Cancer

Jeffrey E. Segall

Read more about Jeffrey E. Segall

Jeffrey E. Segall

https://assets.montefioreeinstein.org/profiles/images/Segall_Jeffrey_PhD_2x.jpg

Faculty

Expert

First Name

Jeffrey

Last Name

Segall

Faculty ID

8206

Patient Type

Adult

Department

einstein-dept-pathology

jeffrey.segall@einsteinmed.edu

Phone

718-430-2484

Titles

Type

Academic

Department

Department of Pathology

Department Link

Rank

Professor Emeritus

Tags

me-patientcare-cancer-research-cdtmi

me-patientcare-cancer-research-cdtmi-members

Type

Administrative

Title

Betty and Sheldon Feinberg Senior Faculty Scholar in Cancer Research

Locations

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Golding Building

Room

603

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

As of July 1, 2023 I have shifted to emeritus status.  My deepest thanks and gratitude for the many students and colleagues with whom I have collaborated over the past forty years.  I have closed my lab and am no longer taking on new staff.  However, I am happy to collaborate and discuss research by zoom or in person.
My scientific interests remain focused on the mechanisms by which tumor cells invade and metastasize. Tumor cell motility and the orientation of tumor cells by chemotaxis make important contributions to invasion and metastasis.  My expertise is in breast cancer, head and neck cancer, and glioblastoma. Breast cancer, although the primary tumor can be fully removed, metastasizes to distant sites, and the resulting metastases can lead to poor prognosis.  Glioblastoma and head and neck cancer invade locally into critical areas and the primary tumors are not fully removable by surgery.  I have familiarity with tissue culture studies of invasion and signaling of these cancers and in vivo analysis in mice. 
In addition, due to my long time association with the Einstein Senate, I am working on bringing all the minutes of the Senate along with brief summaries onto the Einstein website.  Einstein is a remarkable medical school with accomplishments that we are all proud of.  The minutes provide an interesting perspective on the trials and triumphs of this amazing place.

Research Areas

mechanisms of tumor cell invasion, intravasation and metastasis; mechanical effects of the tumor microenvironment; macrophage tumor cell interactions; breast cancer; head and neck cancer; glioblastoma; intravital imaging

Specialties

Cancer

Expert Tags

Cancer Biology

Imaging

Areas of Expertise

Brain cancer

Breast cancer

Glioblastoma

Head and neck cancer

Expert Summary

Dr. Segall studies how tumor cells invade tissues and spread through the body. He has developed sophisticated imaging methods for following individual tumor cells moving in living animals. For example, one of his techniques involves a tiny glass window implanted in the skin of a mouse that allows scientists to track individual cancer cells as they spread a tumor site and attack other parts of the body. This technique could one day be used for assessing the effectiveness of specific drugs in preventing cancer from metastasizing.
Dr. Segall studies breast cancer, head and neck cancer and glioblastoma (an aggressive form of brain cancer). He investigates how protein receptors on the surfaces of tumor cells guide the tumor cells in response to signals sent out by the local tumor microenvironment. Dr. Segall has served on study sections for the U.S. Department of Defense Breast Cancer Research Program, the American Cancer Society and the National Institutes of Health. He currently serves on the NIH’s Tumor Microenvironment study section.

Research Profile

https://einsteinmed.edu/faculty/8206/Jeffrey-Segall

CHAM Provider

Off

Professional Title

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/928a83b3-17e3-4dbd-84fd-dadd257df…

Selected Publications

A.        Original Communications in Reviewed Journals
1.      Chiang, P.K., Guranowski, A. and J.E. Segall (1981) Irreversible Inhibition of S-Adenosylhomocysteine Hydrolase by Nucleoside Analogs. Arch. Bioc. Bioph. 207:175:184.
2.      Segall, J.E., Manson, M.D. and H.C. Berg. (1982) Signal Processing Times in Bacterial Chemotaxis.  Nature 296:855-857. PubMed PMID: 7040985.
3.      Block, S.M., Segall, J.E. and H.C. Berg. (1982) Impulse Responses in Bacterial Chemotaxis.  Cell 31:215-226. PubMed PMID: 6760985
4.      Block SM, Segall JE, Berg HC. Adaptation kinetics in bacterial chemotaxis. J Bacteriol. 1983 Apr;154(1):312-23. PubMed PMID: 6339475; PubMed Central PMCID: PMC217461.
5.      Ishihara A, Segall JE, Block SM, Berg HC. Coordination of flagella on filamentous cells of Escherichia coli. J Bacteriol. 1983 Jul;155(1):228-37. PubMed PMID: 6345503; PubMed Central PMCID: PMC217673.
6.      Segall, J.E., Ishihara, A. and H.C. Berg. (1985) Chemotactic Signaling in Filamentous Cells of Escherichia coli. J. Bacter. 161:51-59. PubMed PMID: 3881399; PubMed Central PMCID: PMC214834.
7.      Segall, J.E., Block, S.M, and H.C. Berg. (1986) Temporal Comparisons in Bacterial Chemotaxis.  Proc. Natl. Acad. Sci. USA 83:8987-8991. PubMed PMID: 3024160; PubMed Central PMCID: PMC387059
8.      Segall, J.E., Fisher, P.R. and G. Gerisch. (1987) Selection of Chemotaxis Mutants of Dictyostelium discoideum. J. Cell Biol. 104:151-161. PubMed PMID: 3793759; PubMed Central PMCID: PMC2117037.
9.      Segall, J.E.. (1988) Analysis of Responses of Dictyostelium discoideum Amoebae to Chemoattractant Concentration Changes. J. Muscle Res. Cell Mot. 9:481-490. PubMed PMID: 2850298.
10.   Segall, J.E.,  Bominaar, A., Wallraff, E. and R. de Wit. (1988) Analysis of a Dictyostelium Chemotaxis Mutant with Altered Chemoattractant Binding. J. Cell Sci. 91:479-489. PubMed PMID: 3255752.
11.   Andre, E., Brink, M., Gerisch, G., Isenberg, G., Noegel, A., Schleicher, M., Segall, J. E., and E. A. Wallraff. (1989)  A Dictyostelium Mutant Deficient in Severin, an F-actin Fragmenting Protein,  Shows Normal Motility and Chemotaxis. J. Cell Biol. 108:985-995. PubMed PMID: 2537840; PubMed Central PMCID: PMC2115376.
12.   Brinke, J., Gerisch, G., Isenberg, G., Noegel, A.A., Segall, J.E., Wallraff, E., and M. Schleicher. (1990) A Dictyostelium Mutant lacking an F-actin Crosslinking Protein, the 120 kD Gelation Factor.  J. Cell Biol. 111:1477-1489. PubMed PMID: 1698791; PubMed Central PMCID: PMC2116242.
13.   Barisic, K., Mollner, S., Noegel, A. A., Gerisch, G., and J. E. Segall. (1991) cDNA Sequence of Cyclophilin from Dictyostelium discoideum.  Developmental Genetics, 12:50-53. PubMed PMID: 2049879.
14.   Segall, J.E. (1992) Behavioral responses of streamer F mutants of Dictyostelium discoideum: effects of cyclic GMP on cell motility.  J. Cell Sci., 101:589-597. PubMed PMID: 1325982.
15.   Segall, J.E. (1993) Polarization of yeast cells in spatial gradients of mating factor.  Proc. Natl. Acad. Sci. 90:8332-8336. PubMed PMID: 8397402; PubMed Central PMCID: PMC47350.
16.   Segall, J.E., Kuspa, A., Shaulsky, G., Ecke, M., Maeda, M., Gaskins, C., Firtel, R.A., and W.G. Loomis. (1995) A MAP kinase necessary for receptor-mediated activation of adenylate cyclase in Dictyostelium.  J. Cell Biol. 128:405-413. PubMed PMID: 7844154; PubMed Central PMCID: PMC2120359.
17.   Segall, J.E., Tyrech, S., Boselli, L., W., Masseling, S., Chan, A., Helft, J,  Jones, J. and J. Condeelis.  (1996) EGF stimulates lamellipod extension and chemotaxis in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism.  Clin. Exp. Met. 14:61-72.
18.   Gaskins, C., Clark, A.M., Aubry, L., Segall, J.E., Firtel, R.A. (1996) The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways.  Genes and Dev. 10:118-128. PubMed PMID: 8557190.
19.   Knetsch, M.L.W., Epskamp, S.J.P., Schenk, P.W., Segall, J.E., and B.E. Snaar-Jagalska. (1996) Both G-protein and ras-dependent activation of extracellular signal regulated kinase 2 is antagonized by intracellular cAMP in Dictyostelium discoideum.  EMBO J. 15:3361-3368. PubMed PMID: 8670837; PubMed Central PMCID: PMC451899.
20.   Leberer, E., Wu, C., Leeuw, T., Fourest-Lieuvin, A., Segall, J.E., and D. Y. Thomas (1996) Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase.  EMBO J. 16:83-97. PubMed PMID: 9009270; PubMed Central PMCID: PMC1169616.
21.   Edmonds, B.T., Wyckoff, J., Yeung, Y.-G., Wang, Y., Stanley, E.R., Jones, J., Segall, J.E., and J. Condeelis (1996) Elongation factor-1alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma.  J. Cell Science 109:2705-2714.
22.   Chan, A., Raft, S., Bailly, M., Wyckoff, J., Segall, J. and Condeelis, J. (1998) EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells.  J. Cell Sci. 111:199-211.
23.   Wang, Y., Liu, J. and J.E. Segall (1998) MAP kinase function in amoeboid chemotaxis.  J. Cell Sci. 111:373-383. PubMed PMID: 9427685.
24.   Wang, Y. and J.E. Segall (1998) The Dictyostelium MAP kinase DdERK2 functions as a cytosolic protein in complexes with its substrates in chemotactic signal transduction.  Biochem. Biophys. Res. Comm. 244:149-155. PubMed PMID: 9514860.
25.   Bailly, M., Yan, L., Whitesides, G.M., Condeelis, J.S., and J.E. Segall (1998) Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells.  Exp. Cell Res. 241:285-299.
26.   Farina, K., Wyckoff, J., Rivera, J., Lee, H., Segall, J., Condeelis, J. and Jones, J. (1998) Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein.  Cancer Res. 58:2528-2532.
27.   Wyckoff, J.B., Insel, L., Khazaie, K., Lichtner, R.B., Condeelis, J.S. and J.E. Segall (1998) Suppression of ruffling by EGF in chemotactic cells.  Exp. Cell Res. 242:100-109.
28.   Bailly, M., Macaluso, F., Cammer, M., Chan, A., Segall, J.E., and J.S. Condeelis.  (1999) Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after EGF stimulation.  J. Cell Biol. 145:331-345.
29.   Hill, K., Welti, S., Yu, J., Murray, J.T., Yip, S., Condeelis, J.S., Segall, J.E., Backer, J.M. (2000) Specific requirement for the p85-p110alpha PI 3-kinase during EGF-stimulated actin nucleation in breast cancer cells. J. Biol. Chem. 275:3741-3744.
30.   Chan,A.Y.,  Bailly,M.,  Zebda,N.,  Segall,J.E, and J.S. Condeelis (2000) Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion.  J Cell Biol. 148:531-542. 
31.   Wyckoff, J.B.,Jones, J.G., Condeelis, J. C., and J E. Segall (2000) A critical step in metastasis: In vivo analysis of intravasation at the primary tumor.  Cancer Res. 60:2504-2511.  PubMed PMID: 10811132.
32.   Wyckoff, J.B., Segall, J.E. and Condeelis, J.C. (2000) The collection of the motile population of cells from a living tumor. Cancer Res. 60:5401-5404. 
33.   Bailly,M. , Wyckoff,J.B., Bouzahzah, B., Hammerman,R., Sylvestre,V., Cammer,M., Pestell,R.G., and J. E. Segall (2000) Distribution of the EGF receptor in chemotaxing adenocarcinoma cells. Mol. Biol. Cell. 11:3873-3883. 
34.   Hill, K.M., Huang, Y, Yip, S.-C., Yu, J., Segall, J.E., and J.M. Backer. (2001) N-terminal domains of the class IA phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling.  J. Biol. Chem.  276:16374-16378. 
35.   Bailly, M., Ichetovkin, I., Grant, W., Zebda, N., Machesky, L.M., Segall, J.E., and J. Condeelis (2001)  The F-actin side binding activity of the Arp 2/3 complex is essential for actin nucleation and lamellipod extension.  Curr. Biol. 11: 620-625.
36.   Bouzahzah, B., Albanese, C., Ahmed, F., Pixley, F., Lisanti, M. P, Segall, J.E., Condeelis, J., Joyce, J., Minden, A, Der, C.J., Chan, A., Symons, M. and R. G. Pestell. (2001) Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways.  Mol. Med. 7: 816–830.
37.   Wang, W., Wyckoff, J.B., Frohlich, V.C., Oleynikov, Y., Huttelmaier, S., Zavadil, J., Cermak, L., Bottinger, E.P., Singer, R.H., White, J.G., Segall, J.E., and J.S. Condeelis.  (2002) Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res. 62:6278-88.
38.   Vallier, L.G., Segall, J.E., and M. Snyder. (2002) The alpha-factor receptor C-terminus is important for mating projection formation and orientation in Saccharomyces cerevisiae.  Cell Motil Cytoskeleton 53:251-66. PubMed PMID: 12378535
39.   Butty, A.C., Perrinjaquet, N., Petit, A., Jaquenoud, M., Segall, J.E., Hofmann, K., Zwahlen, C., and M. Peter.  (2002)  A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.  EMBO J 21:1565-76. PubMed PMID: 11927541; PubMed Central PMCID: PMC125953.
40.   Ahmed F, Wyckoff J, Lin EY, Wang W, Wang Y, Hennighausen L, Miyazaki J, Jones J, Pollard JW, Condeelis JS, Segall JE. (2002) GFP Expression in the Mammary Gland for Imaging of Mammary Tumor Cells in Transgenic Mice. Cancer Res. 62:7166-9. PubMed PMID: 12499251.
41.   Wang W, Wyckoff JB, Wang Y, Bottinger EP, Segall JE, Condeelis JS. (2003) Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse.  BMC Biotechnol. 3:13-25.
42.   Kempiak, S., Yip, J.-L., Backer, J., and J. E. Segall (2003) Local signaling by the EGF receptor. J. Cell Biol.162:781-787.  PubMed PMID: 12952932; PubMed Central PMCID: PMC2172819.
43.   Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER, Graf T, Pollard JW, Segall J, Condeelis J (2004 ) A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64:7022-9.
44.   Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E, Singer RH, Segall JE, Condeelis JS. (2004) Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.  Cancer Res. 64:8585-94.
45.   Kempiak SJ, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy RJ, Desmarais V, Way M, Condeelis JS, Segall JE (2005) J. Biol. Chem.  280:5836-5842.
46.   Goswami S, Sahai E, Wyckoff J, Cox D, Pixley F, Stanley ER, Segall JE, Condeelis, J (2005)  Macrophages promote the invasion of carcinoma cells in vitro via a paracrine loop.  Cancer Res. 65:5278-83.
47.   Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, Condeelis J. (2005)  Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.  J Cell Biol. 168(3):441-52.
48.   Sahai E, Wyckoff J, Philippar U, Segall JE, Gertler F, Condeelis J.  (2005) Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnol. 5:14-22.
49.   Soon L, Mouneimne G, Segall J, Wyckoff J, Condeelis J. (2005) Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis. Cell Motil Cytoskeleton. 62(1):27-34.
50.   Xue C, Wyckoff J, Liang F,Sidani M, Violini S, Tsai K-L, Zhang Z-Y, Sahai E, Condeelis J, Segall JE (2006) EGF receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis.  Cancer Res. 66:192-7
51.   Xue C, Liang F, Mahmood R, Vuolo M, Wyckoff J, Qian H, TsaiK-L, Kim M,  Locker J, Zhang Z-Y, Segall JE (2006 ) ErbB3-dependent motility and intravasation in breast cancer metastasis. Cancer Res. 66: 1418-1426.
52.   Chen S, Segall JE (2006) EppA, a putative substrate of DdERK2, regulates cyclic AMP relay and chemotaxis in Dictyostelium discoideum. Eukaryot Cell. 5:1136-46. PubMed PMID: 16835457; PubMed Central PMCID: PMC1489283.
53.   Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER, Segall JE, Pollard JW, Condeelis J.  (2007) Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.  Cancer Res. 67:2649-56.
54.   Wang W, Wyckoff JB, Goswami S, Wang Y, Sidani M, Segall JE, Condeelis JS. (2007) Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.  Cancer Res. 67:3505-11.
55.   Pu J, McCaig CD, Cao L, Zhao Z, Segall JE, Zhao M. (2007) EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells.  J Cell Sci. 120 :3395-403. 
56.   Kedrin D, Gligorijevic B, Wyckoff J, Verkhusha VV, Condeelis J, Segall JE, van Rheenen J (2008) Intravital imaging of metastasis through an orthotopic Mammary Imaging Window.  Nature Methods. Nature Methods. 5:1019-21
57.   Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Stanley ER, Cox D, Muller WJ, Pollard JW, van Rooijen N, Segall JE (2009) EGF/CSF-1 Induced Breast Cancer Cell Invasion is Triggered by Heregulin Beta 1 and CXCL12. Cancer Res. 69:3221-7.
58.   Kedrin D, Wyckoff JB, Hynes NE, Arteaga CL, Segall JE (2009) ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin. Cancer Res. 15: 3733-9.
59.   Gligorijevic B, Kedrin D, Segall JE, Condeelis J, van Rheenen J. (2009) Dendra2 photoswitching through the Mammary Imaging Window.  J Vis Exp. 28:1278.  
60.   Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET, Wu H, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM. (2009) Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.  Cancer Res. 69(23):8868-76. 
61.   Piatkevich KD, Hulit J, Subach OM, Wu B, Abdulla A, Segall JE, Verkhusha VV. (2010) Monomeric red fluorescent proteins with a large Stokes shift. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5369-74.
62.   Hernandez L, Magalhaes MA, Coniglio SJ, Condeelis JS, Segall JE: Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast cancer research : BCR 2011, 13(6):R128.
63.   Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW, Kitsis RN: Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer research 2011, 71(24):7705-7715.
64.   Loudig O, Brandwein-Gensler M, Kim RS, Lin J, Isayeva T, Liu C, Segall JE, Kenny PA, Prystowsky MB: Illumina whole-genome complementary DNA-mediated annealing, selection, extension and ligation platform: assessing its performance in formalin-fixed, paraffin-embedded samples and identifying invasion pattern-related genes in oral squamous cell carcinoma. Human pathology 2011, 42(12):1911-1922.
65.   Boimel PJ, Cruz C, Segall JE: A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer. Genomics 2011, 98(3):164-172.
66.   Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE et al: Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of cell science 2011, 124(Pt 13):2120-2131.
67.   Smirnova T, Adomako A, Locker J, Van Rooijen N, Prystowsky MB, Segall JE: In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. The American journal of pathology 2011, 178(6):2857-2865.
68.   Henkels KM, Farkaly T, Mahankali M, Segall JE, Gomez-Cambronero J: Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3). Journal of molecular biology 2011, 408(5):850-862.
69.   Boimel PJ, Smirnova T, Zhou ZN, Wyckoff J, Park HI, Coniglio SJ, Patel P, Qian BZ, Stanley ER, Bresnick AR et al: Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast cancer research : BCR 2012, 14(1):R23.
70.   Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE: Microglial stimulation of glioblastoma invasion involves EGFR and CSF-1R signaling. Molecular medicine (Cambridge, Mass) 2012.
71.   Harris T, Jimenez L, Kawachi N, Fan JB, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R et al: Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas. The American journal of pathology 2012, 180(3):917-928.
72.   Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS et al: Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene 2012, 31(6):706-71.
73.   Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, Sosa MS, Aguirre-Ghiso JA, Segall JE. (2012). Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PloS one. 7(4):e35569.  PMID: 22530051 / PMCID: PMC3329481.
74.   Ishihara D, Dovas A, Hernandez L, Pozzuto M, Wyckoff J, Segall JE, Condeelis JS, Bresnick AR, Cox D. (2013) Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis. Cell Rep. 4(3):429-36. PubMed PMID: 23911287.
75.   Zhou ZN, Sharma V, Beaty B, Roh-Johnson M, van Rooijen N, Kenny P, Wiley S, Condeelis J, Segall JE.  (2013) Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo.  Oncogene 33(29):3784-93.
76.   Ishihara D, Dovas A, Hernandez L, Pozzuto M, Wyckoff J, Segall JE, Condeelis JS, Bresnick AR, Cox D. WASp is required for tumor associated macrophages to promote breast carcinoma cell invasion and metastasis. Cell Reports. 2013 4:429-36.
77.   Qian X, Hulit J, Suyama K, Eugenin EA, Belbin TJ, Loudig O, Smirnova T, Zhou ZN, Segall J, Locker J, Phillips GR, Norton L, Hazan RB. p21CIP1 mediates reciprocal switching between proliferation and invasion during metastasis. Oncogene. 2013 May 2;32(18):2292-303.
78.   Kim S, Yao J, Suyama K, Qian X, Qian BZ, Bandyopadhyay S, Loudig O, De Leon-Rodriguez C, Zhou ZN, Segall J, Macian F, Norton L, Hazan RB. Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis. Cancer Res. 2014 Jul 15;74(14):3695-706.
79.   Jimenez L, Sharma VP, Condeelis J, Harris T, Ow TJ, Prystowsky MB, Childs G, Segall JE. MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. Arch Pathol Lab Med. 2015 Nov;139(11):1349-61. doi: 10.5858/arpa.2014-0471-OA. Epub 2015 Jul 14.  PubMed PMID: 26172508; PubMed Central PMCID: PMC4628565
80.   Jimenez L, Lim J, Burd B, Harris TM, Ow TJ, Kawachi N, Belbin TJ, Angeletti R, Prystowsky MB, Childs G, Segall JE. miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin. Am J Pathol. 2017 Jul;187(7):1523-1536. doi: 10.1016/j.ajpath.2017.02.019. Epub 2017 May 10. PubMed PMID: 28499703; PubMed Central PMCID: PMC5500828
81.   Jayakar SK, Loudig O, Brandwein-Gensler M, Kim RS, Ow TJ, Ustun B, Harris TM, Prystowsky MB, Childs G, Segall JE, Belbin TJ. Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma. Am J Pathol. 2017 Oct;187(10):2259-2272. doi: 10.1016/j.ajpath.2017.06.016. Epub 2017 Jul 24. PubMed PMID: 28751006; PubMed Central PMCID: PMC5762938.
82.   Donnelly SK, Cabrera R, Mao SPH, Christin JR, Wu B, Guo W, Bravo-Cordero JJ, Condeelis JS, Segall JE, Hodgson L. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017 Dec 4;216(12):4331-4349. doi: 10.1083/jcb.201704048. Epub 2017 Oct 23. PubMed PMID: 29061650; PubMed Central PMCID: PMC5716284. 
83. Suyama K, Yao J, Liang H, Benard O, Loudig OD, Amgalan D, McKimpson WM,Phillips GR, Segall J, Wang Y, Fineberg S, Norton L, Kitsis RN, Hazan RB. An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis. Cancer Res. 2018 Jan 1;78(1):103-114. doi: 10.1158/0008-5472.CAN-15-1462. Epub 2017 Oct 16. PubMed PMID: 29038347.  
84. Cabrera RM, Mao SPH, Surve CR, Condeelis JS, Segall JE. A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration. Breast Cancer Res. 2018 Apr 10;20(1):24. doi: 10.1186/s13058-018-0960-8. PubMed PMID: 29636067; PubMed Central PMCID: PMC5894135. 
85. Mao SPH, Park M, Cabrera RM, Christin JR, Karagiannis GS, Oktay MH, Zaiss DMW, Abrams SI, Guo W, Condeelis JS, Kenney PA, Segall JE. Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth.  Breast Cancer Res. 2018 Oct 26;20(1):131. doi: 10.1186/s13058-018-1057-0. PubMed PMID: 30367629; PubMed Central PMCID: PMC6203982. 
86. Suh YJ, Hall MS, Huang YL, Moon SY, Song W, Ma M, Bonassar LJ, Segall JE, Wu M. Glycation of collagen matrices promotes breast tumor cell invasion. Integr Biol (Camb). 2019 May 1. pii: zyz011. doi: 10.1093/intbio/zyz011. PubMed PMID: 31041443. 
87. Carter KP, Hanna S, Genna A, Lewis D, Segall J E, Cox D.  Macrophages enhance 3D invasion in a breast cancer cell line by induction of tumor cell tunneling nanotubes. Cancer Reports. 2019 Dec;2(6):e1213. doi: 10.1002/cnr2.1213. Epub 2019 Aug 28. PMID: 32467880; PMCID: PMC7254960.  
88. Dalaka E, Kronenberg NM, Liehm P, Segall JE, Prystowsky MB, Gather MC. Direct measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia. Sci Adv. 2020 Mar 11;6(11):eaax6912. doi:10.1126/sciadv.aax6912. PMID: 32195338; PMCID: PMC7065877. 
89. Huang YL, Ma Y, Wu C, Shiau C, Segall JE, Wu M. Tumor spheroids under perfusion within a 3D microfluidic platform reveal critical roles of cell-cell adhesion in tumor invasion. Sci Rep. 2020 Jun 15;10(1):9648. doi:10.1038/s41598-020-66528-2. PMID: 32541776; PMCID: PMC7295764.
 90. Huang YL, Shiau C, Wu C, Segall JE, Wu M. The architecture of co-culture spheroids regulates tumor invasion within a 3D extracellular matrix. Biophys Rev Lett. 2020 Sep;15(3):131-141. doi: 10.1142/s1793048020500034. Epub 2020 Jul 13. PMID: 33033500; PMCID: PMC7540657.
91. Gadsden NJ, Fulcher CD, Li D, Shrivastava N, Thomas C, Segall JE, Prystowsky MB, Schlecht NF, Gavathiotis E, Ow TJ. Palbociclib Renders Human Papilloma Virus-Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax. Mol Cancer Res. 2021 May;19(5):862-873. doi:10.1158/1541-7786.MCR-20-0915. Epub 2021 Jan 25. PMID: 33495400; PMCID: PMC8314015. 
92. Huelsemann M, Sanchez C, Verkhusha PV, Des Marais V, Mao SPH, Donnelly SK, Segall JE, Hodgson L. TC10 regulates breast cancer invasion and metastasis bycontrolling membrane type-1 matrix metalloproteinase at invadopodia. Commun Biol. 2021 Sep 16;4(1):1091. doi: 10.1038/s42003-021-02583-3. PMID: 34531530. 
93. Coniglio SJ, Segall JE. Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin. PLoS One. 2021 Nov 29;16(11):e0260252. doi: 10.1371/journal.pone.0260252. PMID: 34843542; PMCID: PMC8629255. 
94. Cheung BCH, Hodgson L, Segall JE, Wu M. Spatial and temporal dynamics of RhoA activities of single breast tumor cells in a 3D environment revealed by a machine learning-assisted FRET technique. Exp Cell Res. 2022 Jan 15;410(2):112939. doi: 10.1016/j.yexcr.2021.112939. Epub 2021 Nov 20. PMID: 34813733; PMCID: PMC8714707. 
95. Sharma VP, Tang B, Wang Y, Duran CL, Karagiannis GS, Xue EA, Entenberg D, Borriello L, Coste A, Eddy RJ, Kim G, Ye X, Jones JG, Grunblatt E, Agi N, Roy S, Bandyopadhyaya G, Adler E, Surve CR, Esposito D, Goswami S, Segall JE, Guo W, Condeelis JS, Wakefield LM, Oktay MH. Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination. Nat Commun. 2021 Dec 15;12(1):7300. doi: 10.1038/s41467-021-27308-2. PMID: 34911937; PMCID: PMC8674234. 
96. Suh YJ, Pandey M, Segall JE, Wu M. Tumor spheroid invasion in epidermal growth factor gradients revealed by a 3D microfluidic device. Phys Biol. 2022 Mar 10;19(3). doi: 10.1088/1478-3975/ac54c7. PMID: 35158347.
  
B.  Books, Chapters in Books, and Review Articles
 1.      Segall, J.E. and G. Gerisch (1989) Genetic approaches to cytoskeleton function and the control of cell motility.  Curr. Op. Cell Biol.: Cytoplasm and Cell Motility.  1:44-50. PubMed PMID: 2560931.
2.      Gerisch, G., Segall, J.E. and E. Wallraff. (1989) Isolation and Behavioral Analysis of Mutants Defective in Cytoskeletal Proteins.  Cell Motility and the Cytoskeleton.  14:75-79.  PubMed PMID: 2684431.
3.      Segall, J. E. (1990) Mutational Studies of Amoeboid Chemotaxis using Dictyostelium discoideum.  In: Biology of the Chemotactic Response, (J. Armitage and J. Lackie, eds.)  Cambridge University Press, Cambridge, pp 241--272.
4.      Jones, J., Segall, J.E. and J. Condeelis. (1991) Molecular analysis of amoeboid chemotaxids:  parallel observation in amoeboid phagocytes and metastatic tumor cells.  In Cytokines and Cell Motility (I. Goldberg and E. Rosen, eds.) Birkhauser Verlag, New York.  PubMed PMID: 1833224.
5.      Manson, M.D., and J.E. Segall (1992) Chemotaxis.  In The Encyclopedia of Microbiology (J. Lederberg, ed.) Academic Press, San Diego.
6.      Condeelis, J., Jones, J., and J. E. Segall (1992) Chemotaxis of metastatic tumor cells: clues to mechanisms from the Dictyostelium paradigm.  Cancer and Metastasis Reviews 11:55-68.
7.      Mann, S. P. Devreotes, S. Eliott, K. Jermyn, A. Kuspa, M. Fechheimer, R. Furukawa, C. Parent, J. Segall, G. Shaulsky, P. Vardy, J. Williams, and R. Firtel. (1994) Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium.  In: "Cell Biology:  A Laboratory Handbook" (ed J. Celis), Academic Press 1:412-451.
8.      Cammer, M., Wyckoff, J. and J.E. Segall (1997) Computer-assisted analysis of single cell motility.  In: Basic Cell Culture Protocols (eds. J.M. Walker and J.W. Pollard), Methods in Molecular Biology, 75:459-470.
9.      Zigmond, S.H., Foxman, E.F. and J.E. Segall (1998) Chemotaxis Assays for Eukaryotic Cells. In: Current Protocols in Cell Biology (eds) Bonifacino, J.S., et al.  New York, John Wiley & Sons. (in press).
10.   Bailly, M. Condeelis, J. and Segall, J.E. (1998) Chemoattractant-induced lamellipod extension.  Microscopy Research and Technique. 43:433-443
11.   Segall, J.E. (1999) Cell Polarization: Chemotaxis gets cracking. Current Biology  9:R46-R48.
12.   Pestell, R.G., Albanese, C., Reutens , A.T., Segall,  J.E., Lee, R.J., and Arnold, A. (1999) The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20:501-34.
13.   Condeelis, J.S., Wyckoff, J., and J. E. Segall (2000) Imaging of cancer invasion and metastasis using green fluorescent protein.  Eur. J. Cancer 36:1671-1680.
14.   Condeelis. J.S., Wyckoff, J.B., Bailly, M.,  Pestell, R., Lawrence,D., Backer, J., and Jeffrey E. Segall (2001) Lamellipodia in invasion.  Sem. Canc. Biol. 11:119-128.
15.   Condeelis, J. and J.E. Segall (2003) Intravital imaging of cell movements in tumors.  Nat. Rev. Canc. 3:921-930.
16.   Condeelis J, Song X, Backer J, Wyckoff J and JE Segall (2003) Chemotaxis of cancer cells during invasion and metastasis. In: Cell Motility:  from molecules to organisms. (Editors: Anne Ridley, Michelle Peckham, Peter Clark) Wiley & Sons. 175-188.
17.   Kempiak, S.J. and J.E. Segall (2004) Stimulation of cells using EGF-coated magnetic beads. Sci STKE. 218:pl1.
18.   Meili, R., Richard A. Firtel, R.A.  and J. E. Segall. (2004) Molecular Mechanisms of Chemotaxis in Amoebae.  In: Chemotaxis (editor Michael Eisenbach) U.K.,  Imperial College Press. 253-294.
19.   Bozzaro, S., Fisher P.R., Loomis, W., Satir, P. and J. E. Segall (2004) Guenther Gerisch and Dictyostelium, the microbial model for ameboid motility and multicellular morphogenesis.  Trends Cell Biol. 14:585-9.
20.   Wyckoff J, Segall JE, and J Condeelis (2005) “Chapter 22:  Single cell imaging in animal tumors in vivo” in Live Cell Imaging: a Laboratory Manual, Eds.:  D.L. Spector and R.D. Goldman.  CSHL.  Cold Spring Harbor, NY. Pp. 409 - 422.
21.   Wang W, Goswami S, Sahai E, Wyckoff JB, Segall JE, Condeelis JS. (2005) Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol. 15:138-45.
22.   Ingman, W., Wyckoff J, Xue C, Lin EY, Wang W, Goswami S, Pollard JW, Condeelis J, and JE Segall (2005) Imaging Invasion and Metastasis In vivo.  In: Cell Motility in Cancer Invasion and Metastasis (editor Alan Wells), Kluwer Academic Publishers.
23.   Condeelis J, Singer R, Segall JE (2005) The great escape: When cancer cells hijack the genes for chemotaxis and motility.  Ann. Rev. Cell Dev. Biol. 21: 695-718.
24.   Sidani M, Wyckoff J, Xue C, Segall JE, Condeelis J. (2006) Probing the microenvironment of mammary tumors using multiphoton microscopy.  J Mammary Gland Biol Neoplasia. 11:151-63.
25.   Wyckoff JB, Condeelis J, Segall JE (2006) Growth factor receptors – doing more than just stimulating tumor growth?  BIF Futura. 21:219-223.
26.   Kedrin D, Wyckoff J, Sahai E, Condeelis J, Segall JE (2007)  Imaging of tumor cell movement in vivo.  Current Protocols in Cell Biology.  19.7.1 – 19.7.17.
27.   Smirnova T, Segall JE (2007) Amoeboid chemotaxis: future challenges and opportunities.  Cell Adhesion and Migration. 1:4, 1-6.
28.   Kedrin D, van Rheenen J, Hernandez L, Condeelis J, Segall JE (2007) Cell motility and cytoskeletal regulation in invasion and metastasis.  J. Mam. Gland Biol. Neoplasia. 12: 143-52.
29.   Symons M and Segall JE (2009) Rac and Rho driving tumor invasion: who’s at the wheel? Genome Biology.10:213.1 - .4.
30.   Hernandez L, Smirnova T, Wyckoff J, Condeelis J, Segall JE (2009) In vivo assay for tumor cell invasion.  Methods in Molecular Biology. 571:227-38
31.   Zhou ZN, Boimel PJ, Segall JE: Tumor-stroma: In vivo assays and intravital imaging to study cell migration and metastasis. Drug discovery today Disease models 2011, 8(2-3):95-112.
32.   Wyckoff J, Gligorijevic B, Entenberg D, Segall J, Condeelis J: The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harbor protocols 2011, 2011(10):1232-1234.
33.   Wyckoff J, Gligorijevic B, Entenberg D, Segall J, Condeelis J: High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harbor protocols 2011, 2011(10):1167-1184.
34.   Locker J, Segall JE: Breast cancer: the matrix is the message. The American journal of pathology 2011, 178(3):966-968.
35.   Childs G, Segall JE. (2012). Twists and turns of invasion. Nature cell biology. 14(4):337-9.  PMID: 22469829.
36.   Friedl P, Locker J, Sahai E, Segall JE. (2012) Classifying collective cancer cell invasion. Nat Cell Biol. 14(8):777-83. PubMed PMID: 22854810.
37.   Hulit J, Kedrin D, Gligorijevic B, Entenberg D, Wyckoff J, Condeelis J, Segall JE. (2012). The use of fluorescent proteins for intravital imaging of tumor cell invasion. In: In vivo cellular imaging using fluorescent proteins: methods and protocols. Hoffman, Robert M. (Ed.)  Methods in Molecular Biology, Vol. 872. Humana Press, pp 15 – 30.
38.   Entenberg D, Kedrin D, Wyckoff J, Sahai E, Condeelis J, Segall JE. (2013) Imaging tumor cell movement in vivo.  Curr Protoc Cell Biol. Chapter 19:Unit19.7.
39.   Coniglio S, Segall JE. Molecular mechanism of microglia stimulated glioblastoma invasion.  Matrix Biology.  2013 32:372-80.
40.   Jimenez L, Jayakar SK, Ow TJ, Segall JE. Mechanisms of Invasion in Head and Neck Cancer. Arch Pathol Lab Med. 2015 Nov;139(11):1334-48. doi: 10.5858/arpa.2014-0498-RA. Epub 2015 Jun 5. Review. PubMed PMID: 26046491.
41.   Coniglio S, Miller I, Symons M, Segall JE. Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion. J Vis Exp. 2016 Oct 20;(116). doi: 10.3791/53990. PubMed PMID: 27805587.
42.   Chiang SP, Cabrera RM, Segall JE. Tumor cell intravasation. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C1-C14. doi: 10.1152/ajpcell.00238.2015. Epub 2016 Apr 13. Review. PubMed PMID: 27076614; PubMed Central PMCID: PMC4967137.
43.   Huang YL, Segall JE, Wu M. Microfluidic modeling of the biophysical microenvironment in tumor cell invasion. Lab Chip. 2017 Sep 26;17(19):3221-3233.  doi: 10.1039/c7lc00623c. PubMed PMID: 28805874.
44.   Carter KP, Segall JE, Cox D.  Microscopic Methods for Analysis of Macrophage-Induced Tunneling Nanotubes. Meth. Mol. Biol. Methods Mol Biol. 2020;2108:273-279. doi: 10.1007/978-1-0716-0247-8_23. PMID: 31939188; PMCID: PMC7594733.

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Steven C. Almo

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Steven C. Almo

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Faculty

Expert

First Name

Steven

Last Name

Almo

Faculty ID

7091

Patient Type

Adult

Department

einstein-dept-biochemistry

steve.almo@einsteinmed.edu

Phone

718-430-2746

Titles

Type

Academic

Department

Department of Biochemistry

Department Link

Rank

Professor

Type

Administrative

Title

Chair, Department of Biochemistry

Type

Administrative

Title

Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology

Type

Administrative

Title

Director, Einstein Macromolecular Therapeutics Developmental Facility

Type

Administrative

Title

Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Cancer Therapeutics Program

Tags

me-patientcare-cancer-research-therapeutics

Locations

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Type

Academic

Location (Address, State, City, Zip)

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Coordinates

POINT (-73.8459022 40.8504961)

Building

Forchheimer Building

Room

308

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

Our laboratory is interested in the development and application of strategies and technologies that enable the high-throughput/large-scale exploration of biological function. These efforts typically take advantage of automation and robotics to achieve the efficiencies and speed required to realize the desired rates of data generation and discovery. This cutting-edge infrastructure has been applied to a number of important biomedical areas to achieve new understanding and new therapeutic opportunities.
Our work on the large-scale annotation of enzyme function is helping to define the metabolic repertoire that exists in Nature and is providing new insights into the contributions of the gut microbiome to human health, the realization of new chemical processes for industry, and expanding our understanding of critical environmental issues, including global nutrient cycles and the evolution of complex microbial communities. Our high-resolution structural and functional analysis of the mammalian immune system has resulted in unprecedented understanding of the molecular mechanisms that control immunity and are guiding the development of novel strategies and reagents (e.g., biologics) for the treatment of infectious diseases, autoimmune diseases and cancers.

Specialties

Expert Tags

Areas of Expertise

Biochemistry

Drug Discovery

Expert Summary

Dr. Steven Almo is an internationally recognized leader in the field of structural biology. His lab uses high-resolution X-ray crystallography to determine the shapes and structures of proteins to better understand their function and help develop new drugs. The goal is to make immunotherapy treatments that more precisely and effectively treat a variety of cancers while causing far fewer side effects than current therapies. 
Dr. Almo’s large-scale work on enzyme function has provided insights on both the gut microbiome’s contributions to human health and new chemical processes for industry. His research also has expanded the understanding of critical environmental issues, including global nutrient cycles and the evolution of complex microbial communities.
He is a member of the American Society for Cell Biology and the American Crystallographic Association. He has served on NIH study sections and review panels, on the American Cancer Society’s Peer Review Committee on Cancer Drug Development, and on the editorial board of the International Archives of Allergy and Immunology.

Research Profile

https://einsteinmed.edu/faculty/7091/Steven-Almo

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Professional Title

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/054be1ff-29d5-459e-90e7-4f3851a82…

Selected Publications

Quayle SN, Girgis N, Thapa DR, Merazga Z, Kemp MM, Histed A, Zhao F, Moreta M, Ruthardt P, Hulot S, Nelson A, Kraemer LD, Beal DR, Witt L, Ryabin J, Soriano J, Haydock M, Spaulding E, Ross JF, Kiener PA, Almo S, Chaparro R, Seidel R, Suri A, Cemerski S, Pienta KJ, Simcox ME. (2020) "CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies." Clin Cancer Res. 26(8), 1953-1964. PMID:31964784.
Funabashi M, Grove TL, Wang M, Varma Y, McFadden ME, Brown LC, Guo C, Higginbottom S, Almo SC, Fischbach MA. (2020) "A metabolic pathway for bile acid dehydroxylation by the gut microbiome." Nature 582(7813), 566-570. PMC7319900.
Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC. (2019) "Structural Basis of CD160:HVEM Recognition." Structure 27(8), 1286-1295.e4. PMC7477951.
Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.  (2018) “A naturally occurring antiviral ribonucleotide encoded by the human genome.” Nature 558, 610-614.  PMC6026066.
Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz M, Almo SC. (2018) “Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.” Biochemistry 57, 1293-1305. PMC6568269.
Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC. (2017) “Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.”  Proc Natl Acad Sci U S A. 114, E4223-E4232.  PMC5448203.
Lázár-Molnár E, Scandiuzzi L, Basu I, Quinn T, Sylvestre E, Palmieri E, Ramagopal UA, Nathenson SG, Guha C, Almo SC. (2017) “Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.”  EBioMedicine. 17, 30-44. PMC5360572. 
Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC. (2017) “Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.” Mol Immunol. 81, 51-159. PMC5220579.
Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC. (2016) “Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.” Structure 24, 2016-2023. PMID:27806260.
Yadava U, Vetting MW, Al Obaidi N, Carter MS, Gerlt JA, Almo SC. (2016) “Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.” Acta Crystallogr F Struct Biol Commun. 72, 467-472. PMC4909247.
Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC. (2015) “Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.” Mol Biotechnol. 57, 914-922. PMID:26202493.
Kim J, Xiao H, Koh J, Wang Y, Bonanno JB, Thomas K, Babbitt PC, Brown S, Lee YS, Almo SC. (2015) “Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.” Nucleic Acids Res. 43, 4602-4613.  PMC4482062.
 Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, Osterman AL, Cronan JE, Jacobson MP, Gerlt JA, Almo SC. (2015) “Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.” Biochemistry 54, 909-931. PMC4310620.
Samanta D, Almo SC. (2015) “Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity.” Cell Mol Life Sci. 72, 645-658. PMID: 25326769.
Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC. (2014) “Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.” Structure 22, 1252-1262.  PMC4163024.
Bandaranayake AD, Almo SC. (2014) “Recent advances in mammalian protein production.” FEBS Lett. 588, 253-260. PMC3924552.
Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC. (2013) “Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function.” Nature 498, 123-126.  PMC3895326.
Kim J, Almo SC. (2013) “Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC.” BMC Struct Biol. 13:5. PMC3648344.
Vigdorovich V, Ramagopal UA, Lázár-Molnár E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC. (2013) “Structure and T cell inhibition properties of B7 family member, B7-H3.” Structure 21, 707-717. PMC3998375.
Soniat M, Sampathkumar P, Collett G, Gizzi AS, Banu RN, Bhosle RC, Chamala S, Chowdhury S, Fiser A, Glenn AS, Hammonds J, Hillerich B, Khafizov K, Love JD, Matikainen B, Seidel RD, Toro R, Rajesh Kumar P, Bonanno JB, Chook YM, Almo SC. (2013) “Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.” J Struct Funct Genomics 14, 31-35. PMC3681870.
Sampathkumar P, Kim SJ, Upla P, Rice WJ, Phillips J, Timney BL, Pieper U, Bonanno JB, Fernandez-Martinez J, Hakhverdyan Z, Ketaren NE, Matsui T, Weiss TM, Stokes DL, Sauder JM, Burley SK, Sali A, Rout MP, Almo SC. (2013) “Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex.” Structure 21, 560-571. PMC3755625.

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John S. Condeelis

Read more about John S. Condeelis

John S. Condeelis

https://assets.montefioreeinstein.org/profiles/images/Condeelis_John_PhD_2x.jpg

Faculty

Expert

First Name

John

Last Name

Condeelis

Faculty ID

6712

Patient Type

Adult

Department

einstein-dept-cell-biology

einstein-dept-surgery

john.condeelis@einsteinmed.edu

Phone

718-430-2718

Titles

Type

Academic

Department

Department of Cell Biology

Department Link

Rank

Professor

Tags

me-patientcare-cancer-research-cdtmi

me-patientcare-cancer-research-cdtmi-members

Type

Academic

Department

Department of Surgery

Rank

Professor

Type

Administrative

Title

The Judith and Burton P. Resnick Chair in Translational Research

Type

Administrative

Title

Scientific Director, Analytical Imaging Facility

Type

Administrative

Title

Director, Integrated Imaging Program for Cancer Research

Type

Administrative

Title

Director, Basic and Translational Research, Department of Surgery

Locations

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Forchheimer Building

Room

602

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

John Condeelis' research interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. He and his collaborators developed the multiphoton imaging technology and animal models used to identify invasion and dissemination micro-environments in breast, pancreas and lung carcinoma. Integration of intravital multiphoton imaging with computational /systems analysis of living breast tumors identified the dominant tumor cell phenotypes contributing to invasion and dissemination during metastasis. This led to the discovery and verification of the paracrine interaction between tumor cells and macrophages in vivo, the role of macrophages in the migration of tumor cells during HGF-dependent tumor cell streaming to blood vessels and the mechanism of tumor cell dissemination from primary tumors via TMEM (Tumor MicroEnvironment of Metastasis) doorways to distant metastatic sites, and from those metastatic sites. Based on these results, cell collection techniques, including the in vivo invasion assay were developed for the collection of migrating and disseminating macrophages and tumor cells. This led to the discovery of the mouse and human invasion signatures, and the TMEM doorway, MenaCalc and MenaINV markers for assessing risk of metastasis and prediction of response in breast cancer patients to both chemotherapy, and receptor tyrosine kinase and tyrosine kinase inhibitors used to suppress metastasis.
He also helped lead the effort to develop a TMEM-activity-MRI for use in standard of care MRI prognosis of breast cancer patients. He is one of the founding co-directors of the Integrated Imaging Program dedicated to the integration and validation of clinical imaging platforms, including digital pathology, with high resolution optical imaging in the Gruss Lipper Biophotonics Center. He has authored more than 350 scientific papers on various aspects of his research.

Research Areas

Interests are in optical physics, cell biology and biophysics, and cancer biology. Applications of interests are in development of the multiphoton imaging technology used to identify dissemination microenvironments in metastatic tumors.

Specialties

Cancer

Basic Science

Expert Tags

Tumor Microenvironment

Metastasis

Imaging

Areas of Expertise

Multiphoton imaging

Optical microscopy

Biomedical technologies

Tumor microenvironment

Expert Summary

Dr. Condeelis is a pioneer in developing microscope techniques for use in “intravital imaging” – observing the behavior of cells in living animals. His work has led to a clinical test of biopsy tissue to determine whether a woman’s breast cancer will spread (metastasize), which could help determine treatment. Because of the test’s success, Dr. Condeelis and colleagues have licensed the patent rights to a biotech firm, which is developing the tissue test into a commercial product.
A fellow of the American Association for the Advancement of Science, Dr. Condeelis is the recipient of the Allen Foundation Scholar Award and the Hirschl Career Scientist Award. He has served on numerous study sections of the National Institutes of Health and the American Cancer Society, as a consultant to the National Cancer Institute, and on the editorial boards of several prominent journals, including theJournal of Cell Biology.

Research Profile

https://einsteinmed.edu/faculty/6712/John-Condeelis

CHAM Provider

Off

Professional Title

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/9bd9420d-d79f-44fc-8f92-bbc05e519…

Lab Website Link

https://einsteinmed.edu/labs/john-condeelis/

Selected Publications

Selected Publications 2020-2022 (<a title="View complete list of publications" href="/labs/john-condeelis/publications/">See complete list of publications.)</a>
<ul class="no-bullet">
<li>Karagiannis GS, Eddy RJ, Sparano JA, Anampa Mesias J, Rohan TE, Branch CA, Condeelis JS, Entenberg D, Oktay MH. Detection of TMEM Doorways and Their Activity Required for Metastasis. Emerging Technologies for Cancer Detection and DiagnosisIn Submission.</li>
<li>Sanchez LR, Duran CL, Burt J, Lin Y, Eddy R, Harney AS, Entenberg D, Condeelis JS, Oktay MH, Karagiannis GS. The Cxcl12/Cxcr4 Signaling Pathway Biases Breast Cancer Cell Directional Migration toward TMEM Intravasation Doorways. Journal of Leukocyte Biology. In Revision.</li>
<li>Duran C, Surve CR, Ye X, Chen X, Lin Y, Harney AS, Wang Y, Kim G, Sharma VP, Entenberg D, Stanley R, Oktay MH, Condeelis JS. Revealing the signaling events at TMEM doorways provides potential targets for inhibiting breast cancer dissemination. Science Signaling. In Revision.</li>
<li>Lucotti S, Ogitani Y, Kenific C, Geri J, Kim Y, Gu J, Balaji U, Bojmar L, Shaashua Berger L, Song Y, Cioffi M, Lauritzen P, Joseph O, Asao T, Grandgenett P, Hollingsworth M, Peralta C, Pagano A, Molina H, Lengel H, Gilbert Dunne E, Jing X, Schmitter M, Zhang H, Romin Y, Manova K, Paul D, O’Reilly E, Jarnagin W, Kelsen D, Jones D, Condeelis J, Pascual V, Matei I, Bussel J, Coller B, Entenberg D, Bromberg J, Simeone D, Lyden D. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. In Review.</li>
<li>Genna A, Alte J, Poletti M, Meirson T, Sneh T, Gendler M, Saleev N, Karagiannis G, Wang Y, Cox D, Entenberg D, Oktay M, Korcsmaros T, Condeelis J, Gil-Henn H. FAK family proteins regulate in vivo breast cancer metastasis via distinct mechanisms. Nature Communications. In Review.</li>
<li>Dalton K, Howley R, Condeelis J, Entenberg D, Borriello L. Visualization of disseminated tumor cells and metastatic outgrowth in the lung at single cell resolution via intravital imaging. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Ye X, Head T, Duran C, Jafari R, Condeelis JS, Oktay MH, Cady N, Entenberg D. Microfluidic imaging windows for direct localized engineering of the in vivo tumor microenvironment In Progress.</li>
<li>Karagiannis GS, Rivera-Sanchez L, Wang Y, Sharma VP, Entenberg D, Oktay MH, Condeelis JS. Mechanisms of MenaINV induction and host response to chemotherapy.In Progress.</li>
<li>Ye X, Jafari R, Duran C, Du W, Lin Y, Surve C, Wang Y, Hoffmann E, Inman D, Ponik S, Oktay M, Condeelis JS, Entenberg D. Intravital Imaging Tissue AlignmentIn Preparation.</li>
<li>Miller A, Parmar P, Duran C, Porcelli S, Zhang J, Condeelis JS, Entenberg D, Oktay MH. The effect of macrophage cancer cell contact and anti-estrogen therapy on induction of stem cell program using SORE6 biosensor in estrogen receptor positive breast cancer cells.In Preparation.</li>
<li>Miller A, Karadal-Ferrena B, Parmar P, Huang C, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Entenberg D, Xue X, Rohan TE, Oktay MH. The clinical utility of TMEM doorway score in predicting response to treatment in breast cancer patients with estrogen receptor positive and triple negative breast cancer.In Preparation.</li>
<li>Karadal-Ferrena B, Miller A, Adler E, Ginter PS, D'Alfonso T, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Sparano JA, Entenberg D, Xue X, Rohan TE, Oktay MH. A multi-institutional study of TMEM doorway score as prognostic biomarker in a multiracial cohort of breast cancer patients.In Preparation.</li>
<li>Karadal-Ferrena B, DeLuca M, Duran C, Barth N, Jung Y, Eddy R, Lin Y, Chen X, Zintiridou A, Ye X, Karagiannis GS, Condeelis JS, Entenberg D, Oktay MH. TMEM doorway activity and macrophage profile in lung metastasis from breast cancer.In Preparation.</li>
<li>Entenberg D, Kodandaramaiah SB, Ponik SM, Elicieri K. Design considerations for optical intravital imaging windows. J Biomed Opt. In Preparation.</li>
<li>Anampa JM, Flynn DL, Oh S, Sadan S, Xue X, Oktay MH, Condeelis JS, Sparano JA. Phase Ib clinical and pharmacodynamic study of the Tie2 kinase inhibitor rebastinib with paclitaxel or eribulin in HER2-negative metastatic breast cancer.In Preparation.</li>
<li>Yang Y, Wang X, Zhang J. Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2. J Thorac Dis. 2024;16(2):1128-40. Epub 20240226. doi: 10.21037/jtd-23-1057. PubMed PMID: 38505034; PMCID: PMC10944717.</li>
<li>Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024;4(2):e995. doi: 10.1002/cpz1.995. PubMed PMID: 38406895; PMCID: PMC10914332.</li>
<li>Migulina N, de Hilster RHJ, Bartel S, Vedder RHJ, van den Berge M, Nagelkerke A, Timens W, Harmsen MC, Hylkema MN, Brandsma CA, Burgess JK. 3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes. Am J Physiol Cell Physiol. 2024;326(1):C177-C93. Epub 20231113. doi: 10.1152/ajpcell.00374.2023. PubMed PMID: 37955339.</li>
<li>Chioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough JE, Konkimalla A, Kim SH, Nouws J, Gonzalez DG, Traub B, Ye X, Yang T, Entenberg DR, Krishnaswamy S, Hendry CE, Kaminski N, Tata PR, Sauler M. Stem cell migration drives lung repair in living mice. Dev Cell. 2024. Epub 20240214. doi: 10.1016/j.devcel.2024.02.003. PubMed PMID: 38377991.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. Nature Protocols Exchange. 2024. doi: <a title="Read article" href="https://doi.org/10.21203/rs.3.pex-2544/v1" target="_blank" rel="noopener">https://doi.org/10.21203/rs.3.pex-2544/v1</a>.</li>
<li>Barron SL, Wyatt O, O'Connor A, Mansfield D, Suzanne Cohen E, Witkos TM, Strickson S, Owens RM. Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture. Sci Rep. 2024;14(1):240. Epub 20240102. doi: 10.1038/s41598-023-50618-y. PubMed PMID: 38168149; PMCID: PMC10761879.</li>
</ul>

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Julio A. Aguirre-Ghiso

Read more about Julio A. Aguirre-Ghiso

Julio A. Aguirre-Ghiso

https://assets.montefioreeinstein.org/profiles/images/Aguirre-Ghiso_Julio_PhD_2x.jpg

Faculty

Expert

First Name

Julio

Last Name

Aguirre-Ghiso

Faculty ID

16974

Patient Type

Adult

Department

einstein-dept-cell-biology

einstein-dept-oncology

einstein-dept-medicine

julio.aguirre-ghiso@einsteinmed.edu

Phone

718-678-1246

Titles

Type

Academic

Department

Department of Cell Biology

Department Link

Rank

Professor

Type

Academic

Department

Department of Oncology

Rank

Professor

Division

Medical Oncology

Type

Academic

Department

Department of Medicine

Department Link

Rank

Professor

Division

Oncology & Hematology

Type

Administrative

Title

Rose C. Falkenstein Chair in Cancer Research

Type

Administrative

Title

Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Tumor Microenvironment & Metastasis Program

Tags

me-patientcare-cancer-research-tumor-microenvironment-metastatis

Type

Administrative

Type

Administrative

Title

Director, Cancer Dormancy Institute

Tags

me-patientcare-cancer-research-cdicore

Locations

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.845838 40.8516937)

Room

220

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Michael F. Price Center

Address Line 3

1301 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

The major challenge faced by physicians is the prevention and treatment of metastasis, the main reason for cancer mortality. Surprisingly, cancer patients presumed cured after primary tumor removal and therapy, can carry non-proliferating ‘dormant’ disseminated cancer cells (DCCs) for years before reactivating to form incurable metastasis. I focused on understanding the biology of dormant DCCs and their reactivation, to target them and prevent relapse. My team led a paradigm shift that is revealing novel cancer biology that diverges from the notion that cancer is perpetually proliferating.
 
We discovered that a reciprocal crosstalk between DCCs and the microenvironment regulates the inter-conversion between dormancy and proliferation. My lab discovered that an imbalance in p38a/b and ERK1/2 signaling regulates lineage commitment transcription factors (TF) and an epigenetic network that determines dormancy induction (Aguirre-Ghiso et al., JCB 1999, Mol Biol Cell 2001, Oncogene 2002, Liu, Aguirre-Ghiso et al., Cancer Cell, 2002, Aguirre-Ghiso et al., Cancer Res 2004, among others). This work led to identify retinoic acid and TGFb2 in the microenvironment as inducers of the high p38/ERK-signaling ratio, leading to the finding that dormancy  (quiescence) is controlled by mechanisms of adult stem cell quiescence (Adam et al., Cancer Res 2009; Bragado et al., Nat Cell Bio, 2013, Sosa et al., Nat Commun 2015; Fluegen et al., & Nat Cell Bio, 2017; Nobre et al., Nature Cancer 2021). These findings have been expanded to reveal that mesenchymal stem cell niches that control hematopoietic stem cell dormancy control dormancy of breast cancer DCCs through a TGFB2 and BMP7-dependent mechanism (Nobre et al.,Nat Cancer, 2021). My lab was one of the first to show that tumor-initiating properties and DCC dormancy are dynamically linked by epigenetic states and a transcriptional program that affects the histone code (Sosa et al., Nat Commun 2015). This work led to an epigenetic strategy to induce dormancy, which is now a clinical trial funded by the V-Foundation and TCI (NCT03572387). We also identified a “dormancy signature” and specific markers enriched in dormant prostate and breast cancer DCCs as well as in the bone marrow of breast cancer patients that predict for prolonged metastasis-free periods (Borgen et al., Breast Cancer Res 2018; Nobre et al., Nature Cancer 2021). We also found how the hypoxic microenvironment in primary tumors primes DCCs epigenetically to become dormant and evade chemotherapy (Fluegen et al., Nat Cell Bio, 2017).
 
My lab’s work has propelled new questions to the forefront of cancer research, with the unexpected discovery of the mechanisms that allow dormant breast cancer DCCs and metastasis to be initiated very early during cancer evolution disseminating during pre-malignant stages (Harper and Sosa et al., Nature, 2016 and Hosseini et al., Nature, 2016). We further discovered that innate immune cells are key to launch the early dissemination process and the success on metastatic colonization (Linde et al., Nature Commun. 2018). Our program’s impact is further highlighted by the development of successful collaborations with industry that identified pathways (Ranganathan et al., Cancer Ress 2006; 2008; Schewe and Aguirre-Ghiso, PNAS 2008; Cancer Res 2009) and drugs to kill dormant DCCs or induce dormancy of DCCs that are now part of a patent (WO201919111) and developed by a new startup company (HiberCell)(<a style="color: #903638;" href="http://www.hibercell.com/">www.hibercell.com</a>), which is conducting clinical trials developed from our findings (NCT04834778, NCT04995094),identification of potential biomarkers and the development of the first clinical trials to induce dormancy of metastatic disease in prostate cancer (NCT03572387).

Research Areas

Metastasis biology
Cancer cell dormancy
Signal transduction
Extracellular matrix
Innate immune cell function
tumor and normal organ microenvironment

Specialties

Cancer

Basic Science

Expert Tags

Tumor Microenvironment

Metastasis

Dormancy

Areas of Expertise

Tumor microenvironment

Expert Summary

Julio Aguirre-Ghiso, Ph.D., is an international leader in cancer cell dormancy and metastasis. He has helped lead a major shift in the cancer biology field by investigating how cancer cells hibernate, undetected, for long periods of time and what causes them to suddenly awaken to seed deadly, treatment-resistant metastases.
Dr. Aguirre-Ghiso’s work is revealing ways to maintain residual cancer-cell dormancy, kill dormant cancer cells, and identify biomarkers for cancer recurrence. He has founded a start-up company, HiberCell, which is developing treatments to prevent relapse. 
Dr. Aguirre-Ghiso is founding director of the <a href="https://montefioreeinstein.org/cancer/research/cdtmi">Cancer Dormancy and Tumor Microenvironment Institute</a> at the Montefiore Einstein Cancer Center. The goal of the institute is to integrate research from a range of specialties—including the biology of aging, stem cells, epigenetics, and systems biology—to address how residual cancer cells, aging, lifestyle, genetics, and treatments influence relapse across all cancers.
Dr. Aguirre-Ghiso is a reviewer for top-tier scientific journals and for federal, private, and international agencies.  His work has been published in Nature, Nature Cell Biology, Nature Cancer, Science, and Cancer Cell. He is also president of the Metastasis Research Society and has served at several leadership levels at American Association for Cancer Research.

Research Profile

https://einsteinmed.edu/faculty/16974/Julio-Aguirre-Ghiso

CHAM Provider

Off

Professional Title

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/111272a9-13f2-4f87-ae26-6869ef0cd…

Lab Website Link

https://einsteinmed.edu/labs/julio-aguirre-ghiso/

Selected Publications

<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Pre-Prints Available Online
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
1.     Deepak K. Singh, Eduardo Farias, Saul Carcamo, Dan Hasson, Dan Sun, Julie Cheung, Ana Rita Nobre, Nupura Kale, Maria Soledad Sosa, Emily Bernstein, Julio A. Aguirre-Ghiso. Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ–SMAD4 signaling bioRxiv 2021.08.01.454684; doi: <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.08.01.454684">https://doi.org/10.1101/2021.08.01.454684</a>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
2.     Aguirre-Ghiso JA, Nobre AR, Dalla E, et al. A Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a Barrier to Metastatic Progression of Early Disseminated Cancer Cells. 18 January 2021, PREPRINT (Version 1) available at Research Square. <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-145308/v1">https://doi.org/10.21203/rs.3.rs-145308/v1</a>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
3.     Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Rodriguez Martinez A, Miles B, Farias E, Mezei M, Cheung JF, Nobre AR, Kale N, Sproll KC, Sosa MS, Aguirre-Ghiso JA. A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy. bioRxiv(2021).01.30.428967; doi: <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.01.30.428967">https://doi.org/10.1101/2021.01.30.428967</a>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
4.     Borriello L, Coste A, Sharma VP, Karagiannis GS, Lin Y, Wang Y, Ye X, Duran C, Chen X, Dalla E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis J, Entenberg D. Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. bioRxiv (2021).02.04.429798; doi: <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.02.04.429798">https://doi.org/10.1101/2021.02.04.429798</a>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
5.     Mitchell Fane, Stephen Douglass, Gretchen Alicea, Marie Webster, Vito Rebecca, Gloria Marino, Yash Chhabra, Filipe Almeida, Brett Ecker, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, David Speicher, Julio Aguirre-Ghiso, Ashani Weeraratna,  Stromal Changes In The Aged Lung Induce An Emergence From Melanoma Dormancy, 16 September (2020), PREPRINT (Version 1) available at Research Square <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-61165/v1">https://doi.org/10.21203/rs.3.rs-61165/v1</a>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Peer Reviewed Original Research Contributions 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-align: justify; line-height: 24px;"> 
1.     Di Martino J, Nobre AR, Mondal C, Taha I, Farias EF, Fertig E, Naba A, Aguirre-Ghiso JA, Bravo-Cordero JJ. A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy, 22 June 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-580847/v1]. Nature Cancer (2021) (Accepted for Publication)
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
2.     Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang M, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikov A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown B, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Lineage tracing reveals the unique pro-tumorigenic niche role of tissue-resident macrophages in early cancer lesions. Nature 595, 578–584 (2021). In the top 5% of all research outputs scored by Altmetric
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
3.     Nobre R, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, Aguirre-Ghiso JA. Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2. Nature Cancer 2, 327–339 (2021). <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-021-00179-8">https://doi.org/10.1038/s43018-021-00179-8</a> In the top 5% of all research outputs scored by Altmetric
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
4.     Lam T, Aguirre-Ghiso JA, Geller MA, Aksan A, Azarin SM. Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancy. Biotechnol Bioeng. (2020) Oct;117(10):3066-3080. doi: 10.1002/bit.27479. Epub 2020 Jul 9.
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5.     Teh JL, Purwin TJ, Han A, Chua V, Patel P, Baqai U, Liao C, Bechtel N, Sato T, Davies MA, Aguirre-Ghiso JA, Aplin AE. Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma. Mol Cancer Ther. (2020) May 19: molcanther.1016.2019. doi: 10.1158/1535-7163.MCT-19-1016. Epub ahead of print. PMID: 32430489.
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6.     Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. (2019) Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21.
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
7.     Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso JA, Benovic JL. Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. (2019) Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19. In the top 5% of all research outputs scored by Altmetric and picked up by 16 news stories from 15 outlets.
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8.     Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, Lønning PE, Synnestvedt M, Aguirre-Ghiso JA, Naume B. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients. Breast Cancer Research(2018) 20 (1), 120. In the top 5% of all research outputs scored by Altmetric and picked up by 9 news stories from 9 outlets.
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9.     Linde N, Casanova-Acebes M, Sosa MS, Mortha A, Rahman A, Farias EF, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, and Aguirre-Ghiso JA. Macrophages orchestrate breast cancer early dissemination and metastasis. Nature Communications 9, 21(2018) doi:10.1038/s41467-017-02481-5. In the top 5% of all research outputs scored by Altmetric. Highlighted in Faculty of 1000 Prime: El-Deiry W and Zhao S: F1000Prime Recommendation of [Linde N et al., Nat Commun 2018 9(1):21]. In F1000Prime, 11 Jan 2018; 10.3410/f.732394311.793541160. Highlighted in Science Translational Medicine:
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: 22.5pt; vertical-align: baseline;"><a style="color: #903638; text-decoration: underline;" href="https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm">… style="background-color: white;">https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm</…;
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;">10.  Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS, Aguirre-Ghiso JA, Condeelis J. Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics. Methods(2017) Sep 1; 128:65-77. doi: 10.1016/j.ymeth.2017.07.019.
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;">11.  Fluegen G, Avivar-Valderas A, WangY, PadgenM, WilliamsJK, Verkhusha V, Cheung JF, Entenberg D, Castracane J, Keely PJ, Condeelis J, Aguirre-Ghiso JA.  Phenotypic heterogeneity of disseminated tumor cells is predetermined by primary tumor hypoxic microenvironments. Nature Cell Biology (2017) doi:10.1038/ncb3465.Cover Article. Highlighted in Science Translational Medicine Editor’s Choice, Science Translational Medicine 15 Feb 2017: Vol. 9, Issue 377, eaam6063 DOI: 10.1126/scitranslmed.aam6063
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;">12.  Harper K, Sosa MS, Hosseini H, Entenberg D, Avivar-Valderas A, Nagi C, Davis RJ, Farias EF, Condeelis J, Klein C, Aguirre-Ghiso JA. Mechanism of early dissemination and metastasis during early stages of HER2+ mammary cancer. Nature (2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000. <a style="color: #903638; text-decoration: underline;" href="https://f1000.com/prime/727099751">https://f1000.com/prime/727099751</a><… style="font-size: 12pt; color: #ff6600;">; Highlighted in Nature Reviews  Cancer <a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html">… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</e…;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;">13.  Hosseini, H, Harper K, Obradovic M, Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G, Aguirre-Ghiso JA, Klein CA. Early dissemination seeds metastasis in breast cancer. Nature. (2016) Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted in Nature Reviews Cancer <a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html">… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</e…;
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14.  Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E, Nobre AR, Aguirre-Ghiso JA, Jung Y, Taichman RS. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow. Scientific Reports (2016) Nov 7; 6:36520. doi: 10.1038/srep36520.
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15.  Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS, Aguire-Ghiso JA, Castracane J, Denu JM, Keely PJ. Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells. EBioMedicine (2016) Nov; 13:146-156. doi: 10.1016/j.ebiom.2016.10.012. PubMed PMID: 27743905.
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16.  Cackowski FC, Eber MR, Rhee J, Decker A, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y, Aguirre-Ghiso JA,Taichman RS. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy. J Cell Biochem(2016) Oct 18. doi: 10.1002/jcb.25768. PMID: 27753136
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17.  Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parsons R, Aguirre-Ghiso JA, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E. Cbx8 acts non-canonically in breast cancer to promote Notch signaling. Cell Reports (2016) Jul 12;16(2):472-86. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23. PMID: 27346354
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18.  Williams JK, Entenberg D, Wang Y, Avivar-Valderas A, Padgen M, Clark A, Aguirre-Ghiso JA, Castracane J, Condeelis JS. Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging. Intravital. (2016)
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19.  Szulczewski JM, Inman DR, Entenberg D, Aguirre-Ghiso JA, Castracane J, Condeelis J, Eliceiri KW, Keely PJ. In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging. Scientific Reports(2016) May 25; 6:25086. doi: 10.1038/srep25086. PMID: 27220760
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20.  Li M, Pathak RR, Lopez-Rivera E, Friedman SL, Aguirre-Ghiso JA, Sikora AG. The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma. J Vis Exp. (2015) Oct 9; (104). doi: 10.3791/52411.
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21.  Alsadeq A, Strube S, Krause S, Carlet M, Jeremias I, Vokuhl C, Loges S, Aguirre-Ghiso JA, Trauzold A, Cario G, Stanulla M, Schrappe M, Schewe DM. Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo. Leukemia. (2015) Jun 24. doi: 10.1038/leu.2015.153. [Epub ahead of print] PMID: 26104660
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> 
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM, Aguirre-GhisoJA. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer (2015) May 30; 15:444. doi: 10.1186/s12885-015-1460-1. PMCID: PMC4448210. Highlighted by BMC Cancer in the “Highly Accessed” category.
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22.  Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, Aguirre-Ghiso JA, Friedman SL. Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development. Mol Cell Biol. (2015) Feb 23. pii: MCB.00136-15. PMID: 25713103. Cover article for the Feb 23 issue of Mol Cell Biol.
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"> 
23.  Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E, Aguirre-Ghiso JA. NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes. Nat Commun (2015) Jan 30; 6:6170. doi: 10.1038/ncomms7170. PubMed PMID:25636082; PubMed Central PMCID: PMC4313575. In the top 10% of all articles ever tracked by Altmetric.
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24.  Chéry L, Lam HM, Coleman I, Lakely B, Coleman R, Larson S, Aguirre-Ghiso JA, Xia J, Gulati R, Nelson PS, Montgomery B, Lange P, Snyder LA, Vessella RL, Morrissey C. Characterization of single disseminated prostate cancer cells Reveals tumor cell heterogeneity and identifies dormancy associated pathways. Oncotarget (2014) Oct 30;5(20):9939-51. PubMed PMID: 25301725; PubMed Central PMCID: PMC4259449.
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25.  Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso JA, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.Cancer Res. (2014) Feb 15;74(4):1067-78. doi: 10.1158/0008-5472.CAN-13-0588. Epub 2014 Jan 7. PMID: 24398473 [PubMed - indexed for MEDLINE]
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26.  Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM, Aguirre-Ghiso JA. TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling. Nat. Cell. Bio. (2013).Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27. PMID: 24161934;PMCID: not available. Featured in Nat Cell Bio Cover same issue. Highlighted in Science Signaling Editor’s Choice, Cancer Research Breaking Advances section and several public news outlets. Featured in the Cover of the November 15th issue of Nat Cell Bio. Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric. 
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27.  Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CTY, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T. A human tRNAmethyltransferase 9-like protein prevents tumor growth by regulating LIN9 and the hypoxic response. EMBO Mol Med (2013) Feb 4. doi: 10.1002/emmm.201201161.
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28.  Avivar-Valderas A, Bobrovnikova-Marjon E, Diehl JA, Bardeesy N, Debnath J, Aguirre-Ghiso JA. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.  Oncogene(2012), Nov 19. doi: 10.1038/onc.2012.512. 
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29.  Kim RS, Avivar-Valderas A, Estrada A, Bragado P, Sosa MS, Aguirre-Ghiso JA, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive breast cancer. PLoS One (2012); 7(4):e35569. Epub 2012 Apr 18.
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30.  Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E, Aguirre-Ghiso JA. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One. (2012); 7(1):e29974. PMCID: PMC3262798. 
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31.  Tong CC, Lau KH, Rivera M, Cannan D, Aguirre-Ghiso JA, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J. Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy. Oncol Rep. (2012) May; 27(5):1580-6. doi: 10.3892/or.2012.1679.
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32.  Gutiérrez-Uzquiza Á, Arechederra M, Bragado P, Aguirre-Ghiso JA, Porras A. p38a mediates cell survival in response to oxidative stress via induction of antioxidant genes. Effect on p70S6K pathway. J Biol Chem. (2012)Jan 20;287(4):2632-42. Epub 2011 Dec 2.
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33.  Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS, Aguirre-Ghiso JA, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy. J Cell SciTher (2011) S1:002. doi:10.4172/2157-7013.S1-002.
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34.  Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JS, Nagi C, Debnath J, Aguirre-Ghiso JA, PERK integrates autophagy and oxidative stress  responses to promote survival during ECM detachment. Mol Cell Biol. (2011) Sep; 31(17):3616-29. PMC3165554 (Cover article) 
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35.  Wen HC, Avivar-Valderas A, Sosa MS, Girinius N, Farias EF, Davis R, Aguirre-Ghiso JA. p38 signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis. Science Signaling (2011) 4 (174), ra34. [DOI: 10.1126/scisignal.2001684].http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/174/ra34</sp…;
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36.  Ishii Y, Papa Y, Bahadur U, Yue Z, Aguirre-Ghiso JA, Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of theestrogen receptor, which leads to a pro-apoptotic unfolded protein response. Clin. Cancer Res. (2011) Feb 3. 
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37.  Sequeira SJ, Wen HC, Avivar-Valderas A, Aguirre-Ghiso JA. Inhibition of eIF2a dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.BMC Cell Biology. (2009) Sep 15;10:64. 
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38.  Schewe DM. Aguirre-Ghiso JA. Inhibition of eIF2 dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. (2009) Feb 15;69(4):1545-52.
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39.  Adam AP, George A, Bragado P, Iglesias BV, Schewe D, Ranganathan A, Kourtidis A, Conklin DS, Aguirre-Ghiso JA. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. Cancer Res. (2009) Jul 15; 69(14):5664-72. Epub 2009 Jul 7.
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40.  Schewe DM, Aguirre-Ghiso JA. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci USA (2008) Jul 29;105(30):10519-24. Highlighted in “This week in PNAS” section of the journal. <a style="color: #903638; text-decoration: underline;" href="http://www.pnas.org/content/105/30/10271.full?sid=79541a8a-11a2-41cc-ae… style="color: #ff6600;"> Faculty of 1000 evaluation: <a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/id/1119501/evaluation">…;
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41.  Ranganathan AC, Ohja S, Kourtidis A, Conklin D, Aguirre-Ghiso JA. Dual function of PERK in tumor cell growth arrest and survival. Cancer Res (2008); 68(9): 1–9.
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42.  Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF, Aguirre-Ghiso JA. Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation. PLoS ONE. (2007) Jul 18; 2:e615.
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43.  Baron TE, Lastro MT, Ranganathan AC, Tenenbaum SA, Conklin DS, Aguirre-Ghiso JA. Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest. Methods Mol Biol. (2007); 383:227-44. 
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44.  Shinohara M, Mikhailov AV, Aguirre-Ghiso JA, Rieder CL. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells. Molecular Biology of the Cell. (2006) Dec 1st.17: 5227-5240.
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45.  Chaurasia P, Aguirre-Ghiso JA, Liang OD, Gardsvoll H, Ploug M, Ossowski LA. Region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth. J. Biol. Chem. (2006) May 26; 281(21): 14852-63.
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46.  Ranganathan AC, Zhang L, Adam AP, Aguirre-Ghiso JA. <a name="OLE_LINK9"></a>Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase–like ER kinase (PERK) to drug resistance of dormant carcinoma cells. Cancer Research (2006); 66: (3) 1702-11.
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47.  Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso JA, Flores  SC, Melendez JA. Mitochondrial H2O2 Regulates the Angiogenic Phenotype Via PTEN Oxidation.  J. Biol. Chem. (2005) 29; 280(17): 16916-24.
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<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 56.0pt 84.0pt 112.0pt 140.0pt 168.0pt 196.0pt 224.0pt 3.5in 280.0pt 308.0pt 336.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;">48.  Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res (2004); 64(20): 7336-45.Faculty of 1000 evaluation at: <a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/15492254/evaluation">ww…;
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49.  Mazzoni E, Adam A, Bal de Kier Joffe E, Aguirre-Ghiso JA. Immortalized mammary epithelial cells overexpressing PKC acquire a malignant phenotype and become tumorigenic in vivo. Molecular Cancer Res. (2003) 1:776-787
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50.  Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L. ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK). Cancer Res. (2003); 63(7): 1684-95.
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51.  Puricelli L, Proiettii CJ, Labriola L, Salatino M, Balana ME, Aguirre-Ghiso JA, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. Int. J. Cancer. (2002) 100(6): 642-53.
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52.  Liu D, Aguirre-Ghiso JA, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell (2002); 1: 445-457(Cover). Preview in the same issue: <a style="color: #903638; text-decoration: underline;" href="http://www.cell.com/cancer-cell/abstract/S1535-6108(02)00076-4"><strong… style="text-transform: uppercase;"> Faculty of 1000 Evaluation at: <a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/12124174/evaluation">ww…;
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53.  Aguirre-Ghiso JA. Inhibition of FAK signaling activated by urokinase receptor induces human carcinoma dormancy in vivo. Oncogene (2002) 21(16): 2513-24.
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54.  Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E, Aguirre-Ghiso JA. RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts. BiochemBiophys Res Commun. (2001) 283(4): 854-61.
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55.  Aguirre-Ghiso JA, Liu D, Mignatti D, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol. Biol. Cell (2001). 12, 4, 863-879. 
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56.  Aguirre-Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy due to urokinase receptor down-regulation in human carcinoma involves integrin and MAPK signaling. J. Cell Biol. (1999) 147, 89-103. Highlighted in the In Brief section of JCB.
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57.  Aguirre-Ghiso JA, Frankel P, Farías E, Lu Z, Jiang H, Olsen A, Feig L, Bal de Kier Joffé E, Foster D. Ral-A requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator. Involvement of metalloproteinases. Oncogene (1999), 18, 4718-4725.
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58.  Urtreger AJ, Aguirre-Ghiso JA, Werbahj S, Puricelli L, Muro A, Bal de Kier Joffé E. Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells.Int. J. Cancer, (1999), vol. 82, 748-753.
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59.  Ladeda V, Aguirre-Ghiso JA, Bal de Kier Joffé E. Function and Expression of CD44 During Spreading and Migration of Murine Carcinoma cells. Exp. Cell Res. (1998); 242:515-527.
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60.  Aguirre-Ghiso JA, Farías EF, Alonso DF, Bal de Kier Joffé E. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine-kinase pathway in mammary tumor cells. Int. J.  Cancer (1998) 76: 362-367.
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61.  Farías EF, Aguirre-Ghiso JA, Ladeda V, Bal de Kier Joffé E. Verapamil Inhibits Proteases Production, Local Invasion and Metastasis Development of Murine Carcinoma Cells. Int. J. Cancer. (1998) 78 (6): 727-734.
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62.  Aguirre-Ghiso JA, Farías EF, Alonso DF, Arregui C, Bal de Kier Joffé E E. A Phospholipase D and Protein Kinase C Inhibitor Blocks the Spreading of Murine Mammary Adenocarcinoma Cells Altering F-Actin and Integrin Point Contact Distribution. Int. J. Cancer. (1997) 71: 881-890.
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63.  Aguirre-Ghiso JA, Alonso DF, Farías E, Bal de Kier Joffé E. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C pathways in murine mammary adenocarcinoma cells. Biochem. Biophys. Acta (1997) 1356: 171-184. 
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64.  Aguirre-Ghiso JA, Diament M, D'elia I, Bal de Kier Joffé E, Klein S. Effect of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth. Tumor Biol. (1997); 18: 41-52.
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65.  Aguirre-Ghiso JA, Farías E, Fernandez DM, Alonso DF, Bal de Kier Joffé E. Down modulation of tumor cells-associated proteolytic activity by n-butanol treatment in cultured murine mammary adenocarcinoma cells. Int. J Oncol. (1996); 8: 35-39.
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66.  Klein S, Jasnis MA, Diament M, Davel L, Aguirre Ghiso JA, de Bonaparte YP. Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers. Tumor Biol. (1994);15: 160-165.
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<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">Reviews, Commentaries, Perspectives and other Peer Reviewed Publications 
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1.     Aguirre-Ghiso JA. Translating the Science of Cancer Dormancy to the Clinic. Cancer Res (2021)August 24. DOI: 10.1158/0008-5472.CAN-21-1407
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2.     Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H, Aguirre-Ghiso JA, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB, Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G. The State of Melanoma: Emergent Challenges and Opportunities. Clin Cancer Res. (2021) Jan 7:clincanres.4092.2020. doi: 10.1158/1078-0432.CCR-20-4092.
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3.     Risson E, Nobre AR, Maguer-Satta V, Aguirre-Ghiso JA. The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nat Cancer (2020). <a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-020-0088-5">https://doi.org/10.1038/s43018-020-0088-5</a>. In the top 5% of all research outputs scored by Altmetric
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4.     Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salomé B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gümüş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunology of COVID-19: Current State of the Science. Immunity. (2020) Jun 16;52(6):910-941. doi: 10.1016/j.immuni.2020.05.002. Epub 2020 May 6.
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5.     Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA; Board Members of the Metastasis Research Society. The importance of developing therapies targeting the biological spectrum of metastatic disease. Clin. Exp. Metastasis. (2019) Aug;36(4):305-309. doi: 10.1007/s10585-019-09972-3. Epub 2019 May 17.
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6.     Aguirre-Ghiso JA. How dormant cancer persists and reawakens. Science. (2018) Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191.
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7.     Aguirre-Ghiso JA, MS Sosa. Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis. Annual Review of Cancer Biology (2018), 2, 377-393
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8.     Nobre AR, Entenberg D, Wang Y, Condeelis J, Aguirre-Ghiso JA. The Different Routes to Metastasis via Hypoxia-Regulated Programs. Trends Cell Biol. (2018) Jul 21. pii: S0962-8924(18)30109-0. doi: 10.1016/j.tcb.2018.06.008. [Epub ahead of print] Review. PMID: 30041830
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9.     Fingleton B, Lange K, Caldwell B, Bankaitis KV; Board of the Metastasis Research Society. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example. ClinExp Metastasis. (2017) Dec;34(8):443-447. doi: 10.1007/s10585-017-9872-8. Epub 2018 Feb 26 PMID: 29484519
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;">10.  Linde N, Fluegen G, Aguirre-Ghiso JA. The Relationship Between Dormant Cancer Cells and Their Microenvironment. Adv Cancer Res. (2016); 132:45-71. doi: 10.1016/bs.acr.2016.07.002. Epub 2016 Aug 25. PMID:27613129.
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;">11.  Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2016) Jan 2;12(1):1-222. No abstract available. PMID: 26799652
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12.  Goossens N, Hoshida Y, Aguirre-Ghiso JA. Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance. EMBO Mol Med (2015) Aug 3. pii: e201505284. doi: 10.15252/emmm.201505284. [Epub ahead of print]
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
13.  Sosa MS, Bragado P, Aguirre-Ghiso JA. Mechanisms of disseminated cancer cell
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">dormancy: an awakening field. Nat Rev Cancer (2014) Sep;14(9):611-22. doi:
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">10.1038/nrc3793. Epub 2014 Aug 14. Review. PubMed PMID: 25118602; PubMed Central 
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<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">-Cover article for the September 14th issue of Nat Rev Cancer
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">-Ranks 6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric. 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
14.  Linde N, Sosa MS, Aguirre-Ghiso JA. Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression. EMBO J. (2014) Aug 18;33(16):1737-9. doi: 10.15252/embj.201489364. Epub 2014 Jul 14. PubMed PMID: 25024435; PubMed Central PMCID: PMC4195757. 
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
15.  Avivar-Valderas A, Wen HC, Aguirre-Ghiso JA. Stress signaling and the shaping 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">of the mammary tissue in development and cancer. Oncogene (2014) Nov
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">27;33(48):5483-90. doi: 10.1038/onc.2013.554. Epub 2014 Jan 13. Review. PubMed
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMID: 24413078; PubMed Central PMCID: PMC4096615. 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
16.  Aguirre-Ghiso, JA, Bragado P, Sosa MS. Metastasis awakening: targeting dormant cancer. Nat Med. (2013) Mar;19(3):276-7. doi: 10.1038/nm.3120. PMID: 23467238 [PubMed - indexed for MEDLINE] PMCID: PMC3651698 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
17.  Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. Regulation of tumor cell dormancy by tissue microenvironments and autophagy. AdvExp Med Biol. (2013);734:73-89. doi: 10.1007/978-1-4614-1445-2_5. 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
18.  Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) Apr;8(4):445-544.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
19.  Bragado P, Sosa MS, Keely P, Condeelis J, Aguirre-Ghiso JA. Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res. (2012); 195:25-39. 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
20.  Cagan RL, Aguirre-Ghiso JA. A local view of cancer. Dev Cell. (2012) Mar 13;22(3):472-4. 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
21.  Genden EM, Aguirre-Ghiso JA. Oropharyngeal cancer biology and treatment: insights from messenger RNA sequence analysis and transoral robotic surgery. Mayo Clin Proc. (2012) Mar;87(3):211-2.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
22.  Sosa MS, Avivar-Valderas A, Bragado P, Wen HC, Aguirre-Ghiso JA. Molecular Pathways: ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Invited Article. Clin. Cancer Res. (2011) Sep 15;17(18):5850-7.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
23.  Prince A, Aguirre-Ghiso JA, Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies. Mt. Sinai J. Med. (2010). 77 (6): 684-99. 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
24.  Aguirre-Ghiso JA. On the theory of tumor self-seeding: implications for metastasis progression in humans. Breast Cancer Res. (2010) Apr 28;12(2):304. Viewpoint 
<p class="MsoNormal" style="margin: 0in 9pt 2pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
25.  Ossowski L, Aguirre-Ghiso JA. Dormancy of metastatic melanoma. Pigment Cell Melanoma Res. (2010)Feb;23(1):41-56. Epub 2009 Oct 19. 
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
26.  Allgayer H, Aguirre-Ghiso JA. The urokinase receptor (u-PAR) - a link between tumor cell dormancy and minimal residual disease in bone marrow? APMIS (2008);116 (7-8) 602-614.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
27.  Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nature Reviews Cancer. (2007). Nov; 7(11): 834-46. Invited peer reviewed article (Cover and featured article).  <a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v7/n11/index.html">http:/…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 41.05pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -35.65pt;"> 
28.  Aguirre-Ghiso JA. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle. (2006) Aug; 5(16): 1740-3. (Guest Editor). Introductory Review. Invited peer reviewed article. Cover.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
29.  Ranganathan AC, Adam AP and Aguirre-Ghiso JA. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle. (2006) Aug; 5(16): 1799-807. Cover.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
30.  Ranganathan AC, Adam AP, Zhang L, and Aguirre-Ghiso JA. Tumor cell dormancy induced by p38SAPK and ER-stress signaling; an adaptive advantage for metastatic cells? Cancer Biology & Therapy (2006) Jul; 5(7): 729-35.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
31.  Tenenbaum SA, Aguirre-Ghiso JA. Dephosphorylation Shows SR Proteins the Way Out. Molecular Cell (2005); 20 (4); 499-501.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
32.  Ossowski L, Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Current Opinion in Cell Biology (2000) 12(5): 613-20.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
33.  Bal de Kier Joffe E, Mazzoni EO, Aguirre-Ghiso JA. Signaling pathways regulating the expression of proteases during tumor progression. (In Spanish) Medicina (B Aires) (2000); 60:34-40.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
34.  Ossowski L, Aguirre-Ghiso JA, Liu D, Yu W, Kovalski K. The role of plasminogen activator receptor in cancer invasion and dormancy. Medicina (Buenos Aires) (1999) 59, 547-552.
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"> 
35.  Aguirre-Ghiso JA, Alonso DF, Farías EF, Gomez D, Bal de Kier Joffé E. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur. J. Biochem.(1999) 263, 2, 295-304 (Cover).
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">Books and Book Chapters
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="1" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy. Systems Biology of Tumor Dormancy. Editors, Enderling H, Almog N and Hlatky L. (2012) Springer Science + Business Media, INC.<a style="color: #903638; text-decoration: underline;" href="http://www.springerlink.com/content/u44l178561014r11/">http://www.sprin…;
</ol>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="2" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Bragado P, Sosa MS, Keely P, Condeelis J, Aguirre-Ghiso JA. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. (Eds: K. Pantel, C. Sotiriou, M. Ignatiadis). Recent Results Cancer Res. (2012); 195:25-39. doi: 10.1007/978-3-642-28160-0_3. </li>
</ol>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0.25in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-pagination: none; mso-list: l16 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none; text-autospace: none;">Aguirre-Ghiso JA, Alonso DF, Farias EF. Function and expression of the uPA/uPAR system in cancer metastasis.  Cancer Metastasis: Biologic Basis and Therapeutics. Cambridge University Press, Editors: Danny Welch, Danny R. Welch, Ph.D., David C. Lyden, MD, PhD, and Beth Psaila, MD. (2009).<a style="color: #903638; text-decoration: underline;" href="http://www.springer.com/biomed/cancer/book/978-1-4419-6614-8">http://ww…;
</ol>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"> 
 
<ol style="margin-bottom: 0in; margin-top: 0in;" start="4" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Bragado P, Ranganathan AC, Aguirre-Ghiso JA. Dormancy of Disseminated Tumor Cells: Reciprocal crosstalk with the microenvironment. The Tumor Microenvironment-Cancer Drug Discovery and Development. Springer Science + Business Media LLC, Humana Press. Dr. Rebecca Bagley, Editor. (2010), Part 2, pp229-254. <a href="http://www.cambridge.org/gb/knowledge/isbn/item5738926/?site_locale=en_…;
</ol>

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Edward Chu

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Edward Chu

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POINT (-73.8459022 40.8504961)

Building

Chanin Building

Room

209

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Specialties

Cancer

Expert Tags

Colorectal Cancer

Areas of Expertise

Colorectal cancer research & treatment

Cancer pharmacology & drug development

Chinese herbal medicine & chemotherapy side effects

Expert Summary

Dr. Chu is an NIH-funded basic, translational, and clinical investigator, and clinical oncologist, with a long history of developing and leading phase I and phase II clinical trials, particularly for colorectal cancer and other gastroenterology cancers. His research has also focused on the molecular mechanisms underlying drug resistance. Additionally, he has studied Chinese herbal medicine and its integration with standard care with the goal of improving outcomes and reducing the toxic side effects of chemotherapy.

Research Profile

https://einsteinmed.edu/faculty/16610/Edward-Chu

CHAM Provider

Off

Professional Title

M.D.

M.M.S.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/97d8f496-64c0-4fd2-a418-1853a17c1…

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Julia K. Gittler

Read more about Julia K. Gittler

Julia K. Gittler

https://assets.montefioreeinstein.org/profiles/images/physphoto/Gittler_Julia_MD_420x504.jpg

Provider

Faculty

First Name

Julia

Last Name

Gittler

NPI

1427492081

Faculty ID

16099

CMO Specialties

Pediatric Dermatology

Clinical Terms

Anti-aging Product Recommendation

Bruising Due To Chemo/Radiation

Cystic Nodule Removal

Cyst

Crusty Skin

Cosmetic Skin Tag Removal

Cosmetic Seborrheic Keratosis Removal

Cosmetic Rejuvenation for Wrinkles

Cosmetic Angiomas Removal

Cosmetic

Consultation for Stretch Marks

Congential Skin Disorder

Comedones

Circumscribed Scleroderma

Clogged Pores

Chemotherapy Reaction

Chemotherapy Burn

Chemo Reaction

Chemical Peel for Wrinkles

Chemical Peel for pigmentation

Candidiasis Of Skin And Nails

Laser Treatment for Acne

Laser Fraxel

Laser for Rosacea/Redness of Face

Laser for Rejuvenation

Laser for Red Acne Scarring

Laser for Acne Scarring

Keratosis

Kenalog Injections for Scars and Keloids

Kenalog Injections for Alopecia and Hair Loss

Hair removal for certain skin types (when Sciton)

Merkel Cell Carcinoma

Skincare consultation

Pus-Bump

PRP (platelet rich plasma) injections for hair loss or alopecia

Pregnancy-Related

Posion Ivy

Polyp

Plugged Hair Follicle

Pigmentation on Face and Body

Phototherapy

Photodynamic Therapy (PDT) for Pre-cancer and Cancer Treatment

Photodynamic Therapy (PDT) for Acne

Periorifical Dermatitis

Skincare and peel for melasma

Molluscum Contagiosum

Lichen Simplex Chronicus

Hidradenitis Suppurativa

Sclerotherapy for small veins

PRP (platelet rich plasma)

Skincare and peel for melasma

Plugged Hair Follicle

Pigmentation on Face and Body

Photodynamic Therapy (PDT) for Pre-cancer and Cancer Treatment

Photodynamic Therapy (PDT) for Acne

Periorifical Dermatitis

Swollen Blood Vessels

Suture Removal

Suspicious Skintag

Suspicious Portwine Stain

Squamous cell Carcinoma

Suspicious Mole

Suspected Cancer

Subcision for acne scarring

Employment Status

part-time

Patient Type

Pediatric

Department

einstein-dept-medicine

einstein-dept-pediatrics

Gender

Female

jgittler@montefiore.org

Phone

718-920-2680

Titles

Type

Academic

Department

Department of Medicine

Department Link

Rank

Assistant Professor

Division

Dermatology

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Assistant Professor

Type

Clinical

Title

Pediatric Dermatologist

Type

Clinical

Title

Assistant Professor of Dermatology and Pediatrics

Locations

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84534 40.845)

Address Line 1

1628 Eastchester Road

City

Bronx

State

Zip

10461-2663

Location Title

Montefiore at 1628 Eastchester

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84154 40.84612)

Address Line 1

1250 Waters place

City

Bronx

State

Zip

10461-2720

Location Title

Montefiore at 1250 Waters Place

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8782381 40.8799784)

Address Line 1

Montefiore Medical Center

Address Line 3

3411 Wayne Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

Albert Einstein College of Medicine

Education Type Label

Fellowship

Education Institution

Columbia University Medical Center

Education Type Label

Residency

Education Institution

New York University Medical Center

Professional Interests

Julia K. Gittler, MD, is an attending physician and Assistant Professor at Montefiore-Einstein. Dr. Gittler’s clinical areas of focus include all areas of pediatric dermatology, including eczema, vascular and other birthmarks, acne, genetic skin disorders and other pediatric dermatologic conditions.
Dr. Gittler earned her Bachelor of Arts at the University of Pennsylvania College of Arts and Sciences in 2008 and graduated summa cum laude. From 2008 to 2013, she attended the Albert Einstein College of Medicine, receiving her Doctor of Medicine and earning distinction in dermatology research through a research fellowship at the Rockefeller University. Her training also includes completion of a yearlong pediatrics internship at Cohen Children’s Medical Center in 2014, a three-year dermatology residency at New York University in 2017 and a yearlong pediatric dermatology fellowship at Columbia University in 2018.
Following her clinical interests, Dr. Gittler’s research focus is on pediatric dermatology. Her work has been published in many peer-reviewed journals. She has also shared her research through poster presentations and lectures at regional and national conferences.
Dr. Gittler is certified in pediatric dermatology by the American Board of Dermatology. She is a member of the American Academy of Dermatology and the Society of Pediatric Dermatology.

Research Areas

Pediatric Dermatology

Research Profile

https://einsteinmed.edu/faculty/16099/Julia-Gittler

Clinical Profile

https://montefioreeinstein.org/profiles/1427492081/julia-k-gittler

CHAM Provider

Off

Professional Title

M.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/a3079dec-bdda-4dce-869f-42d34e96c…

EMR ID

102886

Is Open Scheduling

Ulrich G. Steidl

Read more about Ulrich G. Steidl

Ulrich G. Steidl

https://assets.montefioreeinstein.org/profiles/images/Steidl_Ulrich_MD_PhD_2x.jpg

Faculty

Expert

First Name

Ulrich

Last Name

Steidl

Faculty ID

11118

Patient Type

Adult

Department

einstein-dept-cell-biology

einstein-dept-oncology

einstein-dept-medicine

ulrich.steidl@einsteinmed.edu

Phone

718-430-3437

Titles

Type

Academic

Department

Department of Cell Biology

Department Link

Rank

Professor

Type

Academic

Department

Department of Oncology

Rank

Professor

Type

Academic

Department

Department of Medicine

Department Link

Rank

Professor

Type

Administrative

Title

Chair, Department of Cell Biology

Tags

me-patientcare-cancer-research-stem-cell-cancer-biology

Type

Administrative

Title

Edward P. Evans Endowed Professor for Myelodysplastic Syndromes

Type

Administrative

Title

Co-Director, Blood Cancer Institute

Tags

me-patientcare-cancer-research-blood-cancer-institute-directors

Type

Administrative

Type

Administrative

Title

Deputy Director, and Associate Director for Basic Science, Montefiore Einstein Comprehensive Cancer Center

Tags

me-patientcare-cancer-about-directors-deputy-directors

me-patientcare-cancer-research-cdtmi

me-patientcare-cancer-research-cdtmi-members

Type

Administrative

Locations

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Chanin Building

Room

601

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

<h6>Molecular Mechanisms and Targeting of Pre-Leukemic Stem Cells in Normal and Malignant Hematopoiesis</h6>
Hematopoiesis maintains a life-long supply of the entire spectrum of highly specialized blood cells. This process relies on a small number of pluripotent hematopoietic stem cells (HSC).
Recent experimental evidence has shown that acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS) arise from an unexepctedly diverse pool of pre-leukemic stem cells (preL-SC), preceding the formation of fully transformed leukemia stem cells (LSC). Polyclonal Pre-LSC as well as LSC are also key drivers of therapy resistance and disease progression. Defining the molecular mechanisms in pre-LSC and their progression to fully transformed LSC is critical to understanding the genesis of leukemia and to developing therapeutic strategies by which these processes can be targeted.
Recent findings from our own group and others have demonstrated a critical role of transcription dynamics and plasticity, as well as mediators of aberrant signaling in the genesis and function of HSC, pre-LSC and LSC. To identify and functionally study implicated pathways we are studying murine genetic models as well as primary human samples from patients with MDS and leukemia. Our studies aim at the development of targeted, pre-LSC- and LSC-directed therapies, which could ultimately also be employed for precision prevention of relapse/progression, or "cancer interception".

Research Areas

hematopoiesis; stem cell origin of cancer; leukemia; AML; MDS; hematopoietic stem cells (HSC); (pre)leukemic stem cells (LSC); transcription dynamics; molecular noise; epigenetics; targeted therapy; drug development; translational computational biology

Specialties

Cancer

Expert Tags

Cancer Stem Cells

Leukemias and Myelodisplasic Syndromes

Areas of Expertise

Molecular therapy

Transcriptional regulation

Microbiology & Immunology

Molecular and Cell Biology

Stem cell research

Expert Summary

Dr. Steidl studies the molecular and cellular mechanisms that lead to two related blood diseases, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). His NIH-funded basic and translational research seeks to define the characteristics of pre-leukemic stem cells (pre-LSC), understand their progression to leukemic stems cells, and develop drug strategies to target the process. Dr. Steidl is co-director of the Albert Einstein Cancer Center's Blood Cancer Institute.
He was among the first researchers to demonstrate that MDS, a common precursor of AML, arises from defective blood-forming stem cells. As a result of his work, several experimental drugs targeting abnormal stem cells in patients with MDS and AML are in clinical trials.
In 2021, Dr. Steidl received a prestigious Outstanding Investigator Award from the National Cancer Institute (NCI) and a seven-year, $7 million grant for his research. He is author of more than 150 research papers, and has published studies in Nature, Nature Medicine, Cancer Cell, Nature Immunology, Nature Chemical Biology, Science Translational Medicine, and many others.

Research Profile

https://einsteinmed.edu/faculty/11118/Ulrich-Steidl

CHAM Provider

Off

Professional Title

M.D.

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/cf3e8062-d6d5-45c2-a8e3-7f38809ea…

Selected Publications

Selected recent publications (from a total of 176):
Taylor SJ, Stauber J, Bohorquez O, Tatsumi G, Kumari R, Chakraborty J, Bartholdy BA, Schwenger E, Sundaravel S, Farahat AA, Wheat JC, Goldfinger M, Verma A, Kumar A, Boykin DW, Stengel KR, Poon GMK, Steidl U. Genomic binding site restriction redirects pioneer transcription factor activity. Nat Genet. 2024 Sept 18; doi.org/10.1038/s41588-024-01911-7

Gao X*, Carpenter RS*, Boulais PE*, Zhang D, Marlein CR, Li H, Smith M, Chung DJ, Maryanovich M, Will B#, Steidl U#, Frenette PS#. Regulation of the hematopoietic stem cell pool by C-Kit-associated trogocytosis. Science. 2024 Aug 9; 385(6709):eadp2065.
Terrell JR, Taylor SJ, Schneider AL, Lu Y, Vernon TN, Xhani S, Gumpper RH, Luo M, Wilson WD, Steidl U#, Poon GMK#. DNA selection by the master transcription factor PU.1. Cell Rep. 2023; 42(7):112671.
Piszczatowski RT*, Schwenger E*, Sundaravel S, Stein CM, Liu Y, Stanley P, Verma A, Zheng D, Seidel RD, Almo SC, Townley RA#, Bülow HE#, Steidl U#. A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm. J Exp Med. 2022; 219(11):e20212552. 
Ueda K, Kumari R, Schwenger E, Wheat JC, Bohorquez O, Narayanagari SR, Taylor SJ, Carvajal LA, Pradhan K, Bartholdy B, Todorova TI, Goto H, Sun D, Chen J, Shan J, Song Y, Montagna C, Xiong S, Lozano G, Pellagatti A, Boultwood J, Verma A, Steidl U. MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism. Cancer Cell. 2021; 39:529-547 
Wheat JC, Sella Y, Willcockson M, Skoultchi AI, Bergman A, Singer RH, Steidl U. Single Molecule Imaging of Transcription Dynamics in Somatic Stem Cells. Nature. 2020; 583:431-436
Chen J, Kao YR, Sun D, Todorova TI, Reynolds D, Narayanagari SR, Montagna C, Will B, Verma A*, Steidl U*. Myelodysplastic Syndrome Progression to Acute Myeloid Leukemia at the Stem Cell Level. Nat Med. 2019; 25:103-110
Mitchell K, Barreyro L, Todorova TI, Taylor SJ, Antony Debré I, Narayanagari SR, Carvajal LA, Leite J, Piperdi Z, Pendurti G, Mantzaris I, Paietta E, Verma A, Gritsman K, Steidl U. IL1RAP Potentiates Multiple Oncogenic Signaling Pathways in AML. J Exp Med. 2018; 215:1709-1727
Carvajal LA, Ben-Neriah D, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, Narayanagari SR, Wheat JC, Todorova TI, Mitchell KM, Kenworthy C, Guerlavais V, Annis DA, Bartholdy B, Will B, Anampa JD, Mantzaris I, Aivado M, Singer RH, Coleman RA, Verma A, Steidl U. Dual inhibition of MDMX and MDM2 as a Therapeutic Strategy in Leukemia. Science Transl Med. 2018 Apr 11; 10:eaao3003
Antony-Debré I, Paul A, Leite J, Mitchell K, Kim HM, Carvajal LA, Tidorova TI, Huang K, Kumar A, Farahat AA, Bartholdy B, Narayanagari SR, Chen J, Ambesi-Impiombato A, Ferrando AA, Mantzaris I, Gavathiotis E, Verma A, Will B, Boykin DW, Wilson WD, Poon GMK, Steidl U. Pharmacological Inhibition of the Transcription Factor PU.1 in Leukemia. J Clin Invest. 2017; 127:4297-4313
Stanley RF*, Piszczatowski RT*, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari SR, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U.  A Myeloid Tumor Suppressor Role for NOL3.  J Exp Med. 2017; 214:753-771
Okoye-Okafor UC, Bartholdy B, Cartier J, Gao EN, Pietrak B, Rendina AR, Rominger C, Quinn C, Smallwood A, Wiggall KJ, Reif AJ, Schmidt SJ, Qi H, Zhao H, Joberty G, Faelth-Savitski M, Bantscheff M, Drewes G, Duraiswami C, Brady P, Groy A, Narayanagari SR, Antony-Debre I, Mitchell K, Wang HR, Kao YR, Christopeit M, Carvajal L, Barreyro L, Paietta E, Makishima H, Will B, Concha N, Adams ND, Schwartz B, McCabe MT, Maciejewski J, Verma A, Steidl U. New IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia. Nat Chem Biol. 2015; 11:878-886
Will B*, Vogler TO*, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Ben Neriah D, Roth M, van Oers J, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U. Minimal PU.1 Reduction Induces a Preleukemic State and Promotes Development of Acute Myeloid Leukemia. Nat Med. 2015; 21:1172-1181
Pandolfi A*, Stanley RF*, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U. PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome. Blood. 2015; 126:1118-27
Bartholdy B*, Christopeit M*, Will B, Mo Y, Barreyro L, Yu Y, Bhagat TD, Okoye-Okafor UC, Todorova TI, Greally JM, Levine RL, Melnick A, Verma A#, Steidl U#. A human hematopoietic stem cell-commitment related DNA cytosine methylation signature is prognostic for overall survival in acute myeloid leukemia.      J Clin Invest. 2014; 124:1158-1167
Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, Steidl U. Special AT-rich Sequence-Binding Protein 1 (Satb1) regulates hematopoietic stem cell self-renewal by promoting quiescence and repressing differentiation commitment. Nat Immunol. 2013; 14:437-45
Kawahara M*, Pandolfi A*, Bartholdy B*, Barreyro L, Will B, Roth M, Okoye-Okafor UC, Todorova TI, Figueroa ME, Melnick A, Mitsiades CS, Steidl U. H2.0-like Homeobox (HLX) Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia. Cancer Cell. 2012; 22:194–208
Will B, Zhou L, Vogler TO, Ben-Neriah S, Schinke C, Tamari R, Yu Y, Bhagat T, Bhattacharya S, Barreyro L, Heuck C, Mo Y, Parekh S, McMahon C, Pellagatti A, Boultwood J, Montagna C, Silverman L, Maciejewski J, Greally J, Ye BH, List A, Steidl C, Steidl U*, Verma A*. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations. Blood. 2012; 120:2076-2086
Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, Ben-Neriah S, Montagna C, Parekh S, Pellagatti A, Boultwood J, Paietta E, Ketterling RP, Cripe L, Fernandez HF, Greenberg PL, Tallman MS, Steidl C, Mitsiades CS, Verma A, Steidl U. Overexpression of interleukin 1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood. 2012; 120:1290-1298
Roth M, Will B, Simkin G, Rao S, Barreyro L, Bartholdy B, Tamari R, Mitsiades CS, Verma A, Steidl U. Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood. 2012; 120:386-394
Will B, Kawahara M, Luciano JP, Bruns I, Parekh S, Erickson-Miller CL, Aivado MA, Verma A, Steidl U. Effect of the nonpeptide thrombopoetin receptor agnoist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. Blood. 2009; 114:3899-3908
 Review Articles and Commentaries:

Taylor SJ, Steidl U. Chemical restriction of PU.1 genomic binding sites activates alternate gene networks. Nat Genet. 2024; doi.org/10.1038/s41588-024-01912-6

Piszczatowski RT, Buelow HE, Steidl U. Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis. Blood. 2024; 143:2571-2587
Wheat JC, Steidl U. Posttranscriptional Arid3a Deregulation in AMKL. Blood. 2022; 139:637-638
Tatsumi G, Steidl U. Transcriptional circuit dynamics in HSPC. Blood. 2021; 138:1382-1384
Taylor SJ, Sundaravel S, Steidl U. Exploting a key transcriptional dependency: ZMYND8 and IRF8 in AML. Mol Cell. 2021; 81:3445-3446
Wheat JC, Steidl U. Gene expression at a single molecule level: Implications for MDS and AML. Blood. 2021; 138:625-636
Ueda K, Steidl U. Epigenetic Achilles' heel of AML. Nature Cancer. 2021; 2:481-483 Schwenger E, Steidl U. An evolutionary approach to clonally complex hematologic disorders. Blood Cancer Discov. 2021 May;2(3):201-215.
Sundaravel S, Steidl U. Stem cell origins of JMML. J Exp Med. 2021; 218:e20202152 
Stauber J, Greally JM, Steidl U. Preleukemic and leukemic evolution at the stem cell level. Blood. 2021; 137:1013-1018
Ueda K, Kumari R, Steidl U. Fueling clonal dominance through TRAFficking of NF-kB signaling. Nat Immunol. 2020; 21:489-490
Mitchell K, Steidl U. Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML). Cold Spring Harb Perspect Med. 2020; 10:a036251
Piszczatowski RT, Steidl U. Aurora Kinase A Inhibition: A Mega-Hit for Myelofibrosis Therapy? Clin Cancer Res. 2019; 25:4868-4870
Chen J, Steidl U. Inhibition of HIF1α Signaling: A Grand Slam for MDS Therapy ? Cancer Discovery. 2018; 8:1355-1357
Wheat JC, Steidl U. Linking histone methylation, transcription rates, and stem cell robustness. Haematologica. 2018; 103:1093
Taylor SJ, Steidl U. Metabolic strugGLS after FLT3 inhibition in AML. Blood. 2018; 131:1631-1632
Wheat JC, Steidl U.  ETO2-GLIS2: A chimeric transcription factor drives leukemogenesis through a neomorphic transcription network. Cancer Cell. 2017; 31:307-308
Shastri A, Will B, Steidl U*, Verma A*. Stem and Progenitor Cell Alterations in Myelodysplastic Syndromes. Blood. 2017; 129:1586-1594
Carvajal L, Steidl U. Eliminating cancer stem cells in CML with combination transcriptional therapy. Cell Stem Cell. 2016; 19:6-8 
Stanley RF, Steidl U. Molecular mechanism of mutant CALR-mediated transformation. Cancer Discovery. 2016; 6:344-346
Stanley RF, Steidl U. Ectopic Dnmt3b Expression Delays Leukemogenesis. Blood. 2016; 127:1525-6
Antony-Debre I, Steidl U. Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies. Cancer Cell. 2015; 27:609-611
Verma A, Steidl U. A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia. Nat Med. 2015;21:113-114
Will B, Steidl U. Combinatorial haplo-deficient tumor suppression in 7q-deficient myelodysplastic syndrome and acute myeloid leukemia. Cancer Cell. 2014; 25:555-557
Will B, Steidl U. Stem cell fate regulation by dynein motor protein Lis1. Nat Genet. 2014; 46:217-218
Antony-Debre I, Steidl U. CDK6, a new target in MLL-driven leukemia. Blood. 2014; 124:5-6
Elias HK, Schinke C, Bhattacharyya S, Will B, Verma A, Steidl U. Stem cell origin of myelodysplastic syndromes. Oncogene. 2013 Dec 16. doi: 10.1038/onc.2013.520
Pandolfi A, Barreyro L, Steidl U. Pre-leukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Transl Med. 2013; 2:143–150

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Jose Moonjely Davis

Read more about Jose Moonjely Davis

Jose Moonjely Davis

https://assets.montefioreeinstein.org/profiles/images/17613-jose-moonjely-davis.jpg

Provider

Faculty

First Name

Jose

Last Name

Moonjely Davis

NPI

1972983336

Faculty ID

17613

CMO Specialties

Clinical Terms

Interstitial Lung Disease

Lung Cancer

Lung Nodules

Mesothelioma

Mycobacterial Infections

Pulmonary Hypertension

Pulmonary Rehabilitation

Pulmonary Function Test

Pulmonary Function Tests

Pulmonary Function Testing

Allergic Rhinitis

Legionnaires' Disease

Acute Pulmonary Edema

Asthma

Acute Bronchitis

Afebrile Pneumonia Syndrome

Asbestos Related

Atypical Mycobarterial Infection

Bronchoscopy Procedure

Chronic Lung Disease

Clearance for future Operation

Gastric Bypass Pulmonary Clearance

General/Other

Granuloma

Hay fever

Hilar Lymphadenopathy

Hypersensitivity Pneumonitis

Idiopathic Pulmonary Fibrosis

ILD

Infection

Inflamed Bronchial Tubes

Lung disease/abnormalities

Mediastinal Lymphadenopathy

Mediastinitis

Mild Asthma

Moderate Asthma

Mycobacterial Infection

Mycoplasma Pneumoniae

Neoplasm

Obstructive Pulmonary Disease

Obstructive Sleep Apnea

Respiratory Infection

Thickened Lung Tissue

Tracheal Stenosis

Uncomfortable Breathing

Upper Respiratory Infection

Employment Status

Full Time

Patient Type

Adult

Department

einstein-dept-medicine

Gender

Male

josedavis@montefiore.org

Phone

866-633-8255

Titles

Type

Academic

Department

Department of Medicine

Department Link

Rank

Assistant Professor

Division

Pulmonary Medicine

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84154 40.84612)

Address Line 1

1250 Waters place

City

Bronx

State

Zip

10461-2720

Location Title

Montefiore at 1250 Waters Place

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.839137 40.8526781)

Building

Tower 2

Address Line 1

Montefiore Medical Center

Address Line 3

1250 Waters Place

City

Bronx

State

Zip

10461

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

Rajiv Gandhi University of Health and Science

Education Type Label

Fellowship

Education Institution

Baylor College of Med

Education Type Label

Residency

Education Institution

Western Reserve Health Education- NEOMED

Education Type Label

Residency

Education Institution

San Antony's Mission Hospital

Education Type Label

Residency

Education Institution

Kristu Jayanti Hospital

Research Profile

https://einsteinmed.edu/faculty/17613/Jose-Moonjely Davis

Clinical Profile

https://montefioreeinstein.org/profiles/1972983336/jose-moonjely-davis

CHAM Provider

Off

Professional Title

M.B.,B.S.

EMR ID

180097

Visit Type ID

2542

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David M. Loeb

Read more about David M. Loeb

David M. Loeb

https://assets.montefioreeinstein.org/profiles/images/Loeb_David_MD_2x.jpg

Provider

Faculty

Expert

First Name

David

Last Name

Loeb

NPI

1841236676

Faculty ID

15556

CMO Specialties

Pediatric Hematology-Oncology

Clinical Terms

Myelodysplastic Syndromes

Ankle Pain

Chronic Lymphocytic Leukemia

Thrombocytopenia

Suicidal Thoughts

Hospital-Associated Pneumonia

Acute Lymphoblastic Leukemia

Hypertensive Emergency

Abnormal Uterine Bleeding

Knee Pain

Chronic Constipation

CMV Infection

Urinary Tract Infection

Acute Respiratory Distress Syndrome

Hydronephrosis

Unresolved or Complicated Grief

Bone Marrow Transplant

Headaches in Children

Diabetic Peripheral Neuropathy

Mucositis

Boil

Headache

Numbness And Tingling

Grief

Lung Nodules

Secondary Adrenal Insufficiency

Fever

Addison's Disease

Opioid Overdose

Clostridium Difficile Colitis

Secondary High Blood Pressure

Painful Urination

Blood In Stool

Embolism And Thrombosis

Acute Pancreatitis

Deep Vein Thrombosis (DVT)

Elevated Blood Pressure

Hemorrhoids

Congenital Hydrocephalus

Disruptive Behavior Disorder

Peripheral Neuropathy

Abdominal Pain

Electrolyte Imbalance

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

einstein-dept-developmental-molecular-biology

Gender

Male

david.loeb@einsteinmed.edu

Phone

718-920-4664

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Pediatric Hematology-Oncology

Type

Academic

Department

Department of Developmental & Molecular Biology

Department Link

Rank

Professor

Type

Clinical

Title

Chief, Division of Pediatric Hematology, Oncology, and Cellular Therapy

Type

Clinical

Title

Director, Sarcoma Program

Type

Clinical

Title

Professor, Pediatrics and Developmental and Molecular Biology

Tags

me-patientcare-cancer-research-cdtmi

me-patientcare-cancer-research-cdtmi-members

Type

Administrative

Title

Chief, Division of Pediatric Hematology / Oncology, Department of Pediatrics

Type

Administrative

Title

Linda and Earle Altman Faculty Scholar in Cancer Research

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8782381 40.8799784)

Room

910

Address Line 1

Montefiore Medical Center

Address Line 3

3411 Wayne Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

Columbia University

Education Type Label

Fellowship

Education Institution

Johns Hopkins University

Education Type Label

Residency

Education Institution

Johns Hopkins University

Professional Interests

Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis.  His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process.  More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma migration, invasion, and metastasis.  Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA. More recently, the laboratory has developed an interest in targeting the metabolic reprogramming associated with metastasis as a way to prevent the outgrowth of distant metastases from disseminated tumor cells.
 
Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3.  He serves as the local PI for a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors.  Finally, as an offshoot of his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents, and young adults with sarcomas.

Research Areas

Dr. Loeb has a translational research laboratory focused on the biology and treatment of bone tumor metastasis, especially the role of Wnt signaling pathways. Other areas of interest include the role of the RNA helicase, DDX3, in bone sarcomas and the met

Specialties

Expert Tags

Bone Marrow Transplant

Areas of Expertise

Childhood cancer

Treatments for childhood cancer including bone marrow transplant

Musculoskeletal Tumors

Sarcoma

Expert Summary

Dr. Loeb is a leading pediatric oncologist and NIH-funded researcher. He has extensive expertise in sarcoma research and clinical care and is a bone marrow transplantation specialist. Dr. Loeb’s research spans the spectrum from basic and translational studies to clinical trials using novel therapies.

Research Profile

https://einsteinmed.edu/faculty/15556/David-Loeb

Clinical Profile

https://montefioreeinstein.org/profiles/1841236676/david-m-loeb

CHAM Provider

Professional Title

M.D.

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/9bfd753a-1293-4fdf-ac41-fd352bc7d…

Selected Publications

Dr. Loeb's PubMed bibliography can be found here:  
<a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1fiIspwqfwUE46/bibliography/5…;

EMR ID

6405

Biography

David Loeb, MD, PhD, is Chief, Pediatric Hematology, Oncology and Cellular Therapy at Children’s Hospital at Montefiore and Professor, Pediatrics and Professor, Developmental and Molecular Biology at Montefiore Einstein. His clinical work focuses on tumors of connective tissue, such as bone and muscle. He also has expertise in the care of children with other solid tumors. As a member of the bone marrow transplantation team, Dr. Loeb also cares for patients with acute leukemias and has expertise in the application of immunotherapy to childhood cancer.Dr. Loeb earned his Bachelor of Arts in biology in 1987 at Johns Hopkins University. In 1993, he received his Doctor of Philosophy in Pathology and, in 1994, his Doctor of Medicine at Columbia University. In 1994, he also began an internship in Pediatrics at the Johns Hopkins University School of Medicine, followed by a residency in 1995 and a fellowship in Pediatric Hematology Oncology at the same institution.Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis and has used this model to perform preclinical testing of novel agents that can interfere with this process. One area of focus is the metabolic differences between cancer cells and normal cells, and between metastases and the primary tumor, with the intention of targeting these differences therapeutically. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma and osteosarcoma migration, invasion and metastasis. Dr. Loeb also studies the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA.Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He has also directed a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. Stemming from his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents and young adults with sarcomas. Dr. Loeb’s original research, based on his clinical and laboratory studies, has been published in multiple journals and books.Dr. Loeb has been a recipient of many awards, including the Director’s Teaching Award in Clinical Science from Sidney Kimmel Comprehensive Cancer Center in 2006, 2010 and 2015, and The Justin Straus Chordoma Research Award in 2009.

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Heyi Li

Read more about Heyi Li

Heyi Li

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Provider

Faculty

First Name

Heyi

Last Name

NPI

1265986178

Faculty ID

17368

CMO Specialties

Pulmonary Disease

Critical Care Medicine

Clinical Terms

Interstitial Lung Disease

Lung Cancer

Lung Nodules

Mesothelioma

Mycobacterial Infections

Pulmonary Hypertension

Pulmonary Rehabilitation

Pulmonary Function Test

Pulmonary Function Tests

Pulmonary Function Testing

Allergic Rhinitis

Legionnaires' Disease

Acute Pulmonary Edema

Asthma

Acute Bronchitis

Afebrile Pneumonia Syndrome

Asbestos Related

Atypical Mycobarterial Infection

Bronchoscopy Procedure

Chronic Lung Disease

Clearance for future Operation

Gastric Bypass Pulmonary Clearance

General/Other

Granuloma

Hay fever

Hilar Lymphadenopathy

Hypersensitivity Pneumonitis

Idiopathic Pulmonary Fibrosis

ILD

Infection

Inflamed Bronchial Tubes

Lung disease/abnormalities

Mediastinal Lymphadenopathy

Mediastinitis

Mild Asthma

Moderate Asthma

Mycobacterial Infection

Mycoplasma Pneumoniae

Neoplasm

Obstructive Pulmonary Disease

Obstructive Sleep Apnea

Respiratory Infection

Thickened Lung Tissue

Tracheal Stenosis

Uncomfortable Breathing

Upper Respiratory Infection

Employment Status

Full Time

Patient Type

Adult

Department

einstein-dept-medicine

Gender

Female

heli@montefiore.org

Phone

718-920-6054

Titles

Type

Academic

Department

Department of Medicine

Department Link

Rank

Assistant Professor

Division

Pulmonary Medicine

Type

Clinical

Title

Attending Physician

Type

Clinical

Title

Assistant Professor

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87862 40.88032)

Address Line 1

3400 Bainbridge Avenue

City

Bronx

State

Zip

10467-240

Location Title

Montefiore Greene Medical Arts Pavilion

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8782381 40.8799784)

Address Line 1

Montefiore Medical Center

Address Line 3

3411 Wayne Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

Zhejiang Medical University

Education Type Label

Fellowship

Education Institution

Mayo Medical School

Education Type Label

Residency

Education Institution

Cook County Hospital

Research Profile

https://einsteinmed.edu/faculty/17368/Heyi-Li

Clinical Profile

https://montefioreeinstein.org/profiles/1265986178/heyi-li

CHAM Provider

Off

Professional Title

M.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/72c4af1f-7850-4c1c-ac26-3cde57f39…

EMR ID

173372

Biography

Heyi Li, MD, is an attending physician and Assistant Professor, Pulmonary and Critical Care Medicine at Montefiore Einstein. Her clinical focus is on the management of acute and chronic disorders of the lung and breathing, such as chronic obstructive lung diseases, asthma, interstitial lung diseases, infectious lung diseases and lung nodules. She performs airway and chest procedures including bronchoscopies and thoracentesis, and also provides consultations on smoking cessation and respiratory rehabilitation.After earning her Bachelor of Engineering degree at Zhejiang University, Hangzhou, China in 2011, she continued her education with the institution’s School of Medicine, earning her Doctor of Medicine in 2015. Dr Li’s postdoctoral training brought her to the United States, completing a three-year residency in internal medicine at John H. Stroger Jr. Hospital of Cook County in 2019 and a pulmonary and critical care fellowship at Mayo Clinic at Rochester, Minnesota in 2022.Dr. Li’s clinical research focuses on care delivery research and implementation science. Her goal is to develop a mature line of inquiry in implementation science, focused on both conceptual frameworks and pragmatic implementation strategies. She has shared her work through peer-reviewed journals and has presented it at regional and national conferences. Dr. Li has also been a periodic reviewer for Critical Care Medicine and the American Journal of Respiratory and Critical Care Medicine.Dr. Li is board certified in Internal Medicine and Pulmonary Medicine by the American Board of Internal Medicine. She is a member of the American College of Chest Physicians, the American Thoracic Society and the Society of Critical Care Medicine.

Visit Type ID

2542

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