Complement C3 and autophagy keep the Beta cell alive. Toledo M, Singh R. Cell Metabolism. 2019; doi.org/10.1016/j.cmet.2018.12.010
Autophagy regulates the liver clock and glucose metabolism by degrading CRY1. Toledo M, Batista-Gonzalez A, Merheb E, Aoun ML, Tarabra E, Feng D, Sarparanta J, Merlo P, Botre F, Schwartz GJ, Pessin JE, Singh R. Cell Metabolism. 2018; DOI: https://doi.org/10.1016/j/cmet.2018.05.023
Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes.
Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL. Journal of Clinical Investigation. 2018; Epub ahead of print. PubMed
System-wide benefits of intermeal fasting by autophagy.
Martinez-Lopez N, Tarabra E, Toledo E, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R. Cell Metabolism. 2017; 26: 856-871. PubMed
Highlighted: Nature Reviews in Endocrinology
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K. Science. 2016; 354: 1156-1160. PubMed
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, … Singh R, … Zughaier SM. Autophagy. 2016; 12: 1-222. PubMed
Autophagy in the CNS and periphery coordinate lipophagy and lipolysis in the brown adipose tissue and liver.
Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R. Cell Metabolism. 2016; 23: 113-127. PubMed
Autophagy and lipid droplets in the liver.
Martinez-Lopez N, Singh R. Annual Review of Nutrition. 2015; 35: 215-237. PubMed
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM. Genes & Development. 2015; 29: 934-947. PubMed
Autophagy proteins regulate ERK phosphorylation.
Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R. Nature Communications. 2013; 4: 2799. PubMed
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R. EMBO Reports. 2013; 14(9): 795-803. PubMed
Mapping autophagy onto your metabolic radar.
Yamada E, Singh R. Diabetes. 2012; 61: 272-280. PubMed
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis.
Kaushik S, Arias E, Kwon H, Martinez-Lopez N, Sahu S, Schwartz GJ, Pessin JE, Singh R. EMBO Reports. 2012; 13(3): 258-265. PubMed
Comment: Rubinsztein DC. Autophagy-alias self-eating-appetite and ageing. EMBO Reports 2012;13(3):173-174.
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Autophagy in the cellular energetic balance.
Singh R, Cuervo AM. Cell Metabolism. 2011; 13: 495-504. PubMed
Cell Metabolism: Top 10 Reviews, 2005-2014, as chosen by the readers
Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance.
Kaushik S, Rodriguez-Navarro, JA, Arias E, Kiffin R, Sahu S, Schwartz GJ, Cuervo AM, Singh R. Cell Metabolism. 2011; 14: 173-183. PubMed
Featured: The Scientist magazine, The Los Angeles Times, Fox News, EurekAlert.com, Jay Leno, National Public Radio
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Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity.
Wang Y, Singh R, Xiang Y, Greenbaum LE, Czaja MJ. Hepatology. 2010; 52: 2118-2126. PubMed
Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress.
Wang Y, Singh R, Xiang Y, Czaja MJ. Hepatology. 2010; 52: 266-277. PubMed
Autophagy regulates adipose mass and differentiation.
Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. Journal of Clinical Investigation. 2009; 119(11): 3329-3339. PubMed
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Autophagy regulates lipid metabolism.
Singh R,* Kaushik S,* Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo, AM, Czaja, MJ. Nature. 2009; 458: 1131-1135. *co-first authors PubMed
Nature News and Views: Zechner R, Madeo F. Cell biology: Another way to get rid of fat. Nature 2009; 458: 1118-1119.
Preview: Weidberg H, Shvets E, Elazar Z. Lipophagy: Selective catabolism designed for lipids. Dev Cell 2009; 16: 628-30.
Hepatology Elsewhere: Kersten S, Müller M. Dropping liver fat droplets. Hepatology 2009; 50: 645-647.
Featured in communication media: ABC, BBC, Discover Magazine, Science Central, Science Daily, Washington Post
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Differential effects of JNK1 and JNK2 inhibition on insulin resistance and steatohepatitis.
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, and Czaja MJ. Hepatology. 2009; 49: 87-96. PubMed
Comment: c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Kodama Y, Brenner DA. Hepatology 2009; 49: 6-8.