Dr. Angela Lombardi is Assistant Professor of Medicine in the Division of Endocrinology at Albert Einstein College of Medicine. She received her PhD in Italy and completed her postdoctoral training at Icahn School of Medicine at Mount Sinai in New York. Dr. Lombardi’s expertise comprises both translational and basic research topics in diabetes and thyroid autoimmunity. She is the recipient of several awards, including a JDRF Immunotherapies award, and the KL2 Mentored Translational Research Career Development Award. The goal of her current research is to find innovative targeted immunotherapies to prevent and treat autoimmune destruction of beta cells in type 1 diabetes.

1. Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C. IN SKELETAL MUSCLE, ADVANCED GLYCATION END PRODUCTS INHIBIT INSULIN ACTION AND INDUCE THE FORMATION OF MULTIMOLECULAR COMPLEXES INCLUDING THE   RECEPTOR FOR AGES. J Biol Chem 2008; 283(52): 36088-99.

2. Fiory F, Lombardi A, Miele C, Giudicelli J, Beguinot F, Van Obberghen E. METHYLGLYOXAL IMPAIRS INSULIN SIGNALLING AND INSULIN ACTION ON GLUCOSE-INDUCED INSULIN SECRETION IN THE PANCREATIC BETA CELL LINE INS-1E. Diabetologia 2011; 54(11): 2941-2952.

3. Lombardi A, Ulianich L, Treglia AS, Nigro C, Parrillo L, Lofrumento DD, Nicolardi G, Garbi C, Beguinot F, Miele C, Di Jeso B. INCREASED HEXOSAMINE BIOSYNTHETIC PATHWAY FLUX DEDIFFERENTIATES INS-1E CELLS AND MURINE ISLETS BY AN EXTRACELLULAR SIGNAL-REGULATED KINASE ERK (1/2)-MEDIATED SIGNAL TRANSMISSION PATHWAY. Diabetologia 2012; 55(1): 141-53.

4. Santulli G*, Lombardi A*, Sorriento D, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G. AGE-RELATED IMPAIRMENT IN INSULIN RELEASE: THE ESSENTIAL ROLE OF BETA2-ADRENERGIC RECEPTOR. Diabetes 2012; 61(3): 692-53. *Co-First Authorship

5. Brown RS*, Lombardi A*, Hasham A, Greenberg DA, Gordon J, Concepcion E, Hammerstad SS, Lotay V, Zhang W, Tomer Y. GENETIC ANALYSIS IN YOUNG-AGE-OF-ONSET GRAVES’ DISEASE REVEALS NEW SUSCEPTIBILITY LOCI. J Clin Endocrinol Metab 2014; 99(7): E1387-91. *Co-First Authorship

6. Stefan M, Wei C, Lombardi A, Li CW, Concepcion E, Inabnet III WB, Owen R, Zhang W, Tomer Y. GENETIC-EPIGENETIC DYSREGULATION OF THYMIC TSH RECEPTOR GENE EXPRESSION TRIGGERS THYROID AUTOIMMUNITY. Proc Natl Acad Sci USA 2014; 111(34): 12562-7.

7. Lombardi A*, Inabnet III WB, Owen R, Farenholtz K, Tomer Y. ENDOPLASMIC RETICULUM STRESS AS A NOVEL MECHANISM IN AMIODARONE-INDUCED DESTRUCTIVE THYROIDITIS. J Clin Endocrinol Metab 2015; 100(1): E1-10. *Corresponding Author

8. Lombardi A*, Menconi F, Greenberg DA, Concepcion E, Leo M, Rocchi R, Marinó M, Keddache M, Tomer Y. DISSECTING THE GENETIC SUSCEPTIBILITY TO GRAVES’ DISEASE IN A COHORT OF PATIENTS OF ITALIAN ORIGIN. Frontiers in Endocrinology 2016; 7: 21. *Corresponding Author

9. Lee H, Lombardi A, Stefan M, Li CW, Inabnet III WB, Owen R, Concepcion E, Tomer Y. CD40 SIGNALING IN GRAVES’ DISEASE IS MEDIATED THROUGH CANONICAL AND NONCANONICAL THYROIDAL NUCLEAR FACTOR KB ACTIVATION. Endocrinology 2017; 158(2): 410-418. 2017.

10. Lombardi A*, Yaron Tomer. INTERFERON-ALPHA IMPAIRS INSULIN PRODUCTION IN HUMAN BETA CELLS VIA ENDOPLASMIC RETICULUM STRESS. Journal of Autoimmunity 2017; 80: 48-55. *Corresponding Author

11. Lombardi A, Trimarco B, Iaccarino G, Santulli G. IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE CAUSED BY TACROLIMUS UNDERLIES BETA-CELL FAILURE. Cell Communication and Signaling 2017; 15(1): 47.

12. Blackard JT, Kong L, Lombardi A, Homann D, Hammerstad SS, Tomer Y. A PRELIMINARY ANALYSIS OF HEPATITIS C VIRUS INFECTION OF PANCREATIC ISLET CELLS. Virology Journal 2017; 14:237.

13. Lombardi A, Gambardella J, Du XL, Sorriento D, Mauro M, Trimarco B, Iaccarino G, Santulli G. SIROLIMUS INDUCES DEPLETION OF INTRACELLULAR CALCIUM STORES AND MITOCHONDRIAL DYSFUNCTION IN PANCREATIC BETA CELLS. Nature Scientific Reports 2017; 7(1): 15823.

14. Faustino LC, Lombardi A, Matute JM, Owen R, Libutti SK, Tomer Y. INTERFERON ALPHA TRIGGERS AUTOIMMUNE THYROID DISEASES VIA LYSOSOMAL-DEPENDENT DEGRADATION OF THYROGLOBULIN. J Clin Endocrinol Metab 2018; 103(10):3678-3687.

15. Lombardi A, Tsomos E, Hammerstad SS, Tomer Y. INTERFERON ALPHA: THE KEY TRIGGER OF TYPE 1 DIABETES. Journal of Autoimmunity 2018; 94: 7-15. *Corresponding Author

16. Hammerstad SS, Blackard JT, Lombardi A, Owen RP, Concepcion E, Yi Z, Zhang W, Tomer Y. HEPATITIS C VIRUS INFECTION OF HUMAN THYROCYTES: METABOLIC, HORMONAL, AND IMMUNOLOGICAL IMPLICATIONS. J Clin Endocrinol Metab 2020; 105(4).

17. Gambardella J, Lombardi A, Morelli MB, Ferrara J, Santulli G. INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS IN HUMAN DISEASE: A COMPREHENSIVE UPDATE. Journal of Clinical Medicine 2020; 9(4):1096.