Aviv Bergman

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Full Name
Aviv Bergman
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/9760-aviv-bergman.jpg
Type
Faculty
Expert
First Name
Aviv
Last Name
Bergman
Faculty ID
9760
Patient Type
Adult
Department
einstein-dept-systems-computational-biology
einstein-dept-pathology
einstein-dept-neuroscience
Email
aviv@einsteinmed.edu
Phone
718-678-1063
Titles
Type
Academic
Department
Department of Systems & Computational Biology
Department Link
Rank
Professor
Type
Academic
Department
Department of Pathology
Department Link
Rank
Professor
Type
Academic
Department
Dominick P. Purpura Department of Neuroscience
Department Link
Rank
Professor
Tags
einstein-dept-neuroscience
Type
Administrative
Title
Chair, Department of Systems & Computational Biology
Type
Administrative
Title
Harold and Muriel Block Chair in Systems & Computational Biology
Tags
me-patientcare-cancer-clinical-gastrointestinal
Type
Administrative
Title
Director, Albert Einstein Institute for Advanced Study in the Life Sciences
Locations
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Type
Academic
Location (Address, State, City, Zip)
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Coordinates
POINT (-73.845838 40.8516937)
Room
153C
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Michael F. Price Center
Address Line 3
1301 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>My research agenda addresses quantitative problems in evolutionary and developmental biology by using a combination of computational, mathematical and experimental tools. Starting with biologically relevant models, we comb for data from existing studies, and in close collaboration with experimentalists, we generate new data. In turn, this data allows us to refine the models, thus guiding both experimental and modeling processes. The ability to test models in this way is facilitated by data generated from systematic genomics efforts undertaken in recent years. Central to my approach is an evolutionary perspective in examining the hypotheses arising from the combination of theoretical model and biological data.</p>

Research Areas
My research agenda addresses quantitative problems in evolutionary systems and developmental biology by using a combination of computational, mathematical and experimental tools, as it pertains to complex traits.
Specialties
Areas of Expertise
Evolutionary biology
Expert Summary

<p>&nbsp;<span style="font-family: Arial, sans-serif; font-size: 9pt; line-height: 15.6pt;">Dr. Bergman combines data from basic and clinical research to create computer models of complex biological systems. As these models evolve, his work could contribute to calculating individualized medical outcomes and guiding treatment for patients based on their personal genetic make-up. Dr. Bergman has teamed with colleagues to study a variety of complex conditions, including aging, cancer and neurodegenerative diseases.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt; font-family: &quot;Arial&quot;,&quot;sans-serif&quot;;">Central to his approach is an evolutionary perspective in examining the hypotheses arising from the combination of theoretical models and biological data. His studies have focused on the causes and consequences of &ldquo;robustness&rdquo; (an organism&rsquo;s ability to withstand stresses, pressures or changes in its environment), the evolution of gene networks and the genetic hallmarks of human longevity and cancer as it relates to the loss of robustness.</span></p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p>Mark L. Siegal, Daniel Promislow and Aviv Bergman, 2005, Functional and evolutionary inference in gene networks: Does topology matter? Genetica, special issue on "The microevolution of development: Patterns, processes, and mechanisms".</p>
<p>Aviv Bergman and Mark L. Siegal, 2003, Evolutionary Capacitance as a General Feature of Complex Gene Networks. Nature 424, 549-552.</p>
<p>Joanna Masel and Aviv Bergman, 2003, The Evolution of the Evolvability Properties of the Yeast Prion [PSI+]. Evolution 57(7) 1498-1512.</p>
<p>Mark L. Siegal and Aviv Bergman, 2002, Waddington's Canalization Revisited: Developmental Stability and Evolution. Proceedings of the National Academy of Sciences USA Vol. 99 No. 16 10528-10532.</p>
<p>Samuel Karlin, Luciano Brocchieri, Aviv Bergman, Jan Mrzek and Andrew J. Gentles, 2002, Amino Acid and Charge Runs in Complete Eukaryotic Genomes and Disease Associations. Proceedings of the National Academy of Sciences USA Vol. 99 No. 1 333-338.</p>
<p>Samuel Karlin, Aviv Bergman and Andrew Gentles, 2001, Annotation of the Drosophila genome. Nature 411, 259-260.</p>

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Gary J. Schwartz

Submitted by Anonymous (not verified) on
Full Name
Gary J. Schwartz
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/9621-gary-schwartz.jpg
Type
Faculty
Expert
First Name
Gary
Last Name
Schwartz
Faculty ID
9621
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-neuroscience
einstein-dept-psychiatry-behavioral-sciences
Email
gary.schwartz@einsteinmed.edu
Phone
718-430-2263
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Endocrinology
Type
Academic
Department
Dominick P. Purpura Department of Neuroscience
Department Link
Rank
Professor
Tags
einstein-dept-neuroscience
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Professor
Type
Administrative
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Golding Building
Room
501
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Gary J. Schwartz, Ph.D., studies how the gut and the brain interact with each other to regulate food intake and associated metabolic processes.&nbsp; Dr. Schwartz and his colleagues aim to identify therapeutic targets for eating behaviors associated with obesity, diabetes and related diseases.</p>
<p>Our research focuses on the sensory neural controls of energy homeostasis in health and disease. We use rodent models to examine how food stimuli act at oral and gastrointestinal sites to affect food intake, energy balance, and gastrointestinal physiology.We approach this problem from multiple levels of analysis including behavioral, physiological, neurophysiological, and molecular-genetic. We have identified the type of food stimuli that activate vagal and splanchnic sensory fibers supplying the gut, and have revealed the extent to which these stimuli influence gut-brain communication. Our most recent efforts involve the analysis of gut-brain communication in the control of energy homeostasis in mouse models of obesity and diabetes.We have identified neurons in the periphery, brainstem and hypothalamus that integrate food-elicited signals with peptide signals that have profound effects food intake and metabolism. Data from these studies reveal that central hypothalamic and brainstem neuropeptides affect food intake and body weight by modulating the neural potency of food stimulated signals from the mouth and gut. This novel, synthetic conceptual framework is critical because it links forebrain hypothalamic structures, long known to be involved in the control of energy balance, to the sensory and motor systems in the brainstem that control ingestion, digestion, and metabolic processing of food. Future studies will use genetic mouse models of obesity and diabetes with targeted conditional neuropeptide/ receptor knockdown or replacement to determine how central neuropeptide signaling affects the neural processing of metabolic sensory signals critical to energy homeostasis.</p>

Research Areas
Obesity/ diabetes, gut-brain neuroendocrine communication in the control of feeding and energy balance, neuronal nutrient sensing, neural control of thermogenesis, lipolysis and gastrointestinal function.
Specialties
Areas of Expertise
Energy balance
Gut -brain communication
Nutrient sensing
Obesity
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz studies how the gut and the brain act together to determine how much people eat. He has identified sites in the gastrointestinal tract and brain that detect nutrients and has discovered how these regions are linked to food intake, obesity and diabetes. He also studies gastric-bypass surgery and the key neural and hormonal mechanisms responsible for the significant and long-lasting improvements in body weight, food intake and diabetes following the procedure.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz is Director of the Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core at Einstein and Director of the Animal Phenotyping Core of the Columbia University- Einstein New York Obesity Research Center. He also serves on multiple NIH study sections and on scientific grant review panels of the United States Department of Veterans Affairs, American Diabetes Association, Endocrine Fellows Foundation and Obesity Society. He is a member of the editorial boards of several journals, including&nbsp;<em>Diabetes</em>,&nbsp;<em>Endocrinology </em>and serves as an associate editor of the&nbsp;<em>American Journal of Physiology, Endocrinology &amp; Metabolism Section</em>.</span></p>

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Professional Title
Ph.D.
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Ana Maria Cuervo

Submitted by Anonymous (not verified) on
Full Name
Ana Maria Cuervo
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Cuervo_Ana_Maria_2x.jpg
Type
Faculty
Expert
First Name
Ana Maria
Last Name
Cuervo
Faculty ID
8784
Patient Type
Adult
Department
einstein-dept-developmental-molecular-biology
einstein-dept-medicine
Email
ana-maria.cuervo@einsteinmed.edu
Phone
718-430-2689
Titles
Type
Academic
Department
Department of Developmental & Molecular Biology
Department Link
Rank
Distinguished Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Distinguished Professor
Division
Hepatology
Type
Administrative
Title
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Chanin Building
Room
504
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Cuervo is co-director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. In October 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders.</p>
<p>Dr. Cuervo&rsquo;s group is interested in understanding how altered proteins can be eliminated from the cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy)&nbsp;with different neurodegenerative diseases including Parkinson&rsquo;s, Alzheimer&rsquo;s and Huntington&rsquo;s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pionered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity.</p>
<p>Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director&rsquo;s, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdoxk, the Gerry Aurbach, the SEBBM L&rsquo;Oreal-UNESCO for Women in Science, the&nbsp;C. Ronald Kahn Distinguished Lecture&nbsp;and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell.</p>
<p>Dr. Cuervo has served in NIH advisory panels, special emphasis panels, and study sections, the NIA Scientific Council and the NIH Council of Councils and &nbsp;has been recently elected member of the NIA Board of Scientific Counselors and member of the of the Advisory Committee to the NIH Deputy Director.. She has received numerous awards for the pioneerign work of her team such as &nbsp;the 2005 P. Benson Award in Cell Biology, the 2005/8 Keith Porter Fellow in Cell Biology, the 2006 Nathan Shock Memorial Lecture Award, the 2008 Vincent Cristofalo Rising Start in Aging Award, the 2010 Bennett J. Cohen Award in Aging Biology, the 2012 Marshall S. Horwitz, MD Faculty Prize for Research Excellence and the 2015 Saul Korey Prize in Translational Medicine Science. She has also received twice the LaDonne Schulman Teaching Award. In 2015 she was elected International Academic of the Royal Academy of Medicine of the Valencia Community and in 2017, she was elected member of the Real Academia de Ciencias Exactas, Fisicas y Naturales. She was elected member of the American Academy of Arts and Sciences in 2018 and member of the National Academy of Science in 2019.</p>

Research Areas
Understanding the molecular basis of malfunctioning of autophagy (cellular quality control system) with age and the contribution of defects on this cellular pathway to age-related disorders such as neurodegeneration, metabolic disorders and cancer.
Specialties
Areas of Expertise
Cancer
Cell biology
Huntington’s disease
Metabolism
Parkinson’s disease
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is considered a leader in the field of autophagy&mdash; the process by which cells remove and recycle their waste. The Barcelona, Spain native is also an expert on the cellular biology of aging. Dr. Cuervo has been quoted in numerous publications, including <em>The New York Times</em>, <em>Nature, Science</em>, <em>Scientific American</em>, and <em>The Scientist</em>.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is co-editor-in-chief of <em>Aging Cell</em> and has served on various National Institutes of Health (NIH) advisory panels and study sections, the National Institute on Aging&rsquo;s Council, and the NIH Council of Councils. She is currently a member of the Advisory Committee to the NIH deputy director, and chair of the NIA Board of Scientific Counselors. She is an elected member of the National Academy of Sciences and of the American Academy of Arts and Sciences.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo&rsquo;s work focuses on the causes of age-related diseases including degenerative disorders such as Alzheimer&rsquo;s disease and Parkinson&rsquo;s disease, metabolic conditions such as diabetes, and cardiovascular disorders. Her goal is to develop therapies that will restore normal cellular housekeeping and thus prevent the accumulation of toxic protein byproducts and the death of affected cells in age-related disorders. Dr. Cuervo was named to the Highly Cited Researchers List (ranking of top 1% cited researchers) since 2018.</p>

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Professional Title
M.D.
Ph.D.
Selected Publications

<p>(selected from &gt;200 per review publications)</p>
<ol>
<li>Cuervo, A.M.*; Stephanis, L.; Freundberg, R.; Lansbury, P.; Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Science</span></em>305, 1292-1295, 2004</li>
<li>Kaushik, S.; Massey, A.C.; Kiffin, R., Cuervo, A.M*. Role of lysosomal lipid microdomains in the regulation of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">EMBO J.</span> </em>25, 3921-33, 2006</li>
<li>Zhang, C., Cuervo, AM*. Restoration of chaperone-mediated autophagy in aging improves cellular maintenance and organ function. <em><span style="text-decoration: underline;">Nat. Med.</span> </em>14: 959-65, 2008</li>
<li>Singh, R.; Kaushik, S.; Wang, Y.; Xiang, Y.; Novak, I; Komatsu, M.; Tanaka, K.; Cuervo, A.M*.; Czaja, M.J*.&nbsp; Autophagy regulates lipid metabolism. <em><span style="text-decoration: underline;">Nature</span></em> 458:1131-5, 2009</li>
<li>Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, de Vries R, Kaushik S, Arias E, Harris S, Sulzer D, Cuervo AM*&nbsp; Cargo recognition failure is responsible for inefficient autophagy in Huntington&rsquo;s Disease. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>13:567-76, 2010</li>
<li>Bandyopadhyay U, Shridar S, Kaushik S, Kiffin R, Cuervo AM*, Identification of regulators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol Cell</span> </em>39: 535-47, 2010.</li>
<li>Koga H., Kaushik S., Macian F. Verkushka, V. Cuervo AM* A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat Comm</span></em>&nbsp;2: 386, 2011</li>
<li>Kon, M, Koga, Hl, Kiffin, R., Chapochnick, J. Macian, F, Vartikovski L., Cuervo AM*. Chaperone-mediated autophagy is required for turmor growth. <em><span style="text-decoration: underline;">Science TM</span> </em>3:109ra117, 2011</li>
<li>Wong E, Bejarano E, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM*. Molecular determinants of selective clearance of protein inclusions by autophagy. <em><span style="text-decoration: underline;">Nat Comm</span> </em>3:1240, 2012</li>
<li>Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes, E., Honig, L.S., Dauer, W., Consiglio A, Raya A, Sulzer, D, Cuervo AM. Interplay of LRRK2 with chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>16:394-406, 2013</li>
<li>Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Chemical modulation of Chaperone-mediated autophagy by novel retinoic acid derivatives. <em><span style="text-decoration: underline;">Nat. Chem. Biol.</span> 9:374-82</em>, 2013</li>
<li>Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM Functional interaction between autophagy and ciliogenesis. <em><span style="text-decoration: underline;">Nature</span> 502:194-200, 2013 </em></li>
<li>Bejarano, E, Yuste, A, Patel B, Stout, RJ, Spary, D Cuervo AM. <em>Connexins modulate autophagosome biogenesis. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 16:401-14, 2014</em></li>
<li>Schneider JL, Suh Y, Cuervo AM*.&nbsp; Deficient chaperone-mediated autophagy in liver leads to metabolic disregulation. <em><span style="text-decoration: underline;">Cell Metab</span>.</em> 20:417-432, 2014</li>
<li>Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM*. Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging. <em><span style="text-decoration: underline;">Aging Cell,</span></em> 14:249-64, 2015</li>
<li>Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming ER, Bellen H, Cuervo AM*, Zhang S*. Huntingtin functions as a scaffold for selective macroautophagy. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 17: 262-75, 2015</li>
<li>Park C, Shu Y, Cuervo AM*.Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. <em><span style="text-decoration: underline;">Nat. Commun.</span> </em>6:6823 doi: 10.1038/ncomms7823, 2015</li>
<li>Kaushik, S. Cuervo AM*. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. <em><span style="text-decoration: underline;">Nat. Cell. Biol. </span></em>17: 759-70, 2015</li>
<li>Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM*. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol. Cell</span> </em>59, 270-84, 2015</li>
<li>Kaushik, S. Cuervo AM*. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. <span style="text-decoration: underline;"><em>Autophagy.</em> </span>12(2):432-438, 2016</li>
<li>Maus M, Cuk M, Patel B, Lian J, Qimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do H-T, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.<span style="text-decoration: underline;"><em>Cell Metab</em></span> 25: 698-712, 2017</li>
<li>Beckerman P, Karchin JB, Park ASD , Dummer P, Soomro I, Boustany-Kari C, Pullen S Qiu C, Miner JH, Hu C-A, Rohacs T, Inoue K, Shuta I, Saleem M, Palmer M, Cuervo AM, Kopp J, Susztak K. Transgenic Expression of Human APOL1 Risk Variants in Podocytes Induces Kidney Disease in Mice. <span style="text-decoration: underline;"><em>Nat Med</em></span> 23: 429-438, 2017</li>
<li>&nbsp;Gomes LR, Menck, CFM, Cuervo AM*, Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. <em><span style="text-decoration: underline;">Autophagy</span></em> 13: 928-940, 2017</li>
<li>Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-, Mandelkow E, Cuervo AM*. Interplay of pathogenic forms of human tau with different autophagic pathways. <em><span style="text-decoration: underline;">Aging Cell</span> </em>17(1): doi: 10.2222/acel.12692, 2017 PMID: 29024336</li>
<li>Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM*, Muzumdar R. Humanin is an endogenous activators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">J Cell Biol</span> </em>&nbsp;&nbsp;217:635-647, 2018 PMID:2918752</li>
<li>Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. <em><span style="text-decoration: underline;">Autophagy</span> </em>doi: 10.1080/15548627.2018.1474992, 2018</li>
<li>Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. <em><span style="text-decoration: underline;">Aging Cell</span> </em>&nbsp;doi: 10.1111/acel.12777, 2018</li>
<li>Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS Farnesyl Transferase Inhibition for the Treatment of Tauopathies.<em><span style="text-decoration: underline;"> Science TM. </span></em>2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed. aat3005.</li>
<li>Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. <em><span style="text-decoration: underline;">PLOs Biology</span></em>, 17(5):e3000301. doi: 10.1371/journal.pbio.3000301, 2019</li>
<li>Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo. <span style="text-decoration: underline;"><em>Nature Comm.</em></span>&nbsp;11(1):645. doi: 10.1038/s41467-019-14164-4, 2020</li>
<li>Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D&rsquo;Alessandro A, Will B, Cuervo AM. Chaperone-mediated autophagy sustains hematopoietic stems cell function. <span style="text-decoration: underline;"><em>Nature</em> </span>591:117-123, 2021&nbsp;</li>
<li>Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate A, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Inhibition of chaperone-mediated autophagy by acetylated tau promotes disease propagation. <span style="text-decoration: underline;"><em>Nat. Comm.</em></span> 12(1):2238 doi: 10.1038/s41467-021-22501-9, 2021</li>
<li>Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. <span style="text-decoration: underline;"><em>Cell</em> </span>184: 1-19&nbsp; doi: 10.1016/j.cell.2021.03.048, 2021</li>
<li>Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu Vincent, Krause GJ, Jafari M, Singh R, Mu&ntilde;<span lang="EN-GB" style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">oz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated </span><span style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">autophagy and the circadian clock. <em><u>Nat. Cell Biol.</u> 23(12):1255-1270 10.1038/s41556-021-00800-z. 2021, 2022</em></span></li>
<li>Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernald DF, Diaz A, Tasset I, Mart&iacute;n-Segura A, Gijbel MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker A, Jin H, Sibinga N, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berb&eacute;e JFP, Pasterkamp G, Sluimerc JC, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">.</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">&nbsp;</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Protective role of chaperone-mediated autophagy against atherosclerosis. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Proc. Nat. Acad. Sci.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> Inaugural Paper, 2022</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">119(14):e2121133119. doi: 10.1073/pnas.2121133119, 2022</span></li>
<li>Barbaro JM, Sidoli S, Cuervo AM, Berman JW. <span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis.</span> <em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u>B</u></em><em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u><span style="font-size: 11pt; line-height: 115%;">iomedicines</span></u></em><span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">. 10(6):1257., 2022</span></li>
<li>Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fern&aacute;ndez O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Aging Cell.</u> </em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">e13713. doi: 10.1111/acel.13713, 2022</span></li>
<li>Rovira M, Sereda R, Pladevall-Morera D, Ramponi V, Marin I, Maus M, Madrigal-Matute J, D&iacute;az A, Garc&iacute;a F, Mu&ntilde;oz J, Cuervo AM, Serrano M. The lysosomal proteome of senescent cells contributes to the senescence secretome. <em><u>Aging Cell.</u></em><span style="font-size: 11pt; line-height: 115%;"> e13707. doi: 10.1111/acel.13707, 2022</span></li>
<li>Gomez-Sintes R Xin Q, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, McCabe M, Dong S, Reynolds CA, Patel B de la Villa P, Macian F, Boya P, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Targeting NCoR-RAR interaction activates chaperone-mediated autophagy and protects against retinal degeneration. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Nat. Comm</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. 13(1): 4220, doi: 10.1038/s41467-022-31869-1, 2022</span></li>
<li>Kaushik S, Juste YR, Lindenau K, Dong S, Macho-Gonzales A, Santiago-Fernandez O, McCabe M, Singh R, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Chaperone-mediated autophagy regulates adipocyte differentiation. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Sci. Adv.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> 8 (46) DOI: 10.1126/sciadv.abq2733 , 2022</span></li>
</ol>
<p><em>RECENT REVIEWS</em></p>
<ol>
<li>Kaushik S, Cuervo AM. Proteostasis and aging. <span style="text-decoration: underline;"><em>Nat Med.</em></span> 21:1406-15, 2015</li>
<li>Tekirdag KA, Cuervo AM. Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. <em><span style="text-decoration: underline;">J. Biol. Chem</span>. </em>&nbsp;293:5414-5424, 2018</li>
<li>Kaushik K, Cuervo AM. The coming of age of Chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Rev. Cell. Mol. Biol.</span></em> Doi: doi.org/10.1038/s41580-018-0001-6, 2018</li>
<li>Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Selective autophagy as a potential therapeutic target for neurodegenerative disorders. <em><span style="text-decoration: underline;">Lancet Neuro</span></em><span style="text-decoration: underline;">l</span> 17(9):802-815, 2018</li>
<li>Arias E, Cuervo AM. Pros and cons of chaperone-mediated autophagy in cancer. <span style="text-decoration: underline;"><em>Trends. Endocrinol Metab</em></span>. S1043-2760(19)30208-5. doi: 10.1016/j.tem.2019.09.007, 2019</li>
<li>Krause GJ, Cuervo AM. Assessment of mammalian endosomal microautophagy. <span style="text-decoration: underline;"><em>Methods Cell Bio</em></span><em>l</em> 164:167-185, 2021</li>
<li><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span><span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Autophagy and the Hallmarks of Aging. <em><u>Ageing Res Rev.</u></em></span> <span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;doi: 10.1016/j.arr.2021.101468, 2022</span></li>
<li>Jafari, M., McCabe, M, <strong>Cuervo AM</strong>. <span style="text-align: justify; text-indent: -22.5pt; font-family: Arial, sans-serif; font-size: 11pt;">Chaperone-mediated autophagy: mechanisms and physiological relevance &nbsp;<em><u>Current. Opin. Physiol</u>. </em>Available online 26 September 2022. doi: doi.org/10.1016/j.cophys.2022.100597</span></li>
</ol>

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Vern L. Schramm

Submitted by Anonymous (not verified) on
Full Name
Vern L. Schramm
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/7856-vern-schramm.jpg
Type
Faculty
Expert
First Name
Vern
Last Name
Schramm
Faculty ID
7856
Patient Type
Adult
Department
einstein-dept-biochemistry
Email
vern.schramm@einsteinmed.edu
Phone
718-430-2813
Titles
Type
Academic
Department
Department of Biochemistry
Department Link
Rank
Professor
Type
Administrative
Title
Ruth Merns Chair in Biochemistry
Tags
me-patientcare-cancer-research-therapeutics
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Golding Building
Room
301
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p><strong>Overview</strong></p>
<p>Enzymes catalyze virtually all of the chemical transformations necessary for biological life. Knowledge of the transition-state structure of enzymatic reactions permits the design of powerful inhibitors. Methods have been developed in this laboratory for the experimental determination of the geometric and charge features which characterize enzymatic transition states. This information is then used for the logical design of transition-state inhibitors which have the potential to be new biologically active agents. Specific projects include:</p>
<p>Human genetic deficiency of purine nucleoside phosphorylase causes a specific T-cell insufficiency. Our inhibitors of this enzyme are powerful anti T-cell agents. Two inhibitors are now in human clinical trials against human T-cell cancers and gout. Three T-cell cancer indications for these drugs have received orphan drug status from the FDA and several phase II trials are in progress. Phase II clinical trials have been completed for gout using our second-generation inhibitor. Third-generation and fourth-generation inhibitors are now being characterized.</p>
<p>Purine salvage is essential for growth of parasitic protozoa. A family of powerful inhibitors has been prepared against these enzymes from the malaria parasite. Promising results have been obtained in cell culture studies. One of these inhibitors stops the growth of malaria parasites in primate malaria. Preclinical research is underway, intended to lead to human trials in the next few years.</p>
<p>Experimental cancer chemotherapy uses plant toxins coupled to a recognition element for cancer cells. The transition state structure of saporin is being determined to guide the design of inhibitors. These will limit the side-effects of the toxin molecules remaining in the circulation or released from lysed cancer cells. Inhibitors are being synthesized and tested for efficiency, and constructs with saporin are being investigated as anticancer agents.</p>
<p>Research projects also involve S-adenosylmethionine recycling and methyl transfer reactions.&nbsp; Methyltransfer reactions are central to the epigenetic control pathways regulating growth, development, gene expression and cancer.&nbsp; New targets for transition state analysis and drug design are DNA methyltransferases, protein methyltransferases and metabolic enzymes forming and using S-adenosylmethionine.&nbsp; Related to these pathways are MTAP, a cancer target and MTAN, a target for bacterial antibiotics.</p>
<p>Students in this laboratory can receive training in enzymology, catalysis, protein expression, inhibitor design, computer modeling, inhibitor synthesis, and in drug metabolism studies in cells and animals. Active collaborations occur with laboratories specializing in NMR, X-ray crystallography, mass spectroscopy, synthetic organic chemistry, cancer and medicine. Projects can be designed to include several of these research approaches through active collaborative research programs.</p>
<p>&nbsp;</p>

Research Areas
Enzymatic transition states are solved by isotope effects and quantum chemistry. This knowledge permits drug design for cancers, antibiotics and other disorders. Protein dynamics in catalysis is a second focus.
Specialties
Areas of Expertise
Antibiotics
Cancer
Gout
Gout
Ricin
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schramm is a member of the National Academy of Sciences and associate editor of the<span>&nbsp;</span><em>Journal of the American Chemical Society</em>.&nbsp; His pioneering work in biochemistry has resulted in powerful new strategies for treating cancer, antibiotic resistance and autoimmune diseases.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schramm has created molecules that block key enzymes from functioning. These powerful inhibitors have shown promise in muzzling cancers and bacteria that depend on those key enzymes to grow and spread. Two of those inhibitors have entered clinical trials: one for treating leukemia that does not respond to other therapies and another for possible treatment for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and for preventing tissue transplant rejection in organ transplantation.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schramm&rsquo;s other recent work includes developing a simple and highly sensitive test to detect ricin, the potent toxin with potential use as a bioterrorism agent. He is also using his enzyme-inhibiting strategy to create novel antibiotics that do not provoke bacterial resistance.</span></p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p>Harijan, R.K., Zoi, I., Antoniou, D., Schwartz, S.D., Schramm, V.L. &ldquo;Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels&rdquo;.&nbsp; <em>Proc Natl Acad Sci U S A. 115</em>, E6209-E6216 (2018).&nbsp; PMC29915028</p>
<p>Schramm, V.L., Schwartz, S.D. &ldquo;Promoting Vibrations and the Function of Enzymes.&nbsp; Emerging Theoretical and Experimental Convergence.&rdquo; <em>Biochemistry 57</em>, 3299-3308 (2018). PMC6008225</p>
<p>Ducati, R.G., Namanja-Magliano, H.A., Harijan, R.K., Fajardo, J.E., Fiser, A., Daily, J.P., Schramm, V.L. &ldquo;Genetic resistance to purine nucleoside phosphorylase inhibition in <em>Plasmodium falciparum</em>&rdquo;.&nbsp; <em>Proc Natl Acad Sci U S A. </em>115, 2114-2119 (2018).&nbsp; PMC5834662</p>
<p>Harris, L.D., Harijan, R.K., Ducati, R.G., Evans, G.B., Hirsch, B.M., Schramm, V.L. &ldquo;Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.&rdquo;&nbsp; <em>ACS Chem Biol. 13, </em>152-160 (2018).&nbsp; PMID29178779</p>
<p>Evans, G.B., Tyler, P.C., Schramm, V.L. &ldquo;Immucillins in Infectious Diseases.&rdquo;&nbsp; <em>ACS Infect Dis.</em> 4, 107-117 (2018). PMC6034505</p>
<p>Ducati RG, Firestone RS, Schramm VL. &ldquo;Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from <em>Plasmodium</em> <em>falciparum</em>.&rdquo; <em>Biochemistry</em> <em>56</em>, 6368-6376 (2017).&nbsp; PMC5926801</p>
<p>Stratton, C.F., Poulin, M.B., Schramm, V.L. &ldquo;Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions.&rdquo; <em>Methods Enzymol 596</em>, 1-21 (2017).&nbsp; PMID28911767</p>
<p>Firestone, R.S., Schramm, V.L. &ldquo;The Transition-State Structure for Human MAT2A from Isotope Effects.&rdquo; <em>J. Am. Chem. Soc</em><em>. 139</em>, 13754-13760 (2017).&nbsp; PMC5674783</p>
<p>Moggr&eacute;, G.J., Poulin, M.B., Tyler, P.C., Schramm, V.L., Parker, E.J. &ldquo;Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.&rdquo; <em>ACS Chem Biol</em><em>.</em> <em>12</em>, 2662-2670 (2017).&nbsp; PMID28872824</p>
<p>Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL. &ldquo;Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from <em>Mycobacterium tuberculosis</em>.&rdquo; <em>Biochemistry</em><em> 56</em>, 5090-5098 (2017).&nbsp; PMC6019266</p>
<p>Gebre, S.T., Cameron, S.A., Li, L., Babu, Y.S., Schramm, V.L. &ldquo;Intracellular rebinding of transition-state analogues provides extended <em>in vivo</em> inhibition lifetimes on human purine nucleoside phosphorylase. <em>J. Biol. Chem</em><em>. 292</em>, 15907-15915 (2017). PMC5612120</p>
<p>Harijan, R.K., Zoi, I., Antoniou, D., Schwartz, S.D. and Schramm, V.L. &ldquo;Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.&rdquo;&nbsp; <em>Proc. Natl. Acad. Sci. </em>114, 6456-6461 (2017).&nbsp; PMC5488955</p>
<p>Firestone, R.S., Cameron, S.A., Karp, J.M., Arcus, V.L. and Schramm, V.L. &ldquo;Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5&rsquo;-Methylthioadenosine.&rdquo;&nbsp; <em>ACS Chem Biol</em> 12, 464-473 (2017).&nbsp; PMC5462123</p>
<p>Stratton, C.F., Poulin, M.B., Du, Q. and Schramm, V.L. &ldquo;Kinetic Isotope Effects and Transition state Strucutre for Human Phenylethanolamine N-Methyltransferase.&rdquo;&nbsp; <em>ACS Chem Biol</em>&nbsp; 12, 342-346 (2017) PMC5553282</p>
<p><span style="font-family: Calibri; font-size: medium;">&nbsp;</span></p>

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Robert H. Singer

Submitted by Anonymous (not verified) on
Full Name
Robert H. Singer
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Singer_Robert_PhD_2x.jpg
Type
Faculty
Expert
First Name
Robert
Last Name
Singer
Faculty ID
7137
Patient Type
Adult
Department
einstein-dept-cell-biology
einstein-dept-neuroscience
Email
robert.singer@einsteinmed.edu
Phone
718-430-8646
Titles
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Professor
Type
Academic
Department
Dominick P. Purpura Department of Neuroscience
Department Link
Rank
Professor
Tags
einstein-dept-neuroscience
Type
Administrative
Title
Harold and Muriel Block Chair in Anatomy & Structural Biology
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Golding Building
Room
601
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p><strong>Studying Single mRNA Molecules from Cradle to Grave<br /></strong>We seek to understand the expression and movement of mRNA from transcription through degradation and the effect that defects in these processes have on health. We develop methods to label RNA in fixed and living cells using fluorescent probes and develop microscopy techniques and image analysis algorithms to visualize and quantify many mRNAs simultaneously. Using these technologies, we can observe single mRNAs localizing to cytoplasmic compartments such as the leading edge of a fibroblast, the bud tip of yeast or the axonal process of neurons and follow these single mRNAs from transcription, nuclear export through translation and degradation. Because these techniques yield quantitative fluorescence data, we are able to apply mathematical modeling to test mechanistic hypotheses.</p>
<p><a href="https://www.ibiology.org/biophysics/rna-localization/&quot; target="_blank" rel="noopener">RNA Localization: Following Single mRNAs from Birth to Death in Living Cells</a></p>

Research Areas
We study single mRNA molecules from cradle to grave in single living cells using high resolution imaging. We develop trafficking microscopy and approaches to image RNA using fluorescent probes to visualize and quantify mRNA.
Specialties
Expert Tags
Areas of Expertise
Molecular and Cell Biology
Neuroscience
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Singer is a leader in the field of biophotonics, which enables scientists to observe activities within living cells at the molecular level, and in the study of mRNA, a molecule that controls the expression and positioning of proteins within cells. Dr. Singer, who was called a &ldquo;pioneer&rdquo; by&nbsp;<em>Science</em>&nbsp;magazine, leads a robust lab that focuses on how RNA is expressed by the genome and how it travels from the site of its birth to its ultimate location in the cell where it makes proteins.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Singer made his mark with the development of fluorescent in-situ hybridization (FISH), a widely used research tool for studying the activity of genes and their messages at the tissue level. More recently, he has improved the technique so that scientists, for the first time, can observe single molecules, such as mRNA, in single cells in real time, providing new understandings of how cells live and die.&nbsp;</span></p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p><a href="http://www.einstein.yu.edu/labs/robert-singer/publications/">Click this link to view the Singer Lab Publications</a></p>

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Steven C. Almo

Submitted by Anonymous (not verified) on
Full Name
Steven C. Almo
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Almo_Steve_2x.jpeg
Type
Faculty
Expert
First Name
Steven
Last Name
Almo
Faculty ID
7091
Patient Type
Adult
Department
einstein-dept-biochemistry
Email
steve.almo@einsteinmed.edu
Phone
718-430-2746
Titles
Type
Academic
Department
Department of Biochemistry
Department Link
Rank
Professor
Type
Administrative
Title
Chair, Department of Biochemistry
Type
Administrative
Title
Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology
Type
Administrative
Title
Director, Einstein Macromolecular Therapeutics Developmental Facility
Type
Administrative
Title
Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Cancer Therapeutics Program
Tags
me-patientcare-cancer-research-therapeutics
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Forchheimer Building
Room
308
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p style="text-align: justify;">Our laboratory is interested in the development and application of strategies and technologies that enable the high-throughput/large-scale exploration of biological function. These efforts typically take advantage of automation and robotics to achieve the efficiencies and speed required to realize the desired rates of data generation and discovery. This cutting-edge infrastructure has been applied to a number of important biomedical areas to achieve new understanding and new therapeutic opportunities.</p>
<p style="text-align: justify;">Our work on the large-scale annotation of enzyme function is helping to define the metabolic repertoire that exists in Nature and is providing new insights into the contributions of the gut microbiome to human health, the realization of new chemical processes for industry, and expanding our understanding of critical environmental issues, including global nutrient cycles and the evolution of complex microbial communities. Our high-resolution structural and functional analysis of the mammalian immune system has resulted in unprecedented understanding of the molecular mechanisms that control immunity and are guiding the development of novel strategies and reagents (e.g., biologics) for the treatment of infectious diseases, autoimmune diseases and cancers.</p>

Specialties
Areas of Expertise
Biochemistry
Drug Discovery
Expert Summary

<p>Dr. Steven Almo is an internationally recognized leader in the field of structural biology. His lab uses high-resolution X-ray crystallography to determine the shapes and structures of proteins to better understand their function and help develop new drugs. The goal is to make immunotherapy treatments that more precisely and effectively treat a variety of cancers while causing far fewer side effects than current therapies.&nbsp;</p>
<p>Dr. Almo&rsquo;s large-scale work on enzyme function has provided insights on both the gut microbiome&rsquo;s contributions to human health and new chemical processes for industry. His research also has expanded the understanding of critical environmental issues, including global nutrient cycles and the evolution of complex microbial communities.</p>
<p>He is a member of the American Society for Cell Biology and the American Crystallographic Association. He has served on NIH study sections and review panels, on the American Cancer Society&rsquo;s Peer Review Committee on Cancer Drug Development, and on the editorial board of the <em>International Archives of Allergy and Immunology</em>.&nbsp;</p>

CHAM Provider
Off
Professional Title
Ph.D.
Selected Publications

<p style="text-align: justify;">Quayle SN, Girgis N, Thapa DR, Merazga Z, Kemp MM, Histed A, Zhao F, Moreta M, Ruthardt P, Hulot S, Nelson A, Kraemer LD, Beal DR, Witt L, Ryabin J, Soriano J, Haydock M, Spaulding E, Ross JF, Kiener PA, Almo S, Chaparro R, Seidel R, Suri A, Cemerski S, Pienta KJ, Simcox ME. (2020) "CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies." <em>Clin Cancer Res.</em> <strong>26(8)</strong>, 1953-1964. PMID:31964784.</p>
<p style="text-align: justify;">Funabashi M, Grove TL, Wang M, Varma Y, McFadden ME, Brown LC, Guo C, Higginbottom S, Almo SC, Fischbach MA. (2020) "A metabolic pathway for bile acid dehydroxylation by the gut microbiome." <em>Nature</em>&nbsp;<strong>582(7813)</strong>, 566-570. PMC7319900.</p>
<p style="text-align: justify;">Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC. (2019) "Structural Basis of CD160:HVEM Recognition." <em>Structure</em> <strong>27(8)</strong>, 1286-1295.e4. PMC7477951.</p>
<p style="text-align: justify;">Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC. &nbsp;(2018) &ldquo;A naturally occurring antiviral ribonucleotide encoded by the human genome.&rdquo; <em>Nature </em><strong>558</strong>, 610-614.&nbsp; PMC6026066.</p>
<p style="text-align: justify;">Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz M, Almo SC. (2018) &ldquo;Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.&rdquo; <em>Biochemistry</em> <strong>57, </strong>1293-1305. PMC6568269.</p>
<p style="text-align: justify;">Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC. (2017) &ldquo;Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.&rdquo; &nbsp;<em>Proc Natl Acad Sci U S A</em>. <strong>114</strong>, E4223-E4232. &nbsp;PMC5448203.</p>
<p style="text-align: justify;">L&aacute;z&aacute;r-Moln&aacute;r E, Scandiuzzi L, Basu I, Quinn T, Sylvestre E, Palmieri E, Ramagopal UA, Nathenson SG, Guha C, Almo SC. (2017) &ldquo;Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.&rdquo; &nbsp;<em>EBioMedicine.</em> <strong>17</strong>, 30-44. PMC5360572.&nbsp;</p>
<p style="text-align: justify;">Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC. (2017) &ldquo;Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.&rdquo; <em>Mol Immunol</em>. <strong>81</strong>, 51-159. PMC5220579.</p>
<p style="text-align: justify;">Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC. (2016) &ldquo;Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.&rdquo; <em>Structure</em> <strong>24</strong>, 2016-2023. PMID:27806260.</p>
<p style="text-align: justify;">Yadava U, Vetting MW, Al Obaidi N, Carter MS, Gerlt JA, Almo SC. (2016) &ldquo;Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.&rdquo; <em>Acta Crystallogr F Struct Biol Commun.</em> <strong>72</strong>, 467-472. PMC4909247.</p>
<p style="text-align: justify;">Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC. (2015) &ldquo;Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.&rdquo; <em>Mol Biotechnol.</em><strong> 57</strong>, 914-922. PMID:26202493.</p>
<p style="text-align: justify;">Kim J, Xiao H, Koh J, Wang Y, Bonanno JB, Thomas K, Babbitt PC, Brown S, Lee YS, Almo SC. (2015) &ldquo;Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.&rdquo; <em>Nucleic Acids Res</em>. <strong>43</strong>, 4602-4613.&nbsp; PMC4482062.</p>
<p style="text-align: justify;">&nbsp;Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, Osterman AL, Cronan JE, Jacobson MP, Gerlt JA, Almo SC. (2015) &ldquo;Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.&rdquo; <em>Biochemistry </em><strong>54</strong>, 909-931. PMC4310620.</p>
<p style="text-align: justify;">Samanta D, Almo SC. (2015) &ldquo;Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity.&rdquo; <em>Cell Mol Life Sci</em>. <strong>72</strong>, 645-658. PMID: 25326769.</p>
<p style="text-align: justify;">Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC. (2014) &ldquo;Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.&rdquo; <em>Structure</em> <strong>22</strong>, 1252-1262.&nbsp; PMC4163024.</p>
<p style="text-align: justify;">Bandaranayake AD, Almo SC. (2014) &ldquo;Recent advances in mammalian protein production.&rdquo; <em>FEBS Lett.</em> <strong>588</strong>, 253-260. PMC3924552.</p>
<p style="text-align: justify;">Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC. (2013) &ldquo;Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function.&rdquo; <em>Nature </em><strong>498</strong>, 123-126. &nbsp;PMC3895326.</p>
<p style="text-align: justify;">Kim J, Almo SC. (2013) &ldquo;Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC.&rdquo; <em>BMC Struct Biol. </em><strong>13:</strong>5. PMC3648344.</p>
<p style="text-align: justify;">Vigdorovich V, Ramagopal UA, L&aacute;z&aacute;r-Moln&aacute;r E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC. (2013) &ldquo;Structure and T cell inhibition properties of B7 family member, B7-H3.&rdquo; <em>Structure </em><strong>21</strong>, 707-717. PMC3998375.</p>
<p style="text-align: justify;">Soniat M, Sampathkumar P, Collett G, Gizzi AS, Banu RN, Bhosle RC, Chamala S, Chowdhury S, Fiser A, Glenn AS, Hammonds J, Hillerich B, Khafizov K, Love JD, Matikainen B, Seidel RD, Toro R, Rajesh Kumar P, Bonanno JB, Chook YM, Almo SC. (2013) &ldquo;Crystal structure of human Karyopherin &beta;2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.&rdquo; <em>J Struct Funct Genomics </em><strong>14</strong>, 31-35. PMC3681870.</p>
<p style="text-align: justify;">Sampathkumar P, Kim SJ, Upla P, Rice WJ, Phillips J, Timney BL, Pieper U, Bonanno JB, Fernandez-Martinez J, Hakhverdyan Z, Ketaren NE, Matsui T, Weiss TM, Stokes DL, Sauder JM, Burley SK, Sali A, Rout MP, Almo SC. (2013) &ldquo;Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex.&rdquo; <em>Structure </em><strong>21</strong>, 560-571. PMC3755625.</p>

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John S. Condeelis

Submitted by Anonymous (not verified) on
Full Name
John S. Condeelis
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Condeelis_John_PhD_2x.jpg
Type
Faculty
Expert
First Name
John
Last Name
Condeelis
Faculty ID
6712
Patient Type
Adult
Department
einstein-dept-cell-biology
einstein-dept-surgery
Email
john.condeelis@einsteinmed.edu
Phone
718-430-2718
Titles
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Professor
Tags
me-patientcare-cancer-research-cdtmi
me-patientcare-cancer-research-cdtmi-members
Type
Academic
Department
Department of Surgery
Rank
Professor
Type
Administrative
Title
The Judith and Burton P. Resnick Chair in Translational Research
Type
Administrative
Title
Scientific Director, Analytical Imaging Facility
Type
Administrative
Title
Director, Integrated Imaging Program for Cancer Research
Type
Administrative
Title
Director, Basic and Translational Research, Department of Surgery
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Forchheimer Building
Room
602
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>John Condeelis' research interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. He and his collaborators developed the multiphoton imaging technology and animal models used to identify invasion and dissemination micro-environments in breast, pancreas and lung carcinoma. Integration of intravital multiphoton imaging with computational /systems analysis of living breast tumors identified the dominant tumor cell phenotypes contributing to invasion and dissemination during metastasis. This led to the discovery and verification of the paracrine interaction between tumor cells and macrophages in vivo, the role of macrophages in the migration of tumor cells during HGF-dependent tumor cell streaming to blood vessels and the mechanism of tumor cell dissemination from primary tumors via TMEM (Tumor MicroEnvironment of Metastasis) doorways to distant metastatic sites, and from those metastatic sites. Based on these results, cell collection techniques, including the in vivo invasion assay were developed for the collection of migrating and disseminating macrophages and tumor cells. This led to the discovery of the mouse and human invasion signatures, and the TMEM doorway, MenaCalc and MenaINV markers for assessing risk of metastasis and prediction of response in breast cancer patients to both chemotherapy, and receptor tyrosine kinase and tyrosine kinase inhibitors used to suppress metastasis.</p>
<p>He also helped lead the effort to develop a TMEM-activity-MRI for use in standard of care MRI prognosis of breast cancer patients. He is one of the founding co-directors of the Integrated Imaging Program dedicated to the integration and validation of clinical imaging platforms, including digital pathology, with high resolution optical imaging in the Gruss Lipper Biophotonics Center. He has authored more than 350 scientific papers on various aspects of his research.</p>

Research Areas
Interests are in optical physics, cell biology and biophysics, and cancer biology. Applications of interests are in development of the multiphoton imaging technology used to identify dissemination microenvironments in metastatic tumors.
Specialties
Areas of Expertise
Multiphoton imaging
Optical microscopy
Biomedical technologies
Tumor microenvironment
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Condeelis is a pioneer in developing microscope techniques for use in &ldquo;intravital imaging&rdquo; &ndash; observing the behavior of cells in living animals. His work has led to a clinical test of biopsy tissue to determine whether a woman&rsquo;s breast cancer will spread (metastasize), which could help determine treatment. Because of the test&rsquo;s success, Dr. Condeelis and colleagues have licensed the patent rights to a biotech firm, which is developing the tissue test into a commercial product.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A fellow of the American Association for the Advancement of Science, Dr. Condeelis is the recipient of the Allen Foundation Scholar Award and the Hirschl Career Scientist Award. He has served on numerous study sections of the National Institutes of Health and the American Cancer Society, as a consultant to the National Cancer Institute, and on the editorial boards of several prominent journals, including the<em>Journal of Cell Biology</em>.</span></p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p><strong>Selected Publications 2020-2022</strong> (<a title="View complete list of publications" href="/labs/john-condeelis/publications/">See complete list of publications.)</a></p>
<ul class="no-bullet">
<li>Karagiannis GS, Eddy RJ, Sparano JA, Anampa Mesias J, Rohan TE, Branch CA, Condeelis JS, Entenberg D, Oktay MH. Detection of TMEM Doorways and Their Activity Required for Metastasis. Emerging Technologies for Cancer Detection and DiagnosisIn Submission.</li>
<li>Sanchez LR, Duran CL, Burt J, Lin Y, Eddy R, Harney AS, Entenberg D, Condeelis JS, Oktay MH, Karagiannis GS. The Cxcl12/Cxcr4 Signaling Pathway Biases Breast Cancer Cell Directional Migration toward TMEM Intravasation Doorways. Journal of Leukocyte Biology. In Revision.</li>
<li>Duran C, Surve CR, Ye X, Chen X, Lin Y, Harney AS, Wang Y, Kim G, Sharma VP, Entenberg D, Stanley R, Oktay MH, Condeelis JS. Revealing the signaling events at TMEM doorways provides potential targets for inhibiting breast cancer dissemination. Science Signaling. In Revision.</li>
<li>Lucotti S, Ogitani Y, Kenific C, Geri J, Kim Y, Gu J, Balaji U, Bojmar L, Shaashua Berger L, Song Y, Cioffi M, Lauritzen P, Joseph O, Asao T, Grandgenett P, Hollingsworth M, Peralta C, Pagano A, Molina H, Lengel H, Gilbert Dunne E, Jing X, Schmitter M, Zhang H, Romin Y, Manova K, Paul D, O&rsquo;Reilly E, Jarnagin W, Kelsen D, Jones D, Condeelis J, Pascual V, Matei I, Bussel J, Coller B, Entenberg D, Bromberg J, Simeone D, Lyden D. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. In Review.</li>
<li>Genna A, Alte J, Poletti M, Meirson T, Sneh T, Gendler M, Saleev N, Karagiannis G, Wang Y, Cox D, Entenberg D, Oktay M, Korcsmaros T, Condeelis J, Gil-Henn H. FAK family proteins regulate in vivo breast cancer metastasis via distinct mechanisms. Nature Communications. In Review.</li>
<li>Dalton K, Howley R, Condeelis J, Entenberg D, Borriello L. Visualization of disseminated tumor cells and metastatic outgrowth in the lung at single cell resolution via intravital imaging. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Ye X, Head T, Duran C, Jafari R, Condeelis JS, Oktay MH, Cady N, Entenberg D. Microfluidic imaging windows for direct localized engineering of the in vivo tumor microenvironment In Progress.</li>
<li>Karagiannis GS, Rivera-Sanchez L, Wang Y, Sharma VP, Entenberg D, Oktay MH, Condeelis JS. Mechanisms of MenaINV induction and host response to chemotherapy.In Progress.</li>
<li>Ye X, Jafari R, Duran C, Du W, Lin Y, Surve C, Wang Y, Hoffmann E, Inman D, Ponik S, Oktay M, Condeelis JS, Entenberg D. Intravital Imaging Tissue AlignmentIn Preparation.</li>
<li>Miller A, Parmar P, Duran C, Porcelli S, Zhang J, Condeelis JS, Entenberg D, Oktay MH. The effect of macrophage cancer cell contact and anti-estrogen therapy on induction of stem cell program using SORE6 biosensor in estrogen receptor positive breast cancer cells.In Preparation.</li>
<li>Miller A, Karadal-Ferrena B, Parmar P, Huang C, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Entenberg D, Xue X, Rohan TE, Oktay MH. The clinical utility of TMEM doorway score in predicting response to treatment in breast cancer patients with estrogen receptor positive and triple negative breast cancer.In Preparation.</li>
<li>Karadal-Ferrena B, Miller A, Adler E, Ginter PS, D'Alfonso T, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Sparano JA, Entenberg D, Xue X, Rohan TE, Oktay MH. A multi-institutional study of TMEM doorway score as prognostic biomarker in a multiracial cohort of breast cancer patients.In Preparation.</li>
<li>Karadal-Ferrena B, DeLuca M, Duran C, Barth N, Jung Y, Eddy R, Lin Y, Chen X, Zintiridou A, Ye X, Karagiannis GS, Condeelis JS, Entenberg D, Oktay MH. TMEM doorway activity and macrophage profile in lung metastasis from breast cancer.In Preparation.</li>
<li>Entenberg D, Kodandaramaiah SB, Ponik SM, Elicieri K. Design considerations for optical intravital imaging windows. J Biomed Opt. In Preparation.</li>
<li>Anampa JM, Flynn DL, Oh S, Sadan S, Xue X, Oktay MH, Condeelis JS, Sparano JA. Phase Ib clinical and pharmacodynamic study of the Tie2 kinase inhibitor rebastinib with paclitaxel or eribulin in HER2-negative metastatic breast cancer.In Preparation.</li>
<li>Yang Y, Wang X, Zhang J. Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2. J Thorac Dis. 2024;16(2):1128-40. Epub 20240226. doi: 10.21037/jtd-23-1057. PubMed PMID: 38505034; PMCID: PMC10944717.</li>
<li>Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024;4(2):e995. doi: 10.1002/cpz1.995. PubMed PMID: 38406895; PMCID: PMC10914332.</li>
<li>Migulina N, de Hilster RHJ, Bartel S, Vedder RHJ, van den Berge M, Nagelkerke A, Timens W, Harmsen MC, Hylkema MN, Brandsma CA, Burgess JK. 3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes. Am J Physiol Cell Physiol. 2024;326(1):C177-C93. Epub 20231113. doi: 10.1152/ajpcell.00374.2023. PubMed PMID: 37955339.</li>
<li>Chioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough JE, Konkimalla A, Kim SH, Nouws J, Gonzalez DG, Traub B, Ye X, Yang T, Entenberg DR, Krishnaswamy S, Hendry CE, Kaminski N, Tata PR, Sauler M. Stem cell migration drives lung repair in living mice. Dev Cell. 2024. Epub 20240214. doi: 10.1016/j.devcel.2024.02.003. PubMed PMID: 38377991.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. Nature Protocols Exchange. 2024. doi: <a title="Read article" href="https://doi.org/10.21203/rs.3.pex-2544/v1&quot; target="_blank" rel="noopener">https://doi.org/10.21203/rs.3.pex-2544/v1</a>.</li&gt;
<li>Barron SL, Wyatt O, O'Connor A, Mansfield D, Suzanne Cohen E, Witkos TM, Strickson S, Owens RM. Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture. Sci Rep. 2024;14(1):240. Epub 20240102. doi: 10.1038/s41598-023-50618-y. PubMed PMID: 38168149; PMCID: PMC10761879.</li>
</ul>

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Steven A. Porcelli

Submitted by Anonymous (not verified) on
Full Name
Steven A. Porcelli
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/6474-steven-porcelli.jpg
Type
Faculty
Expert
First Name
Steven
Last Name
Porcelli
Faculty ID
6474
Patient Type
Adult
Department
einstein-dept-microbiology-immunology
einstein-dept-medicine
Email
steven.porcelli@einsteinmed.edu
Phone
718-430-3228
Titles
Type
Academic
Department
Department of Microbiology & Immunology
Department Link
Rank
Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Rheumatology
Type
Administrative
Title
Chair, Department of Microbiology & Immunology
Type
Administrative
Title
Murray and Evelyne Weinstock Chair in Microbiology & Immunology
Type
Administrative
Title
Scientific Director, Flow Cytometry Core Facility
Tags
me-patientcare-cancer-research-therapeutics
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Forchheimer Building
Room
416
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Porcelli's laboratory focuses on the control of acquired immune responses by T cells, which are the master regulatory and key effector cells of host defense and immune tolerance. In broad terms, the research being pursued in the laboratory covers two interrelated areas. The first is to understand the role of regulatory T cells, with particular emphasis on the activities of a specialized T cell subset known as CD1d-restricted NKT cells. These T cells have the highly unusual property of responding to specific glycolipid antigens, which they recognize in combination with a specialized lipid antigen presenting molecule known as CD1d. The laboratory is studying the details of the cellular mechanisms that lead to the uptake and presentation of lipid antigens by CD1d, and is using synthetic lipid antigens recognized by NKT cells to determine how antigen structure controls the immune responses that are generated by NKT cell activation. Methods for using lipid antigens that stimulate NKT cells to treat cancer or improve vaccination are also being studied. The laboratory's second major research area is the study of T cell responses against pathogenic microorganisms, especially <em>Mycobacterium tuberculosis.</em> Work in this area has led to significant progress in understanding how mycobacteria block effective host T cell responses, and this information is now being used to further the design of more effective vaccines for prevention of tuberculosis. A major near term goal of this research is to broaden the understanding of how organisms like <em>M. tuberculosis</em> successfully evade eradication by the immune system. The major long term goal is to create a genetically modified live attenuated <em>M. tuberculosis</em> strain that will be safe and effective as a vaccine against tuberculosis. Another related area of our work uses vaccine strains of mycobacteria to enhance antibody responses against pathogenic viruses including Ebola and SARS-CoV-2 viruses.</p>

Research Areas
We study many aspects of T cell immunology and antigen presentation, with a particular interest in protective immunity to Mycobacterium tuberculosis. We also study new approaches to vaccines for viral diseases and immunotherapy of cancer.
Specialties
Areas of Expertise
Antigen presentation
Immune evasion
Vaccines
Microbiology & Immunology
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Porcelli studies the control of acquired immunity &ndash; the type that develops when our bodies generate specific responses involving antibodies or T cells following exposure to vaccines or infection by disease-causing microbes. &nbsp;In particular, he investigates how T cells &ndash; which supervise both defense against microbes and immune tolerance &ndash; control the acquired immune response.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Porcelli focuses on particular specialized T cells known as CD1d-restricted NKT cells. Using mouse models of autoimmune disorders, infections, and cancer, Dr. Porcelli is studying how the function of these specialized T cells can be altered to produce immune responses that are optimal for human health.&nbsp;&nbsp;&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Another area of Dr. Porcelli&rsquo;s research involves&nbsp;<em>Mycobacterium tuberculosis</em>, the bacterial species that causes tuberculosis (TB). With colleagues at Einstein, he has identified&nbsp;<em>M. tuberculosis</em>&nbsp;genes that help the microbe evade the body&rsquo;s cell-mediated immunity. The Einstein researchers are using this information to create strains of TB bacteria that may be more effective than the existing vaccine at producing protective immunity against TB.&nbsp;&nbsp;Dr. Porcelli is a fellow of the American Society for Clinical Investigation.</span></p>

CHAM Provider
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Professional Title
M.D.
Selected Publications

<ol>
<li><span class="underline">Porcelli, SA</span>. Tuberculosis: Shrewd survival strategy. Nature 454:702-3 (2008).</li>
<li>Im JS, Arora P, Bricard G, Molano A, Venkataswamy MM, Baine I, Jerud ES, Goldberg MF, Yu KOA, Ndonye RM, Howell AR, Yuan W, Cresswell P, Chang YT, Illarionov PA, Besra GS and <span class="underline">Porcelli SA</span>. Kinetics and cellular site of glycolipid loading control the outcome of Natural Killer T cell activation. Immunity 30:888-98 (2009).</li>
<li>Venkataswamy MM, Baena A, Goldberg M, Bricard G, Im JS, Besra GS, Chan J, Jacobs Jr. WR and <span class="underline">Porcelli SA</span>. Enhancement of immunogenicity of <em>M. bovis</em> BCG by incorporation of NKT cell activating glycolipids. J Immunol. 183:1644-56 (2009).</li>
<li>Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carre&ntilde;o LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 40:105-16 (2014).</li>
<li>Singh M, Quispe-Tintaya W, Chandra D, Jahangir A, Venkataswamy MM, Ng TW, Sharma S, Carre&ntilde;o LJ, <span class="underline">Porcelli SA</span>*, Gravekamp C*. Direct incorporation of the NKT cell activator a-galactosylceramide improves efficacy and safety of a recombinant Listeria monocytogenes breast cancer vaccine. (*Joint senior/corresponding author). Br J Cancer. 2014 Nov 11;111(10):1945-54.</li>
<li><span style="font-size: 11.0pt; font-family: 'Arial',sans-serif; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreno L, Xu J, Chan J, Larsen MH, Jacobs Jr. WR, <strong style="mso-bidi-font-weight: normal;">Porcelli SA</strong>.<span style="mso-spacerun: yes;">&nbsp; </span>Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.<span style="mso-spacerun: yes;">&nbsp; </span>Nat Microbiol (9):16133 (2016).</span> <span style="font-size: 11.0pt; font-family: 'Arial',sans-serif; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">PMID: 27562263</span></li>
<li><span style="font-size: 11.0pt; font-family: 'Arial',sans-serif;">Saavedra-Avila NA, Keshipeddy S, Guberman-Pfeffer MJ, P&eacute;rez-Gallegos A, Saini NK, Sch&auml;fer C, Carre&ntilde;o LJ, Gasc&oacute;n JA, Porcelli SA, Howell AR. Amide-Linked C4&Prime;-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model.<span style="mso-spacerun: yes;">&nbsp; </span>ACS Chem Biol. 2020 Dec 18;15(12):3176-3186. doi: 10.1021/acschembio.0c00707. Epub 2020 Dec 9. PMID: 33296161</span> <!-- [if gte mso 9]><xml>
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Name="Body Text First Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Note Heading"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Body Text Indent 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Block Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Hyperlink"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="FollowedHyperlink"/>
<w:LsdException Locked="false" Priority="22" QFormat="true" Name="Strong"/>
<w:LsdException Locked="false" Priority="20" QFormat="true" Name="Emphasis"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Document Map"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Plain Text"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="E-mail Signature"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Top of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Bottom of Form"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal (Web)"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Acronym"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Address"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Cite"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Code"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Definition"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Keyboard"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Preformatted"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Sample"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Typewriter"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="HTML Variable"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Normal Table"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="annotation subject"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="No List"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Outline List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Simple 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Classic 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Colorful 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Columns 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Grid 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 4"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 5"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 6"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 7"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table List 8"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table 3D effects 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Contemporary"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Elegant"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Professional"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Subtle 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 1"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 2"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Web 3"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Balloon Text"/>
<w:LsdException Locked="false" Priority="39" Name="Table Grid"/>
<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
Name="Table Theme"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Placeholder Text"/>
<w:LsdException Locked="false" Priority="1" QFormat="true" Name="No Spacing"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading"/>
<w:LsdException Locked="false" Priority="61" Name="Light List"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 1"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 1"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 1"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 1"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 1"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 1"/>
<w:LsdException Locked="false" SemiHidden="true" Name="Revision"/>
<w:LsdException Locked="false" Priority="34" QFormat="true"
Name="List Paragraph"/>
<w:LsdException Locked="false" Priority="29" QFormat="true" Name="Quote"/>
<w:LsdException Locked="false" Priority="30" QFormat="true"
Name="Intense Quote"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 1"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 1"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 1"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 1"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 1"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 1"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 1"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 1"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 2"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 2"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 2"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 2"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 2"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 2"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 2"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 2"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 2"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 2"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 2"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 2"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 2"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 2"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 3"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 3"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 3"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 3"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 3"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 3"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 3"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 3"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 3"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 3"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 3"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 3"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 3"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 3"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 4"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 4"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 4"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 4"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 4"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 4"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 4"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 4"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 4"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 4"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 4"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 4"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 4"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 4"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 5"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 5"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 5"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 5"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 5"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 5"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 5"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 5"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 5"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 5"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 5"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 5"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 5"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 5"/>
<w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 6"/>
<w:LsdException Locked="false" Priority="61" Name="Light List Accent 6"/>
<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 6"/>
<w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 6"/>
<w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 6"/>
<w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 6"/>
<w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 6"/>
<w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 6"/>
<w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 6"/>
<w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 6"/>
<w:LsdException Locked="false" Priority="70" Name="Dark List Accent 6"/>
<w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 6"/>
<w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 6"/>
<w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 6"/>
<w:LsdException Locked="false" Priority="19" QFormat="true"
Name="Subtle Emphasis"/>
<w:LsdException Locked="false" Priority="21" QFormat="true"
Name="Intense Emphasis"/>
<w:LsdException Locked="false" Priority="31" QFormat="true"
Name="Subtle Reference"/>
<w:LsdException Locked="false" Priority="32" QFormat="true"
Name="Intense Reference"/>
<w:LsdException Locked="false" Priority="33" QFormat="true" Name="Book Title"/>
<w:LsdException Locked="false" Priority="37" SemiHidden="true"
UnhideWhenUsed="true" Name="Bibliography"/>
<w:LsdException Locked="false" Priority="39" SemiHidden="true"
UnhideWhenUsed="true" QFormat="true" Name="TOC Heading"/>
<w:LsdException Locked="false" Priority="41" Name="Plain Table 1"/>
<w:LsdException Locked="false" Priority="42" Name="Plain Table 2"/>
<w:LsdException Locked="false" Priority="43" Name="Plain Table 3"/>
<w:LsdException Locked="false" Priority="44" Name="Plain Table 4"/>
<w:LsdException Locked="false" Priority="45" Name="Plain Table 5"/>
<w:LsdException Locked="false" Priority="40" Name="Grid Table Light"/>
<w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark"/>
<w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful"/>
<w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 1"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 1"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 1"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 1"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 1"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 2"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 2"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 2"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 2"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 2"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 3"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 3"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 3"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 3"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 4"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 4"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 4"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 4"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 5"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 5"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 5"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 5"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 5"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="46"
Name="Grid Table 1 Light Accent 6"/>
<w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 6"/>
<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 6"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 6"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 6"/>
<w:LsdException Locked="false" Priority="51"
Name="Grid Table 6 Colorful Accent 6"/>
<w:LsdException Locked="false" Priority="52"
Name="Grid Table 7 Colorful Accent 6"/>
<w:LsdException Locked="false" Priority="46" Name="List Table 1 Light"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark"/>
<w:LsdException Locked="false" Priority="51" Name="List Table 6 Colorful"/>
<w:LsdException Locked="false" Priority="52" Name="List Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 1"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 1"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 1"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 1"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 1"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 1"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 2"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 2"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 2"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 2"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 2"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 2"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 3"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 3"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 3"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 3"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 3"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 4"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 4"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 4"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 4"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 4"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 4"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 5"/>
<w:LsdException Locked="false" Priority="47" Name="List Table 2 Accent 5"/>
<w:LsdException Locked="false" Priority="48" Name="List Table 3 Accent 5"/>
<w:LsdException Locked="false" Priority="49" Name="List Table 4 Accent 5"/>
<w:LsdException Locked="false" Priority="50" Name="List Table 5 Dark Accent 5"/>
<w:LsdException Locked="false" Priority="51"
Name="List Table 6 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="52"
Name="List Table 7 Colorful Accent 5"/>
<w:LsdException Locked="false" Priority="46"
Name="List Table 1 Light Accent 6"/>
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Eric E. Bouhassira

Submitted by Anonymous (not verified) on
Full Name
Eric E. Bouhassira
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/4981-eric-bouhassira.jpg
Type
Faculty
Expert
First Name
Eric
Last Name
Bouhassira
Faculty ID
4981
Patient Type
Adult
Department
einstein-dept-cell-biology
einstein-dept-medicine
einstein-dept-oncology
Email
eric.bouhassira@einsteinmed.edu
Phone
718-430-2188
Titles
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Professor
Tags
me-patientcare-cancer-clinical-gastrointestinal
me-patientcare-cancer-research-stem-cell-cancer-biology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Oncology & Hematology
Type
Academic
Department
Department of Oncology
Rank
Professor
Division
Hematology
Type
Administrative
Title
Ingeborg and Ira Leon Rennert Professor of Stem Cell Biology and Regenerative Medicine
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
903A
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Eric E. Bouhassira joined the Albert Einstein College of Medicine in 1990. He began studying human embryonic stem cells in 2001. He is director of the medical school's Center for Human Embryonic Stem Cell Research and professor of medicine and of cell biology. Dr. Bouhassira's research focuses on developing hematopoietic (blood forming) stem cells that can differentiate into red blood cells, T cells, platelets, and all other cell types that comprise blood. This work could potentially aid patients needing transfusions and also save lives by expanding the immunology diversity of hematopoietic stem cells available for transplant. Dr. Bouhassira is also interested in epigentic regulation in the erythoid and hematopoeitic lineag with a focus on DNA replication and DNA methylation. Dr. Bouhassira received his B.S., M.S., and Ph.D. degrees from the Universit&eacute; Pierre et Marie Curie in Paris, France. Dr. Bouhassira also holds the Ingeborg and Ira Rennert Chair in Stem Cell Biology and Regenerative Medicine.</p>
<p><strong>Current Clinical Protocols</strong></p>
<ol>
<li>In vitro red blood cell production</li>
<li>Feasibility pilot study of therapies for sickle cell disease and Thalassemia</li>
<li>Quartet sequencing and genome phasing</li>
</ol>

Research Areas
Pluripotent stem cells, erythroid differentiation, red blood cells, gene therapy, hemoglobinopathies, genome modification, TTP, hemophilia A
Specialties
Expert Tags
Areas of Expertise
Bioinformatics
Embryonic stem cells
Gene therapy
Globin genes
Hematopoiesis
Red blood cells
Sickle cell anemia
Thalassemia
Transcriptional regulation
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Bouhassira&rsquo;s work focuses on prompting human embryonic stem cells to develop into hematopoietic (blood-forming), as well as stem cells, and into red blood cells. This work could potentially help patients needing transfusions and save lives by expanding the production of customized cells that could be transplanted without risk of rejection. The cells produced by Dr. Bouhassira can also be used to deliver therapeutic proteins to the circulatory system.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Bouhassira&rsquo;s research also aims to find cures for sickle cell disease by developing novel gene therapy strategies.</p>

CHAM Provider
Off
Professional Title
Ph.D.
Selected Publications

<p class="MsoNormal"><strong style="mso-bidi-font-weight: normal;">&nbsp;</strong> <strong><span style="font-family: Arial, sans-serif;">Complete bibliography:</span></strong>&nbsp;<span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; font-size: 11.5pt; font-family: Helvetica, sans-serif; color: #212121;">&nbsp;</span><a href="https://www.ncbi.nlm.nih.gov/myncbi/14gVia2i54M5O/bibliography/public/"… style="font-size: 11.5pt; font-family: Helvetica, sans-serif; color: #4c2c92; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">https://www.ncbi.nlm.nih.gov/myncbi/14gVia2i54M5O/bibliography/public/<…;
<p class="MsoNormal" style="text-indent: .25in;"><strong style="mso-bidi-font-weight: normal;"><span style="background: lightgrey; mso-highlight: lightgrey;">Research areas:</span></strong></p>
<p class="MsoNormal" style="text-indent: .25in;"><strong style="mso-bidi-font-weight: normal;"><span style="background: lightgrey; mso-highlight: lightgrey;">Development of methods to produce cultured red blood cells from hematopoietic stem cells and from pluripotent stem cells.</span></strong></p>
<p class="MsoNormal"><span style="text-align: justify; text-indent: 0.25in;">Progress in cell culture methods has open up the possibility of manufacturing red blood cells (RBCs) for transfusion. We have developed methods to produce large number of red blood cells from hematopoietic stem cells and from pluripotent stem cells. Using detailed analysis of globin chain expression, we were the first to demonstrate that differentiation of hESCs and iPSCs into erythroid cells faithfully recapitulates the embryonic and fetal stages of human erythropoiesis but do not yield red blood cells with an adult phenotype. We also demonstrated that fetal stage erythroid cells derived from pluripotent cells can enucleate </span><em style="text-align: justify; text-indent: 0.25in;">in vitro</em><span style="text-align: justify; text-indent: 0.25in;">.</span>Since these early studies, observations that cells produced from pluripotent cells are developmentally immature have been made in many other lineages, by others. Finding methods to produce developmentally mature cells from pluripotent stem cells has become a central focus of many labs including my own. We recently obtained NIH funding to apply our advanced culture methods and translate our results into a commercial product by developing a panel of IPSC lines from patients carrying very rare blood groups that can be used as universal donor for transfusion and as reagent RBCs that will be used to type antibodies in allo-immunized patients with sickle cell disease.</p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="FR" style="mso-bidi-font-family: Arial; mso-ansi-language: FR;">Olivier EN, Qiu C, Velho M, Hirsch RE, Bouhassira EE. </span><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-font-family: Arial;">Large-scale production of embryonic red blood cells from human embryonic stem cells.</span></strong> <span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Exp Hematol. 2006 Dec;34(12):1635-42.</span> <span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">PMID: 17157159 <u>Cited by 161</u></span>&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><span style="mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="FR" style="mso-ansi-language: FR;">Qiu C, Olivier EN, Velho M, Bouhassira EE. </span><strong style="mso-bidi-font-weight: normal;">Globin switches in yolk sac primitive and fetal definitive RBCs produced from human embryonic stem cells</strong>. Blood. 2008; 111(4):2400-8. PMID: 18024790 <u>Cited by 154</u></p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 9.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]-->Wang K, Guzman AK, Yan Z, Zhang S, Hu MY, Hamaneh MB, Yu YK, Tolu S, Zhang J, Kanavy HE, Ye K, Bartholdy B, Bouhassira EE. <strong style="mso-bidi-font-weight: normal;">Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells.</strong> <span style="mso-bidi-font-size: 9.0pt;">Cell Rep. 2019 Mar 5;26(10):2580-2592.e7<span style="mso-spacerun: yes;">&nbsp; </span>PMID: 30840883 <u>Cited by 2</u></span></p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]-->Olivier EN, Zhang S, Yan Z, Suzuka S, Roberts K, Wang K, Bouhassira EE. <strong style="mso-bidi-font-weight: normal;">RED, an Albumin-Free Robust Erythroid Differentiation Method to Produce Enucleated Red Blood Cells from Human Pluripotent and Adult Stem Cells. </strong><span style="mso-bidi-font-size: 11.0pt;">Exp Hematol. 2019 Jul;75:31-52.e15 </span><span style="mso-bidi-font-size: 11.0pt; font-family: 'Helvetica',sans-serif; mso-bidi-font-family: 'Times New Roman'; color: #212121; background: white;">PMID: 31176681</span></p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><span style="font-size: 9.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="FR" style="mso-ansi-language: FR;">Olivier EN, Wang K, Grossman J, Mahmud N, Bouhassira EE. </span><strong style="mso-bidi-font-weight: normal;">Differentiation of Baboon (Papio anubis) Induced-Pluripotent Stem Cells into Enucleated Red Blood Cells.</strong> <span style="font-size: 9.0pt;">Cells. 2019 Oct 19;8(10).PMID: 31635069.</span></p>
<p class="MsoListParagraph" style="margin-left: .25in; text-align: justify; text-indent: -.25in; mso-list: l5 level1 lfo5;"><!-- [if !supportLists]--><strong style="mso-bidi-font-weight: normal;"><span style="background: lightgrey; mso-highlight: lightgrey;">Gene therapy for the hemoglobinopathies</span></strong></p>
<p class="MsoListParagraph" style="text-autospace: ideograph-numeric ideograph-other;"><strong style="mso-bidi-font-weight: normal;">&nbsp;</strong><span style="text-align: justify; text-indent: 0.25in;">Lentiviral based gene therapy for the hemoglobinopathies is coming of age. We have contributed to the field by studying at the basic science level the major causes of transgene silencing in erythroid cells. Using the RMCE method we have demonstrated that in eukaryotic cells, silencing is not primarily caused by integration near heterochromatin but rather by transcriptional interferences between the transgenes and neighboring sequences. By studying cassettes that were either devoid of any CpG dinucleotides, or that were pre-methylated prior to integration, we were able to demonstrate that DNA methylation is not necessary for silencing but that it confers an epigenetic memory.</span></p>
<p class="MsoNormal" style="text-align: justify; text-indent: .25in; text-autospace: ideograph-numeric ideograph-other;">We also demonstrated that inclusion of insulators in gene therapy cassettes was a double edged sword since these elements can prevent silencing and insertional mutagenesis at some genetic loci, but can also cause silencing and insertional mutagenesis at other locations. Some of these basic science findings were applied to design the gene therapy cassettes that were used, in collaboration with the Leboulch lab, to provide the first proof of principle in mice that gene therapy could be used to cure sickle cell disease. These vectors are currently tested by BlueBird therapeutics in human clinical trials that have had encouraging results.</p>
<p class="MsoNormal" style="margin-left: 13.5pt; text-indent: -.25in; mso-list: l4 level1 lfo1; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Feng YQ, Warin R, Li T, Olivier E, Besse A, Lobell A, Fu H, Lin CM, Aladjem MI, Bouhassira EE. (2005): <strong style="mso-bidi-font-weight: normal;">The Human </strong></span><strong style="mso-bidi-font-weight: normal;"><span style="font-family: Symbol; mso-bidi-font-family: Arial;">b</span></strong><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-font-family: Arial;">-Globin Locus Control Region Can Silence as Well as Activate Gene Expression</span></strong><span style="mso-bidi-font-family: Arial;">. </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Mol Cell Biol.25: (10):3864-74.</span> <span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">PMID: 15870261 <u>Cited by 44</u></span></p>
<p class="MsoNormal" style="margin-left: 13.5pt; text-indent: -.25in; mso-list: l4 level1 lfo1; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Feng YQ, Desprat R, Fu H, Olivier E, Lin CM, Lobell A, Gowda SN, Aladjem MI, Bouhassira EE. (2006). <strong style="mso-bidi-font-weight: normal;">DNA methylation supports intrinsic epigenetic memory in mammalian cells. </strong></span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">PLoS Genet. </span><span lang="FR" style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial; mso-ansi-language: FR;">2006 Epub 2006 Apr 28.</span> <span lang="FR" style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial; mso-ansi-language: FR;">PMID: 16683039 <u>Cited by 75</u></span></p>
<p class="MsoNormal" style="margin-left: 13.5pt; text-indent: -.25in; mso-list: l4 level1 lfo1; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Pawliuk R., KA Westerman, ME Fabry, E Payen, R Tighe, EE Bouhassira, SA Acharya, J Ellis, IM London, CJ Eaves, RK Humphries, Y Beuzard, RL Nagel, P Leboulch<span style="mso-spacerun: yes;">&nbsp; </span>(2001):<span style="mso-spacerun: yes;">&nbsp; </span><strong>Correction of sickle cell disease in transgenic mouse models by gene therapy.</strong> </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Science<span style="mso-spacerun: yes;">&nbsp; </span>294:2368-71. PMID: 11743206 <u>Cited by 574</u></span>&nbsp;</p>
<p class="MsoNormal" style="margin-left: 13.5pt; text-indent: -.25in; mso-list: l4 level1 lfo1; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Boulad F, Maggio A, Xiuyan Wang X, Moi P, Acuto S, Kogel F, Takpradit A, Prockop S, Mansilla-Soto J, Cabriolu A, Odak A. Thummar K, Du F, Shen L, Raso s, Barone R, Di Maggio R, Pitrolo L, Giambona A, Mingoia M, Everett JK, Hokama P, Roche A, Cantu A, Adhikari H, Reddy S, Bouhassira EE, Mohandas N, Bushman FD, Rivi&egrave;re I, Sadelain M (2001) <strong>Lentiviral globin gene therapy with reduced-intensity conditioning in adults with &beta;-thalassemia: a phase 1 trial.<span style="mso-spacerun: yes;">&nbsp;&nbsp;</span></strong></span><span style="font-family: Arial, sans-serif; font-size: 10.5pt;">Nat Med. 2022 Jan;28(1):63-70.</span></p>
<p class="MsoNormal" style="margin-left: 13.5pt; text-indent: -.25in; mso-list: l4 level1 lfo1; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><strong style="mso-bidi-font-weight: normal;"><span style="background: lightgrey; mso-highlight: lightgrey;">Development of Recombinase-Mediated Cassette Exchange and safe harbor concept</span></strong></p>
<p class="MsoNormal" style="text-align: justify; text-indent: .25in; text-autospace: ideograph-numeric ideograph-other;">Lentiviral transduction, stable transfection and transgenesis results in random integration of transgenes which leads to positive or negative position-effects. Position-effects greatly complicate gene therapy as well as the interpretation of most stable transfection or transduction experiments. To eliminate these problems, we have developed RMCE, a method that allows site-specific integration of cassettes at predetermined chromosomal locations in mammalian cells. We used the method extensively to better understand the molecular basis of position-effects in erythroid cells (see above). Many other labs, all over the world, have adopted RMCE, and adapted it to many cell types and many organisms. Over 500 studies that take advantage of RMCE have been published.</p>
<p class="MsoNormal" style="text-align: justify; text-autospace: ideograph-numeric ideograph-other;"><span style="mso-tab-count: 1;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>The use of the RMCE led us to develop the concept of safe harbors as an efficient method to perform gene therapy safely and cost efficiently, without having to design and test novel vector or gene editing strategy for every mutation in every defective human gene. We demonstrated the concept by correcting alpha-thalassemia in iPSCs by targeting constructs to the AAVS1.</p>
<p class="MsoNormal" style="margin-left: .25in; text-indent: -.25in; mso-list: l0 level1 lfo2; mso-layout-grid-align: none;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Bouhassira EE., K Westerman, P Leboulch: (1997) <strong>Transcriptional Behavior Of LCR Elements Integrated At The Same Chromosomal Locus By RMCE.</strong> </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Blood, 90: 3332-3244.</span> <span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">PMID: 9345015 <u>Cited by 177</u></span></p>
<p class="MsoNormal" style="margin-left: .25in; text-indent: -.25in; mso-list: l0 level1 lfo2; mso-layout-grid-align: none;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Feng YQ, Seibler J, Alami R, Eisen A, Fiering SN, Bouhassira EE: (1999) <strong>Site-Specific Chromosomal Integration In Mammalian cells: Highly Efficient CRE Recombinase-Mediated Cassette Exchange.</strong> </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">J. Mol. Biol. 292 (4): 779-785. PMID: 10525404 <u>Cited by 249</u></span></p>
<p class="MsoNormal" style="margin-left: .25in; text-indent: -.25in; mso-list: l0 level1 lfo2; mso-layout-grid-align: none;"><!-- [if !supportLists]--><span style="font-size: 9.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Chang CJ and Bouhassira EE. <strong style="mso-bidi-font-weight: normal;">Zinc-finger nuclease mediated correction of &alpha;-thalassemia in iPS cells</strong>. Blood. 2012; Nov 8;120(19):3906-14. PMID: 23002118 <u>Cited by 100</u></span></p>
<p class="MsoNormal" style="margin-left: .25in; text-indent: -.25in; mso-list: l0 level1 lfo2; mso-layout-grid-align: none;"><!-- [if !supportLists]--><strong style="mso-bidi-font-weight: normal;"><span style="background: lightgrey; mso-highlight: lightgrey;">Molecular basis of Thrombotic Thrombocytopenic Purpura</span></strong></p>
<p class="MsoNormal" style="text-autospace: ideograph-numeric ideograph-other;">In collaboration with Dr. Han-Mou Tsai we have demonstrated that ADAMTS13 is responsible for congenital TTP, that auto-antibody resistant forms of the protein could be generated, that ADMTS13 is expressed predominantly in stellate cells, and we have explored some of the molecular mechanisms associated with low levels of ADAMTS13 expression in human population.<span style="mso-spacerun: yes;">&nbsp;</span></p>
<p class="MsoListParagraph" style="margin-left: 31.5pt; text-indent: -.25in; mso-list: l2 level1 lfo4; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H, Bouhassira EE, Upshaw JD Jr, Ginsburg D, Tsai HM. <strong style="mso-bidi-font-weight: normal;">Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. </strong></span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Nature. 2001; 413(6855):488-94. PMID: 11586351. <u>Cited by 1683</u></span></p>
<p class="MsoListParagraph" style="margin-left: 31.5pt; text-indent: -.25in; mso-list: l2 level1 lfo4; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Zhou W, Dong L, Ginsburg D, Bouhassira EE, Tsai HM. <strong style="mso-bidi-font-weight: normal;">Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?</strong> </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">The Journal of biological chemistry. 2005; 280(48):39934-41. PMID: 16203734</span><span style="mso-bidi-font-size: 11.0pt;"> <span style="mso-spacerun: yes;">&nbsp;&nbsp;</span></span><u><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Cited by 59</span></u><span style="mso-bidi-font-size: 11.0pt;"><span style="mso-spacerun: yes;">&nbsp;</span></span></p>
<p class="MsoListParagraph" style="margin-left: 31.5pt; text-indent: -.25in; mso-list: l2 level1 lfo4; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="mso-bidi-font-family: Arial;">Zhou W, Inada M, Lee TP, Benten D, Lyubsky S, Bouhassira EE, Gupta S, Tsai HM.<strong style="mso-bidi-font-weight: normal;"> ADAMTS13 is expressed in hepatic stellate cells. </strong>Laboratory investigation; </span><span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">a journal of technical methods and pathology. 2005; 85(6):780-8. PMID: 15806136<span style="mso-spacerun: yes;">&nbsp; </span><u>Cited by 162</u></span><span style="mso-bidi-font-size: 11.0pt;"><span style="mso-spacerun: yes;">&nbsp;</span></span></p>
<p class="MsoListParagraph" style="margin-left: 31.5pt; text-indent: -.25in; mso-list: l2 level1 lfo4; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="FR" style="mso-bidi-font-family: Arial; mso-ansi-language: FR;">Zhou W, Bouhassira EE, Tsai HM. </span><strong style="mso-bidi-font-weight: normal;"><span style="mso-bidi-font-family: Arial;">An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.</span></strong> <span style="mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;">Blood. 2007; 110(3):886-93. PMID: 17426255<span style="mso-spacerun: yes;">&nbsp;&nbsp; </span><u>Cited by 38</u></span></p>
<p class="MsoListParagraph" style="margin-left: 31.5pt; text-indent: -.25in; mso-list: l2 level1 lfo4; mso-layout-grid-align: none; text-autospace: ideograph-numeric ideograph-other;"><strong><span style="background: lightgrey;">Characterization of replication timing and replication origins in human primary erythroid cells</span></strong></p>
<p class="MsoNormal" style="text-align: justify; text-indent: 0.25in;">Gene transcription is regulated by transcription factors and by chromatin structure. Using the Recombinase-Mediated Cassette Exchange (RMCE) method and&nbsp;<span style="font-family: Symbol;">b</span>-globin transgenes as a model, we demonstrated that replication timing plays a critical role in gene expression at some genetic loci in erythroid cells. This prompted us to investigate the mechanisms that regulate replication timing in basophilic erythroblasts. In collaboration with the Schildkraut and Mieg labs, we developed the TimEX and TimEX-seq method to measure replication timing genome-wide using tiling micro-arrays and massively parallel sequencing. We applied these methods to generate genome-wide maps of replication timing in several cell types that demonstrated that replication timing is very tightly regulated in mammalian cells and that the timing of replication and gene expression levels are very closely linked.&nbsp;</p>
<p class="MsoNormal" style="margin-left: 4.5pt; text-align: justify; text-indent: 0.25in;">In collaboration with the Aladjem lab, we also developed methods to generate allele-specific profiles of replication timing and replication origins. Using these maps and a novel analytic approach, we show that the two chromosome homologs replicate within a few minutes of each other in about 92% of the genome but that about 8% of the genome replicate asynchronously. Asynchrony is associated with imprinting random mono-allelic expression and proximity to large structural variants. We also showed that an asymmetry in nucleotide distribution, which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ability to form G4-quadruplexes, is directly associated with origin activity. This work also led to the development of GenPlay, a powerful, JAVA, open-source genome browser and analyzer application that is available online and currently utilized by over 100 labs worldwide.</p>
<p class="MsoListParagraph" style="margin-left: 0.25in; text-align: justify; text-indent: -0.25in;">1.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;</span>Fu H., Lixin W., Lin CH, Singhania S, Bouhassira EE, Aladjem MI.&nbsp;<strong>Human Replicators Can Prevent Gene Silencing</strong>.&nbsp;Nature Biotech.&nbsp;&nbsp;2006, 24(5):572-6. PMID: 16604060&nbsp;<u>Cited by 37</u>&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 0.25in; text-align: justify; text-indent: -0.25in;">2.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;</span>Desprat R, Thierry-Mieg D, Lailler N, Lajugie J, Schildkraut C, Thierry-Mieg J, Bouhassira EE.&nbsp;<strong>Predictable dynamic program of timing of DNA replication in human cells.</strong>&nbsp;Genome Research. 2009 Dec;19(12):2288-99. PMID: 19767418&nbsp;<u>Cited by 117</u></p>
<p class="MsoListParagraph"><span style="text-align: justify; text-indent: -0.25in;">3.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;</span></span><span style="text-align: justify; text-indent: -0.25in;">Mukhopadhyay R, Lajugie J, Fourel&nbsp;&nbsp;N, Selzer A, Schizas M, Bartholdy B, Mar&nbsp;&nbsp;J, Lin&nbsp;&nbsp;CM, Martin MM , Ryan&nbsp;&nbsp;M, Aladjem MI and Bouhassira EE.&nbsp;<strong>Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization.&nbsp;</strong></span><span style="text-align: justify; text-indent: -0.25in;">PLoS Genet. 2014 May 1;10(5):e1004319.&nbsp;&nbsp;PMID: 24787348&nbsp;&nbsp;<u>Cited by 42</u></span>&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 0.25in; text-align: justify; text-indent: -0.25in;">4.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;</span>Bartholdy B, Mukhopadhyay R, Lajugie J, Aladjem MI, Bouhassira EE.&nbsp;<strong>Allele-specific analysis of DNA replication origins in mammalian cells.</strong>&nbsp;Nat Commun. 2015 May 19;6:7051.&nbsp;PMID: 25987481&nbsp;<u>Cited by 32</u></p>

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Julio A. Aguirre-Ghiso

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Full Name
Julio A. Aguirre-Ghiso
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Aguirre-Ghiso_Julio_PhD_2x.jpg
Type
Faculty
Expert
First Name
Julio
Last Name
Aguirre-Ghiso
Faculty ID
16974
Patient Type
Adult
Department
einstein-dept-cell-biology
einstein-dept-oncology
einstein-dept-medicine
Email
julio.aguirre-ghiso@einsteinmed.edu
Phone
718-678-1246
Titles
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Professor
Type
Academic
Department
Department of Oncology
Rank
Professor
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Oncology & Hematology
Type
Administrative
Title
Rose C. Falkenstein Chair in Cancer Research
Type
Administrative
Title
Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Tumor Microenvironment & Metastasis Program
Tags
me-patientcare-cancer-research-tumor-microenvironment-metastatis
Type
Administrative
Type
Administrative
Title
Director, Cancer Dormancy Institute
Tags
me-patientcare-cancer-research-cdicore
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845838 40.8516937)
Room
220
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Michael F. Price Center
Address Line 3
1301 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">The major challenge faced by physicians is the prevention and treatment of metastasis, the main reason for cancer mortality.&nbsp;Surprisingly, cancer patients presumed cured after primary tumor removal and therapy, can carry non-proliferating &lsquo;dormant&rsquo; disseminated cancer cells (DCCs) for years before reactivating to form incurable metastasis. I focused on understanding the biology of dormant DCCs and their reactivation, to target them and prevent relapse. My team led a paradigm shift that is revealing novel cancer biology that diverges from the notion that cancer is perpetually proliferating.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">We discovered that a reciprocal crosstalk between DCCs and the microenvironment regulates the inter-conversion between dormancy and proliferation. My lab discovered that an imbalance in p38<span style="font-family: Symbol;">a/b</span>&nbsp;and ERK1/2 signaling regulates lineage commitment transcription factors (TF) and an epigenetic network that determines dormancy induction (<strong><em>Aguirre-Ghiso et al., JCB 1999, Mol Biol Cell 2001, Oncogene 2002, Liu, Aguirre-Ghiso et al., Cancer Cell, 2002, Aguirre-Ghiso et al., Cancer Res 2004,</em></strong>&nbsp;among others). This work led to identify retinoic acid and TGF<span style="font-family: Symbol;">b</span>2 in the microenvironment as inducers of the high p38/ERK-signaling ratio, leading to the finding that dormancy &nbsp;(quiescence) is controlled by mechanisms of adult stem cell quiescence&nbsp;<em>(<strong>Adam et al., Cancer Res 2009</strong>;&nbsp;<strong>Bragado et al., Nat Cell Bio, 2013, Sosa et al., Nat Commun 2015; Fluegen et al., &amp; Nat Cell Bio, 2017; Nobre et al., Nature Cancer 2021</strong>)</em>. These findings have been expanded to reveal that mesenchymal stem cell niches that control hematopoietic stem cell dormancy control dormancy of breast cancer DCCs through a TGFB2 and BMP7-dependent mechanism (<strong><em>Nobre et al.,</em><em>Nat Cancer, 2021</em></strong>). My lab&nbsp;was one of the first to show that tumor-initiating properties and DCC dormancy are dynamically linked by epigenetic states and a transcriptional program that affects the histone code&nbsp;<em>(<strong>Sosa et al., Nat Commun 2015</strong>).</em>&nbsp;This work led to an epigenetic strategy to&nbsp;<em>induce dormancy</em><em>,</em>&nbsp;which is now a clinical trial funded by the V-Foundation and TCI (<strong>NCT03572387</strong>). We also identified a &ldquo;dormancy signature&rdquo; and specific markers enriched in dormant prostate and breast cancer DCCs as well as in the bone marrow of breast cancer patients that predict for prolonged metastasis-free periods (<strong><em>Borgen et al., Breast Cancer Res 2018; Nobre et al., Nature Cancer 2021</em></strong>).&nbsp;We also found how the hypoxic microenvironment in primary tumors primes DCCs epigenetically to become dormant and evade chemotherapy (<strong><em>Fluegen et al., Nat Cell Bio, 2017</em></strong>).</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">My lab&rsquo;s work has propelled new questions to the forefront of cancer research, with the unexpected discovery of the mechanisms that allow dormant breast cancer DCCs and metastasis to be initiated very early during cancer evolution disseminating during pre-malignant stages (<strong><em>Harper and Sosa et al., Nature, 2016 and Hosseini et al., Nature, 2016</em></strong>). We further discovered that&nbsp;innate immune cells are key to launch the early dissemination process and the success on metastatic colonization (<strong><em>Linde et al., Nature Commun. 2018</em></strong>). Our program&rsquo;s impact is further highlighted by the&nbsp;development of successful collaborations with industry that identified pathways (<strong><em>Ranganathan et al., Cancer Ress 2006; 2008; Schewe and Aguirre-Ghiso, PNAS 2008; Cancer Res 2009</em></strong>) and drugs to kill dormant DCCs or induce dormancy of DCCs that are now part of a patent (WO201919111) and developed by a new startup company (HiberCell)(<a style="color: #903638;" href="http://www.hibercell.com/">www.hibercell.com</a&gt;), which is conducting clinical trials developed from our findings&nbsp;(NCT04834778, NCT04995094),identification of potential biomarkers and the development of the first clinical trials to induce dormancy of metastatic disease in prostate cancer&nbsp;(<strong>NCT03572387</strong>).</p>

Research Areas
Metastasis biology
Cancer cell dormancy
Signal transduction
Extracellular matrix
Innate immune cell function
tumor and normal organ microenvironment
Specialties
Areas of Expertise
Tumor microenvironment
Expert Summary

<p>Julio Aguirre-Ghiso, Ph.D., is an international leader in cancer cell dormancy and metastasis. He has helped lead a major shift in the cancer biology field by investigating how cancer cells hibernate, undetected, for long periods of time and what causes them to suddenly awaken to seed deadly, treatment-resistant metastases.</p>
<p>Dr. Aguirre-Ghiso&rsquo;s work is revealing ways to maintain residual cancer-cell dormancy, kill dormant cancer cells, and identify biomarkers for cancer recurrence. He has founded a start-up company, HiberCell, which is developing treatments to prevent relapse.&nbsp;</p>
<p>Dr. Aguirre-Ghiso is founding director of the <a href="https://montefioreeinstein.org/cancer/research/cdtmi">Cancer Dormancy and Tumor Microenvironment Institute</a> at the Montefiore Einstein Cancer Center. The goal of the institute is to integrate research from a range of specialties&mdash;including the biology of aging, stem cells, epigenetics, and systems biology&mdash;to address how residual cancer cells, aging, lifestyle, genetics, and treatments influence relapse across all cancers.</p>
<p>Dr. Aguirre-Ghiso is a reviewer for top-tier scientific journals and for federal, private, and international agencies.&nbsp; His work has been published in <em>Nature</em>, <em>Nature Cell Biology</em>, <em>Nature Cancer</em>, <em>Science</em>, and <em>Cancer Cell</em>. He is also president of the Metastasis Research Society and has served at several leadership levels at American Association for Cancer Research.</p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Pre-Prints Available Online</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Deepak K. Singh, Eduardo Farias, Saul Carcamo, Dan Hasson, Dan Sun, Julie Cheung, Ana Rita Nobre, Nupura Kale, Maria Soledad Sosa, Emily Bernstein, Julio A. Aguirre-Ghiso. Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGF&beta;&ndash;SMAD4 signaling bioRxiv 2021.08.01.454684; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.08.01.454684"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.08.01.454684</span></a></p&gt;
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt; color: black;">, Nobre AR, Dalla E, et al. A&nbsp;Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a&nbsp;Barrier&nbsp;to Metastatic Progression of Early Disseminated Cancer Cells. 18 January&nbsp;2021,&nbsp;PREPRINT (Version 1) available at&nbsp;<strong><em>Research&nbsp;Square.</em></strong>&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-145308/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-145308/v1</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Rodriguez Martinez A, Miles B, Farias E, Mezei M, Cheung JF, Nobre AR, Kale N, Sproll KC, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. A specific agonist of the orphan nuclear receptor NR2F1&nbsp;suppresses metastasis through the induction of cancer cell dormancy.&nbsp;<strong><em>bioRxiv</em></strong>(2021).01.30.428967; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.01.30.428967"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.01.30.428967</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Borriello L,&nbsp;Coste A, Sharma VP, Karagiannis GS, Lin Y, Wang Y, Ye X, Duran C, Chen X, Dalla E, Singh DK, Oktay MH,&nbsp;<strong>Aguirre-Ghiso JA<em>,&nbsp;</em></strong>Condeelis J, Entenberg D. Primary tumor associated macrophages activate programs of&nbsp;invasion and dormancy in disseminating tumor cells.&nbsp;<strong><em>bioRxiv</em></strong>&nbsp;(2021).02.04.429798; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.02.04.429798"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.02.04.429798</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Mitchell Fane, Stephen Douglass, Gretchen Alicea, Marie Webster, Vito Rebecca, Gloria Marino, Yash Chhabra, Filipe Almeida, Brett Ecker, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, David Speicher,&nbsp;<strong>Julio Aguirre-Ghiso</strong>, Ashani Weeraratna,&nbsp;&nbsp;</span><span style="font-size: 12pt; color: black;">Stromal Changes In The Aged Lung Induce An&nbsp;Emergence From&nbsp;Melanoma Dormancy, 16 September (2020), PREPRINT (Version 1) available at R<strong><em>esearch&nbsp;Square</em></strong>&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-61165/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-61165/v1</span></a></p&gt;
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Peer Reviewed Original Research Contributions&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-align: justify; line-height: 24px;"><em><sup><span style="color: black;">&nbsp;</span></sup></em></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Di Martino J, Nobre AR, Mondal C, Taha I, Farias EF, Fertig E, Naba A,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Bravo-Cordero JJ. A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy, 22 June 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-580847/v1].&nbsp;<strong><em>Nature Cancer</em></strong>&nbsp;(2021) (Accepted for Publication)</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang M, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikov A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agull&oacute;-Pascual E, Schober M, Brown B, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Merad M. Lineage tracing reveals the unique pro-tumorigenic niche role of tissue-resident macrophages in early cancer lesions.&nbsp;<strong><em>Nature&nbsp;</em></strong>595, 578&ndash;584 (2021).&nbsp;<strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre R, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Bone marrow NG2+/Nestin+&nbsp;mesenchymal stem cells drive DTC dormancy via TGF-&beta;2.&nbsp;<strong><em>Nature Cancer</em></strong>&nbsp;2,&nbsp;327&ndash;339 (2021).&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-021-00179-8"><span style="font-size: 12pt;">https://doi.org/10.1038/s43018-021-00179-8</span></a><span style="font-size: 12pt;">&nbsp;<strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Lam T,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Geller MA, Aksan A, Azarin SM. Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancy.&nbsp;<strong><em>Biotechnol Bioeng</em></strong>. (2020) Oct;117(10):3066-3080. doi: 10.1002/bit.27479. Epub 2020 Jul 9.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Teh JL, Purwin TJ, Han A, Chua V, Patel P, Baqai U, Liao C, Bechtel N, Sato T, Davies MA,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Aplin AE. Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma.&nbsp;<strong><em>Mol Cancer Ther</em></strong>. (2020) May 19: molcanther.1016.2019. doi: 10.1158/1535-7163.MCT-19-1016. Epub ahead of print. PMID: 32430489.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>, Heymach JV, Lu KP,&nbsp;Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy.&nbsp;<strong><em>Nat Cell Biol.&nbsp;</em></strong>(2019) Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Lapadula D, Farias E, Randolph CE, Purwin TJ,&nbsp;McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>, Benovic JL. Effects of Oncogenic G&alpha;q&nbsp;and G&alpha;11&nbsp;Inhibition by FR900359 in Uveal Melanoma.&nbsp;<strong><em>Mol Cancer Res</em></strong>. (2019) Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.</span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;">&nbsp;In the top 5% of all research outputs scored by Altmetric and picked up by 16 news stories from 15 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-family: inherit, serif;">&nbsp;</span></p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; font-family: inherit, serif;">Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, L&oslash;nning PE, Synnestvedt M,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Naume B. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients.&nbsp;<strong><em>Breast Cancer Research</em></strong>(2018) 20 (1), 120.&nbsp;</span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric and picked up by 9 news stories from 9 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; vertical-align: baseline;"><span style="font-family: inherit, serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; vertical-align: baseline;"><!-- [if !supportLists]--><span style="font-family: 'inherit',serif; mso-fareast-font-family: inherit; mso-bidi-font-family: inherit;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-family: inherit, serif;">Linde<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;N</span>, Casanova-Acebes<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;M</span>, Sosa<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;MS</span>, Mortha<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;A</span>, Rahman<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;A</span>, Farias EF,&nbsp;Harper K, Tardio E, Reyes Torres I, Jones<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;J</span>, Condeelis J, Merad&nbsp;<span style="border: 1pt none windowtext; padding: 0in;">M,</span>&nbsp;and&nbsp;<strong><span style="border: 1pt none windowtext; padding: 0in;">Aguirre-Ghiso JA.</span></strong><br /><span style="border: 1pt none windowtext; padding: 0in;">Macrophages orchestrate breast cancer early dissemination and metastasis.&nbsp;<strong><em>Nature Communications</em></strong></span>&nbsp;9, 21(2018)&nbsp;doi:10.1038/s41467-017-02481-5.&nbsp;</span><strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric. Highlighted in Faculty of 1000 Prime: El-Deiry W and Zhao S: F1000Prime Recommendation of [Linde N et al., Nat Commun 2018 9(1):21]. In F1000Prime, 11 Jan 2018; 10.3410/f.732394311.793541160. Highlighted in Science Translational Medicine:</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: 22.5pt; vertical-align: baseline;"><a style="color: #903638; text-decoration: underline;" href="https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm">… style="background-color: white;">https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm</…;
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS,&nbsp;<strong>Aguirre-Ghiso</strong>&nbsp;<strong>JA</strong>, Condeelis J.&nbsp;Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics.&nbsp;<strong><em>Methods</em></strong>(2017) Sep 1; 128:65-77. doi: 10.1016/j.ymeth.2017.07.019.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Fluegen G, Avivar-Valderas A, WangY, PadgenM, WilliamsJK, Verkhusha V, Cheung JF, Entenberg D, Castracane J, Keely PJ, Condeelis J,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>.&nbsp;<sup>&nbsp;</sup>Phenotypic heterogeneity of disseminated tumor cells is predetermined by primary tumor hypoxic microenvironments.<strong><em>&nbsp;Nature Cell Biology&nbsp;</em><span style="color: #262626;">(2017)<em>&nbsp;</em></span></strong><span style="color: #262626;">doi:10.1038/ncb3465.</span><strong><em><span style="color: #ff6600;">Cover Article.&nbsp;</span></em></strong></span><strong><em><span style="font-size: 12pt; font-family: inherit, serif; color: #ff6600; border: 1pt none windowtext; padding: 0in;">Highlighted in Science Translational Medicine Editor&rsquo;s&nbsp;Choice,&nbsp;Science Translational Medicine&nbsp;15 Feb 2017:&nbsp;Vol. 9, Issue 377, eaam6063&nbsp;DOI: 10.1126/scitranslmed.aam6063</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Harper K, Sosa MS, Hosseini H, Entenberg D, Avivar-Valderas A, Nagi C, Davis RJ, Farias EF, Condeelis J, Klein C,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Mechanism of early dissemination and metastasis during early stages of HER2+ mammary cancer.<strong>&nbsp;<em>Nature&nbsp;</em></strong><span style="color: #262626;">(2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799</span><strong>.<em><span style="color: #ff6600;">&nbsp;Paper highlighted in Nature News and Views.&nbsp;Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000.&nbsp;</span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="https://f1000.com/prime/727099751"><strong><em><span style="font-size: 12pt;">https://f1000.com/prime/727099751</span></em></strong></a><strong><em><… style="font-size: 12pt; color: #ff6600;">; Highlighted in Nature Reviews &nbsp;Cancer&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Hosseini, H, Harper K, Obradovic M, Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Klein CA.&nbsp;Early dissemination seeds metastasis&nbsp;in breast cancer.<em>&nbsp;<strong>Nature</strong></em>. (2016)<strong>&nbsp;</strong>Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798.&nbsp;<strong><em><span style="color: #ff6600;">Paper highlighted in Nature News and Views.&nbsp;Nature. 2016 Dec 14. doi: 10.1038/nature21104.&nbsp;Highlighted in Nature Reviews Cancer&nbsp;</span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E,&nbsp;Nobre AR,<strong>&nbsp;</strong><strong>Aguirre-Ghiso JA</strong>, Jung Y, Taichman RS. Axl is required for TGF-&beta;2-induced dormancy of prostate cancer cells in the bone marrow.&nbsp;<strong><em>Scientific Reports</em></strong>&nbsp;(2016)<strong><em>&nbsp;</em></strong>Nov 7; 6:36520. doi: 10.1038/srep36520.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS,<strong>&nbsp;Aguire-Ghiso JA</strong>, Castracane J, Denu JM, Keely PJ. Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.&nbsp;<strong><em>EBioMedicine</em>&nbsp;</strong>(2016) Nov; 13:146-156. doi: 10.1016/j.ebiom.2016.10.012. PubMed PMID: 27743905.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Cackowski FC, Eber MR, Rhee J, Decker A, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>,Taichman RS.&nbsp;Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy.&nbsp;<strong><em>J Cell Biochem</em></strong>(2016) Oct 18. doi: 10.1002/jcb.25768. PMID: 27753136</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parsons R,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E. Cbx8 acts non-canonically in breast cancer to promote Notch signaling.&nbsp;<strong><em>Cell Reports&nbsp;</em></strong>(2016)&nbsp;Jul 12;16(2):472-86. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23. PMID: 27346354</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Williams JK, Entenberg D, Wang Y, Avivar-Valderas A, Padgen M, Clark A,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Castracane J, Condeelis JS. Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging.&nbsp;<strong><em>Intravital</em></strong>. (2016)</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Szulczewski JM, Inman DR, Entenberg D,&nbsp;</span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, Castracane J, Condeelis J, Eliceiri KW, Keely PJ. In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging.&nbsp;<strong><em>Scientific Reports</em></strong>(2016)<strong>&nbsp;</strong></span><span style="font-size: 12pt;">May 25; 6:25086. doi: 10.1038/srep25086. PMID: 27220760</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Li M, Pathak RR, Lopez-Rivera E, Friedman SL,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, Sikora AG.&nbsp;The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma<em>.&nbsp;</em><strong><em>J Vis Exp</em></strong>. (2015) Oct 9; (104). doi: 10.3791/52411.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Alsadeq A, Strube S, Krause S, Carlet M, Jeremias I, Vokuhl C, Loges S,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, Trauzold A, Cario G, Stanulla M, Schrappe M, Schewe DM.&nbsp;Effects of p38&alpha;/&beta; inhibition on acute lymphoblastic leukemia proliferation and survival in vivo.&nbsp;<strong><em>Leukemia</em></strong>. (2015) Jun 24. doi: 10.1038/leu.2015.153. [Epub ahead of print] PMID: 26104660</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM,&nbsp;<strong>Aguirre-Ghiso</strong><strong>JA</strong>.&nbsp;Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment.&nbsp;<strong><em>BMC Cancer</em></strong>&nbsp;(2015) May 30; 15:444. doi: 10.1186/s12885-015-1460-1. PMCID: PMC4448210.&nbsp;<strong><em><span style="color: #ff6600;">Highlighted by BMC Cancer in the &ldquo;Highly Accessed&rdquo; category.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;">&nbsp;</span></em></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Friedman SL.&nbsp;Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development.&nbsp;<strong><em>Mol Cell Biol</em></strong>. (2015) Feb 23. pii: MCB.00136-15. PMID: 25713103.&nbsp;<strong><em><span style="color: #ff6600;">Cover article for the Feb 23 issue of Mol Cell Biol.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E,&nbsp;<strong>Aguirre-Ghiso JA</strong>. NR2F1 controls tumour cell dormancy via SOX9- and RAR&beta;-driven quiescence programmes.&nbsp;<strong><em>Nat Commun</em></strong>&nbsp;(2015) Jan 30; 6:6170. doi: 10.1038/ncomms7170. PubMed PMID:25636082; PubMed Central PMCID: PMC4313575.&nbsp;<strong><em><span style="color: #ff6600;">In the top 10% of all articles ever tracked by Altmetric.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ch&eacute;ry L, Lam HM, Coleman I, Lakely B, Coleman R, Larson S,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Xia J, Gulati R, Nelson PS, Montgomery B, Lange P, Snyder LA, Vessella RL, Morrissey C. Characterization of single disseminated prostate cancer cells Reveals tumor cell heterogeneity and identifies dormancy associated pathways.&nbsp;<strong><em>Oncotarget</em></strong>&nbsp;(2014) Oct 30;5(20):9939-51. PubMed PMID: 25301725; PubMed Central PMCID: PMC4259449.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Sikora AG.&nbsp;Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.<strong><em>Cancer Res</em></strong>. (2014) Feb 15;74(4):1067-78. doi: 10.1158/0008-5472.CAN-13-0588. Epub 2014 Jan 7. PMID: 24398473 [PubMed - indexed for MEDLINE]</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="EN-GB" style="font-size: 12pt;">Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM,&nbsp;</span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">.</span><span lang="EN-GB" style="font-size: 12pt;">&nbsp;TGF&beta;2 dictates disseminated tumour cell fate in target organs through TGF&beta;-RIII and p38&alpha;/&beta; signalling.&nbsp;<strong><em>Nat. Cell. Bio.&nbsp;</em></strong>(2013).</span><span style="font-size: 12pt;">Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27.</span><span lang="EN-GB" style="font-size: 12pt;">&nbsp;PMID: 24161934;</span><span style="font-size: 12pt;">PMCID: not available.&nbsp;<strong><em><span style="color: #ff6600;">Featured in Nat Cell Bio Cover same issue. Highlighted in Science Signaling Editor&rsquo;s Choice, Cancer Research Breaking Advances section and several public news outlets. Featured in the Cover of the November 15th issue of Nat Cell Bio. Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric.&nbsp;</span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;">&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CTY, Su D, Dedon PC,&nbsp;<strong>Aguirre-Ghiso JA</strong>,&nbsp;Begley T. A human tRNAmethyltransferase 9-like protein prevents tumor growth by regulating LIN9 and the hypoxic response.&nbsp;<strong><em>EMBO Mol Med&nbsp;</em></strong>(2013)&nbsp;Feb 4. doi: 10.1002/emmm.201201161.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Avivar-Valderas A,&nbsp;Bobrovnikova-Marjon E, Diehl JA, Bardeesy N,&nbsp;Debnath J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Regulation of autophagy during ECM detachment is linked to a&nbsp;selective inhibition of mTORC1 by PERK.&nbsp;&nbsp;<strong><em>Oncogene</em></strong>(2012), Nov 19. doi: 10.1038/onc.2012.512.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Kim RS, Avivar-Valderas A, Estrada A, Bragado P, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive breast cancer.&nbsp;<strong><em>PLoS One&nbsp;</em></strong>(2012); 7(4):e35569. Epub 2012 Apr 18.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties.&nbsp;<strong><em>PLoS One</em>.&nbsp;</strong>(2012); 7(1):e29974. PMCID: PMC3262798.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Tong CC, Lau KH, Rivera M, Cannan D,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J.&nbsp;Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy.&nbsp;<strong><em>Oncol Rep.</em>&nbsp;</strong>(2012)&nbsp;May; 27(5):1580-6. doi: 10.3892/or.2012.1679.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span lang="ES">&nbsp;</span></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="ES">Guti&eacute;rrez-Uzquiza &Aacute;, Arechederra M, Bragado P,&nbsp;</span><strong>Aguirre-Ghiso JA</strong><span lang="ES">, Porras A.&nbsp;</span>p38a mediates cell survival in response to oxidative stress via induction of antioxidant genes. Effect on p70S6K pathway.&nbsp;<strong><em>J Biol Chem.&nbsp;</em></strong>(2012)Jan 20;287(4):2632-42. Epub 2011 Dec 2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy<strong><em>. J Cell SciTher&nbsp;</em></strong>(2011)&nbsp;S1:002. doi:10.4172/2157-7013.S1-002.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><span lang="ES-AR">Avivar-Valderas A, Salas E,&nbsp;</span>Bobrovnikova-Marjon E, Diehl JS<span lang="ES-AR">, Nagi C, Debnath J,&nbsp;</span><strong>Aguirre-Ghiso JA</strong>,<strong>&nbsp;</strong>PERK integrates autophagy and oxidative stress&nbsp;&nbsp;responses to promote survival during ECM detachment.&nbsp;<strong><em>Mol Cell Biol</em></strong>.&nbsp;(2011)&nbsp;Sep; 31(17):3616-29. PMC3165554&nbsp;<strong><em><span style="color: #ff6600;">(Cover article)&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="ES-AR">Wen HC, Avivar-Valderas A, Sosa MS, Girinius N, Farias EF, Davis R,&nbsp;</span><strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>p38 signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis<em>.&nbsp;<strong>Science Signaling</strong></em><strong>&nbsp;</strong>(2011) 4 (174), ra34. [DOI: 10.1126/scisignal.2001684].<strong><em><u><span style="color: #ff6600;">http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/174/ra34</sp…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">36.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ishii Y, Papa Y, Bahadur U, Yue Z,&nbsp;<strong>Aguirre-Ghiso&nbsp;</strong><strong>JA</strong>,&nbsp;Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of theestrogen receptor, which leads to a pro-apoptotic unfolded protein response.&nbsp;<strong><em>Clin. Cancer Res.&nbsp;</em></strong>(2011)&nbsp;Feb 3.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">37.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sequeira SJ, Wen HC, Avivar-Valderas A,&nbsp;<strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>Inhibition of eIF2a dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.<strong><em>BMC Cell Biology.&nbsp;</em></strong>(2009)&nbsp;Sep 15;10:64.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">38.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Schewe DM.&nbsp;<strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>Inhibition of eIF2 dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.<strong><em>&nbsp;Cancer Res.&nbsp;</em></strong>(2009)<strong>&nbsp;</strong>Feb 15;69(4):1545-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">39.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><span lang="PT-BR">Adam AP, George A, Bragado P, Iglesias BV, Schewe D, Ranganathan A,&nbsp;</span>Kourtidis A, Conklin DS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Computational identification of a p38<sup>SAPK</sup>&nbsp;regulated transcription factor network required for tumor cell quiescence.&nbsp;<strong><em>Cancer Res</em></strong><em>.</em>&nbsp;(2009)&nbsp;Jul 15; 69(14):5664-72. Epub 2009 Jul 7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">40.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Schewe DM,&nbsp;<strong>Aguirre-Ghiso JA</strong>. ATF6&alpha;-Rheb-mTOR signaling promotes survival of dormant tumor cells&nbsp;<em>in vivo</em>.&nbsp;<strong><em>Proc Natl Acad Sci USA&nbsp;</em></strong>(2008)<strong>&nbsp;</strong>Jul 29;105(30):10519-24<strong><em>.&nbsp;<span style="color: #ff6600;">Highlighted in &ldquo;This week in PNAS&rdquo; section of the journal.&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.pnas.org/content/105/30/10271.full?sid=79541a8a-11a2-41cc-ae… style="color: #ff6600;">&nbsp;Faculty of 1000 evaluation:&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/id/1119501/evaluation"><strong><em>…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">41.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ranganathan AC, Ohja S, Kourtidis A, Conklin D,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Dual function of PERK in tumor cell growth arrest and survival.&nbsp;<strong><em>Cancer Res&nbsp;</em></strong>(2008); 68(9): 1&ndash;9.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">42.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF,&nbsp;<strong>Aguirre-Ghiso JA</strong><em>.</em>&nbsp;Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation.&nbsp;<strong><em>PLoS ONE</em></strong>. (2007) Jul 18; 2:e615.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em>&nbsp;</em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">43.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Baron TE, Lastro MT, Ranganathan AC, Tenenbaum SA, Conklin DS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest.&nbsp;<strong><em>Methods Mol Biol</em></strong>. (2007);<strong><em>&nbsp;</em></strong>383:227-44.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">44.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Shinohara M, Mikhailov AV,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Rieder CL. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells<strong>.&nbsp;<em>Molecular Biology of the Cell.</em></strong><em>&nbsp;</em>(2006)<strong>&nbsp;</strong>Dec 1<sup>st</sup>.17: 5227-5240.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">45.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Chaurasia P,&nbsp;<strong>Aguirre-Ghiso JA</strong><u>,</u>&nbsp;Liang OD, Gardsvoll H, Ploug M, Ossowski LA. Region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth.&nbsp;<strong><em>J. Biol. Chem.&nbsp;</em></strong>(2006)&nbsp;May 26; 281(21): 14852-63.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">46.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ranganathan AC, Zhang L, Adam AP,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;<a name="OLE_LINK9"></a>Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase&ndash;like ER kinase (PERK) to drug resistance of dormant carcinoma cells.&nbsp;<strong><em>Cancer Research&nbsp;</em></strong>(2006);&nbsp;66: (3) 1702-11.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">47.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Flores&nbsp;&nbsp;SC, Melendez JA. Mitochondrial H2O2 Regulates the Angiogenic Phenotype Via PTEN Oxidation.&nbsp;&nbsp;<strong><em>J. Biol. Chem.</em>&nbsp;</strong>(2005)<strong>&nbsp;</strong>29; 280(17): 16916-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 56.0pt 84.0pt 112.0pt 140.0pt 168.0pt 196.0pt 224.0pt 3.5in 280.0pt 308.0pt 336.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">48.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><strong>,&nbsp;</strong>Ossowski L, Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth.&nbsp;<strong><em>Cancer Res&nbsp;</em></strong>(2004);<strong>&nbsp;</strong>64(20): 7336-45.<strong><em><span style="color: #ff6600;">Faculty of 1000 evaluation at:&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/15492254/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">49.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Mazzoni E, Adam A, Bal de Kier Joffe E,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Immortalized mammary epithelial cells overexpressing PKC acquire a malignant phenotype and become tumorigenic in vivo.&nbsp;<strong><em>Molecular Cancer Res</em></strong>. (2003)<strong>&nbsp;</strong>1:776-787</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">50.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>,&nbsp;Estrada Y, Liu D, Ossowski L. ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK).&nbsp;<strong><em>Cancer Res.</em></strong>&nbsp;(2003); 63(7): 1684-95.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">51.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Puricelli L, Proiettii CJ, Labriola L, Salatino M, Balana ME,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.&nbsp;<strong><em>Int. J. Cancer</em></strong>. (2002)&nbsp;100(6): 642-53.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">52.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Liu D,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.&nbsp;<strong><em>Cancer Cell&nbsp;</em></strong>(2002)<strong>;&nbsp;</strong>1: 445-457<strong><em><span style="color: #ff6600;">(Cover). Preview in the same issue:</span></em></strong>&nbsp;<a style="color: #903638; text-decoration: underline;" href="http://www.cell.com/cancer-cell/abstract/S1535-6108(02)00076-4"><strong… style="text-transform: uppercase;">&nbsp;</span><em><u><span style="color: #ff6600;">Faculty of 1000 Evaluation at:&nbsp;</span></u></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/12124174/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">53.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA.</strong>&nbsp;Inhibition of FAK signaling activated by urokinase receptor induces human carcinoma dormancy in vivo.&nbsp;<strong>Oncogene&nbsp;</strong>(2002)&nbsp;21(16): 2513-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">54.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E,&nbsp;<strong>Aguirre-Ghiso JA</strong><strong>.&nbsp;</strong>RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts<em>.&nbsp;<strong>BiochemBiophys Res Commun.</strong></em><strong>&nbsp;</strong>(2001)<strong>&nbsp;</strong>283(4): 854-61.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">55.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong>&nbsp;Liu D, Mignatti D, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK<sup>MAPK</sup>&nbsp;to p38<sup>MAPK</sup>&nbsp;activity ratios that determine carcinoma cell proliferation or dormancy in vivo.&nbsp;<strong><em>Mol. Biol. Cell&nbsp;</em></strong>(2001). 12, 4, 863-879.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">56.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong>&nbsp;Kovalski K, Ossowski L. Tumor dormancy due to urokinase receptor down-regulation in human carcinoma involves integrin and MAPK signaling.&nbsp;<strong><em>J. Cell Biol.&nbsp;</em></strong>(1999)<strong>&nbsp;</strong>147, 89-103.&nbsp;<strong><em><span style="color: #ff6600;">Highlighted in the In Brief section of JCB.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em>&nbsp;</em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">57.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Frankel P, Far&iacute;as E, Lu Z, Jiang H, Olsen A, Feig L, Bal de Kier Joff&eacute; E, Foster D. Ral-A requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator. Involvement of metalloproteinases<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Oncogene&nbsp;</strong></em>(1999<em>)</em><strong><em>,&nbsp;</em></strong>18, 4718-4725.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">58.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Urtreger AJ,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Werbahj S, Puricelli L, Muro A, Bal de Kier Joff&eacute; E. Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells<em>.<strong>Int. J. Cancer,&nbsp;</strong></em>(1999),<strong>&nbsp;</strong>vol. 82, 748-753.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">59.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ladeda V,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Bal de Kier Joff&eacute; E. Function and Expression of CD44 During Spreading and Migration of Murine Carcinoma cells<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Exp. Cell Res</strong>.&nbsp;</em>(1998);<strong>&nbsp;</strong>242:515-527.</p>
<p class="ColorfulList-Accent11" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="font-size: 12pt;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">60.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as EF, Alonso DF, Bal de Kier Joff&eacute; E. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine-kinase pathway in mammary tumor cells.&nbsp;<strong><em>Int. J.&nbsp;&nbsp;Cancer&nbsp;</em></strong>(1998)<strong>&nbsp;</strong>76: 362-367.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">61.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Far&iacute;as EF,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Ladeda V, Bal de Kier Joff&eacute; E. Verapamil Inhibits Proteases Production, Local Invasion and Metastasis Development of Murine Carcinoma Cells<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Int. J. Cancer</strong></em><strong>.&nbsp;</strong>(1998)<strong>&nbsp;</strong>78 (6): 727-734.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">62.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as EF, Alonso DF, Arregui C, Bal de Kier Joff&eacute; E E.<em>&nbsp;A&nbsp;</em>Phospholipase D and Protein Kinase C Inhibitor Blocks the Spreading of Murine Mammary Adenocarcinoma Cells Altering F-Actin and Integrin Point Contact Distribution<em>.&nbsp;<strong>Int. J. Cancer</strong>.&nbsp;</em>(1997) 71: 881-890.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">63.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Alonso DF, Far&iacute;as E, Bal de Kier Joff&eacute; E. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C pathways in murine mammary adenocarcinoma cells<em>.&nbsp;<strong>Biochem. Biophys. Acta&nbsp;</strong></em>(1997)&nbsp;1356: 171-184.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">64.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Diament M, D'elia I, Bal de Kier Joff&eacute; E, Klein S. Effect of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth.&nbsp;<strong><em>Tumor Biol.</em>&nbsp;</strong>(1997); 18: 41-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">65.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as E, Fernandez DM, Alonso DF, Bal de Kier Joff&eacute; E. Down modulation of tumor cells-associated proteolytic activity by n-butanol treatment in cultured murine mammary adenocarcinoma cells<em>.&nbsp;<strong>Int. J Oncol</strong>.&nbsp;</em>(1996);<strong>&nbsp;</strong>8: 35-39.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">66.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Klein S, Jasnis MA, Diament M, Davel L,&nbsp;<strong>Aguirre Ghiso JA</strong>, de Bonaparte YP. Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers<em>.&nbsp;<strong>Tumor Biol</strong>.&nbsp;</em>(1994);15: 160-165.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 14pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">Reviews, Commentaries, Perspectives and other Peer Reviewed Publications&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">. Translating the Science of Cancer Dormancy to the Clinic.&nbsp;<strong><em>Cancer Res</em></strong>&nbsp;(2021)August 24.</span>&nbsp;<span style="font-size: 12pt;">DOI: 10.1158/0008-5472.CAN-21-1407</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB, Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G. The State of Melanoma: Emergent Challenges and Opportunities.&nbsp;<strong><em>Clin Cancer Res</em></strong>. (2021) Jan 7:clincanres.4092.2020. doi: 10.1158/1078-0432.CCR-20-4092.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; background-color: white;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Risson E, Nobre AR, Maguer-Satta V,<strong>&nbsp;Aguirre-Ghiso JA</strong><em>.&nbsp;</em>The current paradigm and challenges ahead for the dormancy of disseminated tumor cells.&nbsp;<strong><em>Nat Cancer</em></strong>&nbsp;(2020).&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-020-0088-5"><span style="font-size: 12pt; color: windowtext; background-color: white; text-decoration: none;">https://doi.org/10.1038/s43018-020-0088-5</span></a><span style="font-size: 12pt; background-color: white;">.&nbsp;<strong><em><span style="color: #ff6600;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salom&eacute; B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, G&uuml;m&uuml;ş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunology of COVID-19: Current State of the Science.&nbsp;<strong><em>Immunity</em></strong>. (2020) Jun 16;52(6):910-941. doi: 10.1016/j.immuni.2020.05.002. Epub 2020 May 6.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black; background-color: white;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black; background-color: white;">Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL,<span class="apple-converted-space">&nbsp;</span></span><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso<span class="apple-converted-space"><span style="background-color: white;">&nbsp;</span></span><span style="background-color: white;">JA</span></span></strong><span style="font-size: 12pt; color: black; background-color: white;">; Board Members of the Metastasis Research Society.</span><span style="font-size: 12pt; color: black;">&nbsp;The importance of developing therapies targeting the biological spectrum of metastatic disease.&nbsp;<strong><em>Clin. Exp. Metastasis</em></strong>.</span><span class="apple-converted-space"><span style="font-size: 12pt; color: black; background-color: white;">&nbsp;</span></span><span style="font-size: 12pt; color: black; background-color: white;">(2019) Aug;36(4):305-309. doi: 10.1007/s10585-019-09972-3. Epub 2019 May 17.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso</span></strong><span style="font-size: 12pt;">&nbsp;<strong>JA</strong>.&nbsp;How dormant cancer persists and reawakens.&nbsp;<strong><em>Science</em></strong>. (2018) Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">&nbsp;</span></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, MS Sosa. Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis.&nbsp;<strong>Annual Review of Cancer Biology&nbsp;</strong>(2018), 2, 377-393</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre AR, Entenberg D, Wang Y, Condeelis J,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA.</strong>&nbsp;The Different Routes to Metastasis via Hypoxia-Regulated Programs.&nbsp;<strong><em>Trends Cell Biol</em></strong>. (2018<strong>)</strong>&nbsp;Jul 21. pii: S0962-8924(18)30109-0. doi: 10.1016/j.tcb.2018.06.008. [Epub ahead of print] Review. PMID: 30041830</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Fingleton B, Lange K, Caldwell B, Bankaitis KV; Board of the Metastasis Research<strong>&nbsp;</strong>Society.&nbsp;Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.&nbsp;<span class="jrnl"><strong><em>ClinExp Metastasis</em></strong></span>. (2017) Dec;34(8):443-447. doi: 10.1007/s10585-017-9872-8. Epub 2018 Feb 26 PMID: 29484519</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Fluegen G,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA.</strong>&nbsp;The Relationship Between Dormant Cancer Cells and Their Microenvironment.&nbsp;<strong><em>Adv Cancer Res.&nbsp;</em></strong>(2016); 132:45-71. doi: 10.1016/bs.acr.2016.07.002. Epub 2016 Aug 25. PMID:27613129.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV,&nbsp;<strong>Aguirre-Ghiso</strong>&nbsp;<strong>JA</strong>, et al.&nbsp;Guidelines for the use and interpretation of assays for monitoring autophagy.&nbsp;<strong><em>Autophagy</em></strong>&nbsp;(2016) Jan 2;12(1):1-222. No abstract available. PMID: 26799652</span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Goossens N, Hoshida Y,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance.&nbsp;<strong><em>EMBO Mol Med&nbsp;</em></strong>(2015) Aug 3. pii: e201505284. doi: 10.15252/emmm.201505284. [Epub ahead of print]</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Bragado P,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Mechanisms of disseminated cancer cell</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">dormancy: an awakening field.&nbsp;<strong><em>Nat Rev Cancer</em></strong>&nbsp;(2014) Sep;14(9):611-22. doi:</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">10.1038/nrc3793. Epub 2014 Aug 14. Review. PubMed PMID: 25118602; PubMed Central&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMCID: PMC4230700.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Cover article for the September 14<sup>th</sup>&nbsp;issue of Nat Rev Cancer</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Ranks 6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric.&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression.&nbsp;<strong><em>EMBO J</em></strong>. (2014) Aug 18;33(16):1737-9. doi: 10.15252/embj.201489364. Epub 2014 Jul 14. PubMed PMID: 25024435; PubMed Central PMCID: PMC4195757.&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Avivar-Valderas A, Wen HC,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Stress signaling and the shaping&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">of the mammary tissue in development and cancer.&nbsp;<strong><em>Oncogene</em></strong>&nbsp;(2014) Nov</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">27;33(48):5483-90. doi: 10.1038/onc.2013.554. Epub 2014 Jan 13. Review. PubMed</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMID: 24413078; PubMed Central PMCID: PMC4096615.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso, JA,&nbsp;</strong>Bragado P, Sosa MS.&nbsp;Metastasis awakening: targeting dormant cancer.&nbsp;<strong><em>Nat Med.</em></strong>&nbsp;(2013) Mar;19(3):276-7. doi: 10.1038/nm.3120. PMID: 23467238 [PubMed - indexed for MEDLINE] PMCID: PMC3651698&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Bragado P, Debnath J,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA.</strong>&nbsp;Regulation of tumor cell dormancy by tissue microenvironments and autophagy.&nbsp;<strong><em>AdvExp Med Biol</em>.&nbsp;</strong>(2013);734:73-89. doi: 10.1007/978-1-4614-1445-2_5.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, et al.,&nbsp;Guidelines for the use and interpretation of assays for monitoring autophagy.&nbsp;<strong><em>Autophagy</em></strong>&nbsp;(2012) Apr;8(4):445-544.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Bragado P, Sosa MS, Keely P, Condeelis J,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Microenvironments dictating tumor cell dormancy.&nbsp;<strong><em>Recent Results Cancer Res.&nbsp;</em></strong>(2012); 195:25-39.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Cagan RL,&nbsp;<strong>Aguirre-Ghiso JA</strong>. A local view of cancer.&nbsp;<strong><em>Dev Cell</em>.&nbsp;</strong>(2012)&nbsp;Mar 13;22(3):472-4.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Genden EM,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Oropharyngeal cancer biology and treatment: insights from messenger RNA sequence analysis and transoral robotic surgery.&nbsp;<strong><em>Mayo Clin Proc</em></strong>.&nbsp;<strong>(</strong>2012)&nbsp;Mar;87(3):211-2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Avivar-Valderas A, Bragado P, Wen HC,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Molecular Pathways: ERK1/2 and p38&alpha;/&beta; signaling in tumor cell quiescence: opportunities to control dormant residual disease. Invited Article.&nbsp;<strong><em>Clin. Cancer Res</em></strong><em>.&nbsp;</em>(2011)&nbsp;Sep 15;17(18):5850-7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Prince A,<strong>&nbsp;Aguirre-Ghiso JA,&nbsp;</strong>Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies<strong><em>. Mt. Sinai J. Med.&nbsp;</em></strong>(2010). 77 (6): 684-99.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. On the theory of tumor self-seeding: implications for metastasis progression in humans.&nbsp;<strong><em>Breast Cancer Res</em></strong>.&nbsp;(2010)&nbsp;Apr 28;12(2):304. Viewpoint&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 2pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt 2.0pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Dormancy of metastatic melanoma.&nbsp;<strong><em>Pigment Cell Melanoma Res</em></strong>.&nbsp;(2010)Feb;23(1):41-56. Epub 2009 Oct 19.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Allgayer H,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;The urokinase receptor (u-PAR) - a link between tumor cell dormancy and minimal residual disease in bone marrow?&nbsp;<strong><em>APMIS&nbsp;</em></strong>(2008);116 (7-8) 602-614.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><u><span style="text-decoration: none;">&nbsp;</span></u></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. Models, mechanisms and clinical evidence for cancer dormancy.&nbsp;<strong><em>Nature Reviews Cancer</em></strong>.&nbsp;(2007). Nov; 7(11): 834-46. Invited peer reviewed article&nbsp;<strong><em><span style="color: #ff6600;">(Cover and featured article).&nbsp;&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v7/n11/index.html"><strong><em>http:/…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 41.05pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -35.65pt;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities.&nbsp;<strong><em>Cell Cycle.&nbsp;</em></strong>(2006)&nbsp;Aug; 5(16): 1740-3. (Guest Editor). Introductory Review. Invited peer reviewed article. Cover.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ranganathan AC, Adam AP and&nbsp;<strong>Aguirre-Ghiso JA</strong>. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy.&nbsp;<strong><em>Cell Cycle</em></strong>. (2006)&nbsp;Aug; 5(16): 1799-807.&nbsp;<strong><em><span style="color: #ff6600;">Cover.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ranganathan AC, Adam AP, Zhang L, and&nbsp;<strong>Aguirre-Ghiso JA</strong>. Tumor cell dormancy induced by p38SAPK and ER-stress signaling; an adaptive advantage for metastatic cells?&nbsp;<strong><em>Cancer Biology &amp; Therapy&nbsp;</em></strong>(2006)&nbsp;Jul; 5(7): 729-35.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; tab-stops: 45.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Tenenbaum SA,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Dephosphorylation Shows SR Proteins the Way Out.<strong><em>&nbsp;Molecular Cell&nbsp;</em></strong>(2005);&nbsp;20 (4); 499-501.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth<em>.&nbsp;<strong>Current Opinion in Cell Biology</strong>&nbsp;</em>(2000)<strong>&nbsp;</strong>12(5): 613-20.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Bal de Kier Joffe E, Mazzoni EO,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Signaling pathways regulating the expression of proteases during tumor progression<strong><em>.&nbsp;</em></strong>(In Spanish)<strong>&nbsp;<em>Medicina (B Aires)&nbsp;</em></strong>(2000)<strong>;</strong>&nbsp;60:34-40.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Liu D, Yu W, Kovalski K. The role of plasminogen activator receptor in cancer invasion and dormancy.&nbsp;<strong><em>Medicina (Buenos Aires)&nbsp;</em></strong>(1999)&nbsp;59, 547-552.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><u>,</u>&nbsp;Alonso DF, Far&iacute;as EF, Gomez D, Bal de Kier Joff&eacute; E. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype<em>.&nbsp;<strong>Eur. J. Biochem.</strong></em>(1999)<strong>&nbsp;</strong>263, 2, 295-304<strong><em><span style="color: #ff6600;">&nbsp;(Cover).</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;">Books and Book Chapters</span></strong></p>
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="1" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Sosa MS, Bragado P, Debnath J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy.&nbsp;<strong><em>Systems Biology of Tumor Dormancy</em></strong>. Editors, Enderling H, Almog N and Hlatky L.&nbsp;(2012)<strong>&nbsp;</strong><em>Springer Science + Business Media, INC.</em><a style="color: #903638; text-decoration: underline;" href="http://www.springerlink.com/content/u44l178561014r11/">http://www.sprin…;
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<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><em><span style="letter-spacing: 0.25pt;">&nbsp;</span></em></p>
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="ES-TRAD">Bragado P, Sosa MS, Keely P, Condeelis</span>&nbsp;J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer.<em>&nbsp;</em>(Eds: K. Pantel, C. Sotiriou, M. Ignatiadis).&nbsp;<strong><em>Recent Results Cancer Res</em>.</strong>&nbsp;(2012); 195:25-39. doi: 10.1007/978-3-642-28160-0_3<strong>.&nbsp;</strong></li>
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<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0.25in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-pagination: none; mso-list: l16 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none; text-autospace: none;"><strong>Aguirre-Ghiso JA,</strong>&nbsp;Alonso DF, Farias EF. Function and expression of the uPA/uPAR system in cancer metastasis.&nbsp;&nbsp;Cancer Metastasis: Biologic Basis and Therapeutics.<strong>&nbsp;<em>Cambridge University Press</em></strong>, Editors: Danny Welch, Danny R. Welch, Ph.D., David C. Lyden, MD, PhD, and Beth Psaila, MD. (2009).<a style="color: #903638; text-decoration: underline;" href="http://www.springer.com/biomed/cancer/book/978-1-4419-6614-8">http://ww…;
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<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="PT-BR">Bragado P, Ranganathan AC,&nbsp;</span><strong>Aguirre-Ghiso JA.</strong>&nbsp;Dormancy of Disseminated Tumor Cells: Reciprocal crosstalk with the microenvironment.&nbsp;The Tumor Microenvironment-Cancer Drug Discovery and Development.&nbsp;<strong><em>Springer Science + Business Media LLC</em></strong>, Humana Press. Dr. Rebecca Bagley, Editor. (<span lang="PT-BR">2010), Part 2, pp229-254.</span><strong><span lang="PT-BR">&nbsp;</span></strong><a href="http://www.cambridge.org/gb/knowledge/isbn/item5738926/?site_locale=en_…;
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