Ankit Tanwar, Ph.D.
- Staff Scientist, Department of Oncology (Medical Oncology)
Area of research
- Glyco-immuno-toxicology, Herbal Informatics, Notch Glycosylation, Hematopoiesis, Cancer, CAR T-cell Therapy, Adult T-cell Leukemia/Lymphoma (ATLL), Novel Immune Checkpoints
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building 405 Bronx, NY 10461
Research Profiles
Professional Interests
Dr. Ankit Tanwar previously worked as a Post-Doctoral Scientist (2018-2022) with Prof. Stanley (Department of Cell Biology) at Albert Einstein College of Medicine. He was working on Role of Notch Glycosylation in Hematopoiesis. Dr. Tanwar received his Ph.D. degree in Toxicology from the Institute of Nuclear Medicine and Allied Sciences, New Delhi, India in 2018 followed by his master degree in Toxicology in 2014 and bachelor degree in Biochemistry from Shivaji College, University of Delhi, New Delhi, in 2012. He was a key worker of a team who coined the word "Herbal Informatics", which has been used for the initial screening of emergency-approved drug by DCGI: 2-Deoxy-D-glucose (2-DG) for combating the COVID-19 situation in India. He is also serving as an Editorial Board and Co-chair of committees (JoLS/SoLS, USA and JoVE, USA, etc). In July 2022, he joined Prof. Zang's (Department of Microbiology & Immunology) and Dr. Alex Sica (Department of Oncology) group. He is currently investigating the function and mechanism of CAR-T cell therapy and new immune checkpoints.
Selected Publications
Stanley P & Tanwar A et al., In Vivo Evidence for GDP-fucose Transport in the Absence of Transporter SLC35C1 and Putative Transporter SLC35C2 [Revision submitted: JBC-D-23-01480R1: Journal: JBC 2022]
Tanwar A, Stanley P. Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis. Frontiers in Immunology. 2023;14. [F=9.0]
Pulanco MC, Madsen AT, Tanwar A, Corrigan D, Zang XX., 2023. Recent progress in the B7 immune checkpoint family: new mechanisms and clinical therapies, Nature Cell Mol Immunol (2023). https://doi.org/10.1038/s41423-023-01019-8 [IF=22.096]
Videira P & Tanwar A et al., 2023. Generation of monocyte-derived dendritic cells with differing sialylated phenotypes. Journal of Visualized Experiments (JoVE) [Submitted: MS ID-JoVE65525] (Accepted)
Stanley P and Tanwar A., 2022. Regulation of myeloid and lymphoid cell development by O-glycans on Notch. Front. Mol. Biosci. 9:979724. doi: 10.3389/fmolb.2022.979724 [IF-6.113]
Varshney, S., Wei, H.X., Batista, F., Nauman, M., Sundaram, S., Siminovitch, K., Tanwar, A. and Stanley, P., 2019. A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1 [12f/12f] mice. BMC developmental biology, 19(1), p.19.[IF-3.0]
Sharma D., Jain S., Mishra AK., Sharma R*., *Tanwar A., 2022.Medicinal Herbs from Phyto-informatics: An aid for Skin Burn Management, Curr Pharm Biotechnol. 2022 Mar 10. [IF-2.837]
Wardhan, R., *Tanwar, A., Dutta, P., Jha, I., Sharma, R.; Ali Zaidi, A., Chawla, R., Arora, R., Khan, H.A.2020. Herbal Informatics: A Unique Model to Identify the Anti-Cancerous Agents for Targeting Lung Cancer. Preprints, 2020120132 (doi: 10.20944/preprints202012.0132.v1) [Under Press: Elsevier; JAIM Id: JAIM-S-21-00208]
Balkrishna A., Thakur ., Singh S., Singh N., *Tanwar A., Sharma RK., 2021. In silico screening for investigating the potential activity of phytoligands against SARS-CoV-2 Journal of Life Sciences, JoLS, J Life Sci. Vol. 3, No. 1, March 2021:18-39 [IF-Under screening]
Wardhan, R., *Tanwar, A., Gupta A.K., Sharma R., 2020. Understanding the complexity of Multiple Sclerosis: A short communication, Journal of Life Sciences, J Life Sci., Vol. 2, No. 4, December 2020:67-76 [IF-Under screening]
Wardhan, R., *Tanwar, A., Joshi, V., Sharma, M., Sharma, R., Chawla, R., Arora, R., Khan, Ha., 2021. Management of Multiple Sclerosis: Using Herbal Informatics to Identify the Potential Nutraceuticals. UP Journal of Zoology(11), 65-76. [DBT-Star scheme project publication; DU]
*Tanwar, A., Zaidi, A.A., Kaur, H., Rana, N., Chawla, R., Basu, M., Arora, R. and Khan, H.A., 2019. In silico bioprospection analysis for identification of herbal compound targeting Clostridium difficile. Indian Journal of Traditional Knowledge (IJTK), 18(4), pp.655-661.[IF-1.72]
Tanwar, A., Zaidi A.A., Bhardwaj.M., Rathore.A., Chakotiya, A.S., Sharma.N., Sharma.D., Kulshrestha.S., Chawla, R., Basu, M., Arora, R., Asif, M., Sharma, R.K and Khan, H.A., 2018. “Herbal informatic approach for the selection of natural compounds targeting Diabeties mellitus.” Indian J Tradit Knowle, 17(2): 270-275 [IF-1.72]
Tanwar, A., Chawla, R., Ansari, M.M., Thakur, P., Chakotiya, A.S., Goel, R., Ojha, H., Asif, M., Basu, M., Arora, R. and Khan, H.A., 2017. In vivo anti-arthritic efficacy of Camellia sinensis (L.) in collagen induced arthritis model. Biomedicine & Pharmacotherapy, 87, pp.92-101.[IF-7.419]
Tanwar, A., Thakur, P., Chawla, R., Ansari, M.M., Chakotiya, A.S., Gusain, S., Goel, R., Arora, R., Sharma, R.K. and Khan, H.A., 2017. Curative remedies for rheumatoid arthritis: Herbal informatics approach for rational based selection of natural plant products. Indian J Tradit Knowle, 16(1): 128-133 [IF-1.72]
Chakotiya, A.S., Tanwar, A., Narula, A. and Sharma, R.K., 2017. Zingiber officinale: Its antibacterial activity on Pseudomonas aeruginosa and mode of action evaluated by flow cytometry. Microbial pathogenesis, 107, pp.254-260. [IF-3.848]
Chakotiya, A.S., Tanwar, A., Srivastava, P., Narula, A. and Sharma, R.K., 2017. Effect of aquo-alchoholic extract of Glycyrrhiza glabra against Pseudomonas aeruginosa in Mice Lung Infection Model. Biomedicine & Pharmacotherapy, 90, pp.171-178. [IF-7.419]
Tanwar, A., Chawla, R., Chakotiya, A.S., Thakur, P., Goel, R., Basu, M., Arora, R. and Khan, H.A., 2016. Effect of Holarrhena antidysentrica (Ha) and Andrographis paniculata (Ap) on the biofilm formation and cell membrane integrity of opportunistic pathogen Salmonella typhimurium. Microbial pathogenesis, 101, pp.76-82 [IF-3.848]
Tanwar, A., Chawla, R., Ansari, M.M., Thakur, P., Chakotiya, A.S., Dixit.B., Arora, R., Sharma, R.K and Khan HA (2016). Herbal informatics approach for Identification and validation of Natural Compounds targeting Gout. Austin arthritis, 1(2): 1008.
Tanwar, A., Thakur, P., Chawla, R., Jaiswal, S., Chakotiya, A.S., Goel, R., Sharma, R.K., Khan, H.A. and Arora, R., 2015. Targeting antibiotic resistant salmonella enterica: biomatrix based selection and bioactivity prediction of potential nutraceuticals. Biochem Anal Biochem, 4(217), pp.2161-1009.[IF-2.68]
Chakotiya, A.S., Tanwar, A., Narula, A. and Sharma, R.K., 2016. Alternative to antibiotics against Pseudomonas aeruginosa: Effects of Glycyrrhiza glabra on membrane permeability and inhibition of efflux activity and biofilm formation in Pseudomonas aeruginosa and its in vitro time-kill activity. Microbial pathogenesis, 98, pp.98-105. [IF- 3.848]
Chakotiya AS, Chawla R, Tanwar A, Sharma A, Sharma RK. 2016. Molecular Docking Analysis - An aid for Selection of Promising Natural Plant Products against Diphtheria Toxin. JSM Chem 4(1): 1017
Thakur, P., Chawla, R., Chakotiya, A.S., Tanwar, A., Goel, R., Narula, A., Arora, R. and Sharma, R.K., 2016. Camellia sinensis ameliorates the efficacy of last line antibiotics against carbapenem resistant Escherichia coli. Phytotherapy research, 30(2), pp.314-322 [IF-6.388]
Chakotiya, A.S., Chawla, R., Thakur, P., Tanwar, A., Narula, A., Grover, S.S., Goel, R., Arora, R. and Sharma, R.K., 2016. In vitro bactericidal activity of promising nutraceuticals for targeting multidrug resistant Pseudomonas aeruginosa. Nutrition, 32(7), pp.890-897. [IF-4.893]
Thakur, P., Chawla, R., Tanwar, A., Chakotiya, A.S., Narula, A., Goel, R., Arora, R. and Sharma, R.K., 2016. Attenuation of adhesion, quorum sensing and biofilm mediated virulence of carbapenem resistant Escherichia coli by selected natural plant products. Microbial pathogenesis, 92, pp.76-85. [IF-3.848]
Thakur, P., Chawla, R., Chakotiya, A.S., Tanwar A., Narula, A., Goel, R., Arora, R. and Sharma, R. K. (2015). Antibacterial activity of aquo-alcoholic extract of camellia sinensis against isolates of carbapenem resistant Escherichia coli and food borne pathogens. Intl J Biol Pharm Res, 6, 606-616.[IC-IF-4.67]
Thakur, P., Chawla, R., Chakotiya, A.S., Nagpal, R., Tanwar, A., Goel, R., Narula, A., Arora, R. and Sharma, R.K., (2015) In vitro Antibacterial Activity of Camellia sinensis and Andrographis paniculata against Vancomycin Resistant Enterococci. Int J Phar Sci and Drug Res; 7(2): 157–162p.[IC-IF-4.0]
Book/Chapter (National/ International);
1. *Tanwar, A. et al., 2022. A novel herbal informatics approach for the management of skin burn injury. “Nanotechnology Driven Herbal Medicine for Burns”, Bentham Science Publisher. 2022, 152-174 [Chapter 9]
2. Demystifying ESKAPE pathogens, book by center for CBRN mitigation training and research, INMAS, DRDO, Ministry of Defence, Delhi. India [Book]
3. Demystifying EBOLA VIRUS, book by center for CBRN mitigation training and research, INMAS, DRDO, Ministry of Defence, Delhi. India [Book]
Abstracts published in conference proceeding/ Posters Presented;
1. Poster Presentation: Regulation of Notch Signaling By O-Glycans during Lymphopoiesis and Myelopoiesis. 63rd Ash Annual Meeting and Exposition, Georgia World Congress Center - Atlanta, GA, USA, December 11-14, 2021 [Abstract ID:144972 & #2170] Journal: Blood: https://doi.org/10.1182/blood-2021-144972 [IF- 25.476]
2. Presented Poster: “Sugars at Work: How O-glycans on Notch Support the Immune System” in #ScienceStrong Poster (P0827877) Contest and faculty poster presentation at AECOM, NY, USA.
3. Topic: Roles of Notch Glycosylation in Signaling: American Society for Biochemistry & Molecular Biology (ASBMB), Experimental Biology 2021 Meeting: The FASEB Journal: https://doi.org/10.1096/fasebj.2021.35.S1.00061 , April 27–30, 2021 [IF-5.834]
4. Topic: In-vivo efficacy study of sildenafil in the management of radiological skin injuries. ICRR-HHE 2018: international conference on radiation research - impact on human health and environment and second biennial meeting of society for radiation research: abstracts; Hyderabad (India); 1-4 Feb 2018
5. Best Oral presentation on the topic of paper entitled: “Protective effect of Holarrhena antidysentrica (L.) against opportunistic infection in vulnerable animal model of rheumatoid arthritis” in Controversies of Rheumatology and autoimmunity (CORA) held in Bologna, Italy, 9-11 March 2017
6. Poster Presentations on the topic: Rheumatoid arthritis - etiology, pathogenesis and animal models; “FRI0032 Curative effect of camellia sinensis (CS) against opportunistic infection in vulnerable animal model of rheumatoid arthritis”. European League Against Rheumatism (EULAR) 2017 Madrid, Spain 14-17 June 2017: Journal: Annals of Rheumatic Disease: http://dx.doi.org/10.1136/annrheumdis-2017-eular.1057 [IF-28.003]
7. Oral Presentation on the topic; “In vivo anti-arthritic efficacy of Camellia sinensis (L.) in collagen induced arthritis”. 36th Annual Session of the Academy of Environmental Biology and National Symposium on Impact of Emerging Toxic Chemicals on Humans, Plants, Diseases and Sustainable Development. Jamia Hamdard University, New Delhi, India, 2016
8. Poster presented on the topic of Swastha Bharat (Integrated health care including innovative diagnostic aids) “Herbal remedies for the management of challenging opportunistic infections in Rheumatoid Arthritis- A new spectrum of antirheumatic drugs” in India International Science Festival (IISF) - Young Scientists’ Conclave (YSC), Dec 8- 11, 2016Abstract ID: SWAS_13
9. Oral presentation of paper on the topic of Indigenous Science and Technology “Curative Remedies for Rheumatoid arthritis: Herbal Informatics Approach for rational based selection of Natural Plant Products” in India International Science Festival- Young Scientists’ Meet (Make in India) Department of Science and Technology, Government of India – Dec 4-8, 2015 Paper Code: 143
10. Poster presented of paper on the topic of Indigenous Science and Technology- “Herbal Informatics: Bio-prospection model to develop potent nutraceuticals against Multi-Drug Resistant ESKAPE microorganisms”. Proceedings of the India International Science Festival- Young Scientists’ Meet (Make in India) Department of Science and Technology, Government of India – Dec 4-8, 2015 Paper Code: 142
11. Best poster award on topic: “In vitro and In vivo studies of medicinal plant extract against Multi Drug Resistant NDM 1 harbored Escherichia coli infections” in National Conference on ‘Perspectives and Trends in Plant Biotechnology’ held at Panjab University, Chandigarh, 21st -23rd Feb 2014
12. Poster presented on the topic entitled as “Integrated herbal drug development and standardization- an approach for overcoming the challenges of herbal drug industry”- National Seminar on Plant Biotechnology: Challenges and Opportunities in 21st century held at Jamia Hamdard from 3rd-4th March 2014