Core for Single-Molecule Analysis (CSMA)

The Core for Single-Molecule Analysis (CSMA) at Einstein is an advanced facility equipped with state-of-the-art microscopes that enable the visualization and manipulation of single molecules in cells or in vitro systems using purified proteins. CSMA stands out due to the integration of optical tweezers with multi-color fluorescence microscopy, facilitating correlative force measurements and fluorescence analysis across various biological processes. This makes CSMA an ideal choice for conducting single-molecule studies on DNA- and RNA-protein interactions, proteasomal degradation, phase separation, cell-cell signaling, immunology, and more. In addition to our cutting-edge microscopes, CSMA provides a wide range of comprehensive services, including microscope training, assistance with assay development, and support with data analysis. Our primary objective is to empower researchers in groundbreaking basic science and cancer research, including drug screening, by facilitating the pursuit of competitive grant applications. The recent recognition of Arthur Ashkin's Nobel Prize in Physics for his pioneering work on optical tweezers underscores the innovative nature of this technology and the timely services that CSMA offers. By harnessing the power of single-molecule analysis, CSMA drives groundbreaking discoveries, enhances funding opportunities, and elevates the reputation of Einstein and its outstanding faculty.

Almost all aspects of life are engineered at the molecular level, and without understanding single molecules we can only have a very sketchy understanding of life itself

Francis Crick


  • Assistance with the design of experiments
  • Microscope user training
  • Assistance with data acquicition
  • Assistance with data analysis
  • Assistance with the preparation of text and figures for papers and grants

Related Shared Facilities
Related Shared Facilities
Center Affiliations
Center Affiliations

Selected Publications


Location and Contacts

Core for Single-Molecule Analysis (CSMA) Laboratory, Forchheimer Basement B15