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Solomon L. Moshe, M.D.

Solomon L. Moshe, M.D.

Professor, The Saul R. Korey Department of Neurology

Professor, Department of Pediatrics

Professor, Dominick P. Purpura Department of Neuroscience

Charles Frost Chair in Neurosurgery and Neurology

Director, Department of Pediatrics Division of Neurology

Director, The Saul R. Korey Department of Neurology Clinical Neurophysiology

Director, The Saul R. Korey Department of Neurology The Isabelle Rapin Division of Child Neurology

Area of Research: Studies include of antiepileptogenesis following traumatic brain injury, intractable age specific epilepsies and their consequences, and subcortical circuits involving the control of seizures. Model development.

Contact Information

718.430.2447solomon.moshe@einsteinmed.edu

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South, Room 316
Bronx, NY 10461

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More Resources: Developmental Epilepsy LaboratoryClinical Programs in Child Neurology and Neurophysiology at Montefiore Medical Center

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Professional Interests

Solomon L. Moshé, M.D., is the Charles Frost Chair in Neurosurgery and Neurology, and Professor of Neurology, Neuroscience, and Pediatrics at the Albert Einstein College of Medicine/Montefiore Medical Center in the Bronx, New York. He is also the Vice Chair of the Saul R. Korey Department of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology. His area of expertise is in epilepsy and related disorders.

Since 1979, his research has focused on understanding the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. Current research interests include studies on the role of subcortical circuitries involved in the control of seizures as a function of age and sex; the consequences of seizures on the developing brain and the development of models of catastrophic epilepsies. His laboratory has patented a model of infantile spasms that can be used to identify novel treatments. He is co principal investigator of a Center Without Walls grant on interdisciplinary research aimed at accelerating the development of disease modifying or prevention therapies for epilepsy following traumatic brain injuries. He is also involved in a large multicenter study examining the consequences of prolonged febrile seizures. He has over 600 publications as well as He has over 600 publications as well over 35 books and monographs.

over 35 books and monographs.

He has served as President of the International League Against Epilepsy (2009-2013), the American Epilepsy Society (2000-2001), the American Clinical Neurophysiology Society (1996-1997) and the Eastern Association of EEGers (1992-1994). He is the recipient of many awards and honors, including the Teacher-Investigator Development Award from NINDS; the 1995 Jacob Javits Neuroscience Investigator Award from NINDS; the 1984 Michael Prize for Achievements in Epilepsy Research; the 1990 American Epilepsy Society Research Award; the 1999 Ambassador for Epilepsy Award from the International League Against Epilepsy; the 2005 Gloor Award from the American Clinical Neurophysiology Society; the 2007 J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; the 2010 Global and Awareness Award from CURE, Citizens United for Research in Epilepsy; the First 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine and the 2017 Bernard Sachs Award from the Child Neurology Society, and the 2023 Lifetime Achievement Award from the International League against Epilepsy.

He has been asked to deliver over 50 several keynote lectures.

Clinical Focus:

Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents.

Research focus

Dr Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.

Selected Publications

Katsarou A, Moshé SL, Galanopoulou AS. Interneuronopathies and their role in early life epilepsies and neurodevelopmental disorders. Epilepsia Open 3: 284-306 (2017). PMID: 29062978
Moshe SL. The 2017 Sachs lecture: Kindling knowledge in Epilepsy. Pediatric Neurology 85: 5-12 (2018). PMID: 29958806
Saletti PG, Ali I, Casillas-Espinonsa PM, Semple BD, Lisgaras C, Moshe SL, Galanopoulou AS. In search of antiepileptogenic treatments for post-traumatic epilepsy. Neurobiology of Disease 123: 86-99 (2019). PMID: 29936231
Correa DJ, Kwon C, Connors S, Fureman B, Whittemore V, Jette N, Mathern G and Moshe SL. For the EpiBioS4RX Public Engagement Core. Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy. Neurobiology of Disease 123: 137-144 (2019). PMID: 30031158
Molinero I, Galanopoulou AS and Moshe SL. Rodent models: Where it all started with these “truths”. European Journal of Paediatric Neurology 61-65 (2020) PMID: 31875833
Ozlem A, Briggs S, Mowrey W, Moshe SL, Galanopoulou AS Antiepiletogenic effects of rapamycin in a model of infantile spasms due to structural lesions. Epilepsia, 62,1985-1999, (2021) PMID: 34212374
Zuberi S, Wirrell E, Yozawitz E, Wilmshurst J, Specchi N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead O, Wiebe S, Cross H, Tinuper P, Scheffer I, Perucca E and Moshe SL. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1349-1397 (2022) PMID: 35503712
Hirsch E, French J, Scheffer I, Bogacz A, Alsaadi T, Sperling M, Abdulla F, Zuberi S, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst J, Auvin S, Wiebe S, Perucca E, Moshe SL, Tinuper P and Wirrell E. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1475-1499 (2022) PMID: 35503716
Specchio N, Wirrell E, Scheffer I, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi S, Wilmshurst J, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross H, Perucca E, Moshe SL, Tinuper P and Auvin S. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1398-1442 (2022) PMID: 35503717
Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer I, Zuberi S, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lin L, Naiddo A, Perucca E, Moshe SL, Wirrell E and Tinuper P. International League Againist Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions. Epilespia, 63, 1443-1474 (2022) PMID: 35503725
Wirrell E, Nabbout R, Scheffer I, Alsaadi T, Bogacz A, French J, Hirsch E, Jain S, Kaneko S, Riney K, Samia P, Snead O, Somerville E, Specchio N, Trinka E, Zuberi S, Balestrini S, Wiebe S, Cross H, Perucca E, Moshe SL and Tinuper P. Methodology for classification and definition of epilepsy syndromes with list of syndroms: Report of the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1333-1348 (2022) PMID: 35503715
Saletti P, Casillas-Espinosa P, Lisgaras C, Mowrey W, Li Q, Liu W, Brady R, Ali I, Silva J, Yamakawa G, Hudson M, Li C, Braine E, Coles L, Cloyd J, Shultz S, Moshé SL, O’Brien T, Galanopoulou AS for the EpiBioS4RX Group. TAU phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects: An EpiBioS4Rx Project 2 study. Journal of Neurotrauma pgs 1-22, (2023.) PMID: 36950806
Saletti P, Mowrey W, Liu W, Li Q, McCullough J, Aniceto R, Lin I-H, Eklund M, Casillas-Espinosa P, Ali I, Santana-Gomez C, Coles L, Shultz S, Jones N, Staba R, O’Brien T, Moshé SL, Agoston D, Galanopoulou AS for the EpiBioS4RX Study Group. Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam. Epilepsia Open pgs. 586-608 (2023) PMID: 37026764
Coles L, Saletti P, Lisgaras C, Casillas-Espinosa P, Liu W, Li Q, Jones N, Shultz S, Ali I, Brady R, Yamakawa G, Hudson M, Silva J, Braine E, Mishra U, Cloyd J, O’Brien T, Moshé SL, Galanopoulou AS for the EpiBioS4RX Study Group. Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model. Journal of Pharmacology and Experimental Therapeutics pgs 1-30, (2023). PMID: 37316328

In the News

More Media Coverage

Tuesday, June 24, 2014

The Washington Post interviews Solomon Moshé, M.D., about the case of a girl with a rare form of epilepsy that causes uncontrolled bouts of laughter. Dr. Moshe notes that these gelastic seizures aren’t sparked by happiness and can actually be quite scary for the patient. Dr. Moshé is director of the division of pediatric neurology and professor in The Saul R. Korey Department of Neurology and The Dominick P. Purpura Department of Neuroscience at Einstein as well as chief of pediatric neurology at The Children’s Hospital at Montefiore.
Friday, April 29, 2011
WebMD interviews Solomon Moshé, M.D., about a new study that found treatment-resistant epilepsy is linked to autism. Dr. Moshé notes that the research confirms what experts have suspected, but that more studies are needed to determine the cause of this link. Dr. Moshé is division director of pediatric neurology and professor in The Saul R. Korey Department of Neurology and The Dominick P. Purpura Department of Neuroscience at Einstein as well as chief of pediatric neurology at Montefiore.

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Faculty Profile

Solomon L. Moshe, M.D.

Contact Information

Professional Interests

Selected Publications

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Einstein-Montefiore to Play Leadership Role in $21 Million NIH Grant to Study the Onset of Epilepsy after Traumatic Brain Injuries

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Dr. Solomon L. Mosh#e Elected President of The International League Against Epilepsy

In the News