We are focused on identifying and quantifying the connexin-dependent regulatory networks, determining the topology of critical functional genomic fabrics and their remodeling during development, progression of a disease or in response to external stimuli or medical treatments, as well as on developing mathematical models of intercellular Ca2+ signaling in complex structures.

Recently, we developed and tested the experimental protocol and the mathematical algorithm and computer software to identify the Gene Master Regulators (GMR) of cancer cells whose silencing would selectively kill the cancer cells with negligible effects on the normal cells in the tissue.

PubMed publications at: https://pubmed.ncbi.nlm.nih.gov/?term=iacobas+d+or+iacobas+a

Selected not in PubMed papers/book chapters/scipages/patents:

Iacobas DA. (2019). Commentary on “The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy”. J Cancer Immunol 1(1):31-33. DOI No.: 10.33696/cancerimmunol.1.005

Veliskova J, Iacobas DA, Iacobas S, Velisek L. (2017). Hormonal modulation of neuronal excitability. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 1-6. http://dx.doi.org/10.1016/B978-0-12-809324-5.00082-1

Iacobas DA. (2016) The Genomic Fabric Perspective on the Transcriptome between Universal Quantifiers and Personalized Genomic Medicine. Biological Theory. 11(3): 123-137. DOI 10.1007/s13752-016-0245-3

Iacobas DA, Iacobas S, Chachua T, Goletiani C, Sidyelyeva G, Velíšková J, Velíšek L. (2013). Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: Insights from a novel animal model of infantile spasms. In: RC Melcangi, GC Panzica (Editors) Steroids and the Nervous System, 25 (11) 964-979, Wiley Online Library. https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.12061

Iacobas S, Neal-Perry G, Iacobas DA (2013). Analyzing the cytoskeletal transcriptome: sex differences in rat hypothalamus. In: Interdisciplinary Methods for Investigation of the Cytoskeleton, (Editor: R. Dermietzel), in The Cytoskeleton: Imaging, Isolation, and Interaction, Neuromethods, 79: 119:133, Springer New York Heidelberg Dordrecht London, ISBN 978-1-62703-266-7 (eBook).

Iacobas S, Iacobas DA (2012). Effects of Chronic Intermittent Hypoxia on Cardiac Rhythm Transcriptomic Networks. In: Intermittent Hypoxia and Human Diseases, (Editors:L. XI, T.V. Serebrovskaya), ISBN 978-1-4471-2905-9, ISBN 978-1-4471-2906-6 (eBook), DOI 10.1007/978-1-4471-2906-6. Springer Dordrecht Heidelberg New York London. Pp. 15-28.

Desruisseaux M, Iacobas DA, Iacobas S, Mukherjee S, Weiss LM, Tanowitz HB, Spray DC (2010). Alterations in the Brain Transcriptome in Plasmodium Berghei ANKA Infected. J Neuroparasitology. 1: 74-81.

Iacobas DA, Spray DC (2008). Connexin dependent transcriptomic networks. http://topics.scirus.com/Connexin_dependent_transcriptomic_networks.html

Iacobas DA, Iacobas S, Spray DC (2005). Use of cDNA arrays to explore gene expression in genetically manipulated mice and cell lines, in “Practical Methods in Cardiovascular Research” (S Dhein, FW Mohr & M Delmar, editors), Springer-Verlag. ISBN: 3-540-40763-4. pp. 907-915.

Iacobas DA, Urban M, Iacobas S, Spray DC (2001). The “patholog” of the gene expression profile in evaluating the ecotoxin effects. Advances in Ecological Sciences, 10: 733-742.

Selected books:

Iacobas DA. (2000). Ideas and Methods in the Physics of Living. 4^th Ed. Tilia Press Int., Constanta.

Iacobas S, Iacobas DA (2000). Pharmacology of the nervous system (in Romanian). Constanta: Tilia

Press Int. ISBN 973-98470-8-0.

Iacobas DA. (1997). Medical Biostatistics. 3rd Eng Ed. Bucura Mond, Bucharest

Iacobas DA. (1996) Cell Biophysics. 2nd Eng Ed, Bucura Mond, Bucharest

Iacobas DA. (1996) Molecular Biophysics. 2nd Eng Ed. Bucura Mond, Bucharest.

Patents for Inventions (Romania):

Iacobas DA, Ailoaie, C. (1986). Micro-pipette puller. Patent no. 96704.

Iacobas DA, Amuzescu B, Ciontu C. (1988). Procedure to fabricate the micro-pipettes for single-channel current recording. Patent no. 102203.

Iacobas DA, Amuzescu B. (1991). Device to clean and stabilize the patch-clamp pipettes. Patent No. 108844