HIV-Associated Comorbidities, Coinfections and Complications
A complex array of coinfections and comorbid conditions, including end-organ dysfunction, adversely affect the clinical course of HIV. ART significantly improves but does not eliminate the development of HIV-associated comorbidities, coinfections, and complications (CCCs) which entails clinical management of concurrent HIV-associated CCCs across the lifespan. Several ERC-CFAR investigators are focused on determining the mechanistic basis and ameliorating the impact of infections such as tuberculosis (TB), hepatitis B and C, human papillomavirus (HPV), and sexually transmitted infections (STIs) on HIV disease course. Increasing our understanding of the underlying mechanisms responsible for how coinfections and comorbid conditions impact on clinical course should lead to improved treatment and prevention of HIV infection and these related disorders. In addition, ERC-CFAR Investigators are engaged in research relevant to other coinfections and opportunistic infections and HIV-related cancers, neurologic and cognitive disorders, cardiovascular disease, mental illness and substance use, metabolic and bone abnormalities, and liver and renal dysfunction. Listed below are NIH-funded studies by our ERC-CFAR Investigators researching strategies to address HIV-associated Comorbidities, Coinfections, and Complications.
| Investigator | Institution | NIH Grant | Title |
|---|---|---|---|
| Jacqueline Achkar | Einstein | R01AI117927 | Host biomarkers for M. Tuberculosis infection activity in HIV-infected persons |
| Kathryn Anastos | Einstein | U01HL146204 | Clinical research sites for the MACS/WIHS combined cohort study (MACS/WIHS-CCS) |
| Kathryn Anastos | Einstein | U54CA254568 | Einstein/Rwanda DRC consortium for research in HIV/HPV malignancies - project 2 |
| Kathryn Anastos | Einstein | U01AI096299 | Central AFRICA international epidemiologic database to evaluate AIDS |
| Joan Berman | Einstein | R01DA041931 | Effect of buprenorphine on monocytes in the context of neuroAIDS and opioid abuse |
| Joan Berman | Einstein | R01DA044584 | Impact of illicit drugs, HIV, and ART on neuroinflammation and BBB disruption |
| Joan Berman | Einstein | R01DA048609 | Mechanisms of opioid- mediated HIV neuropathogenesis |
| Joan Berman | Einstein | R01MH112391 | Monocyte CNS HIV entry & neurodegeneration: translational studies in the cART era |
| James Brust | Einstein | K24AI155045 | Mentoring of multidisciplinary global health research in tuberculosis and HIV |
| James Brust | Einstein | R01AI145679 | Emergence of bedaquiline and clofazimine resistance after interruption of drug-resistant tb therapy in a high HIV prevalence setting |
| Vilma Gabbay | Einstein | R01DA054885 | The neural underpinnings of depression and cannabis use in young PLWH |
| Vilma Gabbay | Einstein | R01MH128878 | The neuroimmunology of depression in women living with HIV |
| David Hanna | Einstein | K01HL137557 | Prediction of heart failure in HIV-infected individuals |
| Betsy Herold | Einstein | R01AI134367 | Mechanisms underlying the HIV-HSV-2 syndemic |
| Robert Kaplan | Einstein | R01HL148094 | Immunophenotyping for precision medicine for cardiovascular disease in people living with HIV |
| Pedro Mateu-Gelabert | CUNY SPH | R01DA041501 | The staying safe intervention: preventing HCV among young opioid injectors |
| Kerry Murphy | Einstein | K23AG062400 | The impact of HIV on accelerated aging in the female genital tract: a pilot trial of topical estradiol to improve the vaginal microbiome and symptoms of vaginal atrophy in menopausal women with HIV |
| Liise-Anne Pirofski | Einstein | R01AI143453 | Antibodies, B cells and resistance to human cryptococcosis |
| Qibin Qi | Einstein | R01HL140976 | Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites |
| Joanna Starrels | Einstein | K24DA046309 | Mentoring junior investigators to tackle the opioid epidemic |
| Howard Strickler | Einstein | R01CA230331 | Next generation of HPV and cervical cancer research in HIV+ women |
| Marcel Yotebieng | Einstein | R01HD087993 | Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR Congo |
| Marcel Yotebieng | Einstein | R01HD105526 | HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study |