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Robert D. Burk, M.D.

Robert D. Burk, M.D.

Professor and Vice Chair for Translational Research, Department of Pediatrics

Professor, Microbiology & Immunology

Professor, Obstetrics & Gynecology and Women’s Health

Professor, Epidemiology and Population Health

Attending Physician, Pediatrics, the Children's Hospital at Montefiore

Human papillomavirus (HPV)Cervical cancer screeningMolecular evolution

Dr. Burk is an authority on the genomics and evolution of human papillomaviruses (HPV), which cause nearly all cases of cervical cancer. His team was the first to report, in the New England Journal of Medicine, that the vast majority of HPV infections in young women are short-lived and don’t require treatment. More recently, his lab is utilizing Next-Gen sequencing to study papillomavirus genomics and methylation of the viral genome. His lab utilized this new technology to identify HPV16 and beta- and gamma-HPVs associated with head and neck squamous cell cancers (HNSCCs).

Dr. Burk is also currently investigating the role of the human microbiome and cervical HPV natural history. He is a co-PI on a grant with Drs. Kaplan and Rob Knight (UCSD) studying the human gut microbiome and obesity and diabetes in the Hispanic Community Health Study/Study of Latinos. Dr. Burk’s lab has pioneered translational studies of the human microbiome by developing home collection kits that have been used to collect over 5,000 samples.

Dr. Burk was elected in 2015 as a fellow of the American Association for the Advancement of Science (AAAS).
 

Betsy Herold, M.D.

Betsy Herold, M.D.

Professor, Harold and Muriel Block Chair, Pediatrics

Professor, Microbiology & Immunology

Professor, Obstetrics & Gynecology and Women’s Health

Vice Chair, Research, Pediatrics, Einstein and the Children’s Hospital at Montefiore (CHAM)

Chief, Division of Pediatric Infectious Diseases, Einstein and CHAM

Infectious diseasesHerpes simplex virusesCOVID-19 and pediatricsVaccines and antiviralsHIV

Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens. 
 
Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies for young women and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs. 

Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses. 

Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.
 

Solomon L. Moshe, M.D.

Solomon L. Moshe, M.D.

Professor, The Saul R. Korey Department of Neurology, Einstein

Charles Frost Chair in Neurosurgery & Neurology, Einstein

Vice-Chair & Director, Pediatric Neurology & Clinical Neurophysiology, Department of Neurology, Einstein

Chief, Pediatric Neurology, The Children's Hospital at Montefiore

EpilepsyPediatric neurologyNeurophysiology

Translational research

Dr. Moshé is an authority on the mechanisms that underlie the development of epilepsy and on the consequences of the disease in infants and children as a function of gender. read more...

 

Chaim Putterman, M.D.

Chaim Putterman, M.D.

Professor, Medicine (Rheumatology), Einstein

Professor, Microbiology & Immunology, Einstein

Chief, Division of Rheumatology, Department of Medicine, Einstein and Montefiore Health System

ArthritisLupusAutoimmune diseases

Rheumatoid arthritis

Dr. Putterman is a clinical rheumatologist who treats arthritis and related musculoskeletal and autoimmune diseases. Dr. Putterman specializes in lupus, an incurable autoimmune disease affecting 1.5 million Americans that causes inflammation, pain and damage to various parts of the body. read more...

 

Ulrich G. Steidl, Ph.D., M.D.

Ulrich G. Steidl, Ph.D., M.D.

Professor, Cell Biology

Professor, Medicine

Deputy Director, Montefiore Einstein Comprehensive Cancer Center

Rose C. Falkenstein Chair in Cancer Research

Interim Director, The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research

Leukemias and myelodysplastic syndromes Pre-cancerous and cancer stem cellsCell and tumor biology

Dr. Steidl studies the molecular and cellular mechanisms that lead to two related blood diseases, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). His NIH-funded basic and translational research seeks to define the characteristics of pre-leukemic stem cells (pre-LSC), understand their progression to leukemic stems cells, and develop drug strategies to target the process. Dr. Steidl is co-director of the Montefiore Einstein Comprehensive Cancer Center's Blood Cancer Institute. read more...