Name
Wu
NPI
1730538596
Faculty ID
17053
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
bewu@montefiore.org
Phone
718-920-8493
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Dermatology
Type
Clinical
Title
Dermatology Hospitalist for Moses, Wakefield, and CHAM
Type
Clinical
Title
Associate Program Director of Dermatology Residency
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.82894 41.05873)
Address Line 1
555 Taxter Road
City
Elmsford
State
NY
Zip
10523
Location Title
Montefiore at 555 Taxter Road
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Rowan University
Education Type Label
Fellowship
Education Institution
McGaw Medical Center of Northwestern Univ Prog
Education Type Label
Residency
Education Institution
Broward Health Medical Center
Professional Interests

<p>Benedict (Benny) Wu, DO, PhD, is the Director of Inpatient Dermatology and Assistant Professor at Montefiore-Einstein. Dr. Wu&rsquo;s clinical interests extend to inpatient and complex medical dermatology areas, including connective tissue disorders, autoimmune bullous disorders, immunodermatology, cutaneous presentation of systemic conditions, and cutaneous lymphomas.</p>
<p>After earning his Bachelor of Science in biological sciences from the University of California, Irvine, Dr. Wu attended the University of Medicine and Dentistry of New Jersey, earning his Master of Biomedical Sciences. He later attended Rowan University, earning his Doctor of Philosophy in Cell and Molecular Biology in 2014 and his Doctor of Osteopathic Medicine in 2016. His postdoctoral training began with an internship in internal medicine at Drexel University College of Medicine, followed by a clinical research fellowship at Northwestern University. In 2021, he completed his Dermatology residency at Broward Health in Fort Lauderdale, Florida.</p>

Research Areas
Does stress correlate with disease severity in complex medical dermatology disorders?
Increasing the diagnostic accuracy of autoantibody-mediated skin diseases.
Prognostic factors in complex medical dermatologic diseases.
CHAM Provider
Off
Professional Title
D.O.
Ph.D.
Clinical Focus

<span style="color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">&nbsp;Dr. Wu&rsquo;s clinical interests extend to inpatient and complex medical dermatology areas, including connective tissue disorders, autoimmune bullous disorders, immunodermatology, cutaneous presentation of systemic conditions, and cutaneous lymphomas.</span>

Research Focus

<span style="color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">Dr. Wu&rsquo;s research investigates several questions. His research focus spans from his work in the clinic to the basic sciences. For example, does physical and/or emotional stress significantly exacerbate complex medical dermatoses? In the future, he hopes to examine neutrophil dysfunction at the cellular and molecular level from tissue and blood samples from neutrophil-predominant dermatoses.</span>

Selected Publications

<p><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif; color: #212121;">Hopkins ZH, Wu BC, Nousari CH. Rituximab versus Mycophenolate Mofetil in Pemphigus Vulgaris.&nbsp;</span><em><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif; color: #212121;">N Engl J Med</span></em><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif; color: #212121;">. 2021;385(11):1055-1056. doi:10.1056/NEJMc2111763</span></p>
<p><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif; color: #212121;">Nousari Y, Wu BC, Tausk F. From the Caravels to the Wards: Scurvy and Schizophrenia [published online ahead of print, 2021 Jun 8].&nbsp;<em>J Acad Consult Liaison Psychiatry</em>. 2021;S2667-2960(21)00097-5. doi:10.1016/j.jaclp.2021.05.006</span></p>
<p><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif;">Nousari Y, Wu BC, Valenzuela G. Successful use of baricitinib in the treatment of refractory rheumatoid arthritis-associated Sweet syndrome [published online ahead of print, 2021 Apr 29].&nbsp;<span class="em" style="border: none; vertical-align: baseline;"><em><span style="border: none;"><span style="border: none;">Clin Exp Dermatol</span></span></em></span>. 2021;10.1111/ced.14712. doi:10.1111/ced.14712</span></p>
<p><span style="font-size: 11pt; font-family: 'Century Gothic', sans-serif;">Erickson, T. R., Murphrey, M. B., Abu-Zayed, H., Wu, B., Ibler, E., Rangel, S. M., &amp; Paller, A. S. (2020). Transepidermal water loss in the orphan forms of ichthyosis.&nbsp;<span class="em" style="border: none; vertical-align: baseline;"><em><span style="border: none;"><span style="border: none;">Pediatric dermatology</span></span></em></span>,&nbsp;<span class="em" style="border: none; vertical-align: baseline;"><em><span style="border: none;"><span style="border: none;">37</span></span></em></span>(4), 771&ndash;773. https://doi.org/10.1111/pde.14221</span></p&gt;

EMR ID
159114
Biography

<p style="padding-top:0px;color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">Benedict (Benny) Wu, DO, PhD, is the Director of Inpatient Dermatology and Assistant Professor at Montefiore-Einstein. Dr. Wu&rsquo;s clinical interests extend to inpatient and complex medical dermatology areas, including connective tissue disorders, autoimmune bullous disorders, immunodermatology, cutaneous presentation of systemic conditions, and cutaneous lymphomas.</p><p style="padding-top:0px;color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">After earning his Bachelor of Science in biological sciences from the University of California, Irvine, in 2006, Dr. Wu attended the University of Medicine and Dentistry of New Jersey, earning his Master of Biomedical Sciences in 2007. He later attended Rowan University, earning his Doctor of Philosophy in Cell and Molecular Biology in 2014 and his Doctor of Osteopathic Medicine in 2016. His postdoctoral training began with an internship in internal medicine at Drexel University College of Medicine in 2017, followed by a clinical research fellowship at Northwestern University in 2018. In 2021, he completed a three-year dermatology residency at Broward Health.</p><p style="padding-top:0px;color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">Dr. Wu&rsquo;s research investigates several questions. His research focus spans from his work in the clinic to the basic sciences. For example, does physical and/or emotional stress significantly exacerbate complex medical dermatoses? In the future, he hopes to examine neutrophil dysfunction at the cellular and molecular level from tissue and blood samples from neutrophil-predominant dermatoses. He has shared his research in many oral and poster presentations, as well as in peer-reviewed publications.</p><p style="padding-top:0px;color:#525458;font-family:Arial, Helvetica, sans-serif;background-color:#ffffff;">Dr. Wu is a member of several professional societies, including the American Academy of Dermatology, the Medical Dermatology Society, the Society for Dermatological Hospitalists, and the Society for Investigative Dermatology.</p>

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On

Ellen D. Teplitz

Submitted by Anonymous (not verified) on
Full Name
Ellen D. Teplitz
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/2882-teplitz.jpg
Type
Provider
Faculty
First Name
Ellen
Last Name
Teplitz
NPI
1174683742
Faculty ID
2882
CMO Specialties
Clinical Terms
Employment Status
Per Diem
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
warhit@aol.com
Phone
914-337-9100
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Clinical Assistant Professor
Division
Dermatology
Type
Administrative
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88486 40.96815)
Address Line 1
984 North Broadway, Suite 503
City
Yonkers
State
NY
Zip
10701
Location Title
West Derm Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8308221 40.9511215)
Room
2B
Address Line 1
1 Elm Street
City
Tuckahoe
State
NY
Zip
10707
Location Title
1 Elm Street
Education and Trainings
Education Type Label
Medical Education
Education Institution
Icahn School of Medicine at Mt. Sinai
Education Type Label
Residency
Education Institution
SUNY Downstate
CHAM Provider
Off
Professional Title
M.D.
EMR ID
3602
Is Open Scheduling
Off

Lisa B. Teh

Submitted by Anonymous (not verified) on
Full Name
Lisa B. Teh
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Teh_Lisa_PhD_420x504.jpg
Type
Provider
Faculty
First Name
Lisa
Last Name
Teh
NPI
1215243951
Faculty ID
16520
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-psychiatry-behavioral-sciences
Gender
Female
Email
lteh@montefiore.org
Phone
718-920-4797
Titles
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Assistant Professor
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Fellowship
Education Institution
Indiana University School of Medicine
CHAM Provider
Off
Professional Title
Ph.D.
EMR ID
121676
Is Open Scheduling
Off

Sarah Sungurlu

Submitted by Anonymous (not verified) on
Full Name
Sarah Sungurlu
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/8d27d5c0-7e34-11ec-abab-b971dcc17ab8.jpg
Type
Provider
Faculty
First Name
Sarah
Last Name
Sungurlu
NPI
1174819478
Faculty ID
17214
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
ssungurlu@montefiore.org
Phone
718-920-6474
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Pulmonary Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845 40.85026)
Address Line 1
1825 Eastchester Road
City
Bronx
State
NY
Zip
10467-2404
Location Title
Montefiore Weiler Hospital
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Room
5H
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Chicago College of Osteopathic Medicine
Education Type Label
Fellowship
Education Institution
Swedish Covenant Hospital
Education Type Label
Residency
Education Institution
Swedish Covenant Hospital
CHAM Provider
Off
Professional Title
D.O.
EMR ID
165589
Visit Type ID
2542
Is Open Scheduling
On

Kate R. Steinberg

Submitted by Anonymous (not verified) on
Full Name
Kate R. Steinberg
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/05b61a40-891d-11ec-a48a-e9e0c9e20faa.jpg
Type
Provider
Faculty
First Name
Kate
Last Name
Steinberg
NPI
1528488459
Faculty ID
16973
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
ksteinberg@montefiore.org
Phone
718-920-6054
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Pulmonary Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
New York Medical College
Education Type Label
Fellowship
Education Institution
Boston Medical Center
Education Type Label
Residency
Education Institution
University of Wisconsin Hospital and Clinics
CHAM Provider
Off
Professional Title
M.D.
EMR ID
141643
Visit Type ID
2542
Is Open Scheduling
On

Simon D. Spivack

Submitted by Anonymous (not verified) on
Full Name
Simon D. Spivack
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Spivack_Simon_MD_2x.jpg
Type
Provider
Faculty
Expert
First Name
Simon
Last Name
Spivack
NPI
1366438475
Faculty ID
11003
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-epidemiology-population-health
einstein-dept-genetics
Gender
Male
Email
simon.spivack@einsteinmed.edu
Phone
718-678-1040
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Pulmonary Medicine
Type
Academic
Department
Department of Epidemiology & Population Health
Department Link
Rank
Professor
Division
Epidemiology
Type
Academic
Department
Department of Genetics
Department Link
Rank
Professor
Type
Administrative
Title
Chief Emeritus, Division of Pulmonary Medicine, Department of Medicine
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.82894 41.05873)
Address Line 1
555 Taxter Road
City
Elmsford
State
NY
Zip
10523
Location Title
Montefiore Einstein Advanced Care -Westchester
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845838 40.8516937)
Room
301
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Michael F. Price Center
Address Line 3
1301 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
SUNY Upstate Medical Center
Education Type Label
Fellowship
Education Institution
Medical Center Hospital of Vermont
Education Type Label
Residency
Education Institution
UMASS Memorial Medical Center - University Campus
Professional Interests

<p>&nbsp;</p>
<p>Focusing diagnostics and therapeutics on those most likely to benefit is a key to successful intervention&nbsp;at both the public health and clinical levels. The translational goal of the Spivack laboratory is to identify individuals at particularly high risk for lung malignancy, and selected non-malignant lung diseases, upon whom to focus smoking/toxin exposure cessation (primary prevention), chemoprevention (secondary prevention), and early disease detection efforts (disease screening, tertiary prevention).</p>
<p>The laboratory is currently exploring individual Gene x Environment signatures as susceptibility markers by exploring quantitative gene (mRNA) expression phenotypes, and the DNA sequence, methylation, microRNA, and other epigenetic features potentially underlying these expression phenotypes, <em>in vitro</em> and in human populations. This is performed in the setting of defined tobacco, diet, and other exposures. There are both mechanistic and translational components to the studies.&nbsp;</p>
<p><br /><strong>Mechanistically</strong>, the role of epigenetic variation in promoter regions in the 5' and 3' regulatory regions of carcinogenesis and oxidant pathway genes is being explored <em>in vitro</em>, using human genomic DNA reporter constructs, and native gene regulation models. High resolution technologies include the realtime quantitation of native mRNA and microRNA by the laboratory's RNA-specific strategy (<em>patented</em>); the&nbsp;tagged-bisulfite genomic sequencing strategy to determine single base resolution CpG methylation status (tBGS, <em>patented</em>);&nbsp;&nbsp;an experimental strategy for assaying microRNA binding to mRNA, for determining the role of miRNA in candidate gene regulation&nbsp;(<em>patented</em>); and evaluation of functional consequences of DNA&nbsp;methylation detail, using a novel patch reporter construct (<em>patented</em>).&nbsp; A new method to engineer methyl-cytosines into the epigenome has recently been developed.</p>
<p>Whole (epi)genome approaches to identify molecular events unique to lung cancer&nbsp;are being completed, which will represent one of the initial cross-platform 'omics level discovery examinations of&nbsp;lung&nbsp;tissues.&nbsp; The execution of each individual discovery platform involves&nbsp;expert local collaborators and cores&nbsp;in (epi)genetics and genomics, and the "integromics" is critically reliant on Einstein strengths in informatics and biostatistical analyses.</p>
<p>&nbsp;</p>
<p><strong>Translationally</strong>, human lung carcinogenesis biomarkers are being established by pairing laser capture microdissected lung with several unique, non-invasively collected surrogate specimens developed in the laboratory. These include mRNA expression signatures from brush-exfoliated buccal mucosa cells, microRNAs detected in exhaled breath condensate representing first reports for a new exhaled airway biomarker class, and exhaled metabolomic signatures. These airway-derived specimens continue to accrue from a sampling (currently n&gt;1000) of a population assembled in a lung cancer case-control context.&nbsp; The specimens are being studied with a view toward developing non-invasive assays in populations.</p>
<p>&nbsp;</p>
<p>The overall aim is to develop informative non-invasive risk profiling, preventive, and early disease detection strategies for the lung in human populations.</p>
<p>&nbsp;</p>
<p>&nbsp;<em>Work is funded by ongoing NIH,</em><em> DoD,&nbsp;and&nbsp;Foundation support.</em></p>
<p>&nbsp;</p>
<p><strong>Clinical Specialties</strong></p>
<ul style="font-size: 1em; color: #333333; padding: 0px; margin: 20px 0px 25px 38px;">
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung nodule evaluation</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung cancer diagnostics and screening</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">interstitial lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">environmental lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">refractory asthma</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">general pulmonary medicine</li>
</ul>

Research Areas
Development of early lung cancer detection strategies; exhaled nucleic acid and other airway biomarkers.
Genome-wide surveys of lung epithelia. Translational lung studies. Mechanistic studies in functional epigenetics.
Areas of Expertise
Interstitial lung disease
Lung nodule evaluation
Lung toxicology
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A researcher and clinician, Dr. Spivack is developing tests for detecting lung cancer at the earliest possible stage&mdash;before it becomes fatal by spreading to other parts of the body. In one of several NIH-funded studies, his laboratory is working on a noninvasive, early-diagnosis test for lung cancer that detects particular genetic elements and chemicals in exhaled breath.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to general pulmonary medicine, Dr. Spivack&rsquo;s clinical practice focuses on lung nodule and lung cancer diagnosis, diffuse interstitial lung diseases, and environmental lung diseases.</span></p>

CHAM Provider
Off
Professional Title
M.D.
M.P.H.
Clinical Focus

Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease.<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;"><strong></strong></span>

Research Focus

Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans.

Selected Publications

<p>&nbsp;</p>
<p><strong><span style="text-decoration: underline;">Selected Publications, as of April, 2023</span>:</strong></p>
<p class="MsoNormal"><span style="text-indent: -0.25in;">Shi M, Han W, Loudig O, Shah C, Dobkin J, Keller S, Sadoughi A, Patel D, Desai A, Gombar S, Suh Y, Fernandez MK, DeLaRosa L, Wang T, Hosgood D, Pradhan K, Ye K, </span><strong style="text-indent: -0.25in;">Spivack SD.</strong><span style="text-indent: -0.25in;">&nbsp; </span><span style="text-indent: -0.25in;">(2023) Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination</span><em style="text-indent: -0.25in;">. [accepted, Scientific Reports, NPG]</em></p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">&nbsp;</p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="color: #212121; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Huang Z, Sun S, Lee M, Maslov AY, Shi M, Waldman S, Marsh A, Siddiqui T, Dong X, Peter Y, Sadoughi A, Shah C, Ye K, *<strong>Spivack SD</strong>, *Vijg J. Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. Nat Genet. 2022 Apr;54(4):492-498. doi: 10.1038/s41588-022-01035-w. Epub 2022 Apr 11. PMID: 35410377. (*co-senior authors).</span></p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">&nbsp;</p>
<p class="MsoNormal"><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span><!--[endif]--><span lang="EN">Cleven KL, Ye K, Zeig-Owens R, Hena KM, Montagna C, Shan J, Hosgood HD 3rd, Jaber N, Weiden MD, Colbeth HL, Goldfarb DG, <strong>Spivack SD</strong>++, Prezant DJ++ (++co-senior authors). </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31126090"><span lang="EN" style="color: windowtext; text-decoration-line: none;">Genetic Variants Associated with FDNY WTC-Related Sarcoidosis.</span></a><span lang="EN"> Int J Environ Res Public Health. 2019 May 23;16(10). pii: E1830. doi: 10.3390/ijerph16101830. PMID:31126090</span>.</p>
<p>Dong X, ShiN, LeeM, ToroR, Gravina S, Han W, Yasuda S, Wang T, Zhang Z, Vijg J, Suh Y, <strong>Spivack SD.</strong> (2018) Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. <em>Epigenetics </em>10.1080/15592294.2018.1441650, 2018.</p>
<p>Mullapudi N, Ye B, Suzuki M, Wang T, Fazarri M,&nbsp;Han W, Shi M, Marquardt G, Lin J, Wang T,&nbsp;Keller S, Zhu C, Locker&nbsp;J, &nbsp;<strong>Spivack SD.</strong> Genome-wide methylome alterations in lung cancer&nbsp;<em> PLoS ONE, </em>Dec. 2015.</p>
<p>Lin J, Marquardt G, Mullapudi N,&nbsp;Wang, T,&nbsp;Han W, Shi W, Zhu C, Keller S,&nbsp;Zhu C,&nbsp;Locker J, <strong>Spivack SD. </strong>Lung cancer transcriptomes refined with laser capture microdissection.<em>&nbsp;Am J Pathology </em>06.028.&nbsp;2014 .</p>
<p>Han W, Shi M, <strong>Spivack SD</strong>. Site-specific methylated reporter constructs for functional analysis of DNA methylation.<em> Epigenetics </em>4; 8(11), 2013.</p>
<p>Shi M, Han W, <strong>Spivack SD</strong>. A quantitative method to identify miRNAs targeting an mRNA using a 3'UTR RNA affinity technique.<em> Analytic Biochem</em>&nbsp;1;443(1):1-12, 2013<em>.</em></p>
<p>Alberg AJ, Brock MV, Ford JG, Samet JM, <strong>Spivack, SD.</strong>&nbsp;&nbsp;Epidemiology of lung cancer.&nbsp; In Evidence-based Practice Guidelines. Diagnosis and Management of Lung Cancer (ACCP position statement). <em>CHEST</em>.&nbsp;&nbsp;May 2013;143(5 Suppl):e1S-e29S. doi: 10.1378/chest.12-2345. PMID: 23649439.</p>
<p>Tan XT, Marquardt G, Shi M, Han W, <strong>Spivack SD.</strong> High throughput library screening identifies phytochemical inducers of phase II mutagen/oxidant metabolism enzymes GSTP1 and NQO1 in human lung cells.<em> Am J Resp Cell Molec Biol, </em>46(3): 365-71, 2012.</p>
<p>Brock GJ,&nbsp;Moschos S, <strong>Sp</strong><strong>ivack SD,</strong> Hurteau GJ.&nbsp;The 3' prime paradigm of the miR-200 family and other microRNAs. <em>Epigenetics</em> (6:3, 1-5), 2011.</p>
<p>Tan XT, &nbsp;Shi M, &nbsp;Minna JD,&nbsp; Han W,&nbsp; <strong>Spivack SD.</strong> Candidate phytopreventive agent modulation of phase II metabolism enzymes <em>GSTP1</em> and <em>NQO1</em> in human bronchial cells<em>. J Nutrition,&nbsp;</em>140(8): 1404-10, 2010<em>.</em></p>
<p>Tan, XT, &nbsp;&nbsp;Wang T,&nbsp; Xiong S,&nbsp; Kumar SV,<strong>&nbsp;</strong> Han W, &nbsp;<strong>Spivack SD.</strong> &nbsp;Smoking-related gene expression in laser capture microdissected human lung. <em>Clin Cancer Res,</em> 15(24): 7562-70, 2009.</p>
<p>Han W, Tang T, Reilly AA, Keller S, <strong>Spivack SD</strong>. Gene promoter methylation analyses from exhaled breath, with differences in smokers and lung cancer cases.&nbsp; <em>Resp Res,</em> 10:86 epubl, 2009.</p>
<p>Tan X-L,&nbsp; Moslehi R, Han W, <strong>Spivack SD</strong>. Haplotype tagging single nucleotide polymorphisms in the glutathione S-transferase P1 gene promoter and susceptibility to lung cancer. <em>Cancer Detection Prev,</em>32:403-415, 2009<em>.</em></p>
<p>Tan X-L,&nbsp;&nbsp;<strong>Spivack SD</strong>. Dietary chemoprevention strategies for&nbsp;induction of phase II metabolism: a review. <em>Lung Cancer,</em>65(2):129-37, 2009.</p>
<p>Hurteau GJ, Carlson AJ, <strong>Spivack, SD,</strong> Brock GJ. Restoration of E-Cadherin expression by over-expression of the microRNA <em>hsa-miR-200c</em> via reduced expression of the transcription factor TCF8. <em>Cancer Res.</em> 67:7972-76, 2007.</p>
<p>Hurteau, GJ, <strong>Spivack</strong> <strong>SD</strong>, Brock G.&nbsp; Parallel identification of miRNA and target mRNA by combined informatics and qRT-PCR approaches: application to <em>has-miR-200c.</em>&nbsp; <em>Cell Cycle</em> 5(17):1951-56, 2006.</p>
<p>Han W, Cauchi S, Herman JG, <strong>Spivack SD</strong>.&nbsp; Methylation mapping of DNA by tag-modified bisulfite genomic DNA sequencing. <em>Analytic Biochem. 355: 50-61,</em> 2006.</p>
<p>Cauchi S, Han W, Kumar SV, <strong>Spivack SD</strong>. Haplotype-environment interactions regulating the human <em>GSTP1</em> promoter <em>Cancer Res</em>. 66(12): 6439-6448, 2006.</p>
<p>Kumar SV, Hurteau GJ, <strong>Spivack SD.</strong> Validity of mRNA expression analyses of human saliva. <em>Clin. Cancer Res.</em> 12: 5033-39, 2006.</p>
<p><strong>Spivack SD</strong>, Hurteau GJ, Jain R, Kumar SV, Aldous KM, Gierthy JF, Kaminsky LS.&nbsp; Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells. <em>Cancer Res,</em> 64:6805-6813, 2004.</p>
<p><strong>Spivack SD</strong>, Hurteau GJ, Fasco MJ, Kaminsky LS.&nbsp; Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors.&nbsp; <em>Clinical Cancer Research</em>, 9:6002-6011, 2003.</p>
<p>&nbsp;</p>

EMR ID
4969
Biography

<p>Simon D. Spivack, MD, MPH, is Professor, Medicine, Epidemiology and Genetics at Montefiore Einstein. He is also former Emeritus Chief, Pulmonary Medicine. Clinically, Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease. </p><p>After obtaining his Bachelor of Science in Psychobiology from McGill University in Montreal, Canada in 1980, Dr. Spivack earned his Doctor of Medicine from the State University of New York Upstate Medical University in 1985. He then completed an internship and residency in internal medicine at the University of Massachusetts Medical Center in 1988. Dr. Spivack then earned his Master of Public Health at Harvard University, School of Public Health in 1989. He completed a clinical pulmonary and critical care medicine and lung research fellowship at the University of Vermont in 1992. </p><p>Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans. His work has been published in numerous peer-reviewed journals, articles, chapters and books, and he has given many national/international presentations, organized symposia and visiting professorships. Dr. Spivack is on the Editorial Board for Scientific Reports and is a reviewer for journals such as <em>PLoS Genetics</em>, <em>Genetics in Medicine</em>, <em>Nature Protocols</em>, <em>American Journal of Respiratory &amp; Critical Care Medicine</em>, <em>Carcinogenesis</em>, <em>Cancer Research</em> and others. He holds multiple United States patents. He has been continually funded by the National Institutes of Health (NIH) for research for over 25 years.
</p><p>Dr. Spivack is board certified in internal medicine, pulmonary medicine and critical care medicine. He is a member of the American Thoracic Society (ATS), the American Association for Cancer Research (AACR) and the American Lung Association (ALA). He is a frequent peer-reviewer on various NIH study sections. In the past, Dr. Spivack won the Excellence in Research Award from ALA and the NIH/National Institute of Environmental Health Sciences (NIEHS) Clinical Scientist Development Award.

</p>

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Chirag D. Shah

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State University of New York at Stony Brook Hosp
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