Daniel Zamith Miranda, Ph.D.

In the Nosanchuk Lab we study a variety of pathogenic fungi and their interactions with the host. We are interested in the mechanisms by which pathogenic fungi cause disease, and how the host reacts when challenged with them. Among the disease-promoting mechanisms employed by fungi, we have a particular interest in extracellular vesicles (EVs) released by these cells, and how they impact the immune response. Our experience shows that the release of EVs by each fungal organism elicits a distinct response in the host that range from stimulation to suppression.

1. This is my complete list of publications.
   Please substitute the one currently in my profile for the one below
2. Krylova SV, Zamith-Miranda D, Xiaoli AM, Yu X, Nosanchuk JD, Yang F, Pessin
   JE, Feng D. Characterization of Adipocyte-Derived Extracellular Vesicle
   Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro. J Vis Exp.
   2025 Dec 5;(226). doi: 10.3791/69670. PMID: 41428712.
3. Botbol Y, Alves V, Nimrichter L, Macian F, Nosanchuk JD, Zamith-Miranda D.
   Extracellular vesicles from Candidozyma (Candida) auris inhibit proliferation of
   CD4 T cells by disrupting the IL-2 axis. J Immunol. 2025 Dec 6:vkaf302. doi:
   10.1093/jimmun/vkaf302. Epub ahead of print. PMID: 41351525.
4. Mendoza SR, Honorato L, Cintra DS, Ferreira MdS, Zamith-Miranda D, Nosanchuk
   JD, Nimrichter L, Guimarães AJ. Lectin-Fc(IgG) fusion proteins exhibit
   antifungal activity against the emerging multidrug-resistant pathogen Candida
   auris. Infect Immun. 2025 Dec 16;93(12):e0032925. doi: 10.1128/iai.00329-25.
   Epub 2025 Oct 29. PMID: 41159718; PMCID: PMC12707105.
5. Cintra DS, Alcantara LM, Nardy KA, Valente MR, De Oliveira PCO, Peixoto BS,
   Veloso MCDC, Romeiro GA, Zamith-Miranda D, Nosanchuk JD, Pinto MR, Guimarães AJ.
   Antifungal efficacy of pyrolysis-derived bio-oil aqueous phases from Tropical
   plant biomass against Candida auris. Sci Rep. 2025 Sep 29;15(1):33514. doi:
   10.1038/s41598-025-17626-6. PMID: 41022927; PMCID: PMC12480081.
6. Valdez AF, Artunduaga Bonilla JJ, Zamith-Miranda D, Montalvão B, Veres É,
   Youngchim S, Tucker C, Draganski A, Gácser A, Nimrichter L, Nosanchuk JD. Nitric
   Oxide-Releasing Microparticles: A Novel Treatment for Onychomycosis. Mol Pharm.
   2025 Sep 1;22(9):5567-5575. doi: 10.1021/acs.molpharmaceut.5c00613. Epub 2025
   Aug 21. PMID: 40839555; PMCID: PMC12406251.
7. Souza TN, Valdez AF, Zimbres ACG, Sena BAG, Reis FCG, Rodrigues ML, Zamith-
   Miranda D, Guimarães AJ, Filardy AA, Nosanchuk JD, Nimrichter L. Extracellular
   vesicles from Distinct Histoplasma capsulatum Strains Modulate Phagocyte
   Function and Promote Fungal Persistence. ACS Infect Dis. 2025 Aug
   8;11(8):2342-2356. doi: 10.1021/acsinfecdis.5c00378. Epub 2025 Jul 13. PMID:
   40653703; PMCID: PMC12340971.
8. Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA,
   Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM, Brown
   Harding H. Extracellular vesicles from diverse fungal pathogens induce species-
   specific and endocytosis-dependent immunomodulation. PLoS Pathog. 2025 May
   30;21(5):e1012879. doi: 10.1371/journal.ppat.1012879. PMID: 40445992; PMCID:
   PMC12157816.
9. Rodrigues ML, Janbon G, O'Connell RJ, Chu TT, May RC, Jin H, Reis FCG, Alves
   LR, Puccia R, Fill TP, Rizzo J, Zamith-Miranda D, Miranda K, Gonçalves T, Ene
   IV, Kabani M, Anderson M, Gow NAR, Andes DR, Casadevall A, Nosanchuk JD,
   Nimrichter L. Characterizing extracellular vesicles of human fungal pathogens.
   Nat Microbiol. 2025 Apr;10(4):825-835. doi: 10.1038/s41564-025-01962-4. Epub
   2025 Mar 27. PMID: 40148564; PMCID: PMC12035713.
10. Alves V, Zamith-Miranda D, Frases S, Nosanchuk JD. Fungal Metabolomics: A
    Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying
    Potential Therapeutics. J Fungi (Basel). 2025 Jan 24;11(2):93. doi:
    10.3390/jof11020093. PMID: 39997385; PMCID: PMC11856446.
11. Kwaku GN, Jensen KN, Simaku P, Floyd DJ, Saelens JW, Reardon CM, Ward RA,
    Basham KJ, Hepworth OW, Vyas TD, Zamith-Miranda D, Nosanchuk JD, Vyas JM,
    Harding HB. Extracellular vesicles from diverse fungal pathogens induce species-
    specific and endocytosis-dependent immunomodulation. bioRxiv [Preprint]. 2025
    Jan 3:2025.01.03.631181. doi: 10.1101/2025.01.03.631181. Update in: PLoS Pathog.
    2025 May 30;21(5):e1012879. doi: 10.1371/journal.ppat.1012879. PMID: 39803513;
    PMCID: PMC11722428.
12. Honorato L, Artunduaga Bonilla JJ, Ribeiro da Silva L, Kornetz J, Zamith-
    Miranda D, Valdez AF, Nosanchuk JD, Gonçalves Paterson Fox E, Nimrichter L.
    Alkaloids solenopsins from fire ants display in vitro and in vivo
    activity against the yeast Candida auris. Virulence. 2024
    Dec;15(1):2413329. doi: 10.1080/21505594.2024.2413329. Epub 2024 Oct 10. PMID:
    39370781; PMCID: PMC11469440.
13. Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski
    R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA,
    Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de
    Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM. Candida
    albicans extracellular vesicles trigger type I IFN signalling via cGAS and
    STING. Nat Microbiol. 2024 Jan;9(1):95-107. doi: 10.1038/s41564-023-01546-0.
    Epub 2024 Jan 2. PMID: 38168615; PMCID: PMC10959075.
14. Valdez AF, de Souza TN, Bonilla JJA, Zamith-Miranda D, Piffer AC, Araujo
    GRS, Guimarães AJ, Frases S, Pereira AK, Fill TP, Estevao IL, Torres A, Almeida
    IC, Nosanchuk JD, Nimrichter L. Traversing the Cell Wall: The Chitinolytic
    Activity of Histoplasma capsulatum Extracellular Vesicles Facilitates
    Their Release. J Fungi (Basel). 2023 Oct 27;9(11):1052. doi: 10.3390/jof9111052.
    PMID: 37998859; PMCID: PMC10672645.
15. Chechi JL, da Costa FAC, Figueiredo JM, de Souza CM, Valdez AF, Zamith-
    Miranda D, Camara AC, Taborda CP, Nosanchuk JD. Vaccine development for
    pathogenic fungi: current status and future directions. Expert Rev Vaccines.
    2023 Jan-Dec;22(1):1136-1153. doi: 10.1080/14760584.2023.2279570. Epub 2023 Nov
    13. PMID: 37936254; PMCID: PMC11500455.
16. Erives VH, Munzen ME, Zamith-Miranda D, Hernandez H, Manepalli S, Nguyen LN,
    Hamed MF, Nosanchuk JD, Martinez LR. Correction for Erives et al.,
    "Methamphetamine Enhances Cryptococcus neoformans Melanization,
    Antifungal Resistance, and Pathogenesis in a Murine Model of Drug Administration
    and Systemic Infection". Infect Immun. 2023 Nov 16;91(11):e0036623. doi:
    10.1128/iai.00366-23. Epub 2023 Oct 25. Erratum for: Infect Immun. 2022 Apr
    21;90(4):e0009122. doi: 10.1128/iai.00091-22. PMID: 37877710; PMCID:
    PMC10652936.
17. Valdez AF, Zamith-Miranda D, Nimrichter L, Nosanchuk JD. Micro- and
    nanoparticles as platforms for the treatment of fungal infections: present and
    future perspectives. Future Microbiol. 2023 Nov;18(15):1007-1011. doi:
    10.2217/fmb-2023-0079. Epub 2023 Sep 18. PMID: 37721209; PMCID: PMC10718170.
18. Liu S, Zamith-Miranda D, Almeida-Paes R, da Silva LBR, Nacharaju P,
    Nosanchuk JD. Nitric oxide-loaded nano- and microparticle platforms serving as
    potential new antifungal therapeutics. Fungal Biol. 2023 Jul-
    Aug;127(7-8):1224-1230. doi: 10.1016/j.funbio.2023.01.007. Epub 2023 Jan 24.
    PMID: 37495312; PMCID: PMC10372338.
19. Smith DFQ, Mudrak NJ, Zamith-Miranda D, Honorato L, Nimrichter L, Chrissian
    C, Smith B, Gerfen G, Stark RE, Nosanchuk JD, Casadevall A. Melanization of
    Candida auris Is Associated with Alteration of Extracellular pH. J Fungi
    (Basel). 2022 Oct 11;8(10):1068. doi: 10.3390/jof8101068. PMID: 36294632; PMCID:
    PMC9604884.
20. Amatuzzi RF, Zamith-Miranda D, Munhoz da Rocha IF, Lucena ACR, de Toledo
    Martins S, Streit R, Staats CC, Trentin G, Almeida F, Rodrigues ML, Nosanchuk
    JD, Alves LR. Caspofungin Affects Extracellular Vesicle Production and Cargo in
    Candida auris. J Fungi (Basel). 2022 Sep 21;8(10):990. doi:
    10.3390/jof8100990. PMID: 36294557; PMCID: PMC9605528.
21. Valdez AF, Miranda DZ, Guimarães AJ, Nimrichter L, Nosanchuk JD.
    Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted
    organism adapted to intracellular environments. Virulence. 2022
    Dec;13(1):1900-1919. doi: 10.1080/21505594.2022.2137987. PMID: 36266777; PMCID:
    PMC9621017.
22. Li KL, Miranda DZ, Cleare LG, Akbar NA, Friedman JM, Draganski A, Nosanchuk
    JD, Abuzeid WM. Nitric oxide-generating microparticles: An in vitro evaluation
    of anti-biofilm efficacy and sinonasal epithelial cell cytotoxicity. Int Forum
    Allergy Rhinol. 2023 May;13(5):954-957. doi: 10.1002/alr.23096. Epub 2022 Oct
    26. PMID: 36208141.
23. Zamith-Miranda D, Alves LR, Rodrigues ML, Nimrichter L, Nosanchuk JD.
    Isolation of Extracellular Vesicles from Candida auris. Methods Mol Biol.
    2022;2517:173-178. doi: 10.1007/978-1-0716-2417-3_13. PMID: 35674953.
24. Honorato L, de Araujo JFD, Ellis CC, Piffer AC, Pereira Y, Frases S, de
    Sousa Araújo GR, Pontes B, Mendes MT, Pereira MD, Guimarães AJ, da Silva NM,
    Vargas G, Joffe L, Del Poeta M, Nosanchuk JD, Zamith-Miranda D, Dos Reis FCG, de
    Oliveira HC, Rodrigues ML, de Toledo Martins S, Alves LR, Almeida IC, Nimrichter
    L. Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha
    Differentiation in Candida albicans. mBio. 2022 Jun 28;13(3):e0030122. doi:
    10.1128/mbio.00301-22. Epub 2022 Apr 14. PMID: 35420476; PMCID: PMC9239257.
25. Erives VH, Munzen ME, Zamith-Miranda D, Hernandez H, Manepalli S, Nguyen LN,
    Hamed MF, Nosanchuk JD, Martinez LR. Methamphetamine Enhances Cryptococcus
    neoformans Melanization, Antifungal Resistance, and Pathogenesis in a Murine
    Model of Drug Administration and Systemic Infection. Infect Immun. 2022 Apr
    21;90(4):e0009122. doi: 10.1128/iai.00091-22. Epub 2022 Mar 31. Erratum in:
    Infect Immun. 2023 Nov 16;91(11):e0036623. doi: 10.1128/iai.00366-23. PMID:
    35357221; PMCID: PMC9022586.
26. Silva VKA, Bhattacharya S, Oliveira NK, Savitt AG, Zamith-Miranda D,
    Nosanchuk JD, Fries BC. Replicative Aging Remodels the Cell Wall and Is
    Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts.
    mBio. 2021 Feb 22;13(1):e0019022. doi: 10.1128/mbio.00190-22. Epub 2022 Feb 15.
    PMID: 35164553; PMCID: PMC8844920.
27. Zamith-Miranda D, Alves LR, Nakayasu ES, Nosanchuk JD. Lessons Learned from
    Studying Histoplasma capsulatum Extracellular Vesicles. Curr Top Microbiol
    Immunol. 2021;432:13-18. doi: 10.1007/978-3-030-83391-6_2. PMID: 34972874.
28. Munhoz da Rocha IF, Martins ST, Amatuzzi RF, Zamith-Miranda D, Nosanchuk JD,
    Rodrigues ML, Alves LR. Cellular and Extracellular Vesicle RNA Analysis in the
    Global Threat Fungus Candida auris. Microbiol Spectr. 2021 Dec
    22;9(3):e0153821. doi: 10.1128/Spectrum.01538-21. Epub 2021 Dec 15. PMID:
    34908466; PMCID: PMC8672890.
29. Zamith-Miranda D, Heyman HM, Burnet MC, Couvillion SP, Zheng X, Munoz N,
    Nelson WC, Kyle JE, Zink EM, Weitz KK, Bloodsworth KJ, Clair G, Zucker JD,
    Teuton JR, Payne SH, Kim YM, Reyes Gil M, Baker ES, Bredeweg EL, Nosanchuk JD,
    Nakayasu ES. A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal
    Targets. mBio. 2021 Dec 21;12(6):e0297221. doi: 10.1128/mBio.02972-21. Epub 2021
    Nov 23. PMID: 34809453; PMCID: PMC8609360.
30. Zamith-Miranda D, Amatuzzi RF, Munhoz da Rocha IF, Martins ST, Lucena ACR,
    Vieira AZ, Trentin G, Almeida F, Rodrigues ML, Nakayasu ES, Nosanchuk JD, Alves
    LR. Transcriptional and translational landscape of Candida auris in
    response to caspofungin. Comput Struct Biotechnol J. 2021 Sep 14;19:5264-5277.
    doi: 10.1016/j.csbj.2021.09.007. PMID: 34630944; PMCID: PMC8481930.
31. Zamith-Miranda D, Heyman HM, Couvillion SP, Cordero RJB, Rodrigues ML,
    Nimrichter L, Casadevall A, Amatuzzi RF, Alves LR, Nakayasu ES, Nosanchuk JD.
    Comparative Molecular and Immunoregulatory Analysis of Extracellular Vesicles
    from Candida albicans and Candida auris. mSystems. 2021 Aug 31;6(4):e0082221.
    doi: 10.1128/mSystems.00822-21. Epub 2021 Aug 24. PMID: 34427507; PMCID:
    PMC8407381.
32. Souza TN, Valdez AF, Rizzo J, Zamith-Miranda D, Guimarães AJ, Nosanchuk JD,
    Nimrichter L. Host cell membrane microdomains and fungal infection. Cell
    Microbiol. 2021 Dec;23(12):e13385. doi: 10.1111/cmi.13385. Epub 2021 Aug 24.
    PMID: 34392593; PMCID: PMC8664998.
33. Zamith-Miranda D, Peres da Silva R, Couvillion SP, Bredeweg EL, Burnet MC,
    Coelho C, Camacho E, Nimrichter L, Puccia R, Almeida IC, Casadevall A, Rodrigues
    ML, Alves LR, Nosanchuk JD, Nakayasu ES. Omics Approaches for Understanding
    Biogenesis, Composition and Functions of Fungal Extracellular Vesicles. Front
    Genet. 2021 May 3;12:648524. doi: 10.3389/fgene.2021.648524. PMID: 34012462;
    PMCID: PMC8126698.
34. Liu S, Youngchim S, Zamith-Miranda D, Nosanchuk JD. Fungal Melanin and the
    Mammalian Immune System. J Fungi (Basel). 2021 Mar 31;7(4):264. doi:
    10.3390/jof7040264. PMID: 33807336; PMCID: PMC8066723.
35. Mendoza SR, Zamith-Miranda D, Takács T, Gacser A, Nosanchuk JD, Guimarães
    AJ. Complex and Controversial Roles of Eicosanoids in Fungal Pathogenesis. J
    Fungi (Basel). 2021 Mar 28;7(4):254. doi: 10.3390/jof7040254. PMID: 33800694;
    PMCID: PMC8065571.
36. Marina CL, Bürgel PH, Agostinho DP, Zamith-Miranda D, Las-Casas LO, Tavares
    AH, Nosanchuk JD, Bocca AL. Nutritional Conditions Modulate C. neoformans
    Extracellular Vesicles' Capacity to Elicit Host Immune Response. Microorganisms.
    2020 Nov 18;8(11):1815. doi: 10.3390/microorganisms8111815. PMID: 33217920;
    PMCID: PMC7698703.
37. Burnet MC, Zamith-Miranda D, Heyman HM, Weitz KK, Bredeweg EL, Nosanchuk JD,
    Nakayasu ES. Remodeling of the Histoplasma Capsulatum Membrane Induced by
    Monoclonal Antibodies. Vaccines (Basel). 2020 Jun 2;8(2):269. doi:
    10.3390/vaccines8020269. PMID: 32498228; PMCID: PMC7349930.
38. Cleare LG, Zamith D, Heyman HM, Couvillion SP, Nimrichter L, Rodrigues ML,
    Nakayasu ES, Nosanchuk JD. Media matters! Alterations in the loading and release
    of Histoplasma capsulatum extracellular vesicles in response to different
    nutritional milieus. Cell Microbiol. 2020 Sep;22(9):e13217. doi:
    10.1111/cmi.13217. Epub 2020 Jun 22. PMID: 32406582; PMCID: PMC7415587.
39. Roth MT, Zamith-Miranda D, Nosanchuk JD. Immunization Strategies for the
    Control of Histoplasmosis. Curr Trop Med Rep. 2019 Jun;6(2):35-41. doi:
    10.1007/s40475-019-00172-3. Epub 2019 Mar 26. PMID: 31772912; PMCID: PMC6879175.
40. Zamith-Miranda D, Heyman HM, Cleare LG, Couvillion SP, Clair GC, Bredeweg
    EL, Gacser A, Nimrichter L, Nakayasu ES, Nosanchuk JD. Multi-omics Signature of
    Candida auris, an Emerging and Multidrug-Resistant Pathogen. mSystems.
    2019 Jun 11;4(4):e00257-19. doi: 10.1128/mSystems.00257-19. PMID: 31186339;
    PMCID: PMC6561322.
41. Alves LR, Peres da Silva R, Sanchez DA, Zamith-Miranda D, Rodrigues ML,
    Goldenberg S, Puccia R, Nosanchuk JD. Extracellular Vesicle-Mediated RNA Release
    in Histoplasma capsulatum. mSphere. 2019 Mar 27;4(2):e00176-19. doi:
    10.1128/mSphere.00176-19. PMID: 30918062; PMCID: PMC6437275.
42. Guimarães AJ, de Cerqueira MD, Zamith-Miranda D, Lopez PH, Rodrigues ML,
    Pontes B, Viana NB, DeLeon-Rodriguez CM, Rossi DCP, Casadevall A, Gomes AMO,
    Martinez LR, Schnaar RL, Nosanchuk JD, Nimrichter L. Host membrane
    glycosphingolipids and lipid microdomains facilitate Histoplasma capsulatum
    internalisation by macrophages. Cell Microbiol. 2019 Mar;21(3):e12976. doi:
    10.1111/cmi.12976. Epub 2018 Dec 7. PMID: 30427108; PMCID: PMC6805151.
43. Zamith-Miranda D, Fox EGP, Monteiro AP, Gama D, Poublan LE, de Araujo AF,
    Araujo MFC, Atella GC, Machado EA, Diaz BL. The allergic response mediated by
    fire ant venom proteins. Sci Rep. 2018 Sep 26;8(1):14427. doi:
    10.1038/s41598-018-32327-z. PMID: 30258210; PMCID: PMC6158280.
44. Baltazar LM, Zamith-Miranda D, Burnet MC, Choi H, Nimrichter L, Nakayasu ES,
    Nosanchuk JD. Concentration-dependent protein loading of extracellular vesicles
    released by Histoplasma capsulatum after antibody treatment and its modulatory
    action upon macrophages. Sci Rep. 2018 May 23;8(1):8065. doi:
    10.1038/s41598-018-25665-5. PMID: 29795301; PMCID: PMC5966397.
45. de-Souza-Silva CM, Guilhelmelli F, Zamith-Miranda D, de Oliveira MA,
    Nosanchuk JD, Silva-Pereira I, Albuquerque P. Broth Microdilution In Vitro
    Screening: An Easy and Fast Method to Detect New Antifungal Compounds. J Vis
    Exp. 2018 Feb 14;(132):57127. doi: 10.3791/57127. PMID: 29553507; PMCID:
    PMC5912413.
46. Zamith-Miranda D, Nimrichter L, Rodrigues ML, Nosanchuk JD. Fungal
    extracellular vesicles: modulating host-pathogen interactions by both the fungus
    and the host. Microbes Infect. 2018 Oct-Nov;20(9-10):501-504. doi:
    10.1016/j.micinf.2018.01.011. Epub 2018 Feb 19. PMID: 29471026; PMCID:
    PMC6098986.
47. Rizzo J, Colombo AC, Zamith-Miranda D, Silva VKA, Allegood JC, Casadevall A,
    Del Poeta M, Nosanchuk JD, Kronstad JW, Rodrigues ML. The putative flippase Apt1
    is required for intracellular membrane architecture and biosynthesis of
    polysaccharide and lipids in Cryptococcus neoformans. Biochim Biophys Acta Mol
    Cell Res. 2018 Mar;1865(3):532-541. doi: 10.1016/j.bbamcr.2017.12.007. Epub 2017
    Dec 29. PMID: 29291962; PMCID: PMC6052768.
48. Liedke SC, Miranda DZ, Gomes KX, Gonçalves JLS, Frases S, Nosanchuk JD,
    Rodrigues ML, Nimrichter L, Peralta JM, Guimarães AJ. Characterization of the
    antifungal functions of a WGA-Fc (IgG2a) fusion protein binding to cell wall
    chitin oligomers. Sci Rep. 2017 Sep 22;7(1):12187. doi:
    10.1038/s41598-017-12540-y. PMID: 28939893; PMCID: PMC5610272.
49. Cleare LG, Zamith-Miranda D, Nosanchuk JD. Heat Shock Proteins in
    Histoplasma and Paracoccidioides. Clin Vaccine Immunol. 2017 Nov
    6;24(11):e00221-17. doi: 10.1128/CVI.00221-17. PMID: 28903987; PMCID:
    PMC5674194.
50. Oliveira DL, Fonseca FL, Zamith-Miranda D, Nimrichter L, Rodrigues J,
    Pereira MD, Reuwsaat JC, Schrank A, Staats C, Kmetzsch L, Vainstein MH,
    Rodrigues ML. The putative autophagy regulator Atg7 affects the physiology and
    pathogenic mechanisms of Cryptococcus neoformans. Future Microbiol. 2016
    Oct;11:1405-1419. doi: 10.2217/fmb-2016-0090. Epub 2016 Oct 18. Erratum in:
    Future Microbiol. 2017 Jan;12:95. doi: 10.2217/fmb-2016-0090c1. PMID: 27750454.
51. Silva-Filho JL, Peruchetti DB, Moraes-Santos F, Landgraf SS, Silva LS,
    Sirtoli GM, Zamith-Miranda D, Takiya CM, Pinheiro AA, Diaz BL, Caruso-Neves C.
    Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium
    Handling in the Kidney. PLoS One. 2016 Jan 28;11(1):e0147785. doi:
    10.1371/journal.pone.0147785. PMID: 26820468; PMCID: PMC4731149.
52. Rodrigues ML, Godinho RM, Zamith-Miranda D, Nimrichter L. Traveling into
    Outer Space: Unanswered Questions about Fungal Extracellular Vesicles. PLoS
    Pathog. 2015 Dec 3;11(12):e1005240. doi: 10.1371/journal.ppat.1005240. PMID:
    26633018; PMCID: PMC4669077.
53. Martinez CG, Zamith-Miranda D, da Silva MG, Ribeiro KC, Brandão IT, Silva
    CL, Diaz BL, Bellio M, Persechini PM, Kurtenbach E. P2×7 purinergic signaling in
    dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors:
    autoantibody levels, heart functionality and cytokine expression. Sci Rep. 2015
    Nov 23;5:16940. doi: 10.1038/srep16940. PMID: 26592184; PMCID: PMC4655336.
54. Palma ML, Zamith-Miranda D, Martins FS, Bozza FA, Nimrichter L, Montero-
    Lomeli M, Marques ET Jr, Douradinha B. Probiotic Saccharomyces cerevisiae
    strains as biotherapeutic tools: is there room for improvement? Appl Microbiol
    Biotechnol. 2015 Aug;99(16):6563-70. doi: 10.1007/s00253-015-6776-x. Epub 2015
    Jul 4. PMID: 26142388.
55. Arcanjo AF, LaRocque-de-Freitas IF, Rocha JD, Zamith D, Costa-da-Silva AC,
    Nunes MP, Mesquita-Santos FP, Morrot A, Filardy AA, Mariano M, Bandeira-Melo C,
    DosReis GA, Decote-Ricardo D, Freire-de-Lima CG. The PGE2/IL-10 Axis Determines
    Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major
    Infection. PLoS One. 2015 May 1;10(5):e0124888. doi:
    10.1371/journal.pone.0124888. PMID: 25933287; PMCID: PMC4416734.
56. Gentile LB, Piva B, Capizzani BC, Furlaneto LG, Moreira LS, Zamith-Miranda
    D, Diaz BL. Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin
    E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha
    and kinase signaling pathways. Prostaglandins Leukot Essent Fatty Acids. 2010
    Feb-Mar;82(2-3):131-9. doi: 10.1016/j.plefa.2009.11.005. Epub 2009 Dec 9. PMID:
    20004562.
57. de Moura RS, Miranda DZ, Pinto AC, Sicca RF, Souza MA, Rubenich LM, Carvalho
    LC, Rangel BM, Tano T, Madeira SV, Resende AC. Mechanism of the endothelium-
    dependent vasodilation and the antihypertensive effect of Brazilian red wine. J
    Cardiovasc Pharmacol. 2004 Sep;44(3):302-9. doi:
    10.1097/01.fjc.0000133060.10597.3c. PMID: 15475826.