Current Members: Lijie Shi

Lijie Shi

Email: lshi@mail.einsteinmed.org 

LinkedIn 

Education:

Ph.D Candidate, Albert Einstein College of Medicine

MS, Shandong University, China 

Research interest:

One allele of Crkl gene is deleted in most of 22q11.2 deletion syndrome patients, and up to 62% of patients in our cohort have congenital heart defects. Crkl gene encodes an adaptor protein involving in many signal pathways in cells. Mice Crkl null embryos exhibit various aspects of heart defects and die around embryonic 16.5 days. My projects mainly focus on the study of the tissue specific function of Crkl in mouse heart development. We use mouse as research model aiming to find out the molecular mechanism of Crkl function in mouse, also in human early heart developments.

Previous publications:

1. Shuai Wang, An-Jing Chen, Lijie Shi (co-first author), Xiaofan Zhao, Jinxing Wang. TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response. PloS ONE. 2012;7(1):e30057. 

2. Shuai Wang, Lijie Shi (co-first author), Ning Liu, An-Jing Chen, Xiaofan Zhao, Jinxing Wang. Involvement of Fenneropenaeus chinensis Cathepsin C in antiviral immunity. Fish & Shellfish Immunology. 2012;33(4):821-828.  

3. Shi Xiuzhen, Lijie Shi (co-first author), Zhao Yanran, Zhao Xiaofan, Wang Jinxing. β-Thymosins participate in antiviral immunity of red swamp crayfish (Procambarus clarkii). Dev Comp Immunol. 2015 Aug;51(2):213-225.