Teresa V. Bowman

Teresa V. Bowman, Ph.D.

Area of research

  • Mechanisms of hematopoietic stem cells formation and regeneration; pre-mRNA splicing regulation of hematopoiesis; identification of novel therapeutics for myelodysplastic syndrome

Email

Phone

Location

  • Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Chanin Building 501 Bronx, NY 10461

Lab of Teresa V. Bowman



Research Profiles

Professional Interests

Hematopoietic stem and progenitor cells (HSPCs) are one of the most widely utilized stem cell populations in the clinic today. Defects in HSPCs result in numerous hematologic diseases such as myelodysplastic syndromes (MDS). We explore how hematopoietic stem and progenitor cells (HSPC) form during development, how these cells function to maintain healthy hematopoiesis lifelong, and how dysfunction in them leads to hematologic malignancies. 

 

Our studies combine the advantages of zebrafish and human cells to explore the development and genetic regulation of HSC biology. Zebrafish offer powerful genetic pliability, easily accessible in vivo imaging, numerous transplantation assays, and screening capabilities. Human cells allow us to decipher the conservation of our novel zebrafish findings to relevant human diseases and treatments. Through these studies, we anticipate identifying factors that are critical in the HSC formation and function, which can be used to inform therapeutic strategies to improve HSC function as well as HSC derivation from pluripotent stem cells.

Projects in the lab cover three main themes: 

i) Defining regulators critical for de novo production of hematopoietic stem cells (HSCs) and HSC-independent progenitors during embryogenesis 

ii) Deciphering how mutations found in human myelodysplastic syndromes (MDS) alter stem cell traits and influence differentiation choices

iii) Understanding how RNA and DNA binding proteins that are mutated in MDS affect R-loop structures in the nucleus

Selected Publications