Deepa Rastogi
<p>We are investigating the mechanisms underlying pediatric obesity-related asthma. Having shown that systemic inflammation associated with obesity-related asthma in children is non-atopic, our lab is investigating the role of epigenetics in establishing the non-atopic inflammatory patterns among obese children with asthma.</p>
<p style="padding-left: 40px;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Yon C, Thompson D, Jude J, Panettieri RA Jr, <u>Rastogi D</u>.</span><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"> Cross Talk between CD4+ T cells and Airway Smooth Muscle in Pediatric Obesity-Related Asthma. Am J Resp Crit Care Med 2023; 207(4):461-474</span></p>
<p style="padding-left: 40px;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: #201f1e; background: white; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Thompson DA, Wood LG, Williams EJ, McLoughlin RF, <u>Rastogi D</u>. Endotyping pediatric obesity-related asthma: contribution of anthropometrics, metabolism, nutrients and CD4+ lymphocytes on pulmonary function. J Allergy Clin Immunol 2022</span><span class="docsum-journal-citation"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">; 150(4):861-871</span></span></p>
<p style="padding-left: 40px;"><span style="font-size: 12.0pt; line-height: 120%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Farhat L, DeVos G, De A, Lee DS, <u>Rastogi D</u>. Atopy and Pulmonary Function Among Healthy-weight and Overweight/ Obese Children with Asthma. Pediatr Pulmonol <span class="docsum-journal-citation">2021; 56(1):34-41.</span></span></p>
<p style="padding-left: 40px;"><u><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Rastogi D</span></u><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">, Johnston AD, Nico J, Loh LN, Jorge Y, Suzuki M, Macian F, Greally JM. Functional genomics of the pediatric obese asthma phenotype reveal enrichment of Rho-GTPase pathways<span style="mso-bidi-font-weight: bold;">.</span> Am J Resp Crit Care Med. 2020<span class="docsum-journal-citation">; 202(2):259-274</span></span></p>
<p style="padding-left: 40px;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Orfanos S, Jude J, Deeney BT, Cao G, <u>Rastogi D</u>, Van Zee M, Pushkarsky I, Di Carlo D, Panettieri RA Jr. Obesity increases airway smooth muscle hyperresponsiveness. J Appl Physiol- Lung Cell Mol Physiol 2018; 315(5): L673-L681</span></p>
<p style="padding-left: 40px;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; color: black; mso-themecolor: text1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Gross E, Lee DS, Hotz A, Ngo KC, <u>Rastogi D</u>. Impact of obesity on asthma morbidity during a hospitalization. <span style="mso-bidi-font-style: italic;">Hosp Pediatr</span> 2018; 8(9): 538-546</span></p>
<p style="padding-left: 40px;"><span style="font-style: normal; font-variant-caps: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman'; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal;"> </span><u style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">Rastogi D</u><strong style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">, </strong><span style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">Nico J, Johnston AD, Tobias TA, Jorge Y, Macian F, Greally JM. CDC42-related genes are upregulated in T helper cells from obese asthmatic children. J Allergy Clin Immunol 2018; 141(2):539-548</span></p>
<p style="padding-left: 40px;"><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Lautenbacher LA, Jariwala SP, Markowitz ME, </span><u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Rastogi D</span></u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">. Vitamin D and pulmonary function in obese asthmatic children. Pediatr Pulmonol. 2016; 51(12): 1276-83 </span></p>
<p style="padding-left: 40px;"><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Vijayakanthi N, Greally JM, <u>Rastogi D</u><strong>.</strong> Pediatric obesity-related asthma: The role of metabolic dysregulation. State of the Art Review. Pediatrics 2016; 137(5): e20150812</span></p>
<p style="padding-left: 40px;"><u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Rastogi D</span></u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">, Fraser S, Oh J, Huber AM, Schulman Y, Bhagtani RH, Khan ZS, Tesfa L, Hall CB, Macian F. Inflammation, metabolic abnormalities and pulmonary function among obese asthmatic urban adolescents. Am J Resp Crit Care Med. 2015; 191(2): 149-160. </span></p>
<p style="padding-left: 40px;"><u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Rastogi D</span></u><span style="font-size: 12pt; font-family: 'Times New Roman', serif;">, Suzuki M, Greally J. Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep 2013; 3: 2164</span></p>
<p style="padding-left: 40px;"><span style="text-align: justify; text-indent: -0.25in; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman'; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal;"> </span><u style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">Rastogi D</u><span style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">, Madhok N, Kipperman S.</span><span style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;"> </span><span style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">Caregiver asthma knowledge, aptitude and practice in high healthcare utilizing children: Effect of an educational intervention. Ped Allergy Immunol Pulmonol 2013</span><span style="font-family: 'Times New Roman', serif; font-size: 12pt; text-align: justify; text-indent: -0.25in;">; 26(3):128-139</span> </p>
<p>Deepa Rastogi, MD, is Division Chief, Pediatric Respiratory and Sleep Medicine at Montefiore Einstein. Dr. Rastogi’s clinical specialty is in taking care of children with asthma, particularly those with severe or difficult-to-control asthma.</p><p>After earning her Bachelor of Medicine, Bachelor of Surgery at Ganesh Shankar Vidyarthi Memorial (GSVM) Medical College in Kanpur, India, Dr. Rastogi completed a yearlong rotatory internship in medicine, surgery, obstetrics and gynecology, pediatrics, cardiology and ophthalmology at the same institution, followed by a two-year residency in pediatrics. She then came to the United States and continued her postdoctoral training, completing a pediatrics internship at The Children’s Medical Center of Brooklyn. SUNY Downstate and a pediatrics residency at Children’s Hospital of New York-Presbyterian, Columbia University College of Physicians and Surgeons. Dr. Rastogi later completed her three-year fellowship in pediatric pulmonology at Children’s Hospital of New York-Presbyterian, Columbia University College of Physicians and Surgeons.</p><p>Dr. Rastogi’s federally funded research investigates the mechanisms that underlie obesity-related asthma. She has shared her work through peer-reviewed journals, abstracts, book chapters, national and international conferences and presentations and media appearances. She has also served on the editorial boards of <em>Pediatric Pulmonology</em> and the <em>American Journal of Respiratory and Critical Care Medicine</em> and as an ad hoc reviewer for many journals including the <em>New England Journal of Medicine, International Journal of Obesity</em> and the <em>Journal of the American Medical Association</em>, among others. She continues to serve on NIH study sections.</p><p>Dr. Rastogi is a Diplomate of the American Board of Pediatrics and board certified in Pediatrics and Pediatric Pulmonology. She is a Fellow of the American Thoracic Society and the American Academy of Pediatrics, and a member of the Society of Pediatric Research.</p>