<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Pre-Prints Available Online</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Deepak K. Singh, Eduardo Farias, Saul Carcamo, Dan Hasson, Dan Sun, Julie Cheung, Ana Rita Nobre, Nupura Kale, Maria Soledad Sosa, Emily Bernstein, Julio A. Aguirre-Ghiso. Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ–SMAD4 signaling bioRxiv 2021.08.01.454684; doi: </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.08.01.454684"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.08.01.454684</span></a></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="color: black;"> </span></p>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt; color: black;">, Nobre AR, Dalla E, et al. A Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a Barrier to Metastatic Progression of Early Disseminated Cancer Cells. 18 January 2021, PREPRINT (Version 1) available at <strong><em>Research Square.</em></strong> </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-145308/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-145308/v1</span></a></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Rodriguez Martinez A, Miles B, Farias E, Mezei M, Cheung JF, Nobre AR, Kale N, Sproll KC, Sosa MS, <strong>Aguirre-Ghiso JA</strong>. A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy. <strong><em>bioRxiv</em></strong>(2021).01.30.428967; doi: </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.01.30.428967"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.01.30.428967</span></a></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Borriello L, Coste A, Sharma VP, Karagiannis GS, Lin Y, Wang Y, Ye X, Duran C, Chen X, Dalla E, Singh DK, Oktay MH, <strong>Aguirre-Ghiso JA<em>, </em></strong>Condeelis J, Entenberg D. Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. <strong><em>bioRxiv</em></strong> (2021).02.04.429798; doi: </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.02.04.429798"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.02.04.429798</span></a></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Mitchell Fane, Stephen Douglass, Gretchen Alicea, Marie Webster, Vito Rebecca, Gloria Marino, Yash Chhabra, Filipe Almeida, Brett Ecker, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, David Speicher, <strong>Julio Aguirre-Ghiso</strong>, Ashani Weeraratna, </span><span style="font-size: 12pt; color: black;">Stromal Changes In The Aged Lung Induce An Emergence From Melanoma Dormancy, 16 September (2020), PREPRINT (Version 1) available at R<strong><em>esearch Square</em></strong> </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-61165/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-61165/v1</span></a></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;"> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Peer Reviewed Original Research Contributions </span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-align: justify; line-height: 24px;"><em><sup><span style="color: black;"> </span></sup></em></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Di Martino J, Nobre AR, Mondal C, Taha I, Farias EF, Fertig E, Naba A, <strong>Aguirre-Ghiso JA</strong>, Bravo-Cordero JJ. A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy, 22 June 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-580847/v1]. <strong><em>Nature Cancer</em></strong> (2021) (Accepted for Publication)</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang M, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikov A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown B, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, <strong>Aguirre-Ghiso JA</strong>, Merad M. Lineage tracing reveals the unique pro-tumorigenic niche role of tissue-resident macrophages in early cancer lesions. <strong><em>Nature </em></strong>595, 578–584 (2021). <strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre R, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, <strong>Aguirre-Ghiso JA</strong>. Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2. <strong><em>Nature Cancer</em></strong> 2, 327–339 (2021). </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-021-00179-8"><span style="font-size: 12pt;">https://doi.org/10.1038/s43018-021-00179-8</span></a><span style="font-size: 12pt;"> <strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Lam T, <strong>Aguirre-Ghiso JA</strong>, Geller MA, Aksan A, Azarin SM. Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancy. <strong><em>Biotechnol Bioeng</em></strong>. (2020) Oct;117(10):3066-3080. doi: 10.1002/bit.27479. Epub 2020 Jul 9.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Teh JL, Purwin TJ, Han A, Chua V, Patel P, Baqai U, Liao C, Bechtel N, Sato T, Davies MA, <strong>Aguirre-Ghiso JA</strong>, Aplin AE. Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma. <strong><em>Mol Cancer Ther</em></strong>. (2020) May 19: molcanther.1016.2019. doi: 10.1158/1535-7163.MCT-19-1016. Epub ahead of print. PMID: 32430489.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, <strong>Aguirre-Ghiso JA</strong>, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. <strong><em>Nat Cell Biol. </em></strong>(2019) Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, <strong>Aguirre-Ghiso JA</strong>, Benovic JL. Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma. <strong><em>Mol Cancer Res</em></strong>. (2019) Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.</span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;"> In the top 5% of all research outputs scored by Altmetric and picked up by 16 news stories from 15 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-family: inherit, serif;"> </span></p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; font-family: inherit, serif;">Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, Lønning PE, Synnestvedt M, <strong>Aguirre-Ghiso JA</strong>, Naume B. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients. <strong><em>Breast Cancer Research</em></strong>(2018) 20 (1), 120. </span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric and picked up by 9 news stories from 9 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; vertical-align: baseline;"><span style="font-family: inherit, serif;"> </span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; vertical-align: baseline;"><!-- [if !supportLists]--><span style="font-family: 'inherit',serif; mso-fareast-font-family: inherit; mso-bidi-font-family: inherit;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-family: inherit, serif;">Linde<span style="border: 1pt none windowtext; padding: 0in;"> N</span>, Casanova-Acebes<span style="border: 1pt none windowtext; padding: 0in;"> M</span>, Sosa<span style="border: 1pt none windowtext; padding: 0in;"> MS</span>, Mortha<span style="border: 1pt none windowtext; padding: 0in;"> A</span>, Rahman<span style="border: 1pt none windowtext; padding: 0in;"> A</span>, Farias EF, Harper K, Tardio E, Reyes Torres I, Jones<span style="border: 1pt none windowtext; padding: 0in;"> J</span>, Condeelis J, Merad <span style="border: 1pt none windowtext; padding: 0in;">M,</span> and <strong><span style="border: 1pt none windowtext; padding: 0in;">Aguirre-Ghiso JA.</span></strong><br /><span style="border: 1pt none windowtext; padding: 0in;">Macrophages orchestrate breast cancer early dissemination and metastasis. <strong><em>Nature Communications</em></strong></span> 9, 21(2018) doi:10.1038/s41467-017-02481-5. </span><strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric. Highlighted in Faculty of 1000 Prime: El-Deiry W and Zhao S: F1000Prime Recommendation of [Linde N et al., Nat Commun 2018 9(1):21]. In F1000Prime, 11 Jan 2018; 10.3410/f.732394311.793541160. Highlighted in Science Translational Medicine:</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: 22.5pt; vertical-align: baseline;"><a style="color: #903638; text-decoration: underline;" href="https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm">… style="background-color: white;">https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm</…;
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS, <strong>Aguirre-Ghiso</strong> <strong>JA</strong>, Condeelis J. Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics. <strong><em>Methods</em></strong>(2017) Sep 1; 128:65-77. doi: 10.1016/j.ymeth.2017.07.019.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Fluegen G, Avivar-Valderas A, WangY, PadgenM, WilliamsJK, Verkhusha V, Cheung JF, Entenberg D, Castracane J, Keely PJ, Condeelis J, <strong>Aguirre-Ghiso JA</strong>. <sup> </sup>Phenotypic heterogeneity of disseminated tumor cells is predetermined by primary tumor hypoxic microenvironments.<strong><em> Nature Cell Biology </em><span style="color: #262626;">(2017)<em> </em></span></strong><span style="color: #262626;">doi:10.1038/ncb3465.</span><strong><em><span style="color: #ff6600;">Cover Article. </span></em></strong></span><strong><em><span style="font-size: 12pt; font-family: inherit, serif; color: #ff6600; border: 1pt none windowtext; padding: 0in;">Highlighted in Science Translational Medicine Editor’s Choice, Science Translational Medicine 15 Feb 2017: Vol. 9, Issue 377, eaam6063 DOI: 10.1126/scitranslmed.aam6063</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Harper K, Sosa MS, Hosseini H, Entenberg D, Avivar-Valderas A, Nagi C, Davis RJ, Farias EF, Condeelis J, Klein C, <strong>Aguirre-Ghiso JA</strong>. Mechanism of early dissemination and metastasis during early stages of HER2+ mammary cancer.<strong> <em>Nature </em></strong><span style="color: #262626;">(2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799</span><strong>.<em><span style="color: #ff6600;"> Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000. </span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="https://f1000.com/prime/727099751"><strong><em><span style="font-size: 12pt;">https://f1000.com/prime/727099751</span></em></strong></a><strong><em><… style="font-size: 12pt; color: #ff6600;">; Highlighted in Nature Reviews Cancer </span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Hosseini, H, Harper K, Obradovic M, Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G, <strong>Aguirre-Ghiso JA</strong>, Klein CA. Early dissemination seeds metastasis in breast cancer.<em> <strong>Nature</strong></em>. (2016)<strong> </strong>Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798. <strong><em><span style="color: #ff6600;">Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted in Nature Reviews Cancer </span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E, Nobre AR,<strong> </strong><strong>Aguirre-Ghiso JA</strong>, Jung Y, Taichman RS. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow. <strong><em>Scientific Reports</em></strong> (2016)<strong><em> </em></strong>Nov 7; 6:36520. doi: 10.1038/srep36520.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS,<strong> Aguire-Ghiso JA</strong>, Castracane J, Denu JM, Keely PJ. Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells. <strong><em>EBioMedicine</em> </strong>(2016) Nov; 13:146-156. doi: 10.1016/j.ebiom.2016.10.012. PubMed PMID: 27743905.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Cackowski FC, Eber MR, Rhee J, Decker A, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y, <strong>Aguirre-Ghiso</strong><strong> JA</strong>,Taichman RS. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy. <strong><em>J Cell Biochem</em></strong>(2016) Oct 18. doi: 10.1002/jcb.25768. PMID: 27753136</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parsons R, <strong>Aguirre-Ghiso JA</strong>, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E. Cbx8 acts non-canonically in breast cancer to promote Notch signaling. <strong><em>Cell Reports </em></strong>(2016) Jul 12;16(2):472-86. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23. PMID: 27346354</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Williams JK, Entenberg D, Wang Y, Avivar-Valderas A, Padgen M, Clark A, <strong>Aguirre-Ghiso JA</strong>, Castracane J, Condeelis JS. Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging. <strong><em>Intravital</em></strong>. (2016)</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Szulczewski JM, Inman DR, Entenberg D, </span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, Castracane J, Condeelis J, Eliceiri KW, Keely PJ. In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging. <strong><em>Scientific Reports</em></strong>(2016)<strong> </strong></span><span style="font-size: 12pt;">May 25; 6:25086. doi: 10.1038/srep25086. PMID: 27220760</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Li M, Pathak RR, Lopez-Rivera E, Friedman SL, <strong>Aguirre-Ghiso</strong><strong> JA</strong>, Sikora AG. The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma<em>. </em><strong><em>J Vis Exp</em></strong>. (2015) Oct 9; (104). doi: 10.3791/52411.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Alsadeq A, Strube S, Krause S, Carlet M, Jeremias I, Vokuhl C, Loges S, <strong>Aguirre-Ghiso</strong><strong> JA</strong>, Trauzold A, Cario G, Stanulla M, Schrappe M, Schewe DM. Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo. <strong><em>Leukemia</em></strong>. (2015) Jun 24. doi: 10.1038/leu.2015.153. [Epub ahead of print] PMID: 26104660</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM, <strong>Aguirre-Ghiso</strong><strong>JA</strong>. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. <strong><em>BMC Cancer</em></strong> (2015) May 30; 15:444. doi: 10.1186/s12885-015-1460-1. PMCID: PMC4448210. <strong><em><span style="color: #ff6600;">Highlighted by BMC Cancer in the “Highly Accessed” category.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;"> </span></em></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, <strong>Aguirre-Ghiso JA</strong>, Friedman SL. Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development. <strong><em>Mol Cell Biol</em></strong>. (2015) Feb 23. pii: MCB.00136-15. PMID: 25713103. <strong><em><span style="color: #ff6600;">Cover article for the Feb 23 issue of Mol Cell Biol.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E, <strong>Aguirre-Ghiso JA</strong>. NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes. <strong><em>Nat Commun</em></strong> (2015) Jan 30; 6:6170. doi: 10.1038/ncomms7170. PubMed PMID:25636082; PubMed Central PMCID: PMC4313575. <strong><em><span style="color: #ff6600;">In the top 10% of all articles ever tracked by Altmetric.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Chéry L, Lam HM, Coleman I, Lakely B, Coleman R, Larson S, <strong>Aguirre-Ghiso JA</strong>, Xia J, Gulati R, Nelson PS, Montgomery B, Lange P, Snyder LA, Vessella RL, Morrissey C. Characterization of single disseminated prostate cancer cells Reveals tumor cell heterogeneity and identifies dormancy associated pathways. <strong><em>Oncotarget</em></strong> (2014) Oct 30;5(20):9939-51. PubMed PMID: 25301725; PubMed Central PMCID: PMC4259449.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, <strong>Aguirre-Ghiso JA</strong>, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.<strong><em>Cancer Res</em></strong>. (2014) Feb 15;74(4):1067-78. doi: 10.1158/0008-5472.CAN-13-0588. Epub 2014 Jan 7. PMID: 24398473 [PubMed - indexed for MEDLINE]</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span lang="EN-GB" style="font-size: 12pt;">Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM, </span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">.</span><span lang="EN-GB" style="font-size: 12pt;"> TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling. <strong><em>Nat. Cell. Bio. </em></strong>(2013).</span><span style="font-size: 12pt;">Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27.</span><span lang="EN-GB" style="font-size: 12pt;"> PMID: 24161934;</span><span style="font-size: 12pt;">PMCID: not available. <strong><em><span style="color: #ff6600;">Featured in Nat Cell Bio Cover same issue. Highlighted in Science Signaling Editor’s Choice, Cancer Research Breaking Advances section and several public news outlets. Featured in the Cover of the November 15th issue of Nat Cell Bio. Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric. </span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;"> </span></em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CTY, Su D, Dedon PC, <strong>Aguirre-Ghiso JA</strong>, Begley T. A human tRNAmethyltransferase 9-like protein prevents tumor growth by regulating LIN9 and the hypoxic response. <strong><em>EMBO Mol Med </em></strong>(2013) Feb 4. doi: 10.1002/emmm.201201161.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Avivar-Valderas A, Bobrovnikova-Marjon E, Diehl JA, Bardeesy N, Debnath J, <strong>Aguirre-Ghiso JA</strong>. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. <strong><em>Oncogene</em></strong>(2012), Nov 19. doi: 10.1038/onc.2012.512. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Kim RS, Avivar-Valderas A, Estrada A, Bragado P, Sosa MS, <strong>Aguirre-Ghiso JA</strong>, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive breast cancer. <strong><em>PLoS One </em></strong>(2012); 7(4):e35569. Epub 2012 Apr 18.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E, <strong>Aguirre-Ghiso JA</strong>. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. <strong><em>PLoS One</em>. </strong>(2012); 7(1):e29974. PMCID: PMC3262798. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;"> </span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Tong CC, Lau KH, Rivera M, Cannan D, <strong>Aguirre-Ghiso JA</strong>, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J. Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy. <strong><em>Oncol Rep.</em> </strong>(2012) May; 27(5):1580-6. doi: 10.3892/or.2012.1679.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span lang="ES"> </span></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span lang="ES">Gutiérrez-Uzquiza Á, Arechederra M, Bragado P, </span><strong>Aguirre-Ghiso JA</strong><span lang="ES">, Porras A. </span>p38a mediates cell survival in response to oxidative stress via induction of antioxidant genes. Effect on p70S6K pathway. <strong><em>J Biol Chem. </em></strong>(2012)Jan 20;287(4):2632-42. Epub 2011 Dec 2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS, <strong>Aguirre-Ghiso JA</strong>, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy<strong><em>. J Cell SciTher </em></strong>(2011) S1:002. doi:10.4172/2157-7013.S1-002.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;"> </span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><span lang="ES-AR">Avivar-Valderas A, Salas E, </span>Bobrovnikova-Marjon E, Diehl JS<span lang="ES-AR">, Nagi C, Debnath J, </span><strong>Aguirre-Ghiso JA</strong>,<strong> </strong>PERK integrates autophagy and oxidative stress responses to promote survival during ECM detachment. <strong><em>Mol Cell Biol</em></strong>. (2011) Sep; 31(17):3616-29. PMC3165554 <strong><em><span style="color: #ff6600;">(Cover article) </span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong> </strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span lang="ES-AR">Wen HC, Avivar-Valderas A, Sosa MS, Girinius N, Farias EF, Davis R, </span><strong>Aguirre-Ghiso JA</strong>.<strong> </strong>p38 signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis<em>. <strong>Science Signaling</strong></em><strong> </strong>(2011) 4 (174), ra34. [DOI: 10.1126/scisignal.2001684].<strong><em><u><span style="color: #ff6600;">http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/174/ra34</sp…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;"> </span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">36.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Ishii Y, Papa Y, Bahadur U, Yue Z, <strong>Aguirre-Ghiso </strong><strong>JA</strong>, Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of theestrogen receptor, which leads to a pro-apoptotic unfolded protein response. <strong><em>Clin. Cancer Res. </em></strong>(2011) Feb 3. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">37.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Sequeira SJ, Wen HC, Avivar-Valderas A, <strong>Aguirre-Ghiso JA</strong>.<strong> </strong>Inhibition of eIF2a dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.<strong><em>BMC Cell Biology. </em></strong>(2009) Sep 15;10:64. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">38.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Schewe DM. <strong>Aguirre-Ghiso JA</strong>.<strong> </strong>Inhibition of eIF2 dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.<strong><em> Cancer Res. </em></strong>(2009)<strong> </strong>Feb 15;69(4):1545-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">39.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><span lang="PT-BR">Adam AP, George A, Bragado P, Iglesias BV, Schewe D, Ranganathan A, </span>Kourtidis A, Conklin DS, <strong>Aguirre-Ghiso JA</strong>. Computational identification of a p38<sup>SAPK</sup> regulated transcription factor network required for tumor cell quiescence. <strong><em>Cancer Res</em></strong><em>.</em> (2009) Jul 15; 69(14):5664-72. Epub 2009 Jul 7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em> </em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">40.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Schewe DM, <strong>Aguirre-Ghiso JA</strong>. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells <em>in vivo</em>. <strong><em>Proc Natl Acad Sci USA </em></strong>(2008)<strong> </strong>Jul 29;105(30):10519-24<strong><em>. <span style="color: #ff6600;">Highlighted in “This week in PNAS” section of the journal. </span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.pnas.org/content/105/30/10271.full?sid=79541a8a-11a2-41cc-ae… style="color: #ff6600;"> Faculty of 1000 evaluation: </span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/id/1119501/evaluation"><strong><em>…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em> </em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">41.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Ranganathan AC, Ohja S, Kourtidis A, Conklin D, <strong>Aguirre-Ghiso JA</strong>. Dual function of PERK in tumor cell growth arrest and survival. <strong><em>Cancer Res </em></strong>(2008); 68(9): 1–9.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em> </em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">42.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF, <strong>Aguirre-Ghiso JA</strong><em>.</em> Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation. <strong><em>PLoS ONE</em></strong>. (2007) Jul 18; 2:e615.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em> </em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">43.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Baron TE, Lastro MT, Ranganathan AC, Tenenbaum SA, Conklin DS, <strong>Aguirre-Ghiso JA</strong>. Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest. <strong><em>Methods Mol Biol</em></strong>. (2007);<strong><em> </em></strong>383:227-44. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">44.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Shinohara M, Mikhailov AV, <strong>Aguirre-Ghiso JA</strong>, Rieder CL. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells<strong>. <em>Molecular Biology of the Cell.</em></strong><em> </em>(2006)<strong> </strong>Dec 1<sup>st</sup>.17: 5227-5240.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">45.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Chaurasia P, <strong>Aguirre-Ghiso JA</strong><u>,</u> Liang OD, Gardsvoll H, Ploug M, Ossowski LA. Region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth. <strong><em>J. Biol. Chem. </em></strong>(2006) May 26; 281(21): 14852-63.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong> </strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">46.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ranganathan AC, Zhang L, Adam AP, <strong>Aguirre-Ghiso JA</strong>. <a name="OLE_LINK9"></a>Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase–like ER kinase (PERK) to drug resistance of dormant carcinoma cells. <strong><em>Cancer Research </em></strong>(2006); 66: (3) 1702-11.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">47.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, <strong>Aguirre-Ghiso JA</strong>, Flores SC, Melendez JA. Mitochondrial H2O2 Regulates the Angiogenic Phenotype Via PTEN Oxidation. <strong><em>J. Biol. Chem.</em> </strong>(2005)<strong> </strong>29; 280(17): 16916-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong> </strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 56.0pt 84.0pt 112.0pt 140.0pt 168.0pt 196.0pt 224.0pt 3.5in 280.0pt 308.0pt 336.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">48.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><strong>, </strong>Ossowski L, Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. <strong><em>Cancer Res </em></strong>(2004);<strong> </strong>64(20): 7336-45.<strong><em><span style="color: #ff6600;">Faculty of 1000 evaluation at: </span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/15492254/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">49.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Mazzoni E, Adam A, Bal de Kier Joffe E, <strong>Aguirre-Ghiso JA.</strong> Immortalized mammary epithelial cells overexpressing PKC acquire a malignant phenotype and become tumorigenic in vivo. <strong><em>Molecular Cancer Res</em></strong>. (2003)<strong> </strong>1:776-787</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">50.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Estrada Y, Liu D, Ossowski L. ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK). <strong><em>Cancer Res.</em></strong> (2003); 63(7): 1684-95.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">51.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Puricelli L, Proiettii CJ, Labriola L, Salatino M, Balana ME, <strong>Aguirre-Ghiso JA</strong>, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. <strong><em>Int. J. Cancer</em></strong>. (2002) 100(6): 642-53.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">52.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Liu D, <strong>Aguirre-Ghiso JA</strong>, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. <strong><em>Cancer Cell </em></strong>(2002)<strong>; </strong>1: 445-457<strong><em><span style="color: #ff6600;">(Cover). Preview in the same issue:</span></em></strong> <a style="color: #903638; text-decoration: underline;" href="http://www.cell.com/cancer-cell/abstract/S1535-6108(02)00076-4"><strong… style="text-transform: uppercase;"> </span><em><u><span style="color: #ff6600;">Faculty of 1000 Evaluation at: </span></u></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/12124174/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">53.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA.</strong> Inhibition of FAK signaling activated by urokinase receptor induces human carcinoma dormancy in vivo. <strong>Oncogene </strong>(2002) 21(16): 2513-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">54.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E, <strong>Aguirre-Ghiso JA</strong><strong>. </strong>RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts<em>. <strong>BiochemBiophys Res Commun.</strong></em><strong> </strong>(2001)<strong> </strong>283(4): 854-61.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">55.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong> Liu D, Mignatti D, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK<sup>MAPK</sup> to p38<sup>MAPK</sup> activity ratios that determine carcinoma cell proliferation or dormancy in vivo. <strong><em>Mol. Biol. Cell </em></strong>(2001). 12, 4, 863-879. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">56.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong> Kovalski K, Ossowski L. Tumor dormancy due to urokinase receptor down-regulation in human carcinoma involves integrin and MAPK signaling. <strong><em>J. Cell Biol. </em></strong>(1999)<strong> </strong>147, 89-103. <strong><em><span style="color: #ff6600;">Highlighted in the In Brief section of JCB.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em> </em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">57.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Frankel P, Farías E, Lu Z, Jiang H, Olsen A, Feig L, Bal de Kier Joffé E, Foster D. Ral-A requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator. Involvement of metalloproteinases<em><span style="text-transform: uppercase;">. </span><strong>Oncogene </strong></em>(1999<em>)</em><strong><em>, </em></strong>18, 4718-4725.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">58.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Urtreger AJ, <strong>Aguirre-Ghiso JA</strong>, Werbahj S, Puricelli L, Muro A, Bal de Kier Joffé E. Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells<em>.<strong>Int. J. Cancer, </strong></em>(1999),<strong> </strong>vol. 82, 748-753.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">59.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ladeda V, <strong>Aguirre-Ghiso JA</strong>, Bal de Kier Joffé E. Function and Expression of CD44 During Spreading and Migration of Murine Carcinoma cells<em><span style="text-transform: uppercase;">. </span><strong>Exp. Cell Res</strong>. </em>(1998);<strong> </strong>242:515-527.</p>
<p class="ColorfulList-Accent11" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="font-size: 12pt;"> </span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">60.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Farías EF, Alonso DF, Bal de Kier Joffé E. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine-kinase pathway in mammary tumor cells. <strong><em>Int. J. Cancer </em></strong>(1998)<strong> </strong>76: 362-367.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">61.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Farías EF, <strong>Aguirre-Ghiso JA</strong>, Ladeda V, Bal de Kier Joffé E. Verapamil Inhibits Proteases Production, Local Invasion and Metastasis Development of Murine Carcinoma Cells<em><span style="text-transform: uppercase;">. </span><strong>Int. J. Cancer</strong></em><strong>. </strong>(1998)<strong> </strong>78 (6): 727-734.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">62.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Farías EF, Alonso DF, Arregui C, Bal de Kier Joffé E E.<em> A </em>Phospholipase D and Protein Kinase C Inhibitor Blocks the Spreading of Murine Mammary Adenocarcinoma Cells Altering F-Actin and Integrin Point Contact Distribution<em>. <strong>Int. J. Cancer</strong>. </em>(1997) 71: 881-890.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">63.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Alonso DF, Farías E, Bal de Kier Joffé E. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C pathways in murine mammary adenocarcinoma cells<em>. <strong>Biochem. Biophys. Acta </strong></em>(1997) 1356: 171-184. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">64.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Diament M, D'elia I, Bal de Kier Joffé E, Klein S. Effect of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth. <strong><em>Tumor Biol.</em> </strong>(1997); 18: 41-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;"> </span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">65.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Farías E, Fernandez DM, Alonso DF, Bal de Kier Joffé E. Down modulation of tumor cells-associated proteolytic activity by n-butanol treatment in cultured murine mammary adenocarcinoma cells<em>. <strong>Int. J Oncol</strong>. </em>(1996);<strong> </strong>8: 35-39.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">66.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Klein S, Jasnis MA, Diament M, Davel L, <strong>Aguirre Ghiso JA</strong>, de Bonaparte YP. Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers<em>. <strong>Tumor Biol</strong>. </em>(1994);15: 160-165.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 14pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;"> </span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">Reviews, Commentaries, Perspectives and other Peer Reviewed Publications </span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">. Translating the Science of Cancer Dormancy to the Clinic. <strong><em>Cancer Res</em></strong> (2021)August 24.</span> <span style="font-size: 12pt;">DOI: 10.1158/0008-5472.CAN-21-1407</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H, <strong>Aguirre-Ghiso JA</strong>, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB, Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G. The State of Melanoma: Emergent Challenges and Opportunities. <strong><em>Clin Cancer Res</em></strong>. (2021) Jan 7:clincanres.4092.2020. doi: 10.1158/1078-0432.CCR-20-4092.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; background-color: white;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Risson E, Nobre AR, Maguer-Satta V,<strong> Aguirre-Ghiso JA</strong><em>. </em>The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. <strong><em>Nat Cancer</em></strong> (2020). </span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-020-0088-5"><span style="font-size: 12pt; color: windowtext; background-color: white; text-decoration: none;">https://doi.org/10.1038/s43018-020-0088-5</span></a><span style="font-size: 12pt; background-color: white;">. <strong><em><span style="color: #ff6600;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salomé B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gümüş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunology of COVID-19: Current State of the Science. <strong><em>Immunity</em></strong>. (2020) Jun 16;52(6):910-941. doi: 10.1016/j.immuni.2020.05.002. Epub 2020 May 6.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black; background-color: white;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt; color: black; background-color: white;">Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL,<span class="apple-converted-space"> </span></span><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso<span class="apple-converted-space"><span style="background-color: white;"> </span></span><span style="background-color: white;">JA</span></span></strong><span style="font-size: 12pt; color: black; background-color: white;">; Board Members of the Metastasis Research Society.</span><span style="font-size: 12pt; color: black;"> The importance of developing therapies targeting the biological spectrum of metastatic disease. <strong><em>Clin. Exp. Metastasis</em></strong>.</span><span class="apple-converted-space"><span style="font-size: 12pt; color: black; background-color: white;"> </span></span><span style="font-size: 12pt; color: black; background-color: white;">(2019) Aug;36(4):305-309. doi: 10.1007/s10585-019-09972-3. Epub 2019 May 17.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso</span></strong><span style="font-size: 12pt;"> <strong>JA</strong>. How dormant cancer persists and reawakens. <strong><em>Science</em></strong>. (2018) Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;"> </span></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, MS Sosa. Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis. <strong>Annual Review of Cancer Biology </strong>(2018), 2, 377-393</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre AR, Entenberg D, Wang Y, Condeelis J, <strong>Aguirre-Ghiso JA.</strong> The Different Routes to Metastasis via Hypoxia-Regulated Programs. <strong><em>Trends Cell Biol</em></strong>. (2018<strong>)</strong> Jul 21. pii: S0962-8924(18)30109-0. doi: 10.1016/j.tcb.2018.06.008. [Epub ahead of print] Review. PMID: 30041830</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Fingleton B, Lange K, Caldwell B, Bankaitis KV; Board of the Metastasis Research<strong> </strong>Society. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example. <span class="jrnl"><strong><em>ClinExp Metastasis</em></strong></span>. (2017) Dec;34(8):443-447. doi: 10.1007/s10585-017-9872-8. Epub 2018 Feb 26 PMID: 29484519</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Fluegen G, <strong>Aguirre-Ghiso JA.</strong> The Relationship Between Dormant Cancer Cells and Their Microenvironment. <strong><em>Adv Cancer Res. </em></strong>(2016); 132:45-71. doi: 10.1016/bs.acr.2016.07.002. Epub 2016 Aug 25. PMID:27613129.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, <strong>Aguirre-Ghiso</strong> <strong>JA</strong>, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. <strong><em>Autophagy</em></strong> (2016) Jan 2;12(1):1-222. No abstract available. PMID: 26799652</span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Goossens N, Hoshida Y, <strong>Aguirre-Ghiso JA</strong>. Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance. <strong><em>EMBO Mol Med </em></strong>(2015) Aug 3. pii: e201505284. doi: 10.15252/emmm.201505284. [Epub ahead of print]</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Sosa MS, Bragado P, <strong>Aguirre-Ghiso JA</strong>. Mechanisms of disseminated cancer cell</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">dormancy: an awakening field. <strong><em>Nat Rev Cancer</em></strong> (2014) Sep;14(9):611-22. doi:</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">10.1038/nrc3793. Epub 2014 Aug 14. Review. PubMed PMID: 25118602; PubMed Central </p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMCID: PMC4230700.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Cover article for the September 14<sup>th</sup> issue of Nat Rev Cancer</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Ranks 6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric. </span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Sosa MS, <strong>Aguirre-Ghiso JA</strong>. Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression. <strong><em>EMBO J</em></strong>. (2014) Aug 18;33(16):1737-9. doi: 10.15252/embj.201489364. Epub 2014 Jul 14. PubMed PMID: 25024435; PubMed Central PMCID: PMC4195757. </span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;"> </span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 12pt;">Avivar-Valderas A, Wen HC, <strong>Aguirre-Ghiso JA</strong>. Stress signaling and the shaping </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">of the mammary tissue in development and cancer. <strong><em>Oncogene</em></strong> (2014) Nov</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">27;33(48):5483-90. doi: 10.1038/onc.2013.554. Epub 2014 Jan 13. Review. PubMed</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMID: 24413078; PubMed Central PMCID: PMC4096615. </p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso, JA, </strong>Bragado P, Sosa MS. Metastasis awakening: targeting dormant cancer. <strong><em>Nat Med.</em></strong> (2013) Mar;19(3):276-7. doi: 10.1038/nm.3120. PMID: 23467238 [PubMed - indexed for MEDLINE] PMCID: PMC3651698 </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Sosa MS, Bragado P, Debnath J, <strong>Aguirre-Ghiso</strong><strong> JA.</strong> Regulation of tumor cell dormancy by tissue microenvironments and autophagy. <strong><em>AdvExp Med Biol</em>. </strong>(2013);734:73-89. doi: 10.1007/978-1-4614-1445-2_5. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, <strong>Aguirre-Ghiso</strong><strong> JA</strong>, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. <strong><em>Autophagy</em></strong> (2012) Apr;8(4):445-544.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Bragado P, Sosa MS, Keely P, Condeelis J, <strong>Aguirre-Ghiso JA.</strong> Microenvironments dictating tumor cell dormancy. <strong><em>Recent Results Cancer Res. </em></strong>(2012); 195:25-39. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Cagan RL, <strong>Aguirre-Ghiso JA</strong>. A local view of cancer. <strong><em>Dev Cell</em>. </strong>(2012) Mar 13;22(3):472-4. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Genden EM, <strong>Aguirre-Ghiso JA</strong>. Oropharyngeal cancer biology and treatment: insights from messenger RNA sequence analysis and transoral robotic surgery. <strong><em>Mayo Clin Proc</em></strong>. <strong>(</strong>2012) Mar;87(3):211-2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Sosa MS, Avivar-Valderas A, Bragado P, Wen HC, <strong>Aguirre-Ghiso JA</strong>. Molecular Pathways: ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Invited Article. <strong><em>Clin. Cancer Res</em></strong><em>. </em>(2011) Sep 15;17(18):5850-7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Prince A,<strong> Aguirre-Ghiso JA, </strong>Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies<strong><em>. Mt. Sinai J. Med. </em></strong>(2010). 77 (6): 684-99. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. On the theory of tumor self-seeding: implications for metastasis progression in humans. <strong><em>Breast Cancer Res</em></strong>. (2010) Apr 28;12(2):304. Viewpoint </p>
<p class="MsoNormal" style="margin: 0in 9pt 2pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt 2.0pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ossowski L, <strong>Aguirre-Ghiso JA.</strong> Dormancy of metastatic melanoma. <strong><em>Pigment Cell Melanoma Res</em></strong>. (2010)Feb;23(1):41-56. Epub 2009 Oct 19. </p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Allgayer H, <strong>Aguirre-Ghiso JA.</strong> The urokinase receptor (u-PAR) - a link between tumor cell dormancy and minimal residual disease in bone marrow? <strong><em>APMIS </em></strong>(2008);116 (7-8) 602-614.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><u><span style="text-decoration: none;"> </span></u></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. Models, mechanisms and clinical evidence for cancer dormancy. <strong><em>Nature Reviews Cancer</em></strong>. (2007). Nov; 7(11): 834-46. Invited peer reviewed article <strong><em><span style="color: #ff6600;">(Cover and featured article). </span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v7/n11/index.html"><strong><em>http:/…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 41.05pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -35.65pt;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. <strong><em>Cell Cycle. </em></strong>(2006) Aug; 5(16): 1740-3. (Guest Editor). Introductory Review. Invited peer reviewed article. Cover.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]-->Ranganathan AC, Adam AP and <strong>Aguirre-Ghiso JA</strong>. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. <strong><em>Cell Cycle</em></strong>. (2006) Aug; 5(16): 1799-807. <strong><em><span style="color: #ff6600;">Cover.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ranganathan AC, Adam AP, Zhang L, and <strong>Aguirre-Ghiso JA</strong>. Tumor cell dormancy induced by p38SAPK and ER-stress signaling; an adaptive advantage for metastatic cells? <strong><em>Cancer Biology & Therapy </em></strong>(2006) Jul; 5(7): 729-35.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; tab-stops: 45.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Tenenbaum SA, <strong>Aguirre-Ghiso JA</strong>. Dephosphorylation Shows SR Proteins the Way Out.<strong><em> Molecular Cell </em></strong>(2005); 20 (4); 499-501.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong> </strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ossowski L, <strong>Aguirre-Ghiso JA</strong>. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth<em>. <strong>Current Opinion in Cell Biology</strong> </em>(2000)<strong> </strong>12(5): 613-20.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong><em> </em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Bal de Kier Joffe E, Mazzoni EO, <strong>Aguirre-Ghiso JA</strong>. Signaling pathways regulating the expression of proteases during tumor progression<strong><em>. </em></strong>(In Spanish)<strong> <em>Medicina (B Aires) </em></strong>(2000)<strong>;</strong> 60:34-40.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong> </strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]-->Ossowski L, <strong>Aguirre-Ghiso JA</strong>, Liu D, Yu W, Kovalski K. The role of plasminogen activator receptor in cancer invasion and dormancy. <strong><em>Medicina (Buenos Aires) </em></strong>(1999) 59, 547-552.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> </p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';"> </span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><u>,</u> Alonso DF, Farías EF, Gomez D, Bal de Kier Joffé E. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype<em>. <strong>Eur. J. Biochem.</strong></em>(1999)<strong> </strong>263, 2, 295-304<strong><em><span style="color: #ff6600;"> (Cover).</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;"> </span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;">Books and Book Chapters</span></strong></p>
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="1" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Sosa MS, Bragado P, Debnath J, <strong>Aguirre-Ghiso JA</strong>. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy. <strong><em>Systems Biology of Tumor Dormancy</em></strong>. Editors, Enderling H, Almog N and Hlatky L. (2012)<strong> </strong><em>Springer Science + Business Media, INC.</em><a style="color: #903638; text-decoration: underline;" href="http://www.springerlink.com/content/u44l178561014r11/">http://www.sprin…;
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<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><em><span style="letter-spacing: 0.25pt;"> </span></em></p>
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="ES-TRAD">Bragado P, Sosa MS, Keely P, Condeelis</span> J, <strong>Aguirre-Ghiso JA</strong>. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer.<em> </em>(Eds: K. Pantel, C. Sotiriou, M. Ignatiadis). <strong><em>Recent Results Cancer Res</em>.</strong> (2012); 195:25-39. doi: 10.1007/978-3-642-28160-0_3<strong>. </strong></li>
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<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0.25in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><u><span style="text-decoration: none;"> </span></u></p>
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-pagination: none; mso-list: l16 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none; text-autospace: none;"><strong>Aguirre-Ghiso JA,</strong> Alonso DF, Farias EF. Function and expression of the uPA/uPAR system in cancer metastasis. Cancer Metastasis: Biologic Basis and Therapeutics.<strong> <em>Cambridge University Press</em></strong>, Editors: Danny Welch, Danny R. Welch, Ph.D., David C. Lyden, MD, PhD, and Beth Psaila, MD. (2009).<a style="color: #903638; text-decoration: underline;" href="http://www.springer.com/biomed/cancer/book/978-1-4419-6614-8">http://ww…;
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="PT-BR">Bragado P, Ranganathan AC, </span><strong>Aguirre-Ghiso JA.</strong> Dormancy of Disseminated Tumor Cells: Reciprocal crosstalk with the microenvironment. The Tumor Microenvironment-Cancer Drug Discovery and Development. <strong><em>Springer Science + Business Media LLC</em></strong>, Humana Press. Dr. Rebecca Bagley, Editor. (<span lang="PT-BR">2010), Part 2, pp229-254.</span><strong><span lang="PT-BR"> </span></strong><a href="http://www.cambridge.org/gb/knowledge/isbn/item5738926/?site_locale=en_…;
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