Gary J. Schwartz

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Full Name
Gary J. Schwartz
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/9621-gary-schwartz.jpg
Type
Faculty
Expert
First Name
Gary
Last Name
Schwartz
Faculty ID
9621
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-neuroscience
einstein-dept-psychiatry-behavioral-sciences
Email
gary.schwartz@einsteinmed.edu
Phone
718-430-2263
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Endocrinology
Type
Academic
Department
Dominick P. Purpura Department of Neuroscience
Department Link
Rank
Professor
Tags
einstein-dept-neuroscience
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Professor
Type
Administrative
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Golding Building
Room
501
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Gary J. Schwartz, Ph.D., studies how the gut and the brain interact with each other to regulate food intake and associated metabolic processes.&nbsp; Dr. Schwartz and his colleagues aim to identify therapeutic targets for eating behaviors associated with obesity, diabetes and related diseases.</p>
<p>Our research focuses on the sensory neural controls of energy homeostasis in health and disease. We use rodent models to examine how food stimuli act at oral and gastrointestinal sites to affect food intake, energy balance, and gastrointestinal physiology.We approach this problem from multiple levels of analysis including behavioral, physiological, neurophysiological, and molecular-genetic. We have identified the type of food stimuli that activate vagal and splanchnic sensory fibers supplying the gut, and have revealed the extent to which these stimuli influence gut-brain communication. Our most recent efforts involve the analysis of gut-brain communication in the control of energy homeostasis in mouse models of obesity and diabetes.We have identified neurons in the periphery, brainstem and hypothalamus that integrate food-elicited signals with peptide signals that have profound effects food intake and metabolism. Data from these studies reveal that central hypothalamic and brainstem neuropeptides affect food intake and body weight by modulating the neural potency of food stimulated signals from the mouth and gut. This novel, synthetic conceptual framework is critical because it links forebrain hypothalamic structures, long known to be involved in the control of energy balance, to the sensory and motor systems in the brainstem that control ingestion, digestion, and metabolic processing of food. Future studies will use genetic mouse models of obesity and diabetes with targeted conditional neuropeptide/ receptor knockdown or replacement to determine how central neuropeptide signaling affects the neural processing of metabolic sensory signals critical to energy homeostasis.</p>

Research Areas
Obesity/ diabetes, gut-brain neuroendocrine communication in the control of feeding and energy balance, neuronal nutrient sensing, neural control of thermogenesis, lipolysis and gastrointestinal function.
Specialties
Areas of Expertise
Energy balance
Gut -brain communication
Nutrient sensing
Obesity
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz studies how the gut and the brain act together to determine how much people eat. He has identified sites in the gastrointestinal tract and brain that detect nutrients and has discovered how these regions are linked to food intake, obesity and diabetes. He also studies gastric-bypass surgery and the key neural and hormonal mechanisms responsible for the significant and long-lasting improvements in body weight, food intake and diabetes following the procedure.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz is Director of the Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core at Einstein and Director of the Animal Phenotyping Core of the Columbia University- Einstein New York Obesity Research Center. He also serves on multiple NIH study sections and on scientific grant review panels of the United States Department of Veterans Affairs, American Diabetes Association, Endocrine Fellows Foundation and Obesity Society. He is a member of the editorial boards of several journals, including&nbsp;<em>Diabetes</em>,&nbsp;<em>Endocrinology </em>and serves as an associate editor of the&nbsp;<em>American Journal of Physiology, Endocrinology &amp; Metabolism Section</em>.</span></p>

CHAM Provider
Off
Professional Title
Ph.D.
Is Open Scheduling
Off
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