Zaher O. Merhi, M.D.
- Research Assistant Professor, Department of Biochemistry
Area of research
- 1) Impact of advanced glycation end products and vitamin D on ovarian physiology, 2) Impact of metabolic syndrome, obesity and bariatric surgery on ovarian function. 3) PCOS
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building 312 Bronx, NY 10461
Research Profiles
Selected Publications
Merhi Z,Buyuk E, Cipolla MJ. Advanced glycation end products alter steroidogenic gene expression by granulosa cells: an effect partially reversible by vitamin D. Mol Hum Reprod.2018 Mar 12.
Buyuk E,Asemota O, Merhi Z, Charron M, Berger D, Zapantis A, Jindal S.Serum and follicular fluid Monocyte Chemotactic Protein-1 levels are elevated in obese women and are associated with poorer pregnancy outcome following in vitro fertilization: a pilot study. Fertil Steril 2017;107:632-640
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS.J Assist Reprod Genet. 2017;34:1507-1513
Zhang J, Liu H, Luo S, Lu Z, Chávez-Badiola A, Liu Z, Yang M, Merhi Z, Silber SJ, Munné S, Konstantinidis M, Wells D, Tang JJ, Huang T. Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reprod Biomed Online.2017;34:361-368.
Zhang JJ, Yang M, Merhi Z. Efficiency of metaphase II oocytes following minimal/mild ovarian stimulation in vitro fertilization. Fertil Res Pract.2016;1;2:2
Scherzer R, Greenblatt RM, Merhi Z,Kassaye S, Lambert-Messerlian G, Maki PM, Murphy K, Karim R, Bacchetti P. Use of antimüllerian hormone to predict the menopausal transition in HIV-infected women. Am J Obstet Gynecol.2016 Jul 26.
Zhang JJ, Yang M, Merhi Z. Reproductive potential of mature oocytes after conventional ovarian hyperstimulation for in vitro fertilization. Int J Gynaecol Obstet.2016;133:230-3.
Merhi Z, Thornton K, Bonney E, Cipolla MJ, Charron MJ, Buyuk E. Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1. J Assist Reprod Genet.2016;33:535-43.
Hessol NA, Holman S, Minkoff H, Cohen MH, Golub ET, Kassaye S, Karim R, Sosanya O, Shaheen C, Merhi Z. Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV. AIDS Care.2016;28:11-21
Zhang JJ, Merhi Z, Yang M, Bodri D, Chavez-Badiola A, Repping S, van Wely M.Minimal stimulation IVF vs conventional IVF: a randomized controlled trial. Am J Obstet Gynecol.2016;214:96.e1-8
Sciaranghella G, Wang C, Hu H, Anastos K, Merhi Z, Nowicki M, Stanczyk FZ, Greenblatt RM, Cohen M, Golub ET, Watts DH, Alter G, Young MA, Tsibris AM.CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception. J Infect Dis.2015;212:1397-401
Zhang JJ, Feret M, Chang L, Yang M, Merhi Z. Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF. Gynecol Endocrinol.2015;31:409-13.
Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015;22:1220-8
Merhi Z,Doswell A, Marilyn Cipolla M. Vitamin D Alters Genes Involved in Follicular Development and Steroidogenesis in Human Cumulus Granulosa Cells. J Clin Endocrinol Metab.2014;99:1137-45.
Merhi Z, Irani M, Doswell AD, Ambroggio J. Follicular Fluid Soluble Receptor for Advanced Glycation End-Products (sRAGE): A Potential Indicator of Ovarian Reserve. J Clin Endocrinol Metab.2014;99:E226-33
Merhi Z.Advanced Glycation End-Products: Pathway of Potentially Significant Pathophysiological and Therapeutic Relevance for Metabolic Syndrome in Menopausal Women. J Clin Endocrinol Metab.2014;99:1146-8.
Irani, Minkoff H, Seifer DB, Merhi Z.Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women with PCOS. J Clin Endocrinol Metab. 2014;99:886-90
Merhi Z. Advanced Glycation End-Products and their Relevance in Female Reproduction.Hum Reprod. 2014;29:135-45.
Berger DS, Zapantis A, Merhi Z, Younger J, Polotsky AJ, Jindal SK. Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF. J Assist Reprod Genet. 2014;31:279-83
Merhi Z, Buyuk E, Berger D, Zapantis A, Israel D, Chua Jr S, Jindal S. Leptin Suppresses Anti-Mullerian Hormone Gene Expression through JAK2/STAT3 Pathway in Luteinized Granulosa Cells of Women Undergoing In Vitro Fertilization. Hum Reprod. 2013;28:1661-9
Merhi Z, Zapantis A, Berger DS, Jindal SK. Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J Assist Reprod Genet.2013;30:1361-5.
Berger DS, Merhi Z,Hogge WA, Ferrell RE. Mannose binding lectin genotypes are not associated with increased risk of unexplained recurrent pregnancy loss. J Assist Reprod Genet.2013;30:723-7
Merhi Z, Keltz J, Zapantis A, Younger J, Berger D, Lieman H, Jindal S, Polotsky A. Male Adiposity Impairs Clinical Pregnancy Rate by In Vitro Fertilization without Affecting Day 3 Embryo Quality. Obesity. 2013;21:1608-12
Merhi Z, Pollack SE. Pituitary origin of persistently elevated human chorionic gonadotropin in a patient with gonadal failure. Fertil Steril.2013;99:293-6
Merhi Z,Seifer D.B.,Weedon J, Adeyemi O., Holman S., Anastos K., Golub E., Young M., Karim R., Greenblatt R., Minkoff H. Circulating Vitamin D Correlates with Serum Anti-Mullerian Hormone Levels in Late Reproductive-Aged Women: Women’s Interagency HIV Study. Fertil Steril. 2012;98:228-34.
Aslam M, Merhi Z, Ahmed S, Kuzbari O, Seifer D, Minkoff H. Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women. Fertil Steril.2011;95:1790-3.
Aslam M., Vemareddy K., Merhi Z., Minkoff H. Unusual case of postpartum hepatitis due to hereditary haemochromatosis. BJOG.2010;117:620-2.
Todd B*, Merhi Z*,Shu J, Etgen A, Neal-Perry G. Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging. Endocrinology.2010;151:1356-66.*both are first authors
Lederman M, Lebesgue D, Gonzalez V, Shu J, Merhi Z, Etgen A, Neal-Perry G. Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to estradiol positive feedback in middle-aged rats. Neuropharmacology. 2010;58:314-20.
Mahmoud M., Merhi Z. Computed tomography-assisted laparoscopic removal of intraabdominally migrated levonorgestrel-releasing intrauterine systems. Arch Gynecol Obstet. 2010;281:627-30.
Haberman S, Feldman J, Merhi Z, Markenson G, Cohen W, Minkoff H. Effect of clinical-decision support on documentation compliance in an electronic medical record. Obstet Gynecol.2009;114:311-7.
Mahmoud M., Fridman D., Merhi Z. Subserosal Misplacement of Essure Device Manifested by Late Onset Acute Pelvic Pain. Fertil Steril.2009;92:2038.e1-3.
Merhi Z.,Minkoff H, Messerlian G, Macura, Feldman J and Seifer D. Plasma Brain-Derived Neurotropic Factor in Women after Bariatric Surgery. Fertil Steril.2009;91:1544-8.
Merhi Z.,Durkin H, Feldman J, Macura J, Rodriguez C and Minkoff H. The Effect of Bariatric Surgery on Peripheral Blood Lymphocyte Subsets in Women. Surg Obes Relat Dis. 2009;5:165-71.
Merhi Z., Messerlian G, Minkoff H, Eklund E, Macura J, Feldman J, Rodriguez C, Seifer D. Comparison of Serum and Plasma Measurements of Mullerian Inhibiting Substance. Fertil Steril. 2008;89:1836-7.
Merhi Z., Minkoff H, Macura J, Feldman J, Rodriguez C, Seifer D. Relationship of Bariatric Surgery to Mullerian-Inhibiting Substance Levels. Fertil Steril.2008;90:221-4.
Arora R., Merhi Z., Khulpateea N., Roth D. and Minkoff H. Ovarian Hyperstimulation Syndrome Following a Molar Pregnancy Evacuation. Fertil Steril.2008;90:1197.e5-7.
Merhi Z. And Santoro N.Postmenopausal Virilization after Spousal Use of Topical Androgens. Fertil Steril.2007;87:976.e13-5.
Awonuga A., Merhi Z.,Awonuga M., Samuels T., Waller J., Pring D. Anthropometric Measurements In the Diagnosis of Pelvic Size: An Analysis of Maternal Height and Shoe Size and Computed Tomography Pelvimetric Data. Arch Gynecol Obstet.2007;276:523-8.
Hammoud A., Merhi Z.,Diamond M., Baumann P. Recurrent Pregnancy Loss and Obstetric Outcome. Int J Gynaecol Obstet.2007;96:28-9.
Awonuga A., Merhi Z., Khulpateea K. An Abdominal Packing Procedure for Intractable Obstetrical and Gynecologic Hemorrhage. Int J Gynaecol Obstet.2006;93:160-3.
Merhi Z., Awonuga A. Acute Abdominal Pain as the Presenting Symptom of Isolated Iliac Vein Thrombosis in Pregnancy. Obstet Gynecol.2006;107:468-470.
Rotas M, Haberman S, Merhi Z.,Morcos M. Prenatal Diagnosis of Giant Fetal Truncal Hemangioma Using Two and Three- Dimensional Ultrasound With Magnetic Resonance Imaging. J Ultrasound Med. 2006;25:527-31.
Merhi Z.,Roberts J, Awonuga A. A Case of 46,X,der(X)t(X;X)(q22.1;p11) Xq22.1®Xqter in a 12 Year Old Girl with Premature Ovarian Failure. Gynecol Obstet Invest.2006;63:137-139.
Awonuga A, Greenbaum L., Merhi Z., Levgur M., Minkoff H. Vesicovaginal Fistula Associated With Cytomegalovirus Infection In An HIV-infected Patient. Gynecol Obstet Invest.2006;63:143-145.
Merhi Z., Haberman S, Roberts J, Sobol-Benin G. Prenatal Diagnosis of Palatal Teratoma by 3-Dimensional Sonography and Color Doppler Imaging. J Ultrasound Med.2005;24:1317-20.