Job Opportunities Position#:03082023Title: Postdoctoral Position, Laboratory of Dr. B. Hilda Ye, PhD JOB DESCRIPTION: A POSTDOCTORAL FELLOWSHIP is available immediately to study the molecular and cellular mechanisms of HTLV-1 driven adult T-cell leukemia/lymphoma (ATLL). Being the only human cancer caused by a retrovirus, ATLL is a fatal disease with no effective therapy. ATLL is distinguished from other types of T cell lymphomas in its unique genetic and phenotypic characteristics as well as clinical behavior. Evidence is also accumulating that ATLL diagnosed in North America and Japan may differ in their mutation patterns and anti-HTLV-1 host immune response. We use patient samples as well as cell line and PDX models to investigate the roles played by epigenetic dysregulation, altered crosstalk of cell signaling pathways, elevated replication stress in ATLL development and targeted therapies. We have also begun to examine how host immunity is impacted during ATLL development. More information about our work can be found at: https://www.einsteinmed.edu/faculty/7901/b-hilda-ye/ Recent PhD or MD graduates with significant research experience are preferred. Proficiency in molecular biology techniques including the manipulation and analysis of gene expression in cultured and primary cells is required. Some knowledge of immunology would be desirable, so are computational skills. First authored publication(s) in peer-reviewed, English language journals are necessary. Ability to work independently, motivation to make new discoveries and a strong work ethic are important. A curriculum vitae with a description of research experiences and contact information for three references should be sent to hilda.ye@einsteinmed.edu . Please make the email subject "Postdoctoral Application - Your name." The Albert Einstein College of Medicine (Einstein) is one of the nation’s premier institutions for basic research and clinical investigation with more than 300 research laboratories funded by more than $220 million from the National Institutes of Health. There are ~200 PhD students and ~250 postdoctoral fellows at Einstein https://www.einsteinmed.edu/about/ Albert Einstein College of Medicine is an Equal Opportunity Employer. Position#:05272021Title: Postdoctoral Position: Mammalian Epigenomics, Chromatin Structure and Function, Cancer. JOB DESCRIPTION: A postdoctoral position is available at Albert Einstein College of Medicine in the laboratory of Dr. Art Skoultchi, Professor and Chair of Cell Biology. The goal is to understand the roles of H1 linker histones in chromatin structure and function, gene regulation and cancer. We have prepared a unique series of knock-out mice and ES cell lines lacking specific H1 histones. Our studies have revealed roles for H1 histones in gene regulation, the epigenetic landscape, nuclear organization and blood cancers:Willcockson et al. Nature 589:293 (2021) Yusufova et al. Nature 589:299 (2021) Healton et al. PNAS 117:14251 (2020) Seeking an accomplished applicant with a strong background in cell and molecular biology. Experience working with embryonic stem cells and mice is a plus. However, in the selection of candidates we will emphasize overall scientific abilities and potential rather than specific experience or technical expertise. Candidates must have a Ph.D. degree or equivalent and possess strong independent research abilities with ambitious scientific interests, self-motivation and the ability to work effectively with a team. Successful candidates will be offered generous salary and benefits, including College-subsidized postdoctoral housing in a pleasant residential neighborhood near the medical school. To apply, please send a CV with a brief description of research experience and career goals, plus contact information for three references to:Arthur I. Skoultchi, Ph.D. Professor and Chair Albert Einstein College of Medicine Department of Cell Biology 1300 Morris Park Avenue New York, New York 10461E-mail: arthur.skoultchi@einsteinmed.orgEOE