I am a Medical Physicist and Assistant Professor of Radiation Oncology originally from Sweden with a M.Sc. in Medical Physics from Lund Univeristy and a Ph.D. in Medical Physics from the University of Copenhagen. I came to Einstein in 2013 where I completed a 3-year post-doctoral reserach fellowship under the mentorship of Dr. Wolfgang Tomé and Dr. Chandan Guha, as well as the Clinical Reserach Training Program here at Einstein in 2018. I currently hold a faculty appointment at Einstein and a clinical appointment as a senior medical physicist at the Department of Radiation Oncology at Montefiore.

My current research efforts are focused on creating data driven decision-support systems for optimizing radiation therapy decision making and risk-stratified treatment adaptation based on quantitative image analysis. The goal of these research avenus is to tailor the individual radiation therapy of patients based on risk/benefit analyses, also focusing on the optimal use of proton therapy in the treatment of cancer patients. I also have an interest in developing protocols for precise small-animal irradiation procedures using image-guided methodologies.

By combining my expertise in radiation physics and data analysis with biology-based approaches I work with the multidisciplinary team at the Institute for Onco-Physics to drive the development of new approaches in radiation-driven immunotherapy and to reduce the severe treatment complications associated with receiving high-dose radiation therapy.

Zhang Y, Brodin NP, Ohri N, Thibaud S, Kaubisch A, Kinkhabwala M, Garg M, Guha C, Kabarriti R. Association between neutrophil-lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma. Hepatology international 2019; 13(5): 609-17.

Brodin NP, Mehta KJ, Basavatia A, Goddard LC, Fox JL, Feldman SM, McEvoy MP, Tome WA. A skin dose prediction model based on in vivo dosimetry and ultrasound skin bridge measurements during intraoperative breast radiation therapy. Brachytherapy 2019; 18(5): 720-6.

Kabarriti R, Brodin NP, Ohri N, Narang R, Huang R, Chuy JW, Rajdev LN, Kalnicki S, Guha C, Garg MK. Human papillomavirus, radiation dose and survival of patients with anal cancer. Acta oncologica 2019: 1-7.

Brodin NP, Kabarriti R, Pankuch M, Schechter CB, Gondi V, Kalnicki S, Guha C, Garg MK, Tome WA. A Quantitative Clinical Decision-Support Strategy Identifying Which Patients With Oropharyngeal Head and Neck Cancer May Benefit the Most From Proton Radiation Therapy. International journal of radiation oncology, biology, physics 2019; 104(3): 540-52.

Kabarriti R, Brodin NP, Ahmed S, Vogelius IR, Guha C, Kalnicki S, Tomé WA, Garg MK. Origin of Locoregional Recurrences After Definitive Intensity-modulated Radiation Therapy (IMRT) for Laryngeal Cancer Determined Based on Follow-up PET/CT Imaging. Cureus 2019 11(1): e3856.

Goddard LC, Brodin NP, Basavatia A, McEvoy MP, Feldman SF, Fox JL, Mehta KJ, Tomé WA. Interstitial Surgical Cavity Sizing Applicators for the Treatment of the Breast Lumpectomy Cavity with Intraoperative Radiation Therapy. Cureus 2018 10(12): e3693.

Brodin NP and Tome WA. Revisiting the dose constraints for head and neck OARs in the current era of IMRT. Oral Oncology. 2018 Nov;86 :8-18.

Gasic D, Rosenschöld PMA, Vogelius IR, Maraldo MV, Aznar MC, Nysom K, Björk-Eriksson T, Bentzen SM, Brodin NP. Retrospective estimation of heart and lung doses in pediatric patients treated with spinal irradiation. Radiother Oncol. 2018 Aug;128(2):209-213.

Kabarriti R, Brodin NP, Lundgren G, Ohri N, Tomé WA, Kalnicki S, Garg MK. Early Response Assessment on Mid-treatment Computed Tomography Predicts for Locoregional Recurrence in Oropharyngeal Cancer Patients Treated With Definitive Radiation Therapy.
Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4): 1036-1045.

Goddard LC, Brodin NP, Bodner WR, Garg MK, Tome WA. Comparing photon and proton-based hypofractioned SBRT for prostate cancer accounting for robustness and realistic treatment deliverability. The British journal of radiology 2018: 20180010.

Tempel DG, Brodin NP, Tome WA. On the Inclusion of Short-distance Bystander Effects into a Logistic Tumor Control Probability Model. Cureus 2018; 10(1): e2012.

Brodin NP, Kabarriti R, Garg MK, Guha C, Tome WA. Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports.
Int J Radiat Oncol Biol Phys. 2018 Feb 1; 100(2):391-407.

Rechner LA, Maraldo MV, Vogelius IR, Zhu XR, Dabaja BS, Brodin NP, Petersen PM, Specht L, Aznar MC. Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: The impact of proton therapy and/or deep inspiration breath hold. Radiotherapy and Oncology. 2017;125(1):41-7. doi: 10.1016/j.radonc.2017.07.033

Goddard L, Bodner W, Brodin NP, Garg M, Lee A, Mani K, Tomé WA, Spine SBRT using VMAT. Journal of Physics: Conf. Series 777(2017). doi:10.1088/1742-6596/777/1/012028.

Brodin NP, Velcich A, Guha C, Tomé WA. A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems. Dose-response. 2017;15(1): doi: 10.1177/1559325816685798.

Saha S, Aranda E, Hayakawa Y, Bhanja P, Atay S, Brodin NP, Li J, Asfaha S, Liu L, Tailor Y, Zhang J, Godwin AK, Tome WA, Wang TC, Guha C, Pollard JW. Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury.
Nature communications. 2016;7: doi: 10.1038/ncomms13096.

Hernández Quintanar LF., López Silva FY., Fabila Bustos DA., Serrano Navarro J, de La Rosa Vázquez JM., Brodin PN., Guha C, Tomé WA., Stolik Isakina S., In Vitro Photoirradiation System for Simultaneous Irradiation with Different Light Doses at a Fixed Temperature. Photomed Laser Surg. 2016 Mar;34(3):108-15. doi:10.1089/pho.2015.4030.

Brodin NP, Partanen A, Asp P, Branch CA, Guha C, Tomé WA. A simple method for determining the coagulation threshold temperature of transparent tissue-mimicking thermal therapy gel phantoms: Validated by magnetic resonance imaging thermometry.
Med Phys. 2016 Mar;43(3):1167. doi: 10.1118/1.4941361.

Brodin NP, Chen Y, Yaparpalvi R, Guha C, Tomé WA. Dosimetry Formalism and Implementation of a Homogenous Irradiation Protocol to Improve the Accuracy of Small Animal Whole-Body Irradiation Using a Cesium-137 Irradiator.
Health Phys. 2016 Feb;110(2 Suppl 1):S26-38. 

Tomé WA, Gökhan S, Gulinello ME, Brodin NP, Heard J, Mehler MF, et al. Hippocampal-dependent Neurocognitive Impairment Following Cranial Irradiation Observed in Preclinical Models: Current Knowledge and Possible Future Directions. Br J Radiol. 2016 Jan;89(1057):20150762. doi: 10.1259/bjr.20150762. Epub 2015 Oct 30.

Tomé WA, Gökhan S, Brodin NP, Gulinello ME, Heard J, Mehler MF, Guha C. A mouse model replicating hippocampal sparing cranial irradiation in humans: A tool for identifying new strategies to limit neurocognitive decline. Sci. Rep. 5, 14384; doi: 10.1038/srep14384 (2015).

Munck af Rosenschold P, Engelholm SA, Brodin PN, Jørgensen M, Grosshans DR, Zhu RX, Palmer M, Crawford CN, Mahajan A. A retrospective evaluation of the benefit of referring pediatric cancer patients to an external proton therapy center.
Pediatr Blood Cancer. 2015 Sep 23. doi: 10.1002/pbc.25768. [Epub ahead of print]

Brodin NP, Guha C, Tome WA. Proposal for a Simple and Efficient Monthly Quality Management Program Assessing the Consistency of Robotic Image-Guided Small Animal Radiation Systems. Health physics. 2015;109(3 Suppl 3):S190-9.

Brodin NP, Tang J, Skalina K, Quinn TJ, Basu I, Guha C, Tomé WA.
Semi-automatic cone beam CT segmentation of in vivo pre-clinical subcutaneous tumours provides an efficient non-invasive alternative for tumour volume measurements. Br J Radiol. 2015;88(1050):20140776.

Aznar MC, Maraldo MV, Schut DA, Lundemann M, Brodin NP, Vogelius IR,
Kiil-Berthelsen A., Specht L., Petersen PM. Minimizing late effects for patients with mediastinal Hodgkin lymphoma: deep inspiration breath-hold, IMRT, or both? International Journal of Radiation Oncology, Biology, Physics. 2015;92(1):169-74.

Kornerup JS, Brodin NP, Björk-Eriksson T, Birk Christensen C, Kiil-Berthelsen A, Aznar MC et al. PET/CT-guided treatment planning for paediatric cancer patients: a simulation study of proton and conventional photon therapy. Br J Radiol. 2015 Feb 2:20140586.

Brodin NP, Guha C, Tomé WA. Photodynamic Therapy and its Role in Combined-Modality Anti-Cancer Treatment.
Technol Cancer Res Treat. 2014 Nov 5.

Ståhl Kornerup J, Brodin NP, Birk Christensen C, Björk-Eriksson T, Kiil-Berthelsen A, Borgwardt L, et al. Use of PET/CT instead of CT-only when planning for radiation therapy does not notably increase life years lost in children being treated for cancer. Pediatr Radiol. 2015;45(4):570-81.

Maraldo MV, Jorgensen M, Brodin NP, Aznar MC, Vogelius IR, Petersen PM, Berthelsen AK, Christensen CB, Hjalgrim LL, Specht L. The impact of involved node, involved field and mantle field radiotherapy on estimated radiation doses and risk of late effects for pediatric patients with Hodgkin lymphoma. Pediatric Blood & Cancer. 2014;61(4):717-22. 

Maraldo MV, Brodin NP, Aznar MC, Vogelius IR, Munck af Rosenschold P, Petersen PM, Specht L. Doses to head and neck normal tissues for early stage Hodgkin lymphoma after involved node radiotherapy. Radiotherapy and Oncology. 2014;110(3):441-7.

Gasic D, Ohlhues L, Brodin NP, Fog LS, Pommer T, Bangsgaard JP, Munck af Rosenschold P. A treatment planning and delivery comparison of volumetric modulated arc therapy with or without flattening filter for gliomas, brain metastases, prostate, head/neck and early stage lung cancer. Acta Oncologica. 2014:1-7.

Brodin NP, Vogelius IR, Bjork-Eriksson T, Munck Af Rosenschold P, Maraldo MV, Aznar MC, Specht L, Bentzen SM. Optimizing the radiation therapy dose prescription for pediatric medulloblastoma: minimizing the life years lost attributable to failure to control the disease and late complication risk. Acta Oncologica. 2014;53(4):462-70.

Brodin NP, Munck af Rosenschold P, Blomstrand M, Kiil-Berthlesen A, Hollensen C, Vogelius IR, Lannering B, Bentzen SM, Bjork-Eriksson T. Hippocampal sparing radiotherapy for pediatric medulloblastoma: impact of treatment margins and treatment technique.
Neuro Oncology. 2014;16(4):594-602.

Brodin NP, Maraldo MV, Aznar MC, Vogelius IR, Petersen PM, Bentzen SM, Specht L. Interactive decision-support tool for risk-based radiation therapy plan comparison for Hodgkin lymphoma. International Journal of Radiation Oncology, Biology, Physics. 2014;88(2):433-45.

Maraldo MV, Brodin P, Aznar MC, Vogelius IR, Munck af Rosenschold P, Petersen PM, Specht L. Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?
International Journal of Radiation Oncology, Biology, Physics. 2013;87(2):297-303.

Maraldo MV, Brodin NP, Aznar MC, Vogelius IR, Munck af Rosenschold P, Petersen PM, Specht L. Estimated risk of cardiovascular disease and secondary cancers with modern highly conformal radiotherapy for early-stage mediastinal Hodgkin lymphoma.
Annals of Oncology. 2013;24(8):2113-8.

Jorgensen AY, Maraldo MV, Brodin NP, Aznar MC, Vogelius IR, Munck af Rosenschold P, Petersen PM, Specht L. The effect on esophagus after different radiotherapy techniques for early stage Hodgkin's lymphoma. Acta Oncologica. 2013;52(7):1559-65.

Brodin NP, Vogelius IR, Bjork-Eriksson T, Munck af Rosenschold P, Bentzen SM. Modeling freedom from progression for standard-risk medulloblastoma: a mathematical tumor control model with multiple modes of failure.
International Journal of Radiation Oncology, Biology, Physics. 2013;87(2):422-9.

Maraldo MV, Brodin NP, Vogelius IR, Aznar MC, Munck af Rosenschold P, Petersen PM, Specht L. Risk of developing cardiovascular disease after involved node radiotherapy versus mantle field for Hodgkin lymphoma.
International Journal of Radiation Oncology, Biology, Physics. 2012;83(4):1232-7. 

Brodin NP, Vogelius IR, Maraldo MV, Munck af Rosenschold P, Aznar MC, Kiil-Berthelsen A, Nilsson P, Bjork-Eriksson T, Specht L, Bentzen SM. Life years lost--comparing potentially fatal late complications after radiotherapy for pediatric medulloblastoma on a common scale. Cancer. 2012;118(21):5432-40.

Blomstrand M*, Brodin NP*, Munck Af Rosenschold P, Vogelius IR, Sanchez Merino G, Kiil-Berthlesen A, Blomgren K, Lannering B, Bentzen SM, Bjork-Eriksson T. Estimated clinical benefit of protecting neurogenesis in the developing brain during radiation therapy for pediatric medulloblastoma. Neuro Oncology. 2012;14(7):882-9.
*Co-first authors 

Brodin NP, Munck Af Rosenschold P, Aznar MC, Kiil-Berthelsen A, Vogelius IR, Nilsson P, Lannering B, Bjork-Eriksson T. Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma.
Acta Oncologica. 2011;50(6):806-16.