Reduce the Incidence of HIV A crucial component of ending the HIV/AIDS epidemic is the development, evaluation and implementation strategies to successfully prevent new infections. ERC-CFAR investigators advance the high priority of the NIH for HIV research, to reduce the incidence of HIV, by developing and testing safe, effective, and affordable biomedical interventions in parallel with establishing and evaluating novel behavioral and social science-based prevention approaches. Our investigators are developing strategies to enhance expanding the uptake and adherence of pre-exposure prophylaxis (PrEP), reduce stigma associated with treatment, expand product delivery options, and implement effective HIV prevention packages. They are also determining the impact of mucosal and microbiome environments on the effectiveness of HIV prevention interventions, as well as evaluating the effectiveness of new strategies for the early diagnosis of infection, such as low-cost self or home testing, to stimulate early initiation into care. Listed below are NIH-funded studies by ERC-CFAR Investigators researching strategies to reduce the incidence of HIV. Investigator Institution NIH Grant Grant Title Matthew Akiyama Einstein DP2DA053730 Leveraging HCV phylogenetic networks to prevent HIV and other blood borne infections among people who inject drugs Amelia Escolano Rockefeller K99AI140770 Design of vaccination strategies to elicit broadly neutralizing antibodies against HIV-1 Sarit Golub Hunter College R01MH123262 Synthesizing best practice to accelerate access to emerging HIV prevention modalities Sarit Golub Hunter College R01MH123262 Synthesizing best practice to accelerate access to emerging HIV prevention modalities Sarit Golub Hunter College R01MH115835 Improving prevention systems to reduce disparities for high priority populations. Christian Grov CUNY SPH UH3 AI133675 Following a U.S. National cohort of vulnerable men to improve hiv prevention and care Betsy Herold Einstein R01HD098977 Impact of the vaginal microbiome on topical HIV pre-exposure prophylaxis (PrEP) Pedro Mateu-Gelabert CUNY SPH R01DA041501 The staying safe intervention: preventing HCV among young opioid injectors Denis Nash CUNY SPH R01MH117793 PROMISE - Program refinements to optimize model impact and scalability based on evidence Denis Nash CUNY SPH R01MH125735 Strengthening the safety net: Testing a novel data-to-suppression (D2S) intervention strategy in the Ryan White HIV/AIDS Program Michel Nussenzweig Rockefeller P01 AI138212 Activation of HIV-1 specific B cell precursors using novel vaccine approaches Viraj Patel Einstein R21MH118102 Impact of multiple stigmas on HIV care continuum outcomes for key populations Viraj Patel Einstein R01MH119001 Chalo!: a mobile technology based intervention to accelerate HIV testing and linkage to prevention and treatment Vinayaka Prasad Einstein R01AI153008 CCL2-CCR2B signaling in HIV-1 fitness and disease; role of host genetic polymorphisms Jonathan Ross Einstein K23MH114752 Minimizing losses from HIV care under universal treatment in Rwanda Tyrel Starks Hunter College R01DA050508 Expanding the potential of couples HIV testing: adjunct modules to reduce drug use among vulnerable male couples Tyrel Starks Hunter College R01DA045613 Intervention to reduce drug use and HIV incidence among high prep priority partnered YMSM Gabriel Victora Rockefeller R01AI119006 Dynamics of antigen-driven selection in germinal centers