Graduate Program in the Biomedical Sciences

2019 PhD Thesis Defenses

MEGYAN LI

Thesis Title: Weaponizing the Immune System to Fight Infectious Diseases: Developing Immunotherapeutics to Amplify and Reinvigorate Potent HIV and CMV-specific CD8+T Cell Responses

Date: Tuesday, December 10, 2019
Time: 1:00 pm
Location: Chanin 425 
Laboratory of Dr. Harris Goldstein
PhD Student, Department of Microbiology and Immunology

BRIAN KOSMYNA

Thesis Title: Transcriptional Analysis of Human snRNA Variants Reveals Homeostasis of U2 snRNA is Provided by an Abundant U2 Variant

Date: Thursday, December 5, 2019
Time: 1:30 pm
Location: 3rd Floor Lecture, Forchheimer 
Laboratory of Dr. Charles Query
PhD Student, Department of Cell Biology

JENS MAXIMILIAN FELS

Thesis Title: Mechanistic Insights into Ebola Virus Entry Through Mutational Dissection of the Spike Glycoprotein

Date: Tuesday, November 19, 2019
Time: 10:00 am
Location: 3rd Floor Lecture, Forchheimer 
Laboratory of Dr. Kartik Chandran
PhD Student, Department of Microbiology and Immunology

JUDY WAN

Thesis Title: Antiviral Strategies to Target the Exit Pathway of Alphavirus Infection

Date: Friday, November 15, 2019
Time: 12:00 pm
Location: 5th Floor Lecture Hall, Forchheimer 
Laboratory of Dr. Margaret Kielian
PhD Student, Department of Cell Biology

VINCENT TU

Thesis Title: The Toxoplasma gondii Cyst Wall: Composition and Interactome

Date: Wednesday, October 16, 2019
Time: 10:00 am
Location: LeFrak Auditorium, Price Center 
Laboratory of Dr. Louis Weiss
PhD Student, Department of Pathology

VICTOR PAI

Thesis Title: Inhibiting the Prostaglandin Transporter PGT Induces Non-Canonical Thermogenesis at Thermoneutrality

Date: Thursday, October 10, 2019
Time: 10:00 am
Location: LeFrak Auditorium, Price Center 
Laboratory of Dr. Victor Schuster
PhD Student, Department of Physiology and Biophysics

SEAN HEALTON

Thesis Title: Roles of Mammalian Linker Histones in the Regulation of Core Histone Post-translational Modifications

Date: Friday, October 4, 2019
Time: 12:00 pm
Location: 3rd Floor Lecture Hall, Forchheimer 
Laboratory of Dr. Arthur Skoultchi
MD-PhD Student, Department of Cell Biology

SAMUEL DOWLING

Thesis Title: Regulation of CD4+ T Cell Activation Through Lysosomal-Mediated Degradation of Signaling and Metabolic Modulators

Date: Thursday, October 3, 2019
Time: 11:00 am
Location: 5th Floor Lecture Hall, Forchheimer 
Laboratory of Dr. Fernando Macian-Juan
MD-PhD Student, Department of Pathology

JEETAYU BISWAS

Thesis Title: RNA Binding Proteins, Mechanics Underlying Recognition of Targets

Date: Wednesday, October 2, 2019
Time: 11:00 am
Location: LeFrak Auditorium, Price Center 
Laboratory of Dr. Robert H. Singer
MD-PhD Student, Department of Anatomy and Structural Biology

NATALIE RAMSEY

Thesis Title: Vaccine Protection Against Herpes Simplex Virus Requires Different Immune Responses in the Eye than in Other Mucosal Sites

Date: Friday, September 27, 2019
Time: 9:30 am
Location: 3rd Floor Lecture Hall, Forchheimer 
Laboratory of Dr. Betsy Herold
MD-PhD Student, Department of Microbiology and Immunology

ADAM KRAMER

Thesis Title: Fidgetin-like 2: A Developmental Gene as a Promising Target to Induce Adult Tissue Repair

Date: Friday, September 20, 2019
Time: 11:00 am
Location: 1st Floor Lecture Hall, Forchheimer 
Laboratory of Dr. David Sharp
PhD Student, Department of Physiology and Biophysics

KYLE JENSEN

Thesis Title: Diverse Mechanisms of Synaptic Plasticity and Metaplasticity in the Hippocampus

Date: Friday, September 13, 2019
Time: 2:00 pm
Location: Kennedy Center Auditorium
Laboratory of Dr. Pablo Castillo
PhD Student, Department of Neuroscience

JOSE QUIROZ

Thesis Title: Human and Engineered Antibodies Against Chikungunya Virus

Date: Wednesday, September 4, 2019
Time: 1:00 pm
Location: LeFrak Auditorium, Price Center 
Laboratory of Dr. Jonathan Lai
MD-PhD Student, Department of Biochemistry

TODD RUBIN

Thesis Title: Risk and Susceptibility to Repetitive Subconcussive Head Injury: Evidence for Sex as a Risk Factor and a New Model for Further Investigation

Date: Wednesday, August 28, 2019
Time: 2:00 pm
Location: Kennedy Center Auditorium
Laboratory of Dr. Micheal Lipton
MD-PhD Student, Department of Neuroscience

NACHIKET KAMATKAR

Thesis Title: Towards Targeted Molecular Therapy for FGF Receptors: Development of Aptamers Specific for FGFR3

Date: Tuesday, August 20, 2019
Time: 1:00 pm
Location: Kennedy Center Auditorium
Laboratory of Dr. Jean Hébert
PhD Student, Department of Neuroscience

RUTH HOWE

Thesis Title: Characterization of the Protein C15orff65/SMALL as a Tumor Suppressor and Epigenetic Regulator in Multiple Myeloma and Plasma Cell Malignancy

Date: Monday, August 5, 2019
Time: 12:00 pm
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Ulrich Steidl
MD-PhD Student, Department of Cell Biology

CINDY BUFFONE

Thesis Title: Elucidating the Role of Cellular Host Factors and Their Mechanisms in Influencing HIV-1 Infection

Date: Monday, July 15, 2019
Time: 1:00 am
Location: 5th Floor Lecture Hall, Forchheimer
Laboratory of Dr. Felipe Diaz-Griffero
PhD Student, Department of Microbiology and Immunology

YILIN ZHAO

Thesis Title: Novel Mechanisms of Lens Cell Differentiation Through Transcriptomic, Chromatin and Proteomic Analysis

Date: Wednesday, July 3, 2019
Time: 11:00 am
Location: 3rd Floor Lecture Hall, Forchheimer
Laboratory of Dr. Ales Cvekl and Dr. Deyou Zheng
PhD Student, Department of Genetics

DAVID AJASIN

Thesis Title: CCL2 Mobilizes ALIX from Actin Cytoskeleton to Enhance Gag Trafficking and HIV Virion Release - Effect of Gag Polymorphism on HIV-1 Viral

Date: Friday, June 14, 2019
Time: 10:00 am
Location: 3rd Floor Lecture Hall, Forchheimer
Laboratory of Dr. Vinayaka Prasad
PhD Student, Department of Microbiology and Immunology

BRENDA GONZALEZ

Thesis Title: Nuclear-Encoded Mitochondrial Genes in Human Aging and Longevity

Date: Tuesday, June 11, 2019
Time: 11:00 am
Location: 5th Floor Lecture Hall, Forchheimer
Laboratory of Dr. Yousin Suh
PhD Student, Department of Genetics

EVAN DER

Thesis Title: Insights from the Comparison of Renal and Skin Single-Cell Transcriptomes in Lupus Nephritis

Date: Sunday, June 04, 2019
Time: 2:00 pm
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Chaim Putterman
PhD Student, Department of Microbiology and Immunology

ARCHANA TARE

Thesis Title: A Functional Genomics Approach to Elucidate the Role of Systemic Geronic Factors in Human Aging and Longevity

Date: Tuesday, May 28, 2019
Time: 10:00 am
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Yousin Suh
PhD Student, Department of Genetics

NILOY IQBAL

Thesis Title: Novel Obesity Suppressor Function of the Retinoblastoma Protein Uncovers Cyclin-Dependent Kinase 4 as a Therapeutic Target for Diet-Induced Obesity

Date: Thursday, May 02, 2019
Time: 12:00 pm
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Liang Zhu
MD-PhD Student, Department of Developmental and Molecular Biology

YIZHOU ZHU

Thesis Title: Elucidating the Enhancer Code in 9p21 Locus Underlying Age-Related Disease Risks

Date: Thursday, April 11, 2019
Time: 11:00 am
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Yousin Suh
PhD Student, Department of Genetics

GABRIELA FARIAS QUIPILDOR

Thesis Title: The Role of Central and Peripheral IGF-1 in the Regulation of Metabolism and Healthspan

Date: Tuesday, April 9, 2019
Time: 1:00 pm
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Derek Huffman
PhD Student, Department of Molecular Pharmacology 

ERICA HASTEN

Thesis Title: Genetic Functions of Tbx1 in Mouse Models of 22q11.2 Deletion and Duplication Syndromes

Date: Friday, April 5, 2019
Time: 10:00 am
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Bernice Morrow
PhD Student, Department of Genetics

SARA NIK

Thesis Title: Deciphering the Role of SF3B1-Regulated R-loops in Development & Disease

Date: Wednesday, March 20, 2019
Time: 11:00 am
Location: LeFrak Auditorium, Price Center
Laboratory of Dr. Teresa Bowman
PhD Student, Department of Developmental and Molecular Biology

LAUREN BOUDEWYN

Thesis Title: Assessment of Therapeutics and Disease Pathogenesis in Mucolipidosis Type IV

Date: Tuesday, March 19, 2019
Time: 2:00 pm
Location: Room 901, Kennedy Center
Laboratory of Dr. Steven Walkley
PhD Student, Department of Developmental and Molecular Biology