Choline, Betaine, TMAO and Creatinine
Choline and betaine are essential nutrients. Choline is important for brain function, liver health, reproduction, and fetal and infant development. Betaine acts as a methyl donor in the liver and as an important osmolyte to protect the cells of medulla in the kidney. Their gut microbial metabolite trimethylamine N-oxide (TMAO) was considered non-toxic, but it recently has been associated with increased risk for cardiovascular disease. This finding has stimulated a growing interest in analyzing these compounds in bio fluids and studying their associations with human health and diseases. This LC/MS/MS assay allows simultaneous quantification of free choline, betaine, TMAO and creatinine in plasma, urine or tissue samples, with a standard curve for each of the metabolites for absolute quantification.
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