Hepatic glucose production
This Module utilizes U13C glucose , or [6,6}-2H glucose in vivo, to examine hepatic glucose production, and for U13C glucose, also recycling. For examples of this module’s utility for Core customers, see:
Xu, J., Xiao, G., Trujillo, C., Chang, V., Blanco, L., Joseph, S. B., Bassilian, S., Saad, M. F., Tontonoz, P., Lee, W. N. & Kurland, I. J. (2002) Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production, The Journal of biological chemistry. 277, 50237-44.
Vaitheesvaran, B., Yang, L., Hartil, K., Glaser, S., Yazulla, S., Bruce, J. E. & Kurland, I. J. Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation, PLoS One. 7, e33717.
Yang, Y., Tarabra, E., Yang, G. S., Vaitheesvaran, B., Palacios, G., Kurland, I. J., Pessin, J. E. & Bastie, C. C. (2013) Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice, PLoS One. 8, e81866.
Xu, J., Gowen, L., Raphalides, C., Hoyer, K. K., Weinger, J. G., Renard, M., Troke, J. J., Vaitheesyaran, B., Lee, W. N., Saad, M. F., Sleeman, M. W., Teitell, M. A. & Kurland, I. J. (2006) Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse, Diabetes. 55, 3372-80.
Vaitheesvaran, B., LeRoith, D. & Kurland, I. J. MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity, Diabetologia. 53, 2224-32.
Vaitheesvaran, B., Chueh, F. Y., Xu, J., Trujillo, C., Saad, M. F., Lee, W. N., McGuinness, O. P. & Kurland, I. J. Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes, Metabolomics. 6, 180-190.
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