Module #3

Glycolysis, Pentose Phosphate and TCA Metabolites   

This LC/MS/MS module measures 17 metabolites, several which cannot be detected by GC/MS (see Module 7), such as fructose 1,6,bisphosphate, phosphoenolpyruvate and uridine diphosphoglucose (UDPG), with a standard curve for each of the metabolites for absolute quantification. For examples of this module’s utility for Core customers, see:

Yang, Y., Tarabra, E., Yang, G. S., Vaitheesvaran, B., Palacios, G., Kurland, I. J., Pessin, J. E. & Bastie, C. C. (2013) Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice, PLoS One. 8, e81866.

Liu, Z., Apontes, P., Fomenko, E. V., Chi, N., Schuster, V. L., Kurland, I. J., Pessin, J. E. & Chi, Y. (2018) Mangiferin Accelerates Glycolysis and Enhances Mitochondrial Bioenergetics, Int J Mol Sci. 19.

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