Department of Cell Biology

Carl Schildkraut, PhD -- Recent Publications

Carl


Professor, Department of Cell Biology
Chanin Bldg., Room 416
718.430.2097

carl.schildkraut@einsteinmed.org

Home Page 
Fragile Genomic Loci
Genomic Instability
Initiation Of DNA Replication
Study Replication Initiation and Fork Progression
Recent Publications 
Biosketch 
Lab Members 
Collaborators
 

   Drosopoulos WC, Vierra DA, Kenworthy CA, Coleman RA and Schildkraut CL. (2020). Dynamic assembly and disassembly of the human DNA polymerase δ holoenzyme on the genome in vivo. Cell Reports, 30 1329-1341.e5. PMID: 32023453.

Drosopoulos WC, Deng Z, Twayana S, Kosiyatrakul ST, Vladimirova O, Lieberman PM, Schildkraut CL. 2020 TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction. Cell Rep.33:108379. doi: 10.1016/j.celrep.108379. PMID: 33176153.

Mei Y, Deng Z, Vladimirova O, Gulve N, Johnson FB, Drosopoulos WC, Schildkraut CL, Lieberman PM. (2021).TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity. (2021) Sci Rep. 11:3509. doi: 10.1038/s41598-021-82406-x. PMID: 33568696.

Chakraborty A, Jenjaroenpun P, Li J, McCulley A, El Hilali S, Haarer B, Hoffman EA, Belak A, Thorland A, Hehnly H, Schildkraut CL, Chen C, Kuznetsov VA, and Feng W. (2020) Replication stress induces global chromosome breakage in the Fragile X genome. Cell Reports. 32. Article 108179.

Cicconi A, Rai R, Xiong X, Broton C, Al-Hiyasat A, Hu C, Dong S, Sun W, Garbarino J, Bindra, R, Schildkraut CL, Chen Y and Chang S. (2020). Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly Nature Communications 11, Article number: 5861.

Pan X, Drosopoulos WC, Sethi L, Madireddy A, Schildkraut CL, Zhang D (2017) FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.. Proc Natl Acad Sci U S A.:E5940-E5949. PMID: 28673972.

Madireddy, A., Kosiyatrakul, S., Boisvert, R.A., Moyano, E.H., García-Rubio, M.L., Gerhardt, J.,Vuono, E.A., Owen, N., Yan, Z., Olson, S., Aguilera, A., Howlett, N., and Schildkraut, C.L. (2016). FANCD2 facilitates replication through common fragile sites. Molecular Cell. 2016; 64(2):388-404. PMID: 27768874.

Madireddy, A., Purushothaman, P., Loosbroock, C. P., Robertson, E. S., Schildkraut, C. L., Verma, S.C. (2016). G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV. Nucleic Acids Res. 44: 3675-3694 PMID: 26837574.

Drosopoulos, W. C., Kosiyatrakul, S.K. and Schildkraut, C.L. (2015). BLM helicase facilitates telomere replication during leading strand synthesis of telomeres. J. Cell Biol. 210: 191-208. PMID: 26195664.

Gerhardt, J., Tomishima, M.J., Zaninovic, N.,Colak, D., Yan, Z., Zhan, Q., Rosenwaks, Z., Jaffrey, S. R., Schildkraut, C. L.. (2014). The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells. Molecular Cell. 53: 19 – 31. PMCID: 3920742. Featured on the Journal Cover.

Gerhardt, J., N. Zaninovic, Q. Zhan, Z. Rosenwaks, A. Madireddy, S. L. Nolin, N. Ersalesi, Z. Yan1, Z. Rosenwaks and C. L. Schildkraut. (2014). Cis-acting DNA sequence at a replication initiation site promotes the expansion of CGG repeats to the fragile X full mutation. J Cell Biol. 206:599-607. PMCID: PMC4151148.

Drosopoulos, W. C., S. Kosiyatrakul, Z. Yan, S. G. Calderano, and C. L. Schildkraut. (2012). Human telomeres replicate using chromosome-specific, rather than universal, replication programs. J Cell Biol. 197: 253- 266. PMID 22508510.

Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C.L., and De Lange, T., Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell, 138: 90-103. (2009). PMID: 19596237.

Norio, P., Schildkraut, C.L. Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes. Science 294: 2361-2364 (2001). PMID: 11743204.

 
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