Kosaku Shinoda, Ph.D.
- Assistant Professor, Department of Medicine (Endocrinology)
- Assistant Professor, Department of Molecular Pharmacology
Area of research
- My lab is focused on the biology of adipocytes. Understanding basic biology of adipocytes is fundamental to the treatment and prevention of type 2 diabetes/obesity.
Phone
Location
- Albert Einstein College of Medicine Michael F. Price Center 1301 Morris Park Avenue 355 Bronx, NY 10461
Research Profiles
Selected Publications
1) Deutsch, A., Reddy, N., McLellan, N.M. and Shinoda, K*. (2022) Single-cell characterization of lipomas and identification of their adipogenic progenitors. J Invest Dermatol., in press *corresponding author
2) Deutsch, A. and Shinoda, K*. (2021) The genesis of brown fat-a smooth muscle origin story revisited. Nature Metabolism, 3, 449-450. *corresponding author
3) Oguri, Y*., Shinoda, K*., Kim, H*., Alba, DL., Bolus, RW., ... Spiegelman, B.M. and Ka- jimura, S. (2020) CD81 controls beige fat progenitor cell growth and energy balance via FAK signaling. Cell, 182, 563-577. *co-first author
4) Deutsch, A., Feng, D., Pessin J.E. and Shinoda, K*. (2020) The Impact of Single-Cell Genomics on Adipose Tissue Research. Int J Mol Sci., 21, 4773 *corresponding author
5) Benitez, G.J. and Shinoda, K*. (2020) Isolation of adipose tissue nuclei for single-cell genomic applications. Journal of Visualized Experiments, 12, 160. *corresponding author
6) Deutsch, A., McLellan B.N. and Shinoda, K*. (2020) Single-cell transcriptomics in dermatology. JAAD International, 1, 182-188. *corresponding author
7) Chen, Y., Ikeda, K., Yoneshiro, T., Scaramozza, A., Tajima, K., Wang, Q., Kim, K., Shinoda, K., Sponton, CH., Brown, Z., Brack, A. and Kajimura, S. (2019) Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature 565, 180–185.
8) Hasegawa, Y., Ikeda, K., Chen, Y., Alba, DL., Stifler, D., Shinoda, K., Hosono, T., Maretich, P., Yang, Y., Ishigaki, Y., Chi, J., Cohen, P., Koliwad, SK. and Kajimura, S. (2018) Repression of adipose tissue fibrosis through a PRDM16-GTF2IRD1 complex improves systemic glucose homeostasis. Cell Metabolism 27, 180–194.
9) Ikeda, K,, Kang, Q,, Yoneshiro, T., Camporez, JP., Maki, H., Homma, M., Shinoda, K., Chen, Y., Lu, X., Maretich, P., Tajima, K., Ajuwon, KM., Soga, T. and Kajimura, S. (2017) UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nature Medicine 23, 1454-1465.
10) Altshuler-Keylin, S., Shinoda, K., Hasegawa, Y., Ikeda, K., Hong, H., Kang, Q., Yang, Y., Perera, R.M., Debnath, J. and Kajimura, S. (2016) Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance. Cell Metabolism 24, 402-419.
11) Ohyama, K., Nogusa, Y., Shinoda, K., Suzuki, K., Bannai, M. and Kajimura, S. (2016) Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes 65, 1410-23.
12) Shinoda, K., Ohyama, K., Hasegawa, Y., Chang, H.Y., Ogura, M., Sato, A., Hong, H., Hosono, T., Sharp, L.Z., Scheel, D.W., Graham, M., Ishihama, Y. and Kajimura, S. Phosphoproteomics identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure. (2015) Cell Metabolism 22, 997-1008.
13) Shinoda, K., Luijten, IHN., Hasegawa, Y., Hong, H., Sonne, S.B., Xue, R., Chondronikola, M., Kim, M., Cypess, A.M., Tseng, Y., Nedergaard, J., Sidossis, L.S. and Kajimura, S. (2015). Genetic and functional characterization of clonally-derived adult human brown adipocytes. Nature Medicine 21, 389-394.
14) Kazak, L., Chouchani, E.T., Jedrychowski, M.P., Erickson, B.K., Shinoda, K., Cohen, P., Vetrivelan, R., Lu, G.Z., Laznik-Bogoslavski, D., Hasenfuss, S.C., Kajimura, S., Gygi, S.P. and Spiegelman, B.M. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. (2015) Cell 22, 643-55.
15) Ohno, H.(*), Shinoda, K.(*), Ohyama, K.(*), Sharp, LZ. and Kajimura, S. (2013) EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature, 504, 163-167. (*co-first author)
16) Shinoda, K., Tomita, M. and Ishihama, Y. (2010) emPAI Calc–for the estimation of protein abundance from large-scale identification data by liquid chromatography-tandem mass spectrometry. Bioinformatics, 26, 576-577.