![Sergei Khrapunov](https://assets.montefioreeinstein.org/profiles/images/275-sergei-khrapunov.jpg)
Sergei Khrapunov, Ph.D.
- Research Professor Emeritus, Department of Biochemistry
Area of research
- Structure and thermodynamics of proteins and protein-DNA complexes. Chromatin structure.
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building 311 Bronx, NY 10461
Professional Interests
Structure and thermodynamics of proteins and protein-DNA complexes. Chromatin structure.
Selected Publications
Selected publications
Khrapunov S, Waterman S, Persaud R and Chang E.P., - "Structure, Function, and Thermodynamics of Lactate Dehydrogenases from Humans and the Malaria Parasite P. falciparum”. Biochemistry 2021, 60, 47, 3582–3595
Khrapunov S, - "The Enthalpy-entropy Compensation Phenomenon. Limitations for the Use of Some Basic Thermodynamic Equations". Current Protein and Peptide Science, 2018, 19, 11, 1088-1091.
Khrapunov S, Chang E, Callender RH., - "Thermodynamic and Structural Adaptation Differences between the Mesophilic and Psychrophilic Lactate Dehydrogenases". Biochemistry, 2017, 56, 3587-3595.
Khrapunov S, Tao Y, Cheng H, Padlan C, Harris R, Galanopoulou AS, Greally JM, Girvin ME, Brenowitz M., - "MeCP2 Binding Cooperativity Inhibits DNA Modification-Specific Recognition". Biochemistry. 2016, 55, 4275-4285
Khrapunov, S., Warren, C., Cheng, H. Y., Berko, E.R., Greally, J.M. & Brenowitz, M.– “Unusual Characteristics of the DNA Binding Domain of Epigenetic Regulatory Protein MeCP2 Determine Its Binding Specificity”.Biochemistry, 2014, 53, 3379−3391.
Khrapunov, S. & Brenowitz, M.– “Stability, denaturation and refolding of Mycobacterium tuberculosis MfpA, a DNA mimicking protein that confers antibiotic resistance”. Biophysical Chemistry, 2011, 159, 33-40.
Khrapunov S.– “Circular dichroism spectroscopy has intrinsic limitations for protein secondary structure analysis”. Anal Biochem. 2009, 389, 174-176
Khrapunov S, Cheng H, Hegde S, Blanchard J, Brenowitz M. –“Solution Structure Refolding of the Mycobacterium tuberculosis Pentapeptide Repeat Protein MfpA” . J Biol. Chem. 2008, 283, 36290-9
Khrapunov, S. and Brenowitz, M. – “Influence of the N-terminal domain and divalent cations on self association and DNA binding by the Saccharomyces cerevisiae TATA Binding Protein" - Biochemistry, 2007, 4876-4887.
Khrapunov, S., Brenowitz, M., Rice, P.A. & Catalano, C.E. - "Binding then bending: A mechanism for wrapping DNA"[Invited commentary] - Proc.Natl.Acad.Sci.USA, 2006, 103, 19217-19218.
Blakaj, B., Kattamuri, C., Khrapunov, S., Rashmi S. Hegde, R.S., Brenowitz, M. - "Indirect Readout of DNA Sequence by Papillomavirus E2 Proteins Depends Upon Net Cation Uptake" - J. Mol. Biol, 2006, 358, 224–240
Khrapunov, S. and M. Brenowitz. - "Comparison of the effect of water release on the interaction of the Saccharomyces cerevisiae TATA binding protein (TBP) with "TATA Box" sequences composed of adenosine or inosine”. -Biophys J., 2004, 86, 371-383.
Khrapunov S., Pastor N. & Brenowitz M. – “Solution structural studies of the Saccharomyces cerevisiae TATA Binding Protein (TBP)” – Biochemistry, 2002, 41, 9559-9571.
Khrapunov S.N., Dragan A.I., Sivolob A.V., Zagariya A.M.-“Mechanisms of Stabilizing Nucleosome Structure. Study of Dissociation of Histone Octamer from DNA”.- Biochim.Biophys.Acta,1997,1351, 213-222.
Sivolob A.V., Khrapunov S.N.-“Electrostatic contribution to the bending of DNA”.-Biophysical Chemistry, 1997,67, 85-89
Sivolob A.V., Khrapunov S.N.-“Translatioal Positioning of Nucleosomes on DNA: The Role of Sequence-dependent Isotropic DNA Bending Stiffness”.-J. Mol. Biol., 1995,247,918-931.