HPV | Montefiore Einstein

Robert D. Burk

Read more about Robert D. Burk

Robert D. Burk

https://assets.montefioreeinstein.org/profiles/images/Burk_Robert_MD_2x.jpg

Provider

Faculty

Expert

First Name

Robert

Last Name

Burk

NPI

1639255904

Faculty ID

8221

CMO Specialties

Clinical Genetics

Cancer

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

einstein-dept-microbiology-immunology

einstein-dept-obstetrics-gynecology-womens-health

einstein-dept-epidemiology-population-health

Gender

Male

robert.burk@einsteinmed.edu

Phone

718-430-3720

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Pediatric Genetic Medicine

Type

Academic

Department

Department of Microbiology & Immunology

Department Link

Rank

Professor

Type

Academic

Department

Department of Obstetrics & Gynecology and Women's Health

Department Link

Rank

Professor

Division

Gynecological Oncology

Type

Academic

Department

Department of Epidemiology & Population Health

Department Link

Rank

Professor

Tags

me-patientcare-cancer-research-epidemiology

Division

Epidemiology

Type

Administrative

Title

Vice Chair for Translational Research, Department of Pediatrics

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8444 40.85103)

Address Line 1

1300 Morris Park Avenue

City

Bronx

State

Zip

10461-1900

Location Title

Montefiore at AECOM

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Forchheimer Building

Room

109

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Education and Trainings

Education Type Label

Medical Education

Education Institution

George Washington University School of Medicine

Education Type Label

Fellowship

Education Institution

John Hopkins Hospital, Maryland

Education Type Label

Residency

Education Institution

University of California, San Francisco

Professional Interests

The main focus of the Burk laboratory is to utilize population-based longitudinal studies from large epidemiological cohorts including those with and without HIV to study the dynamics of host-microbe interactions. These include HPV and development of cancer, and the human microbiome and disease outcomes (cancer, infectious diseases, cardiovascular disease, diabetes, obesity, aging).
To understand complex ecological community of bacteria, fungi, viruses and other organisms and how that might interact for disease outcomes.  These studies are built on understanding the application of laboratory tests to population-based studies. They employ NGS and state of the art bioinformatics.
Other interests of the lab include the genetics of complex human disease (prostate cancer, excessive sweating) using large case-control clinical collections of genomic DNAs with candidate gene sequencing; and, the cell biology of VHL and its role in primary cilia formation and activity and its disruption in renal cancer.
The lab is dedicated to creating a warm environment based on collaborative science and teamwork.  Our mission is to facilitate each individual reaching his or her potential through learning, experimentation and sharing in the pursuit of knowledge to promote human health and development.

Research Areas

laboratory-based translational research;
human microbiome;
HPV molecular epidemiology;
HPV molecular evolution;
HPV and cervical cancer;
prostate cancer;
hyperhidrosis

Specialties

Expert Tags

Areas of Expertise

Animal papillomavirus

HPV

Head and Neck Cancers

Hyperhidrosis

Translational Research

Expert Summary

<div>Dr. Burk is an authority on the genomics and evolution of human papillomaviruses (HPV), which cause nearly all cases of cervical cancer. His team was the first to report, in the New England Journal of Medicine, that the vast majority of HPV infections in young women are short-lived and don’t require treatment. More recently, his lab is utilizing Next-Gen sequencing to study papillomavirus genomics and methylation of the viral genome. His lab utilized this new technology to identify HPV16 and beta- and gamma-HPVs associated with head and neck squamous cell cancers (HNSCCs). </div>
<div>Dr. Burk is also currently investigating the role of the human microbiome and cervical HPV natural history. He is a co-PI on a grant with Drs. Kaplan and Rob Knight (UCSD) studying the human gut microbiome and obesity and diabetes. Dr. Burk’s lab has pioneered translational studies of the human microbiome by developing home collection kits that have been used to collect over 5,000 samples. </div>
<div>Dr. Burk was elected in 2015 as a fellow of the American Association for the Advancement of Science (AAAS).</div>

Research Profile

https://einsteinmed.edu/faculty/8221/Robert-Burk

Clinical Profile

https://montefioreeinstein.org/profiles/1639255904/robert-d-burk

CHAM Provider

Professional Title

M.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/2ec1ce04-4e1b-49a3-b5c7-af0da079c…

Lab Website Link

https://einsteinmed.edu/labs/robert-burk/

Selected Publications

(out of 503 published papers; google h-index 126)
 
Gradissimo A, Clarke MA, Xue X, Castle PE, Raine-Bennett TR, Schiffman M, Wentzensen N, Strickler HD, Burk RD. A Novel HPV/Host DNA Methylation-Score and Detection of Cervical Adenocarcinoma. J Natl Cancer Inst. 2023. Epub 2023/07/19. doi: 10.1093/jnci/djad134. PMID: 37467068; PMC1069984.
 
<span style="font-size: 12pt; font-family: Arial, sans-serif; color: #242424; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Usyk M, Peters B, Karthikeyan S, McDonald D, Sollecito C, Vazquez-Baeza Y, Shaffer J, Gellman M, Talavera G, Daviglus M, Thyagarajan B, K<span style="font-size: 12pt; font-family: Arial, sans-serif; color: #242424; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">night R, Qi Q, Kaplan RC, and Burk, R.D. Comprehensive Evaluation of Shotgun Metagenomics, <span style="font-size: 12pt; font-family: Arial, sans-serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Amplicon Sequencing and Harmonization of These Platforms for Epidemiological Studies. Cell Report Methods 2023 Jan 23;3(1):100391. eCollection 2023 Jan 23. PMID: 36814836; PMC9939430
 
Schiffman M, Mirabello L, Egemen D, Befano B, Xiao Y, Wentzensen N, Raine-Bennett T, Nayar R, Cheung LC, Rositch A, Beaty T, Perkins RB, de Sanjose S, Lorey T, Castle PE, Burk RD. The combined finding of HPV 16, 18, or 45 and cytologic Atypical Glandular Cells (AGC) indicates a greatly elevated risk of in situ and invasive cervical adenocarcinoma. Gynecol Oncol. 2023;174:253-61. Epub 2023/05/27. doi: 10.1016/j.ygyno.2023.05.011. PMID: 37243996
 
Burk RD, Mirabello L, DeSalle R. Distinguishing Genetic Drift from Selection in Papillomavirus Evolution. Viruses. 2023;15(8). Epub 2023/08/26. doi: 10.3390/v15081631. PMID: 37631973; PMC10458755.
 
Usyk M, Schlecht NF, Pickering S, Williams L, Sollecito CC, Gradissimo A, Porras C, Safaeian M, Pinto L, Herrero R, Strickler HD, Viswanathan S, Nucci-Sack A, Diaz A, Burk RD.molBVreveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history. Nat Commun. 2022;13(1):233. Epub 2022/01/13. doi: 10.1038/s41467-021-27628-3. PMID: 35017496; PMC8752746.
 
Schlecht NF, Diaz A, Nucci-Sack A, Shyhalla K, Shankar V, Guillot M, Hollman D, Strickler HD, Burk RD. Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine. JAMA Netw Open. 2021 Aug 2;4(8):e2121893. doi: 10.1001/jamanetworkopen.2021.21893. PMID: 34424304; PMC8383132.
 
Gressel GM, Usyk M, Frimer M, Kuo DYS, Burk RD. Characterization of the endometrial, cervicovaginal and anorectal microbiota in post-menopausal women with endometrioid and serous endometrial cancers. PLoS One. 2021 Nov 5;16(11):e0259188. doi: 10.1371/journal.pone.0259188. PMID: 34739493; PMC8570463.
 
Chen Z, Utro F, Platt D, DeSalle R, Parida L, Chan PKS, Burk RD. K-Mer Analyses Reveal Different Evolutionary Histories of Alpha, Beta, and Gamma Papillomaviruses. Int J Mol Sci. 2021 Sep 6;22(17):9657. doi: 10.3390/ijms22179657. PMID: 34502564; PMC8432194.
 
Kurilshikov,  A. . . . Burk, R.D. . . . Zhernakova, A. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat. Genet. 53: 156-165, 2021. doi: 10.1038/s41588-020-00763-1; PMID: 33462485; PMC8515199.
 
 
Chen, Z., DeSalle, R., Schiffman, M., Herrero, R., Wood, C.E., Ruiz, J.C., Clifford, G.M., Chan, P.K.S. and Burk, R.D.  Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans. PLoS Pathog. 2018, 14(11): e1007352. PMID: 30383862; PMC6211759.
 
Mirabello. L., Yeager, M., Yu, K., Clifford, G.M., Xiao, Y., Zhu, B., Cullen, M., Boland, J.F., Wentzensen, N., Nelson, C.W., Raine-Bennett, T., Chen, Z., Bass, S., Song, L., Yang, Q., Steinberg, M., Burdett, L., Dean, M., Roberson, D., Mitchell, J., Lorey, T., Franceschi, S., Castle, P.E., Walker, J., Zuna, R., Kreimer, A.R., Beachler, D.C., Hildesheim, A., Gonzalez, P., Porras, C., Burk, R.D.* (co-last author), Schiffman, M.*HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis. Cell. 2017 Sep 7;170(6):1164-1174.PMID: 28886384; PMC5674785

EMR ID

3213

Biography

Robert D. Burk, MD, is an attending physician at the Children’s Hospital at Montefiore Einstein. He is Professor and Vice Chair, Translational Research, Pediatrics, Genetic Medicine, and Professor of Microbiology & Immunology; Epidemiology & Population Health; and Obstetrics, Gynecology & Women’s Health at our Albert Einstein College of Medicine. Dr. Burk’s clinical focus centers on cancer genetics and inherited cancer risk.After earning his Doctor of Medicine at George Washington University School of Medicine in 1976, Dr. Burk completed a surgical internship at the University of California, San Francisco, in 1977. He remained at this institution to complete his pediatric residency in 1980, followed by a medical genetics fellowship at The Johns Hopkins University School of Medicine in 1983. He then became a Senior Research Fellow in molecular virology and hepatology at the Albert Einstein College of Medicine until 1984.Dr. Burk’s research focuses on human papillomavirus (HPV) genomics and its association with cancer and human microbiome studies, investigating the role of the human microbiome in health through large epidemiological studies. His work has been published in numerous peer-reviewed journals and shared through community presentations, media appearances, invited lectures, review articles and book chapters. He is a reviewer for many scientific journals, including the New England Journal of Medicine, Hepatology and the Journal of Virology, among others.Dr. Burk is a Diplomate of the National Board of Medical Examiners, the American Board of Pediatrics and the American Board of Medical Genetics as a Clinical Geneticist. He is or has been a member of several professional organizations, including the American Society for Microbiology, the American Society of Human Genetics and the Society for Pediatric Research, among others. In 2013, Dr. Burk received the Honorary Alumnus Award and the Saul R. Korey Award in Translational Science & Medicine from the Albert Einstein College of Medicine. In 2015, he became an Elected Fellow of the American Association for the Advancement of Science.

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