<p class="MsoNormal">&nbsp;</p>
<p class="MsoNormal" style="mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; line-height: normal;"><span style="font-size: 14pt; font-family: 'Times New Roman', serif;">Ruobing Xiao, MD, MSc has professional interests in clinical pathology, hematology, and laboratory improvement. </span><span style="font-size: 14pt; font-family: 'Times New Roman', serif;">Dr. Xiao obtained her medical doctor degree from the University of New Mexico, School of Medicine. She completed her residency in anatomic and clinical pathology, and a hematopathology fellowship at the University of Massachusetts Medical School / UMass Memorial Medical Center.</span></p>

Clinical pathology, hematology, and laboratory improvement

Pathogenesis of multiple myeloma, and environmental factors that may trigger progression of multiple myeloma

<p><span style="color: black;">Xiao R, Cerny J, Dresser K, Nath R, Ramanathan M, Woda B and Yu H, MYC protein expression is detected in plasma cell myeloma but not in monoclonal gammopathy of undetermined significance (MGUS), American Journal of Surgical Pathology 2014; 38:776-783, PMID: 24705315</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Shi M, Xiao R, Woda B, and Yu H, Advances in Hematopathology, Archives of Pathology &amp; Laboratory Medicine, September, 2012, PMID: 24576034</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Hunt K, Xiao R, Thrombocytosis, Diagnostic Pathology: Blood &amp; Bone Marrow. Foucar K, et al. Amirsys Publishing, Salt Lake City, UT. Release Date: September 15, 2011</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Hunt K, Xiao R, Acute Monocytic and Monoblastic Leukemia, Diagnostic Pathology: Blood &amp; Bone Marrow. Foucar K, et al. Amirsys Publishing, Utah. Release Date: September 15, 2011</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Bang R, Bang R, Cooks L, and Xiao R. Multiple Clear Cell Acanthoma with Hepatitis C: A Novel Presentation. The Journal of American Academy of Dermatology, March 2010; vol 62, Supplement 1, Page AB39.</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Xiao R, Yang S, Koster F, Ye C, Stidley C, and Hjelle B. Sin Nombre Viral RNA Load in Patients with Hantavirus Cardiopulmonary Syndrome. The Journal of Infectious Diseases, Nov. 2006; 194 (2): 1403-1409, PMID: 17054070</span></p>
<p style="font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;"><span style="color: black;">Safronetz D, Lindsay R, Dibernadro A, Hjelle B, Xiao R, Artsob H and Drebot M. A Preliminary Study of the Patterns of Sin Nombre Viral Infection and Shedding in naturally Infected Deer Mice. Vector-Borne and Zoonotic Diseases, 2005; 5 (2): 127-132, PMID: 160114282</span></p>

<p>Ruobing Xiao, MD, MSC, is Laboratory Director, Pathology and Laboratory Medicine and Assistant Professor, Pathology and Laboratory Medicine at Montefiore Einstein. Dr. Xiao has professional interests in clinical pathology, hematology and laboratory improvement.</p><p>After earning her Doctor of Medicine at the University of New Mexico in 2008, Dr. Xiao completed her anatomic and clinical pathology residency at the University of Massachusetts in 2012. She remained there to complete her hematopathology fellowship in 2013.</p><p>Building on her clinical focus, Dr. Xiao&rsquo;s research focuses on the pathogenesis of multiple myeloma and environmental factors that may trigger its progression. Her work has been published in numerous peer-reviewed journals, books, chapters and review articles.</p><p>Dr. Xiao is board certified by the American Board of Pathology and is a member of the College of American Pathologists and the New York State Society of Pathologists.</p>

Dr. Szymanski is deeply focused on Immunohematology and Clinical Apheresis, constantly striving to advance patient care in these specialized disciplines. Passionate about data-driven healthcare, they also specialize in Clinical Informatics and Data Science to leverage technology for medical innovation and improved clinical outcomes.<br /><quillbot-extension-portal></quillbot-extension-portal>

Dr. Szymanski centers their research on leveraging data science techniques to gain a deeper understanding of diseases, with the objective of enhancing patient outcomes and patient safety.<br /><quillbot-extension-portal></quillbot-extension-portal>

<p>James M. Szymanski, MD, MHA, is Director, Apheresis, Associate Director, Transfusion Medicine and Assistant Professor, Pathology at Montefiore Einstein. Dr. Szymanski is deeply focused on immunohematology and clinical apheresis, constantly striving to advance patient care in these specialized disciplines. They are passionate about data-driven healthcare and specialize in clinical informatics and data science to leverage technology for medical innovation and improved clinical outcomes.</p><p>After obtaining their Bachelor of General Studies in biology and public health at the University of Michigan in 2001, Dr. Syzmanski earned their Master of Healthcare Administration at the same institution in 2003. Following this, they earned their Doctor of Medicine from Wayne State School of Medicine in 2008.</p><p>Dr. Szymanski centers their research on leveraging data science techniques to gain a deeper understanding of diseases, with the objective of enhancing patient outcomes and patient safety. Their work has been published in numerous peer-reviewed journals and they have given poster presentations and invited lectures nationally.</p><p>Dr. Szymanski is a Diplomat of the American Board of Pathology and is board certified in Clinical Pathology, Transfusion Medicine and Blood Banking and Clinical Informatics. In 2016, they won the Leo M. Davidoff Society Teaching Award and in 2021, Dr Szymanski won the Outstanding Teaching Award from Montefiore Einstein&rsquo;s Department of Pathology.</p>

<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">Dr. Prystowsky has extensive leadership, research, education, program development and administrative experience.&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">Pathology Services:</span></strong><span style="font-size: 12pt;">&nbsp;As Chairman of the unified Department of Pathology at Albert Einstein College of Medicine and Montefiore Medical Center (~700 FTE; budget ~$150M), Dr. Prystowsky has substantial experience in developing and managing service, research and educational programs. Our&nbsp;pathology service line delivers 24/7 service producing about 10 million test results per year for Montefiore patients. Dr. Prystowsky has engaged in many College of American Pathologists (CAP) programs as a governor of the college including both domestic and international laboratory inspections. In addition, the Montefiore women's healthcare team initiated a very successful See, Test &amp; Treat program in May 2015 bringing much needed healthcare to women in the Bronx.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">Education Activities:</span></strong><span style="font-size: 12pt;">&nbsp; Dr. Prystowsky has had a unique opportunity during the past several years to connect pathologists from all practice environments through educational efforts. This is possible because he chaired both the Undergraduate Medical Education Committee of Association of Pathology Chairs (APC) and the Council on Education (COE) for CAP. For undergraduate medical education, pathologists from many practice settings have contributed to developing national standards for teaching pathology to all medical students (</span>https://journals.sagepub.com/page/apc/pcme<span style="font-size: 12pt;">). Another educational effort bridges the Graduate Medical Education (GME) Committee of APC with the COE and Council on Scientific Affairs (CSA); members developed a test utilization course for residents that teaches both common problems in test selection and how to interact with ordering physicians. Dr. Prystowsky has first hand experience with the educational programs and their impact on the trainees (20 residents and 10 fellows) and faculty (greater than 50) whom he oversees and mentors.</span></p>
<p class="DataField11pt-Single" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">Research Focus:</span></strong><span style="font-size: 12pt;">&nbsp;In 1999 Dr. Prystowsky organized a multidisciplinary group including surgery, oncology, pathology, molecular biology, protein chemistry, computational biology and biostatistics to study Head and Neck Squamous Cell Carcinoma (HNSCC). Initial studies on molecular classification of HNSCC using microarray technology demonstrated that patient segregation by gene expression profiling is a better predictor of outcome than established clinicopathological variables. The Head and Neck Program includes multiple laboratories with research exploring basic mechanisms of tumor behavior, developing biomarkers and identifying molecular classifiers that define distinct subsets of patients. The questions arise from the tumor board, from taking care of patients, with the primary goal to develop new diagnostics that will optimize treatment selection at initial diagnosis.</span></p>
<p class="DataField11pt-Single" style="margin-left: .25in; text-indent: -.25in; mso-list: l0 level1 lfo1;"><!-- [if !supportLists]--><strong><span style="font-family: 'Arial',sans-serif; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">A.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></strong><!--[endif]--><strong><span style="font-family: Arial, sans-serif;">&nbsp;Positions and Honors</span></strong></p>
<p class="DataField11pt-Single" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-family: Arial, sans-serif;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; line-height: 12pt;"><strong><u>Professional Experience</u></strong><u>:</u></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; line-height: 12pt;">1978-1979&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Post-Doctoral fellow in Biochemistry, the Rockefeller University</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; line-height: 12pt;">1981-1984&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Resident in Pathology, The University of Chicago</p>
<p class="MsoBodyTextIndent3" style="margin: 0in; font-size: 8pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">1984-1993&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Asst/Assoc Prof, Department of Pathology, University of Pennsylvania</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">1993-present&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Professor, Department of Pathology, Albert Einstein College of Medicine</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">1997-present&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chair, Department of Pathology, Einstein / Montefiore Medical Center</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">2002-2016&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Associate Director, Einstein Cancer Center Shared Facilities</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><u>External Committees:</u></strong></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">2001-2006&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;American Cancer Society, National Council for Extramural Research (Chair 2005-06)</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">2012-2019&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Association of Pathology Chairs, Undergraduate Medical Education Committee (Chair)</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">2012-2018&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;College of American Pathologists, Board of Governors</p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; line-height: 12pt;"><strong><u>Honors and Awards:</u></strong></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; line-height: 12pt;">Bachelor of Science cum laude, Phi Sigma Biological Honorary Society, Phi Kappa Phi Scholastic Honorary Society, Microbiology at Pennsylvania State University; Cancer Research Institute, Postdoctoral Fellow; Hartford Foundation Fellowship; Faculty Research Award, American Cancer Society; Fellow, AAAS; Michele Raible Distinguished Teaching Award, APC</p>
<p class="DataField11pt-Single" style="margin: 0in; font-size: 11pt; font-family: Arial, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-family: Arial, sans-serif;">&nbsp;</span></strong></p>
<p class="DataField11pt-Single" style="margin-left: 22.5pt; text-indent: -22.5pt; mso-list: l0 level1 lfo1;"><!-- [if !supportLists]--><strong><span style="font-family: 'Arial',sans-serif; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">B.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></strong><!--[endif]--><strong><span style="font-family: Arial, sans-serif;">Contribution to Science</span></strong></p>
<p>&nbsp;</p>
<p style="margin-bottom: 12pt;">Dr. Prystowsky has contributed to the understanding of IL2-driven T lymphocyte activation, structural requirements for GM-CSF activity, to the molecular and whole animal studies of inflammation focusing on A1, an anti-apoptotic Bcl-2 family member that he discovered. During the past 18 years he has&nbsp;organized a multidisciplinary group including surgery, oncology, pathology, molecular biology, protein chemistry, computational biology and biostatistics to study Head and Neck Squamous Cell Carcinoma (HNSCC). Initial studies on molecular classification of HNSCC using microarray technology demonstrated that patient segregation by gene expression profiling is a better predictor of outcome than established clinicopathological variables. The Head and Neck Program includes multiple laboratories with research exploring basic mechanisms of tumor behavior, developing biomarkers and identifying molecular classifiers that define distinct subsets of patients. The questions arise from the tumor board, from taking care of patients, with the primary goal to develop new diagnostics that will optimize treatment selection at initial diagnosis.</p>

<span style="color:#616161;font-family:'SF Pro Text', 'Segoe UI', 'Segoe WP', Tahoma, Arial, sans-serif, Roboto;font-size:14px;letter-spacing:-0.24px;background-color:#f5f5f5;">Delivery of pathology services efficiently and effectively to optimize treatment decisions.</span><span style="color:#616161;font-family:'SF Pro Text', 'Segoe UI', 'Segoe WP', Tahoma, Arial, sans-serif, Roboto;font-size:14px;letter-spacing:-0.24px;background-color:#f5f5f5;"></span>

<span style="color:#616161;font-family:'SF Pro Text', 'Segoe UI', 'Segoe WP', Tahoma, Arial, sans-serif, Roboto;font-size:14px;letter-spacing:-0.24px;background-color:#f5f5f5;">Basic studies of molecular mechanisms driving behavior of HNSCC toward clinical translation for better diagnostics to optimize treatment decisions.</span>

<p style="margin-left: .25in; text-indent: -.35in;"><span style="font-family: Arial; font-size: small;">&nbsp;</span><strong style="font-size: 11pt;">Immunology and Inflammation</strong></p>
<p>&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-list: l0 level1 lfo1; tab-stops: list .5in;"><!-- [if !supportLists]-->1.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]--><strong>Prystowsky MB</strong>, Ely JM, Beller DI, Eisenberg LE, Goldman J, Goldman M, Goldwasser E, Ihle J, Quintans J, Remold H, Vogel SN, Fitch FW (1982) Alloreactive cloned T cell lines.&nbsp;&nbsp;VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.&nbsp;&nbsp;J Immunol 129: 2337-2344.</p>
<p class="MsoListParagraphCxSpLast" style="text-indent: -.25in; mso-list: l0 level1 lfo1; tab-stops: list .5in;"><!-- [if !supportLists]-->2.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]--><strong>Prystowsky MB</strong>, Otten G, Naujokas MF, Vardiman J, Ihle JN, Goldwasser E, Fitch FW (1984) Multiple hemopoietic lineages are found after stimulation of mouse bone marrow precursor cells with interleukin 3.&nbsp;&nbsp;Am J Pathol 117: 171-179.&nbsp;&nbsp;PMCID:&nbsp;&nbsp;PMC1900437</p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal">Reed JC, Sabath DE, Hoover RG,&nbsp;<strong>Prystowsky MB</strong>. (1985) Recombinant interleukin 2 regulates levels of c-<em>myc&nbsp;</em>mRNA in a cloned murine T lymphocyte. Mol &amp; Cell Biology 5:3361-3368.</li>
</ol>
<p class="MsoListParagraph" style="text-indent: -.25in; mso-list: l0 level1 lfo1; tab-stops: list .5in;"><!-- [if !supportLists]-->4.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Shipman-Appasamy P, Cohen KS,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(1990) Interleukin 2-induced expression of proliferating cell nuclear antigen is regulated by transcriptional and post-transcriptional mechanisms. J Biol Chem 265: 19180-19184.</p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="5" type="1">
<li class="MsoNormal">Altmann SW, Johnson GD,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(1991) Single proline substitutions in predicted alpha helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation. J Biol Chem 266: 5333-5341.</li>
<li class="MsoNormal">Clevenger CV, Altmann SW,&nbsp;<strong>Prystowsky MB</strong>. (1991) Requirement for nuclear prolactin during interleukin 2 stimulation of T lymphocytes.&nbsp;&nbsp;Science 253:77-79.</li>
<li class="MsoNormal">Lin EY, Orlofsky A, Berger MS,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(1993) Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol 151: 1979-1988.</li>
<li class="MsoNormal">Huang D, Shipman-Appasamy PM, Orten DJ, Hinrichs SH&nbsp;<strong>Prystowsky MB</strong>&nbsp;(1994) Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.&nbsp;&nbsp;Mol Cell Biol 14: 4233-4243.&nbsp;&nbsp;PMCID:&nbsp;&nbsp;PMC358789</li>
<li class="MsoNormal">Orlofsky A, Weiss LM, Kawachi N,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(2002) Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response. J Immunology&nbsp;&nbsp;168:1840-1846.</li>
<li class="MsoNormal">Gonzalez J, Orlofsky A,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(2003) A1 is a growth-permissive anti-apoptotic factor mediating post-activation survival in T cells. Blood, 101:2679-2685.</li>
</ol>
<p class="MsoNormal">&nbsp;</p>
<p class="MsoNormal"><strong>Head and Neck Squamous Cell Carcinoma</strong></p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="1" type="1">
<li class="MsoNormal">Belbin TJ, Singh B, Barber I, Socci N, Wenig B, Smith R,&nbsp;<strong>Prystowsky MB</strong>, Childs G (2002) Molecular Classification of Head and Neck Squamous Cell Carcinoma using cDNA Microarrays. Cancer Research 62:1184-1190.</li>
</ol>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->2.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Belbin TJ, Singh B, Wreesmann VB, Socci ND, Sanchez-Carbayo M, Masterson J, Smith R, Patel S, Cordon-Cardo C,&nbsp;<strong>Prystowsky MB</strong>, Childs G (2005) Molecular profiling of tumor progression in head and neck cancer. Archives of Otolaryngology &ndash; Head &amp; Neck Surgery 131:10-18.</p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal">Loudig O, Milova E, Brandwein-Gensler M, Massimi A, Belbin TJ, Childs G, Singer RH, Rohan T,&nbsp;<strong>Prystowsky MB</strong>. (2007) Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT). Nucleic Acids Research. July 17. Epub, 35:pe94.</li>
</ol>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->4.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Schlecht, N.F., Burk, R.D., Adrien, L., Dunne, A., Kawachi, N., Sarta, C., Chen, Q., Brandwein-Gensler, M.,&nbsp;<strong>Prystowsky, MB</strong>, Childs, G., Smith, R.V. and Belbin, T.J. (2007). Gene expression profiles in HPV infected head and neck cancer.&nbsp;&nbsp;Journal of Pathology. Nov; 213(3):283-93.</p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="5" type="1">
<li class="MsoNormal"><span style="color: #000025;">Belbin TJ, Schlecht NF, Smith RV, Adrien LR, Kawachi N, Brandwein-Gensler M, Bergman A, Chen Q, Childs G,&nbsp;<strong>Prystowsky MB</strong>. (2008) Site-specific molecular signatures predict aggressive disease in HNSCC. Head and Neck Pathology 2(4):243-256.</span></li>
<li class="MsoNormal">Childs G, Fazzari M, Kung G, Kawachi N,<strong>&nbsp;</strong>Brandwein-Gensler M, McLemore M, Chen Q, Burk RD, Smith RV,&nbsp;<strong>Prystowsky MB</strong>, Belbin TJ. Schlecht NF (2009) Low level expression of microRNA's let7-d and miR-205 are prognostic markers of head and neck squamous cell carcinoma.&nbsp;<em>Amer J Pathol</em>&nbsp;174(3):736-745.</li>
<li class="MsoNormal" style="color: #333333; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><strong><span style="color: windowtext;">Prystowsky MB</span></strong><span style="color: windowtext;">, Adomako A, Smith RV, Kawachi N, McKimpson W, Atadja P, Chen Q, Schlecht NF, Parish JL, Childs G, Belbin TJ (2009)&nbsp;</span>The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines. Journal of Pathology, 218-467-477.</li>
</ol>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->8.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Lleras R, Adrien LR, Smith RV, Harris TM, Liveras A, Schlecht NS, Childs G,&nbsp;<strong>Prystowsky MB</strong>, Belbin TJ (2011)^&nbsp;Hypermethylation of a cluster of kruppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma. Am J Pathol, 178:1965-1974.</p>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->9.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Schlecht NF, Brandwein-Gensler M, Nuovo GJ, Li M, Dunne A, Kawachi N, Smith RV, Burk RD,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(2011) A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Modern Pathology 24:1295-1305.</p>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->10.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Smirnova T, Adomako A, Locker J, Van Rooijen N,&nbsp;<strong>Prystowsky MB</strong>, Segall JE (2011)&nbsp;<em>In vivo</em>&nbsp;invasion of head and neck squamous cell carcinoma cells does not require macrophages. Am J Pathol 178:2857-2865.</p>
<p class="MsoBodyText" style="margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->11.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Schlecht N, Brandwein-Gensler M, Smith RV, Kawachi N, Broughel D, Lin J, Keller CE, Reynolds PA, Gunn-Moore FJ, Harris T, Childs G, Belbin TJ,&nbsp;<strong>Prystowsky MB&nbsp;</strong>(2012) Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma. Head and Neck Pathology 6:232-243.</p>
<ol style="margin-bottom: 0in; margin-top: 0in;" start="12" type="1">
<li class="MsoNormal">Harris T, Jimenez L, Kawachi N, Fan J-B, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R,&nbsp;<strong>Prystowsky MB</strong>, Schlecht NF, Segall JE, Childs G (2012) Low-Level expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas Am J Pathol, 180:917-928.</li>
</ol>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: #0e0e0e; mso-bidi-font-weight: bold;">13.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><span style="color: #1a1a1a;">Lleras RA, Smith RV, Adrien LR, Schlecht NF, Burk RD, Harris TM, Childs G,&nbsp;<strong>Prystowsky MB</strong>, Belbin TJ (2013)&nbsp;</span><span style="color: #0e0e0e;">Unique DNA Methylation Loci Distinguish Anatomic Site and HPV Status in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 1</span>9:5444-5455<span style="color: #0e0e0e;">.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-bottom: 12.0pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->14.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]--><strong>Prystowsky M</strong>, Feeney K, Kawachi N, Montagna C, Willmott M, Wasson C, Antkowiak M, Loudig O, Parish J (2013)&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770962/"><span style="color: windowtext; text-decoration: none;">Inhibition of Plk1 and Cyclin B1 Expression Results in Panobinostat-Induced G2 Delay and Mitotic Defects</span></a>. Sci Rep 3:2640.</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-bottom: 12.0pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->15.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Harris TM, Du P, Kawachi N, Belbin TJ, Wang Y, Schlecht NF, Ow TJ, Keller CE, Childs GJ, Smith RV, Angeletti RH,&nbsp;<strong>Prystowsky MB</strong>, Lim J. (2015)&nbsp;&nbsp;Proteomic Analysis of Oral Cavity Squamous Cell Carcinoma Specimens Identifies Patient Outcome&mdash;Associated Proteins. Archives of Pathology &amp; Laboratory Medicine. 139: 494-507</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-bottom: 12.0pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->16.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Schlecht NF, Ben-Dayan M, Anayannis N, Lleras RA, Thomas C, Wang Y, Smith RV, Burk RD, Harris TM, Childs C, Ow TJ,&nbsp;<strong>Prystowsky</strong>,&nbsp;<strong>MB</strong>, Belbin TJ (2015) Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV positive oropharyngeal squamous cell carcinoma. Cancer Medicine DOI:&nbsp;10.1002/cam4.374</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-bottom: 12.0pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->17.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Jimenez L, Sharma VP, Condeelis J, Harris TM, Ow TJ,<strong>&nbsp;Prystowsky MB</strong>, Childs G, Segall JE (2015) MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. Archives of Pathology &amp; Laboratory Medicine. 139:1349-1361</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><!-- [if !supportLists]-->18.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Ben-Dayan M, MacCarthy T, Schlecht NF, Belbin TJ, Childs G, Smith RV,&nbsp;<strong>Prystowsky MB,</strong>&nbsp;Bergman A (2015) Cancer as the disintegration of robustness: population-level variance in gene expression identifies key differences between tobacco- and HPV-associated oropharyngeal carcinogenesis. Archives of Pathology &amp; Laboratory Medicine. 139:1362-1372.</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: #575757;">19.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ben-Dayan^&nbsp;MM, Ow^&nbsp;TJ, Belbin TJ, Wetzler^&nbsp;J, Smith RV, Childs G, Diergaarde B, Hayes DN, Grandis JR,&nbsp;<strong>Prystowsky MB</strong>, Schlecht NF. (2017) Non-promoter Methylation of the CDKN2A Gene with Active Transcription is Associated with Improved Locoregional Control in Laryngeal Squamous Cell Carcinoma. Cancer Medicine 6:397-407.&nbsp;<span style="color: #575757;">PMID:28102032</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><!-- [if !supportLists]-->20.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Jimenez L, Lim J, Burd B, Harris T, Ow TJ, Kawachi N, Belbin T, Angeletti R,&nbsp;<strong>Prystowsky MB</strong>, Childs G, Segall J. (2017) miR-375 regulates invasion related proteins vimentin and L-plastin. Am J Pathology 187:1523-1536.</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->21.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Jayakar^&nbsp;SK, Loudig^&nbsp;O, Brandwein-Gensler^&nbsp;M, Kim^&nbsp;RS, Ow^&nbsp;TJ, Ustun^&nbsp;B, Harris^&nbsp;TM,&nbsp;<strong>Prystowsky^&nbsp;MB</strong>, Childs^&nbsp;G, Segall^&nbsp;JE, Belbin^&nbsp;TJ.&nbsp; (2017)&nbsp;Apolipoprotein E promotes invasion in oral squamous cell carcinoma. Am J Pathology, 187:2259-2272.</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->22.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Anayannis N,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Schlecht NF,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Ben-Dayan M,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Smith RV,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Belbin TJ,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Ow TJ,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Blakaj DM,<span style="letter-spacing: -0.3pt;">&nbsp;</span>Burk RD, Leonard SM, WoodmanCB, Parish JL,<span style="letter-spacing: -1.25pt;">&nbsp;</span><strong>Prystowsky MB</strong>. (2018) Association of an intact&nbsp;<em>E2&nbsp;</em>gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive Head and Neck Squamous Cell Carcinoma. PLoS ONE 13: e0191581.</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-pagination: none; mso-list: l2 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none;"><!-- [if !supportLists]-->23.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;</span><!--[endif]-->Fattouh M, Chang GY, Ow TJ, Shifteh K, Rosenblatt G, Patel VM, Smith RV,&nbsp;<strong>Prystowsky MB</strong>, Schlecht NF. (2019) Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer. Head and Neck 41:707-714.</p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><!-- [if !supportLists]--><span style="font-size: 13.5pt; font-family: -webkit-standard, serif;">24.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span></span><!--[endif]--><span style="font-size: 13.5pt; font-family: -webkit-standard, serif;">Ben-Dayan MM, Li D, Kawachi N, Ow TJ, Belbin TJ, Childs G, Schlecht NF,&nbsp;<strong>Prystowsky MB.</strong>(2020) Human papillomavirus type 16 E6 and E7 expression drives transcription of p14(ARF) and p16(INK4a) prior to intragenic methylation of CDKN2A. Medical Research Archives 8: May.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l2 level1 lfo2; tab-stops: list .5in;"><!-- [if !supportLists]--><span style="font-size: 13.5pt; font-family: -webkit-standard, serif;">25.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span></span><!--[endif]--><span style="font-size: 13.5pt; font-family: -webkit-standard, serif;">Dalaka E, Kronenberg NM, Liehm P, Segall JE,&nbsp;<strong>Prystowsky MB</strong>, Gather MC. (2020) Direct measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia. Science Advances 6: March 11.</span></p>
<p class="MsoListParagraphCxSpLast">&nbsp;</p>
<p class="MsoNormal"><strong>&nbsp;</strong></p>
<p class="MsoNormal"><strong>Education</strong></p>
<p class="MsoNormal">&nbsp;</p>
<p style="margin-top: 0in; margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->1.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Sadofsky M, Knollmann-Ritschel B, Conran R,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(2014) National Standards in Pathology Education: Developing Competencies for Integrated Medical School Curricula. Archives of Pathol &amp; Lab Medicine 138:328&ndash;332.</p>
<p style="margin-top: 0in; margin-bottom: 0in; margin-left: 0.5in; text-indent: -0.25in;"><!-- [if !supportLists]-->2.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Hebert T, Maleki S, Vasovic L, Arnold J, Steinberg J,&nbsp;<strong>Prystowsky MB</strong>&nbsp;(2014) A Team-Based Approach to Autopsy Education: Integrating Anatomic and Clinical Pathology at the Rotation Level. Archives of Pathol &amp; Lab Medicine 138:322&ndash;327. PMID: 24576026</p>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-pagination: none; mso-list: l1 level1 lfo3; mso-layout-grid-align: none;"><!-- [if !supportLists]--><span style="mso-bidi-font-size: 11.0pt; mso-fareast-font-family: Arial; mso-bidi-font-family: Arial; color: #231f20;">3.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span><!--[endif]--><span style="color: #231f20;">Hebert TM, Szymanski J, Mantilla J, McLemore L, Walsh R, Vasovic L, Steinberg JJ,&nbsp;<strong>Prystowsky MB</strong>. (2016) Onboarding for pathology residency programs &ndash; The Montefiore experience. Academic Pathology. 3: 1-4</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-pagination: none; mso-list: l1 level1 lfo3; mso-layout-grid-align: none;"><!-- [if !supportLists]-->4.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]--><span style="color: #231f20;">Black-Schaffer WS, Morrow JS,&nbsp;<strong>Prystowsky MB</strong>, Steinberg JJ. (2016) Training pathology residents to practice 21^st&nbsp;century medicine &ndash; A proposal. Academic Pathology. 3:1-16.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-pagination: none; mso-list: l1 level1 lfo3; mso-layout-grid-align: none;"><!-- [if !supportLists]-->5.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Goldstein DY,&nbsp;<strong>Prystowsky M</strong>. (2017) Autosomal recessive inheritance: Cystic Fibrosis. Academic Pathology 4:1-4.</p>
<p class="MsoListParagraphCxSpLast" style="text-indent: -.25in; mso-pagination: none; mso-list: l1 level1 lfo3; mso-layout-grid-align: none;"><!-- [if !supportLists]-->6.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span><!--[endif]-->Knowellmann-Ritschel BEC, Regula DP, Borowitz MJ, Conran R,&nbsp;<strong>Prystowsky MB</strong>. (2017) Pathology competencies for medical education and educational cases. Academic Pathology 4:1-36.</p>
<p class="MsoListParagraphCxSpLast" style="text-indent: -.25in; mso-pagination: none; mso-list: l1 level1 lfo3; mso-layout-grid-align: none;">7. &nbsp;&nbsp;<span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Hebert TM, Cole A, Panarelli N, Hu S, Jacob J, Ahlstedt J, Steinberg JS,</span><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">&nbsp;</span><strong style="font-family: 'Times New Roman', serif; font-size: 12pt;">Prystowsky MB</strong><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">. (2019) Training the next generation of pathologists: A novel residency program curriculum at Montefiore Medical Center/Albert Einstein College of Medicine. Academic Pathology. 6: May 30.</span></p>

<p>Joseph Justin Mulvey, MD, PhD, is Associate Director, Hematology at Montefiore Einstein and Assistant Professor, Medicine at our Albert Einstein College of Medicine. His clinical interest lies in the intersection of coagulation and immunity. Rare disease, especially related to the immune system, is his greatest challenge and thrill in medicine.</p><p>After obtaining his Bachelor of Arts in chemistry from Columbia University in 2006, Dr. Mulvey earned his Doctor of Medicine and Doctor of Philosophy at the Tri-Institutional MD PhD Program in 2016. He then completed his clinical residency at NewYork-Presbyterian-Weill Cornell Medical College in 2019, and a laboratory medicine fellowship at Memorial Sloan Kettering Cancer Center in 2021.</p><p>Dr. Mulvey's research spans a wide range of topics, including drug and assay design, radiation delivery, nanotechnology, coagulation, microbiome and the mysteries of novel disease mechanisms. He has participated in a number of research projects and his work has been shared through numerous peer-reviewed publications and presentations.</p><p>In 2021 and 2022, Dr. Mulvey won the Best Teaching Faculty Award in Pathology from Montefiore Einstein.</p>