Juan P. Maianti, Ph.D.
- Assistant Professor, Department of Biochemistry
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building 317 Bronx, NY 10461
Research Profiles
Selected Publications
- Nature Chem. Biol. 15 (6), 565-74 (2019), “Substrate-selective inhibitors that reprogram the activity of Insulin-Degrading Enzyme” Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, and Liu DR.
- Nature, 511, 94-8 (2014), “Anti-diabetic activity of Insulin-Degrading Enzyme inhibitors mediated by multiple hormones” Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du X-Q, Leissring MA, Tang W-J, Charron MJ, Seeliger MA, Saghatelian A, and Liu DR.
- This work was highlighted in The Boston Globe, Nature News, Nature Endocrinology, Cell Metabolism, ACS ChemBio, C&EN News, MIT Technology Review, Healthline, Jax.org, and other science news outlets.
- Our IDE inhibitor 6bK is now offered to the scientific community in R&D/Tocris and Phoenix Peptides.
- ACS Chemical Biology, 9 (9), 2067-73 (2014), “Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial Neomycin analogs” Maianti JP, Kanazawa H, Dozzo P, Matias RD,
Feeney LA, Armstrong ES, Kane TR, Gliedt MJ, Goldblum A, Linsell MS, Aggen JB, Kondo J, and Hanessian S.- This work was featured in C&EN News and the ACS Chemical Biology podcast interview of Sept. 2014.
- Med. Chem. Commun. 7, 170-6 (2016), Antibiotic Resistance special issue. “Structural hybridization of multiple aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes” Hanessian S. and Maianti JP.
- Chemical Science, 3, 249-56 (2012), Edge Article, “Structural and kinetic study of self-assembling macrocyclic dimer natural product Aminoglycoside 66-40C and unnatural variants” Hanessian S, Maianti JP, Ly VL, and Deschênes-Simard B.