Selected Recent Publications (Complete publications at PubMed: Goldman ID)
Goldman ID. Hereditary folate malabsorption. GeneReviews (internet). Seattle (WA): University of Washington, Seattle. Updated May 5, 2022
Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S. Structural basis of antifolate recognition and transport by PCFT. Nature 595:130-134, 2021
Zhan H, Najmi M, Lin K, Aluri S, Fiser A, Goldman ID, Zhao R. A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. J. Biol Chem. 295:15650-15661, 2020.
Aluri S, Zhao R, Lin K, Shin DS, Fiser A, Goldman ID. Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation. J Biol Chem. 294:7245-7258, 2019
Aluri S, Zhao R, Lubout C, Goorden SMI, Fiser A, Goldman ID. Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter-SLC46A1. Blood Advances 2:61-68, 2018.
Aluri S, Zhao R, Fiser A, Goldman ID. Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1). Am J Physiol Cell Physiol. Am J of Physiol., Cell Physiol. 314:C289-C296, 2018.
Zhao R, Aluri S, Goldman ID. The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption. Mol Aspects Med. 53:57-72, 2017.
Zhao R, Najmi M, Aluri S, Goldman ID. Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation. Am J Physiol Cell Physiol. 312:C517-C526, 2017.
Aluri S, PhD, Zhao R, Fiser, Goldman ID. Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding. BBA Biomembranes.1859:2193-2202, 2017.
Zhao R, Najmi M, Fiser A, Goldman ID. Identification of an Extracellular Gate for the Proton Coupled Folate Transporter (SLC46A1) by Cysteine Cross-Linking. J Biol Chem. 291:8162- 72, 2016.
Shin DS, Min SH, Russell L, Zhao R, Fiser A and Goldman ID. Functional roles of aspartate residues of the human proton-coupled folate transporter (PCFT; SLC46A1); D156, mutated in hereditary folate malabsorption, is critical for protein stability; D109 is irreplaceable. Blood 116:5162-9, 2010.
Zhao, R., Qiu, A., Tsai, E., Jensen, M., Akabas, M., and Goldman ID. The proton-coupled folate transporter (PCFT): Impact on pemetrexed transport and on antifolate activities as compared to the reduced folate carrier. Mol Pharm, 74:854-862, 2008.
Zhao, R., Min, S.H., Qiu, A., Sakaris, A., Goldberg, G.L., Sandoval, C., Malatack, J.J., Rosenblatt, D.S., and Goldman, I.D. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for Hereditary Folate Malabsorption, Blood 110: 1147-1152, 2007.
Qiu, A., Jansen, M., Sakaris, A., Min, S., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, M., Akabas, M.H., and Goldman, ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell, 127:917-928, 2006