Michael G. Rosenfeld

Michael G. Rosenfeld, M.D.

Email

Phone

Location

  • UCSD/HHMI 9500 Gilman Drive MC-0648 353 La Jolla, CA 92093-0648


Selected Publications

Yang F, Tanasa B, et al. Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Nature. 2021 Jul;595(7867):444-449. doi: 10.1038/s41586-021-03589-x. Epub 2021 Jun 30.PMID: 34194047

Oh S, et al. Enhancer release and retargeting activates disease-susceptibility genes. Nature. 2021 May 26. doi: 10.1038/s41586-021-03577-1. Online ahead of print.PMID: 34040254

Alexanian M,et al. A transcriptional switch governs fibroblast activation in heart disease. Nature. 2021 Jul;595(7867):438-443. doi: 10.1038/s41586-021-03674-1. Epub 2021 Jun 23.PMID: 34163071

Nott A, et al. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 Nov 29;366(6469):1134-1139. doi: 10.1126/science.aay0793. Epub 2019 Nov 14.PMID: 31727856

Nair SJ, et al. Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly. Nature Struct Mol Biol. 2019,26(3):193-203

Kim HS, et al. Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. Nature. 2018 Apr;556(7702):510-514.

Tan Y, et al. Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program. Mol Cell. 2018 Aug 16;71(4):526-539.e8. doi: 10.1016/j.molcel.2018.07.039.

Yang,F, et al. Glucocorticoid receptor: MegaTrans Switching Mediates the Repression of an ERα-Regulated transcriptional Program. Mol Cell. 2017 May4;66(3):321-331
Wang J, et al. LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci. 2015 Sep;18(9):1256-64. doi: 10.1038/nn.4069. Epub 2015 Jul 27.

Telese F, et al. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron. 2015 May 6;86(3):696-710. PMID:2589230

Li W,et al. Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation. Mol Cell. 2015 Jul 16;59(2):188-202. PMID:26166704.

Puc J, et al. Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell. 2015 Jan 29;160(3):367-80. PMID:25619691.

Skowronska-Krawczyk, D., et al. Required Interactions of Enhancers with Matrin-3 Nuclear Architecture for Transcriptional Activation by Homeodomain Factor. Nature 2014;514(7521):257-61. PMID:25119036.

Basnet H, et al. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014 Dec 11;516(7530):267-71. PMID:25252977.

Liu Z, et al. Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell. 2014 Oct 9;159(2):358-73. PMID:25303530.