Bing Chen

Bing Chen, M.D.

Area of research

  • Tuberculosis, herpes simplex and Influenza vaccine development; use of animal models to investigate infections, host-pathogen interaction.

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Location

  • Albert Einstein College of Medicine Michael F. Price Center 1301 Morris Park Avenue 555 Bronx, NY 10461

Lab of Bing Chen

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Research Profiles

Research Profiles

Research Profiles

Professional Interests

I focus on new TB vaccine research and novel anti-tuberculosis agent development, use of animal models to investigate infections and pathogen-host interactions. I am responsible for the safe use of our Bio-Safety Level 3 facility at Einstein, including training and testing post-docs and students according to their own research projects. I also chair the regular meetings of the TB Research Group internal Biosafety Committee for TB research projects and coordinate protocols and resources for BSL3 experiments.

Selected Publications

  1. Bhatt K, Machado H, Osório NS, Sousa J, Cardoso F, Magalhães C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR Jr, Bhatt A, Saraiva M. (2018). “A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis”. mSphere. 3(5). PMCID: PMC6211224.
  2. Tiwari S, vanTonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR Jr. (2018). “Arginine-deprived-induced ozidative damage sterilizes Mycobacterium tuberculosis.” PNAS. 115(39):9779-9784. PMCID: PMC6166831.
  3. Berney M, Berney-Meyer L, Wong KW, Chen B, Chen M, Kim J, Wang J, Harris D, Parkhill J, Chan J, Wang F, Jacobs WR Jr. (2015). “Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis”. PNAS.1513033112. Epub 2015 Jul 28. PMID: 26221021.
  4. Jain P, Hsu T, Arai M, Biermann K, Thaler DS, Nguyen A, González PA, Tufariello JM, Kriakov J, Chen B, Larsen MH, Jacobs WR Jr. (2014). “Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis”. MBio. 2014 Jun 3;5(3):e01245-14. doi: 10.1128/mBio.01245-14. PMID: 24895308.
  5. Junqueira-Kipnis AP, de Oliveira FM, Trentini MM, Tiwari S, Chen B, Resende DP, Silva BD, Chen M, Tesfa L, Jacobs WR Jr, Kipnis A. (2013). “Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis”. PLoS One. 2013 Nov 8;8(11):e78639. doi: 10.1371/journal.pone.0078639. eCollection 2013. PMID: 24250805.
  6. Chen B, Weisbrod TR, Hsu T, Sambandamurthy V, Vieira-Cruz D, Chibbaro A, Ghidoni D, Kile T, Barkley WE, Vilchèze C, Colon-Berezin C, Thaler DS, Larsen MH, Sturm AW, Jacobs WR Jr. (2011). “Einstein Contained Aerosol Pulmonizer (ECAP): Improved Biosafety for Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Mycobacterium tuberculosis Aerosol Infection Studies”. Appl Biosaf. 2011 Oct 27;16(3):134-138. PMID: 23413363.
  7. Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr. (2011). “A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis”. Nat Med. 2011 Sep 4;17(10):1261-8. doi: 10.1038/nm.2420. PMID: 21892180.
  8. Prados-Rosales R, Baena A, Martinez LR, Luque-Garcia J, Kalscheuer R, Veeraraghavan U, Camara C, Nosanchuk JD, Besra GS, Chen B, Jimenez J, Glatman-Freedman A, Jacobs WR Jr, Porcelli SA, Casadevall A. (2011). “Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice”. J Clin Invest. 2011 Apr;121(4):1471-83. doi: 10.1172/JCI44261. PMID: 21364279.
  9. Hinchey J, Jeon BY, Alley H, Chen B, Goldberg M, Derrick S, Morris S, Jacobs WR Jr, Porcelli SA, Lee S. (2011). “Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis”. PLoS One. 2011 Jan 10;6(1):e15857. doi: 10.1371/journal.pone.0015857. PMID: 21264335.
  10. Lázár-Molnár E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR Jr. (2010). “Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis”. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13402-7. doi: 10.1073/pnas.1007394107. Epub 2010 Jul 12. PMID: 20624978.