The Saul R. Korey Department of Neurology


ESCAPE - Effects of Stress on Cognitive Aging, Physiology, and Emotion

ESCAPE examines how environmental, physiological, and psychological stress-related factors accumulate to affect cognitive health. Cognitive health, which reflects our capacity to learn, process and use information, is a vital part of healthy aging that is crucial for maintaining a high quality of life. 

This ESCAPE project is interested in learning more about individuals who range in age from early adulthood to midlife years. This lifespan study aims to better understand how our everyday and life experiences can influence our health, well-being and the aging process.

ESCAPE is funded from a grant provided by the National Institute on Aging (NIA), a division of the National Institute of Health (NIH). The long-term goal of this grant is to better understand healthy aging as well as the special challenges to maintaining cognitive health that face adults as they transition from mid-life into senior years. 

Dr. Martin Sliwinski and Dr. Richard Lipton are co-Principal Investigators of ESCAPE and they lead an interdisciplinary team of neurologists, neuropsychologists, neurochemists, epidemiologists, geneticists,and other health care professionals. 

The ESCAPE project aims to better understand the biological and psychological mechanisms that can explain how life experiences influence cognitive health. The ultimate goal of ESCAPE is to identify modifiable risk and resilience factors that occur during the life course that may prevent cognitive impairment and promote cognitive health in later life.

Recruitment targets individuals from diverse backgrounds between the ages of 25 and 65 years of age. Potential participants must reside in Bronx County, New York, be fluent in English, free of visual impairment, and be ambulatory. 



Department Chairman

Mark Mehler Mark F. Mehler, M.D. (bio)

Professor of Neuroscience
Professor of Psychiatry and Behavioral Sciences
Chair of The Saul R. Korey Department of Neurology
Alpern Family Foundation Chair in Cerebral Palsy Research
Director, Institute for Brain Disorders and Neural Regeneration

Letter from the Chairman