Gaetano Santulli, M.D., Ph.D.
- Associate Professor, Department of Medicine (Cardiology)
- Associate Professor, Department of Molecular Pharmacology
Area of research
- Aging, Cardiology, Endocrinology, Diabetes Mellitus, Gerontology, Heart Failure, Hypertension, Calcium, microRNA, Endothelium, Mitochondria, Exosomes, Angiogenesis, Physiology, Myocardial Infarction, Pancreatic Beta Cells, Fibrosis. Hirsch Index: 69
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building G35A Bronx, NY 10461
Research Profiles
Professional Interests
Prof. Santulli's Lab studies the functional role of intracellular calcium fluxes and non-coding RNAs in the pathophysiology of cardiovascular and metabolic disorders. During his training at Columbia University, he elucidated the fundamental mechanisms underlying the key role of intracellular calcium release channels in heart failure and diabetes, both in patients and in preclinical models of cardiovascular and metabolic diseases.
Cardiovascular Research Institute
FUNDING:
The lab is funded by the NIH [2 R01s as Principal Investigator (1 NHLBI and 1 NIDDK), 3 R01s as Co-Investigator, 2 T32 Training Grants] and by the American Heart Association (AHA: 24IPA1268813),The lab is also funded by the Hirschl-Weill-Caulier Research Award (The Irma T. Hirschl & Monique Weill-Caulier Trust, 2021-2025), by the Waxman Foundation, and by the Diabetes Action Foundation.
-Jessica Gambardella is supported by a postdoctoral fellowship of the American Heart Association (AHA-POST35211151).
-Stanislovas Jankauskas is supported in part by a postdoctoral fellowship of the American Heart Association (AHA-POST836407).
-Fahimeh Varzideh is supported in part by postdoctoral fellowships of the American Heart Association (AHA-POST915561 and POST1195524).
-Urna Kansakar is supported in part by a postdoctoral fellowship of the American Heart Association (AHA-POST1026190) and by the NIH (T32).
CAREER OPPORTUNITIES:
Postdoctoral Fellows and Visiting Scientists
Postdoctoral positions are available. Inquiries from talented prospective research fellows are welcome. Please e-mail (gaetano.santulli AT einsteinmed.edu) your CV including a list of peer-reviewed original articles, a statement of research experience, and contact details to obtain at least three reference letters.
Graduate Students
Students interested in pursuing PhD, MD, MD/PhD studies within the laboratory should apply to the Einstein Graduate Program in the Biomedical Sciences or the Medical Scientist Training Program (MSTP). Students are strongly encouraged to schedule a meeting for the assignment of a thesis project. Students interested in doing a lab rotation can contact Prof. Santulli attaching their updated Curriculum Vitae.
Undergraduate students
The excellent Summer Undergraduate Research Program at Einstein provides a unique opportunity to work for the summer in a research laboratory on campus. Motivated undergraduates with some background in biology are welocme to apply.
High School Students
The Einstein-Montefiore Summer High School Research Program introduces high school students to the excitement of top-notch scientific research.
Selected Publications
Hirsch Index: 69 - (i10 index: 190)
SANTULLI LAB
Chronology of Publications
254) Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling.
Gambardella J, Jankauskas SS, Kansakar U, Varzideh F, Avvisato R, Prevete N, Sidoli S, Mone P, Wang P, Lombardi A, Santulli G.
JACC BTS. 2023;8(9):1123–1137. doi: 10.1016/j.jacbts.2023.03.014.
253) Cardiac Sarcoidosis: Updated Insights on Epidemiology and Diagnostic Criteria.
Santulli G.
American Journal of Cardiology. 2023;204:425. doi: 10.1016/j.amjcard.2023.07.123.
252) Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines.
Gambardella J, Santulli G, Fiordelisi A, Cerasuolo FA, Wang X, Prevete N, Sommella E, Avvisato R, Buonaiuto A, Altobelli GG, Rinaldi L, Chiuso F, Feliciello A, Dal Piaz F, Campiglia P, Ciccarelli M, Morisco C, Sadoshima J, Iaccarino G , Sorriento D.
Cellular and Molecular Life Sciences. 2023;80:323.
251) Molecular Mechanisms Underlying Pluripotency and Self-Renewal of Embryonic Stem Cells.
Varzideh F, Gambardella J, Kansakar U, Jankauskas SS, Santulli G.
Int J Mol Sci. 2023;24(9):8386.
Jankauskas SS, Mone P, Avvisato R, Varzideh F, De Gennaro S, Salemme L, Macina G, Kansakar U, Cioppa A, Frullone S, Gambardella J, Di Mauro M, Tesorio T, Santulli G.
Mech Ageing Dev. 2023;212:111818.
Trimarco V, Izzo R, Gallo P, Manzi MV, Forzano I, Pacella D, Santulli G (Corresponding Author; co-last Author), Trimarco B.
J Pharmacol Exp Ther (JPET). 2023; in press.
248) SGLT2 Inhibitors: an Evidence-Based Update on Cardiovascular Implications.
Forzano I, Wilson S, Lombardi A, Jankauskas SS, Kansakar U, Mone P, Varzideh F, Santulli G.
Expert Opinion on Investigational Drugs. 2023; in press; doi: 10.1080/13543784.2023.2263354.
Gambardella J, Fiordelisi A, Cerasuolo FA, Buonaiuto A, Avvisato R, Viti A, Sommella E, Merciai F, Salviati E, Campiglia P, D'Argenio V, Parisi S, Bianco A, Spinelli L, Di Vaia E, Cuocolo A, Pisani A, Riccio E, Di Risi T, Ciccarelli M, Santulli G, Sorriento D, Iaccarino G.
iScience. 2023;26(3):106074.
246) COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells.
Jankauskas SS, Kansakar U, Sardu C, Varzideh F, Avvisato R, Wang X, Matarese A, Marfella R, Ziosi M, Gambardella J, Santulli G.
Antioxidants. 2023;12(2):326.
Varzideh F, Mone P, Salemme L, Forzano I, Cioppa A, Tesorio T, Santulli G.
JMCC Plus. 2023; in press.
244) Insights in cardiovascular endocrinology: 2023.
Santulli G.
Front Endocrinol. 2023;14:1266221. doi: 10.3389/fendo.2023.1266221.
243) Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.
Dridi H, Santulli G, Bahlouli L, Miotto M, Weninger G, Marks AR.
Biomolecules 2023;13(9):1409. doi: 10.3390/biom2590553
Paolisso P, Bergamaschi L, Cesaro A, Gallinoro E, Gragnano F, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Belmonte M, Esposito G, Morici N, Andrea Oreglia J, Casella G, Mauro C, Vassilev D, Galie N, Santulli G, Calabrò P, Barbato E, Marfella R, Pizzi C.
Diabetes Res Clin Pract. 2023;202:110766.
241) Translational Aspects of Cardiovascular Biology: From Bench to Bedside.
Santulli G.
Biology. 2023;12(5):658. doi: 10.3390/biology12050658.
240) Effects of moderate caffeine intake in athletes.
Mone P, Guerra G, Verderosa S, Santulli G, Komici K.
European Journal of Internal Medicine. 2023; in press.
Trimarco V, Manzi MV, Izzo R, Mone P, Lembo M, Pacella D, Esposito G, Falco A, Morisco C, Gallo P, Santulli G (Corresponding Author), Trimarco B.
Front Cardiovasc Med. 2023;10:1137706.
Mone P, De Gennaro S, Moriello D, Frullone S, D'Amelio R, Ferrante MNV, Marro A, Santulli G.
Eur J Prev Cardiol. 2023;30(12):1283-1288. doi: 10.1093/eurjpc/zwad173.
Avvisato R, Forzano I, Varzideh F, Mone P, Santulli G.
Cardiovasc Res. 2023;119:1458. doi: 10.1093/cvr/cvad065.
Mone P, Martinelli G, Lucariello A, Leo AL, Marro A, De Gennaro S, Marzocco S, Moriello D, Frullone S, Cobellis L, Santulli G.
Cardiovascular Diabetology. 2023;22(1):94.
235) Wnt signaling in endocrine and metabolic disorders.
Cailotto F, Santulli G.
Front Endocrinol. 2023;14:1254977. doi: 10.3389/fendo.2023.1254977.
234) A novel urinary proteomic classifier predicts the risk of coronary artery disease.
Mone P, Tesorio T, De Donato A, Cioppa A, Jankauskas SS, Salemme L, Santulli G.
Eur J Prev Cardiol. 2023; Apr 19:zwad123. doi: 10.1093/eurjpc/zwad123.
233) L-Arginine in diabetes: clinical and preclinical evidence.
Forzano I, Avvisato R, Varzideh F, Jankauskas SS, Cioppa A, Mone P, Salemme L, Kansakar U, Tesorio T, Trimarco V, Santulli G.
Cardiovasc Diabetol. 2023;22(1):89.
Mone P, Kansakar U, Lucariello A, Marro A, Pansini A, Varzideh F, Nittolo G, De Angelis L, Trimarco V, Martinelli G, De Luca A, Santulli G.
Eur J Prev Cardiol. 2023; Apr 18:zwad120. doi: 10.1093/eurjpc/zwad120.
231) Methods and applications in clinical and translational physiology.
Santulli G (Corresponding Author), Pabelick CM, Jan YK, Denise P, de Lucia C.
Front Physiol. 2023;14:1169544.
230) miR-4432 Targets FGFBP1 in Human Endothelial Cells.
Avvisato R, Mone P, Jankauskas SS, Varzideh F, Kansakar U, Gambardella J, De Luca A, Matarese A, Santulli G.
Biology. 2023;12(3):459. doi: 10.3390/biology12030459.
229) Choline supplements: An update.
Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G.
Front Endocrinol. 2023;14:1148166.
Trimarco V, Izzo R, Lombardi A, Coppola A, Fiorentino G, Santulli G.
Pharmacol Res. 2023;191:106702.
227) Transcription factors and arrhythmogenesis.
Kao YH, Chen YJ, Higa S, Chattipakorn N, Santulli G.
Frontiers in Physiology. 2023;14:1169747.
226) Sortilin and hypertension.
Avvisato R, Jankauskas SS, Varzideh F, Kansakar U, Mone P, Santulli G.
Curr Opin Nephrol Hypertens. 2023;32(2):134-140.
Sardu C, Santulli G, Savarese G, Trotta MC, Sacra C, Santamaria M, Volpicelli M, Ruocco A, Mauro C, Signoriello G, Marfella L, D'Amico M, Marfella R, Paolisso G.
Int J Mol Sci. 2023;24(2):1510.
Avvisato R, Jankauskas SS, Santulli G.
J Pharmacol Exp Ther. 2023;384(1):227-230.
223) Reply to SGLT-2 inhibitors: Post-infarction interventional effects.
Paolisso P, Bergamaschi L, Gragnano F, Gallinoro E, Cesaro A, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Esposito G, Morici N, Andrea OJ, Casella G, Mauro C, Vassilev D, Galie N, Santulli G, Marfella R, Calabrò P, Barbato E, Pizzi C.
Pharmacological Research. 2023;189:106664.
222) Hyperglycemia drives the transition from pre-frailty to frailty: The Monteforte study.
Mone P, De Gennaro S, Frullone S, Marro A, Santulli G.
European Journal of Internal Medicine (EJIM). 2023;111:135-137.
Tesorio T, Mone P, de Donato A, Trimarco V, Santulli G.
Atherosclerosis. 2023;367:37-39.
220) Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools.
Santulli G.
Journal of Pharmacology and Experimental Therapeutics. 2023;384:225-226.
Mone P, Lombardi A, Salemme L, Cioppa A, Popusoi G, Varzideh F, Pansini A, Jankauskas SS, Forzano I, Avvisato R, Wang X, Tesorio T, Santulli G.
Diabetes Care. 2023;46(2):450-454.
218) Influence of lifestyle factors in the management of diabetes mellitus.
Sardu C, Santulli G, D' Onofrio N.
Front Endocrinol. 2023;14:1258766.
Mone P, Lombardi A, Kansakar U, Varzideh F, Jankauskas SS, Pansini A, Marzocco S, De Gennaro S, Famiglietti M, Macina G, Frullone S, Santulli G.
J Pharmacol Exp Ther (JPET). 2023;384:116-122.
Paolisso P, Bergamaschi L, Gragnano F, Gallinoro E, Cesaro A, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Esposito G, Morici N, Andrea OJ, Casella G, Mauro C, Vassilev D, Galie N, Santulli G, Marfella R, Calabrò P, Pizzi C, Barbato E.
Pharmacol Res. 2023;187:106597.
215) Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease.
Gambardella J, Fiordelisi A, Sorriento D, Cerasuolo F, Buonaiuto A, Avvisato R, Pisani A, Varzideh F, Riccio E, Santulli G, Iaccarino G.
J Pharmacol Exp Ther. 2023;384(1):72-78.
214) Therapeutic concordance improves blood pressure control in patients with resistant hypertension.
Trimarco V, Izzo R, Mone P, Lembo M, Manzi MV, Pacella D, Falco A, Gallo P, Esposito G, Morisco C, Santulli G (Corresponding Author), Trimarco B.
Pharmacol Res. 2023;187:106557.
Santulli G, Jankauskas SS, Varzideh F, Mone P, Kansakar U.
Eur J Prev Cardiol. 2023;30(4):329-330.
212) Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19.
Gambardella J, Kansakar U, Sardu C, Messina V, Jankauskas SS, Marfella R, Maggi P, Wang X, Mone P, Paolisso G, Sorriento D, Santulli G.
J Pharmacol Exp Ther. 2023;384(1):109-115.
211) Endothelial dysfunction in long-COVID: New insights from the nationwide multicenter LINCOLN Study.
Trimarco V, Izzo R, Zanforlin A, Tursi F, Scarpelli F, Santus P, Pennisi A, Pelaia G, Mussi C, Mininni S, Messina N, Marazzi G, Maniscalco M, Mallardo M, Fazio G, Diana A, Capra Marzani M, Aloè T, Mone P, Trimarco B, Santulli G.
Pharmacol Res. 2022;185:106486.
Santulli G, Frullone S, Morgante M, Macina G, Pansini A, Gambardella J, Lombardi A, Mone P.
Diabetes Care. 2022;45(10):e151-e152.
209) Aprocitentan: New insights.
Varzideh F, Kansakar U, Jankauskas SS, Santulli G.
Front Cardiovasc Med. 2022;9:1093406.
Kansakar U, Gambardella J, Varzideh F, Avvisato R, Jankauskas SS, Mone P, Matarese A, Santulli G.
Int J Mol Sci. 2022;23(18):10242.
207) Beneficial effects of Vitamin C and L-Arginine in the treatment of post-acute sequelae of COVID-19.
Santulli G, Trimarco V, Trimarco B, Izzo R.
Pharmacol Res. 2022;185:106479.
206) Parkin Controls Cardiac Function in Obesity by Regulating Mitochondrial Calcium Uptake.
Jankauskas S, Kansakar U, De Donato A, Mone P, Varzideh F, Santulli G.
JACC Basic Transl Sci. 2022;7(8):797-799.
205) Tirzepatide: A Systematic Update.
Forzano I, Varzideh F, Avvisato R, Jankauskas SS, Mone P, Santulli G.
Int J Mol Sci. 2022;23(23):14631.
Cesaro A, Gragnano F, Paolisso P, Bergamaschi L, Gallinoro E, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Esposito G, Morici N, Oreglia JA, Casella G, Mauro C, Vassilev D, Galie N, Santulli G, Pizzi C, Barbato E, Calabrò P, Marfella R.
Front Cardiovasc Med. 2022;9:1012220.
Jankauskas SS, Mone P, Santulli G.
Cell Mol Life Sci. 2022;79(8):451.
Mone P, Lombardi A, Salemme L, Cioppa A, Popusoi G, Varzideh F, Pansini A, Jankauskas SS, Forzano I, Avvisato R, Wang X, Tesorio T, Santulli G.
Diabetes Care. 2022 Dec 7:dc220783. doi: 10.2337/dc22-0783.
201) Targeting endothelial dysfunction and oxidative stress in Long-COVID.
Trimarco V, Izzo R, Mone P, Trimarco B, Santulli G.
Pharmacol Res. 2022;184:106451.
200) Tirzepatide versus Semaglutide once weekly in Type 2 Diabetes.
Santulli G.
New England Journal of Medicine (NEJM). 2022;386(7):e17.
199) Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey.
Izzo R, Trimarco V, Mone P, Aloè T, Capra Marzani M, Diana A, Fazio G, Mallardo M, Maniscalco M, Marazzi G, Messina N, Mininni S, Mussi C, Pelaia G, Pennisi A, Santus P, Scarpelli F, Tursi F, Zanforlin A, Santulli G (Corresponding Author), Trimarco B.
Pharmacol Res. 2022;183:106360.
Mone P, Varzideh F, Jankauskas SS, Pansini A, Lombardi A, Frullone S, Santulli G.
Hypertension 2022;79(8):1633-1643.
Forzano I, Mone P, Varzideh F, Jankauskas SS, Kansakar U, De Luca A, Santulli G.
Front Endocrinol. 2022;13:1097968.
196) Efficacy of the New Inotropic Agent Istaroxime in Acute Heart Failure.
Forzano I, Mone P, Mottola G, Kansakar U, Salemme L, De Luca A, Tesorio T, Varzideh F, Santulli G.
J Clin Med. 2022;11(24):7503.
Paolisso P, Bergamaschi L, Santulli G, Gallinoro E, Cesaro A, Gragnano F, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Casella G, Mauro C, Vassilev D, Marfella R, Calabrò P, Barbato E, Pizzi C.
Cardiovasc Diabetol. 2022;21(1):77. doi: 10.1186/s12933-022-01506-8.
194) Functional role of miR-34a in diabetes and frailty.
Mone P, de Donato A, Varzideh F, Kansakar U, Jankauskas SS, Pansini A, Santulli G.
Front Aging. 2022 Jul 18;3:949924.
193) L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.
Mone P, Pansini A, Jankauskas SS, Varzideh F, Kansakar U, Lombardi A, Trimarco V, Frullone S, Santulli G.
Front Cardiovasc Med. 2022;9:868521. doi: 10.3389/fcvm.2022.868521.
Paolisso P, Bergamaschi L, Gragnano F, Gallinoro E, Cesaro A, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Esposito G, Nuccia M, Andrea OJ, Casella G, Mauro C, Vassilev D, Galie N, Santulli G, Marfella R, Calabrò P, Pizzi C, Barbato E.
Pharmacol Res. 2022;187:106597. doi: 10.1016/j.phrs.2022.106597.
Trimarco V, Izzo R, Morisco C, Mone P, Virginia Manzi M, Falco A, Pacella D, Gallo P, Lembo M, Santulli G (Corresponding Author), Trimarco B.
Hypertension. 2022;79(10):2355-2363.
[With Cover and interview to Prof. Santulli published in Scientific American]
190) Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure.
Sasset L, Manzo OL, Zhang Y, Marino A, Rubinelli L, Riemma MA, Chalasani MLS, Dasoveanu DC, Roviezzo F, Jankauskas SS, Santulli G, Bucci MR, Lu TT, Di Lorenzo A.
Cardiovasc Res. 2023;119(2):506-519.
189) Empagliflozin improves cognitive impairment in frail older adults with type 2 diabetes and HFpEF.
Mone P, Lombardi A, Gambardella J, Pansini A, Macina G, Morgante M, Frullone S, Santulli G.
Diabetes Care. 2022;45(5):1247-1251.
188) IP3 receptor orchestrates maladaptive vascular responses in heart failure.
Santulli G*, Dridi H* (*Co-First Authors), Gambardella J, Jankauskas SS, Yuan Q, Yang J, Reiken R, Wang X, Wronska A, Liu X, Lacampagne A, Marks A.
Journal of Clinical Investigation. 2022;132(4):e152859.
Varzideh F, Jankauskas SS, Kansakar U, Mone P, Gambardella J, Santulli G.
Journal of Clinical Investigation. 2022;132(3):e156624.
186) Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells.
Varzideh F, Mone P, Santulli G.
Bioengineering. 2022;9(4):168. doi: 10.3390/bioengineering9040168.
Santulli G, Wang X, Mone P.
Eur Heart J (CVP). 2022;8(5):e23. doi: 10.1093/ehjcvp/pvac029.
184) Infarct Size, Inflammatory Burden, and Admission Hyperglycemia in Diabetic patients with Acute Myocardial Infarction Treated with SGLT2-Inhibitors: A Multicenter International Registry.
Paolisso P, Bergamaschi L, Santulli G, Gallinoro E, Cesaro A, Gragnano F, Sardu C, Mileva N, Foà A, Armillotta M, Sansonetti A, Amicone S, Impellizzeri A, Casella G, Mauro C, Vassilev D, Marfella R, Calabrò P, Barbato E, Pizzi C.
Cardiovascular Diabetology. 2022;21(1):77.
Gambardella J, Jankauskas SS, D’Ascia S, Sardu C, Matarese A, Minicucci F, Mone P, Santulli G.
The Journal of Heart and Lung Transplantation. 2022;41(4):438-441.
Mone P, Pansini A, Varzideh F, de Donato A, Jankauskas SS, Santulli G.
JACC Basic Transl Sci. 2022;7(3):262-264. doi: 10.1016/j.jacbts.2022.01.011.
Mone P, Izzo R, Marazzi G, Manzi MV, Gallo P, Campolongo G, Cacciotti L, Tartaglia D, Caminiti G, Varzideh F, Santulli G, Trimarco V.
J Pharmacol Exp Ther. 2022;381:197-203. doi: 10.1124/jpet.122.001149.
180) Omega-3 fatty acids coordinate glucose and lipid metabolism in diabetic patients.
Mone P, Varzideh F, Kansakar U, Infante C, Lombardi A, de Donato A, Frullone S, Santulli G.
Lipids Health Dis. 2022;21(1):31.
179) Functional Role of microRNAs in Regulating Cardiomyocyte Death.
Kansakar U, Varzideh F, Mone P, Jankauskas SS, Santulli G.
Cells. 2022;11(6):983. doi: 10.3390/cells11060983.
178) Physical decline and cognitive impairment in frail hypertensive elders during COVID-19.
Mone P, Pansini A, Frullone S, de Donato A, Buonincontri V, De Blasiis P, Marro A, Morgante M, De Luca A, Santulli G.
European Journal of Internal Medicine. 2022;99:89-92. doi: 10.1016/j.ejim.2022.03.012.
177) Diabetes and restenosis.
Wilson S, Mone P, Kansakar U, Jankauskas SS, Donkor K, Adebayo A, Varzideh F, Eacobacci M, Gambardella J, Lombardi A, Santulli G.
Cardiovasc Diabetol. 2022;21(1):23. doi: 10.1186/s12933-022-01460-5.
176) Exosome-mediated angiogenesis underlies LVAD-induced bleeding in patients with end-stage heart failure.
Mone P, Pansini A, Varzideh F, de Donato A, Jankauskas SS, Santulli G.
JACC Basic Transl Science. 2022;7(3):262-264.
175) Correlation of physical and cognitive impairment in diabetic and hypertensive frail older adults.
Mone P, Gambardella J, Lombardi A, Pansini A, De Gennaro S, Leo AL, Famiglietti M, Marro A, Morgante M, Frullone S, De Luca A, Santulli G.
Cardiovasc Diabetol. 2022;21(1):10. doi: 10.1186/s12933-021-01442-z.
Mone P, Kansakar U, Varzideh F, Boccalone E, Lombardi A, Pansini A, Santulli G.
Journal of Clinical Hypertension. 2022;24(4):395-397.
173) Effects of insulin resistance on mitochondrial (dys)function.
Mone P, Morgante M, Pansini A, Jankauskas SS, Rizzo M, Lombardi A, Frullone S, Santulli G.
Atherosclerosis. 2022;341:52-54. doi: 10.1016/j.atherosclerosis.2021.11.026.
Mone P, Gambardella J, Pansini A, Martinelli G, Minicucci F, Mauro C, Santulli G.
Aging Clin Exp Res. 2022; 34(1):49-53. doi: 10.1007/s40520-021-01897-w.
Mone P, Trimarco B, Santulli G.
Eur Heart J Cardiovasc Pharmacother. 2022;8(3):E7-E8. doi: 10.1093/ehjcvp/pvab081.
Mone P, Santulli G.
Ann Intern Med. 2022;175(2):JC21. (IF: 51.6)
Invited commentary on “AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial” Eur Heart J. 2021;42(46):4731-4739.
Raptis DA, Raptis D, Tinguely P, Mettler T, Clavien PA, Zuber M, Lesurtel M, Graf R, Abidi SR, Ferraro D, Novelli S, Leung S, Palma A, Schütz T, Santulli G, et al. Authorships.org Collaborative
JMIR Form Res. 2022;6(3):e34258. doi: 10.2196/34258.
168) Global cognitive function correlates with P-wave dispersion in frail hypertensive older adults.
Mone P, Pansini A, Calabrò F, De Gennaro S, Esposito M, Rinaldi P, Colin A, Minicucci F, Coppola A, Frullone S, Santulli G.
J Clin Hypertens. 2022; 24(5):638-643. doi: 10.1111/jch.14439.
167) Hyperglycemia drives restenosis in STEMI patients.
Mone P, Gambardella J, Minicucci F, Lombardi A, Mauro C, Santulli G.
Diabetes Care. 2021;44(11):e192. doi: 10.2337/dc21-0939.
166) Heart Failure in Diabetes.
Jankauskas SS, Kansakar U, Varzideh F, Wilson S, Mone P, Lombardi A, Gambardella J, Santulli G.
Metabolism. 2021;125:154910. doi: 10.1016/j.metabol.2021.154910.
165) Role of endothelial miR-24 in COVID-19 cerebrovascular events.
Gambardella J, Coppola A, Izzo R, Fiorentino G, Trimarco B, Santulli G.
Critical Care. 2021;25(1):306. (IF: 19.3)
Fiorentino G, Coppola A, Izzo R, Annunziata A, Bernardo M, Lombardi A, Trimarco V, Santulli G, Trimarco B.
The Lancet - eClinicalMedicine. 2021;40:101125. (IF: 17)
Sardu C, Massetti M, Testa N, Di Martino L, Castellano G, Turriziani F, Sasso FC, Torella M, De Feo M, Santulli G, Paolisso G, Marfella R.
Front Pharmacol. 2021;12:777083. doi: 10.3389/fphar.2021.777083.
162) L-Arginine and COVID-19: An Update.
Adebayo A, Varzideh F, Wilson S, Gambardella J, Eacobacci M, Jankauskas SS, Donkor K, Kansakar U, Trimarco V, Mone P, Lombardi A, Santulli G.
Nutrients. 2021;13(11):3951. doi: 10.3390/nu13113951.
161) Tackling SARS-CoV-2 Variants Using Specific miRNA Tools.
Renwick N, El-Osta A, Salamon I, Broseghini E, Ferracin M, Poliseno L, Jankauskas SS, Santulli G, Xiao H, Shiu PKT, Roy S, Goel A.
Noncoding RNA. 2021;7(3):58. doi: 10.3390/ncrna7030058.
160) Cardiovascular Endocrinology: Evolving Concepts and Updated Epidemiology of Relevant Diseases.
Varzideh F, Kansakar U, Jankauskas SS, Gambardella J, Santulli G.
Front Endocrinol. 2021;12:772876. doi: 10.3389/fendo.2021.772876.
Kansakar U, Varzideh F, Jankauskas SS, Gambardella J, Trimarco B, Santulli G.
Eur Heart J Cardiovasc Pharmacother. 2021;7(6):e91-e93. doi: 10.1093/ehjcvp/pvab069.
158) Cognitive impairment in frail elderly with hypertension: role of hyperglycemia.
Mone P, Gambardella J, Pansini A, de Donato A, Martinelli G, Boccalone E, Matarese A, Frullone S, Santulli G.
Cells. 2021;10(8):2115. doi: 10.3390/cells10082115
157) Functional role of miR-155 in the pathogenesis of diabetes mellitus and its complications.
Jankauskas SS, Gambardella J, Sardu C, Lombardi A, Santulli G.
Noncoding RNA. 2021;7(3):39. doi: 10.3390/ncrna7030039.
156) SGLT2 inhibitors in cardiovascular medicine.
Varzideh F, Kansakar U, Santulli G.
Eur Heart J (Cardiovascular Pharmacotherapy). 2021;7(4):e67-e68.
155) A Retinoic Acid Receptor β2 agonist improves cardiac function in a heart failure model.
Tang XH*, Gambardella J* (*co First Author), Jankauskas SS, Wang X, Santulli G, et al.
JPET. 2021;379(2):182-10. doi: 10.1124/jpet.121.000806. (Journal Cover - Nov 2021)
Mone P, Gambardella J, Wang X, Jankauskas SS, Matarese A, Santulli G.
Noncoding RNA. 2021;7(1):9. doi: 10.3390/ncrna7010009.
153) Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis.
Kansakar U, Jankauskas SS, Gambardella J, Santulli G.
Atherosclerosis. 2021;324:117-120.
152) Mitochondrial remodeling and dynamic inter-organellar contacts in cardiovascular physiopathology.
Santulli G, Monaco G, Parra VM, Morciano G.
Front Cell Dev Biol. 2021;9:679725. doi: 10.3389/fcell.2021.679725.
151) Inclisiran: a new milestone on the PCSK9 road to tackle cardiovascular risk.
Santulli G, Jankauskas SS, Gambardella J.
European Heart Journal CVP. 2021 Feb 28:pvab014. doi: 10.1093/ehjcvp/pvab014.
Wilson S, Mone P, Jankauskas SS, Gambardella J, Santulli G.
J Clin Hypertens. 2021;23(4):831-834. doi: 10.1111/jch.14186.
Santulli G.
Ann Intern Med. 2021;174(1):JC6. doi: 10.7326/ACPJ202101190-006.
Invited commentary on “Early Rhythm-Control Therapy in Patients with Atrial Fibrillation” N Engl J Med. 2020;383(14):1305-1316.
148) Impact of thrombus aspiration in frail STEMI patients.
Mone P, Gambardella J, Pansini A, Rizzo M, Mauro C, Minicucci F, Santulli G.
Aging Clinical and Experimental Research (ACER) 2021; 33(11):3081-3089. doi: 10.1007/s40520-021-01848-5.
147) Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.
Jankauskas SS, Morelli M, Gambardella J, Lombardi A, Santulli G.
J Clin Hypertens. 2021;23(2):373-381. doi: 10.1111/jch.14152.
Gambardella J, Santulli G.
Eur Heart J (CVP). 2021;7(3):e2-e3. doi: 10.1093/ehjcvp/pvaa145.
145) The discovery and development of IP3 receptor modulators: An update.
Gambardella J, Morelli M, Wang X, Castellanos V, Mone P, Santulli G.
Expert Opin Drug Discov. 2021 Jan 6:1-10. doi: 10.1080/17460441.2021.1858792.
144) Effects of Chronic Supplementation of L-Arginine on Physical Fitness in Water Polo Players.
Gambardella J, Fiordelisi A, Spigno L, Boldrini L, Lungonelli G, Di Vaia E, Santulli G, Sorriento D, Cerasuolo FA, Trimarco V, Iaccarino G.
Oxid Med Cell Longev. 2021;2021:6684568. doi: 10.1155/2021/6684568.
Gambardella J, Fiordelisi A, Santulli G, Ciccarelli M, Cerasuolo FA, Sala M, Sommella E, Campiglia P, Illario M, Iaccarino G, Sorriento D.
Cancers. 2020;12(12):3530.
142) Role of endothelial GRK2 in angioedema.
Gambardella J, Sorriento D, Bova M, Rusciano M, Loffredo S, Wang X, Petraroli A, Carucci L, Mormile I, Oliveti M, Morelli M, Fiordelisi A, Spadaro G, Campiglia P, Sala M, Trimarco B, Iaccarino G, Santulli G, Ciccarelli M.
Hypertension. 2020;76(5):1625-1636.
141) miR-98 regulates TMPRSS2 expression in human endothelial cells: Key implications for COVID-19.
Gambardella J, Matarese A, Sardu C, Santulli G.
BioMedicines. 2020;8(11):462. doi:10.3390/biomedicines8110462.
140) Genetics of adrenergic signaling drives coronary artery calcification.
Gambardella J, Wang X, Mone P, Khondkar W, Santulli G.
Atherosclerosis. 2020;310:88-90.
Gambardella J, Lombardi A, Santulli G.
Diabetes. 2020;69(10):2054-2057.
138) Standardizing translational microbiome studies and metagenomics analyses.
Gambardella J, Castellanos V, Santulli G.
Cardiovascular Research. 2020;117(3):640-642.
137) Arginine and endothelial function.
Gambardella J, Khondkar W, Morelli M, Wang X, Santulli G, Trimarco V.
BioMedicines. 2020;8(8):277.
136) No Pleiotropic Effects of Linagliptin on Atherosclerotic Plaques: Case Closed.
Al-Mallah MH, Hyafil F, Santulli G.
Atherosclerosis. 2020;305:61-63. doi: 10.1016/j.atherosclerosis.2020.05.009.
135) Vitamin C and Cardiovascular Disease: An Update.
Morelli M, Gambardella J, Castellanos V, Trimarco V, Santulli G.
Antioxidants. 2020;9(12):1227. doi: 10.3390/antiox9121227.
134) miR-7 regulates GLP-1-mediated insulin release by targeting Beta-Arrestin 1.
Matarese A, Gambardella J, Lombardi A, Wang X, Santulli G.
Cells. 2020;9(7):1621.
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G.
J Clin Med. 2020;9(5):1417. doi: 10.3390/jcm9051417.
Gambardella J, Wang XJ, Ferrara J, Morelli MB, Santulli G.
JACC BTS. 2020;5(6):579-581.
131) Is Endothelial Dysfunction the Concealed Cornerstone of COVID-19?
Santulli G, Morelli M, Gambardella J.
BMJ. 2020; e-letter.
130) Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension.
Gambardella J, Morelli M, Wang X, Santulli G.
J Clin Hypertens. 2020;22(2):291-295.
129) COVID-19 and endothelial dysfunction.
Gambardella J, Sardu C, Santulli G.
JAMA. 2020; e-letter.
128) Implications of ABO blood group in hypertensive patients with COVID-19.
Sardu C, Marfella R, Maggi P, Messina V, Cirillo P, Codella V, Gambardella J, Sardu A, Gatta G, Santulli G, Paolisso G.
BMC Cardiovasc Disord. 2020;20(1):373. doi: 10.1186/s12872-020-01658-z.
127) Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update.
Gambardella J, Lombardi A, Morelli MB, Ferrara J, Santulli G.
J Clin Med. 2020 Apr 12;9(4):1096.
126) A small molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.
Amgalan D, Garner TP, Pekson R, Jia XF, Yanamandala M, Paulino V, Liang FG, Corbalan J, Lee J, Chen Y, Karagiannis GS, Sanchez LR, Liang H, Narayanagari SR, Mitchell K, Lopez A, Margulets V, Scarlata M, Santulli G, Asnani A, Peterson RT, Hazan RB, Condeelis JS, Oktay MH, Steidl U, Kirshenbaum LA, Gavathiotis E, Kitsis RN.
Nature Cancer. 2020;1(3):315-328. doi: 10.1038/s43018-020-0039-1.
Santulli G.
Ann Intern Med. 2020;172(10):JC54. doi: 10.7326/ACPJ202005190-054.
Invited commentary on “Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients with Acute Heart Failure: The GALACTIC Randomized Clinical Trial.” JAMA. 322(23):2292-2302.
Sardu C, Santulli G, Guerra G, Trotta MC, Santamaria M, Sacra C, Testa N, Ducceschi V, Gatta G, D’ Amico M, Sasso FC, Paolisso G, Marfella R.
J Clin Med. 2020;9(2):544; doi: 10.3390/jcm9020544.
123) Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal.
Morelli M, Santulli G, Gambardella J.
Atherosclerosis. 2020;296:68-73. doi: 10.1016/j.atherosclerosis.2020.01.008.
Santulli G.
Ann Intern Med. 2020;172(2):JC6. doi: 10.7326/ACPJ202001210-006.
Invited commentary on “Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease” N Engl J Med. 2019;381(12):1103-1113.
121) Cardiosomal microRNAs are essential in post-infarction myofibroblast phenoconversion.
Morelli MB, Shu J, Sardu C, Matarese A, Santulli G.
Int. J. Mol. Sci. 2020;21(1):201.
Morelli MB, Chavez C, Santulli G.
Expert Opin Ther Targets. 2020;24(1):79-88. doi: 10.1080/14728222.2020.1707806.
Wang X, Morelli M, Matarese A, Sardu C, Santulli G.
ESC Heart Failure. 2020;7(1):284-288. doi: 10.1002/ehf2.12584.
118) Safety in numbers: identifying multiple targets for beta cell proliferation.
Santulli G.
Science Translational Medicine. 2019;11(475). doi: 10.1126/scitranslmed.aaw5312.
Santulli G.
Ann Intern Med. 2019;171(2):JC10. doi: 10.7326/ACPJ201907160-010
Invited commentary on “Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients with Atrial Fibrillation: The CABANA Randomized Clinical Trial” JAMA. 2019;321(13):1275-1285 and “Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients with Atrial Fibrillation: The CAPTAF Randomized Clinical Trial” JAMA. 2019;321(11):1059-1068.
116) We are what we eat: Impact of food from short supply chain on metabolic syndrome.
Santulli G, Pascale V, Finelli R, Visco V, Giannotti R, Massari A, Morisco C, Ciccarelli M, Illario M, Iaccarino G, Coscioni E.
Journal of Clinical Medicine. 2019;8(12):2061. doi: 10.3390/jcm8122061.
115) Pre-eclampsia and future cardiovascular diseases: How to assess the risk?
Santulli G, Al-Mallah MH.
Atherosclerosis. 2019;290:136-137. doi: 10.1016/j.atherosclerosis.2019.07.004.
Santulli G.
Ann Intern Med. 2019 Sep 17;171(6):JC31. doi: 10.7326/ACPJ201909170-031.
Invited commentary on “Intensive Glucose Control in Patients with Type 2 Diabetes - 15-Year Follow-up” N Engl J Med. 2019;380(23):2215-2224.
113) Heparanase in health and disease: the neglected housekeeper of the cell?
Shu J, Santulli G.
Atherosclerosis. 2019;283:124-126. doi: 10.1016/j.atherosclerosis.2019.01.017.
112) Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology.
Santulli G.
Science Translational Medicine. 2018;10(467):eaav9141.
Matarese A, Sardu C, Shu J, Santulli G.
Int J Cardiol. 2019;276:149-151. doi: 10.1016/j.ijcard.2018.10.075.
110) Diabetes, body fat, skeletal muscle, and hypertension: The ominous chiasmus?
Shu J, Matarese A, Santulli G.
J Clin Hypertens. 2019;21(2):239-242.
109) Stroke prevention: Learning from the master (and COMMANDER).
Santulli G.
Science Translational Medicine. 2018;10(459):eaav0340. doi: 10.1126/scitranslmed.aav0340.
Invited commentary on “Rivaroxaban in patients with heart failure, sinus rhythm, and coronary disease” NEJM. 2018;379(14):1332-1342.
De Rosa M, Gambardella J, Shu J, Santulli G.
Cardiovasc. Res. 2018;114(7):925-927. doi: 10.1093/cvr/cvy074.
Xiao H, Shiu PKT, Shu J, Santulli G, Gheybi M, Conn SJ, Bogard B, Hubé F, Taube JH, Mani SA, Song L, Calin GA, Zhang S.
Non-coding RNA. 2018;18;4.
106) Cardioprotective effects of autophagy: Eat your heart out, heart failure!
Santulli G.
Science Transl. Med. 2018;10(443). pii: eaau0462. doi: 10.1126/scitranslmed.aau0462
105) Update on peripheral artery disease: Epidemiology and evidence based facts.
Shu S, Santulli G.
Atherosclerosis. 2018;275:379-381. doi: 10.1016/j.atherosclerosis.2018.05.033
Santulli G.
Ann Intern Med. 2018;169(12):JC67. doi: 10.7326/ACPJC-2018-169-12-067.
Invited commentary on "Effects of aspirin for primary prevention in persons with diabetes mellitus" NEJM. 2018;379:1529-39.
103) The lymphatic border patrol outwits inflammatory cells in myocardial infarction.
Santulli G.
Science Translational Medicine. 2018; Vol. 10, Issue 451, eaau7379; doi: 10.1126/scitranslmed.aau7379. (Editors' Choice)
Sorriento D, Santulli G, Ciccarelli M, Maione AS, Illario M, Trimarco B, Iaccarino G.
Int J Mol Med. 2018;19(3):861. doi: 10.3390/ijms19030861.
101) Ryanodine Receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure.
Kushnir A, Santulli G, Reiken SR, Coromilas E, Godfrey SJ, Brunjes DL, Colombo PC, Yuzefpolskaya M, Sokol SI, et al.
Circulation. 2018; 138(11):1144-1154.
F1000 recommended article.
Santulli G.
Science Translational Medicine. 2018;10(435):eaat3888. doi: 10.1126/scitranslmed.aat3888.
99) Effectiveness of new generation drug-eluting stents in ostial right coronary artery lesions.
De Rosa M, Santulli G.
International Journal of Cardiology. 2018;254:84-86.
98) Ryanodine receptor structure and function in health and disease.
Santulli G, Lewis DR, Marks A, Frank J.
Subcellular Biochemistry. 2018;87:329-352.
F1000 recommended article.
97) Endothelial cells: The heart attack of the Clones.
Santulli G.
Science Translational Medicine. 2018;10(427):eaar7529. doi: 10.1126/scitranslmed.aar7529.
96) Mechanistic role of Beta2 adrenergic receptor in glucose homeostasis.
Santulli G, Iaccarino G.
Circulation. 2017; doi: 10.7916/D89310HZ.
Lombardi A, Gambardella J, Du XL, Sorriento D, Mauro M, Iaccarino G, Trimarco B, Santulli G.
Sci. Reports. 2017;7:15823.
94) Quit smoking to outsmart atherogenesis: Molecular mechanisms underlying clinical evidence
Gambardella J, Sardu C, Sacra C, Del Giudice C, Santulli G.
Atherosclerosis. 2017;257:242-245.
93) Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.
Lombardi A, Trimarco B, Iaccarino G, Santulli G.
Cell Commun. 2017 Nov 13;15(1):47. doi: 10.1186/s12964-017-0203-0.
Cipolletta E, Del Giudice C, Santulli G, Trimarco B, Iaccarino G.
Nutr Metab Cardiovasc Dis. 2017;27:615-623. doi: 10.1016/j.numecd.2017.05.011.
Santulli G, Lewis DR, et al.
J Muscle Res Cell Motil. 2017;38:47-45.
90) Mechanistic role of kinases in the regulation of mitochondrial fitness.
Sorriento D, Gambardella J, Fiordelisi A, Trimarco B, Ciccarelli M, Iaccarino G, Santulli G.
Adv Exp Med Biol. 2017;982:521-528. doi: 10.1007/978-3-319-55330-6-26.
89) Linking inflammation and beta cell death: the functional role of microRNA.
Achour C, Bogard B, Hubé F, Mani SA, Santulli G, Taube JH.
Non-Coding RNA. 2017;3(2):21.
Sardu C, Santulli G, Santamaria M, Barbieri M, Sacra C, Paolisso P, D’Amico F, Testa N, Caporaso I, Paolisso G, Marfella R, Rizzo MR.
Am J Cardiol. 2017;119:1382-1386.
87) Functional role of mitochondria in arrhythmogenesis.
Gambardella J, Sorriento D, Ciccarelli M, Del Giudice C, Fiordelisi A, Napolitano L, Trimarco B, Iaccarino G, Santulli G.
Adv Exp Med Biol. 2017;982:191-202. doi: 10.1007/978-3-319-55330-6_10.
Santulli G.
Nutrients. 2016;13;8(10). pii: E632.
85) Childhood obesity and education.
Santulli G.
The Lancet Diabetes & Endocrinology. 2016;4(11):957.
84) Intracellular calcium release channels: an update.
Santulli G, Nakashima R, et al.
Journal of Physiology. 2017;595:3041-3051.
83) The possible role of chromosome X variability in hypertensive familiarity.
Ciccarelli M, Finelli R, Santulli G, Rivera N,
Journal of Human Hypertension (Nature Publishing Group). 2017;31:37-42.
82) Integrating diet and inflammation to calculate cardiovascular risk.
Gambardella G, Santulli G.
Atherosclerosis. 2016,253:258-261. doi: 10.1016/j.atherosclerosis.2016.08.041.
Sardu C, Santamaria M, Rizzo MR, Barbieri M, di Marino M, Paolisso G, Santulli G, Marfella R.
Int J Clinical Practice. 2016;70:569-76.
80) Microbiome and MicroRNA mediate the communication between gut and vasculature.
Gautheret D, Taube J, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK, et al.
Non-Coding RNA. 2016;2(3)9.
79) Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS.
Yuan Q*, Yang J*, Santulli G.* (*co-First Authorship; Corresponding Author), Reiken S, Wronska A, Kim M, Osborne BW, et al.
PNAS. 2016;113:8532-8537.
78) Adrenergic signaling in heart failure and cardiovascular aging.
Santulli G, Iaccarino G.
Maturitas. 2016;93:65-72.
77) Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation.
Matecki S, Dridi H, Jung B, Saint N, Reiken SR, Scheuermann V, Mrozek S, Santulli G, Umanskaya A, Petrof B, Jaber S, et al.
PNAS. 2016;113(32):9069-74 (Direct Submission)
Santulli G.
Adv Exp Med Biol. 2015;887:53-77.
75) Micromanipulating the behavior via microRNA: New lessons from Drosophila.
Berindan-Neagoe I, Calin GA, Francastel C, Hubé F, Santulli G.
Non-Coding RNA. 2015;1:285-288.
74) Mitochondrial calcium overload is a key determinant in heart failure.
Santulli G, Xie W, et al.
PNAS. 2015;112:11389-94 (with Editorial Commentary).
F1000 recommended article; Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
73) Models for preclinical studies in aging-related disorders: One is not for all.
Santulli G, Borras C, Bousquet J, Calzà L, Cano A, Illario M, Franceschi C, Liotta G, Molloy WD, et al.
Transl Med @ UniSa. 2016;13:4-12.
72) Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis.
Novák J, Olejníčková V, Tkáčová N, Santulli G.
Adv Exp Med Biol. 2015;887:79-100.
71) An interview with Gaetano Santulli.
Santulli G.
European Medical Journal (EMJ). 2015;3.2:35-37.
70) microRNAs and endothelial (dys) function.
Santulli G.
J Cell Physiol. 2015;231:1638-1644. (Invited Review)
69) A leaky endoplasmic reticulum calcium channel impairs insulin secretion
Santulli G.
JCI Impact 2015;May Issue:p10. Editor’s picks.
68) Essential roles of intracellular calcium release channels in muscle, brain, and metabolism.
Santulli G. et al.
Current Molecular Pharmacology. 2015;8:206-22.
Santulli G.
Adv Exp Med Biol. 2015;888:1-3.
66) Targeting the CaMKII/ERK interaction in the heart prevents cardiac hypertrophy.
Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, et al.
PLoS One. 2015;10(6):e0130477.
65) Integrating GRK2 and NFkappaB in the pathophysiology of cardiac hypertrophy.
Sorriento D, Santulli G, Franco A, et al.
J Card Transl Res. 2015; 8:493-502.
64) Mitochondrial oxidative stress promotes atrial fibrillation.
Xie W*, Santulli G* (*co-First Authorship), Reiken SR, Yuan Q, Osborne B, et al.
Sci Reports. 2015;5:11427.
63) Mitochondrial calcium overload and oxidative stress in cardiomyocytes are linked by microRNA.
Francastel C, Hubé F, Mani S, Santulli G, et al.
Non-Coding RNA. 2015;1:167-169.
62) Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, et al.
Journal of Clinical Investigation. 2015;125(5):1968-1978.
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
61) A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics.
Santulli G.
Adv Exp Med Biol. 2015;887:1-14.
60) Application of microRNAs in diagnosis and treatment of cardiovascular disease.
Wronska A, Kurkowska-Jastrzebska I, Santulli G.
Acta Physiol. 2015;213(1):60-83.
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
59) Beta-blockers in diabetic patients with heart failure.
Santulli G.
JAMA Internal Medicine. 2015;175(4):657.
58) Effects of low-carbohydrate and low-fat diets.
Santulli G.
Ann Intern Med. 2015;162(5):392.
57) Functional role of Calstabin2 in age-related cardiac alterations.
Yuan Q*, Chen Z*, Santulli G* (*co-First Authorship), Gu L, Yang ZG, Yuan ZQ, et al.
Sci Reports. 2014;4:7425.
56) Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.
Umanskaya U*, Santulli G* (*co-First Authorship), Xie W, et al.
PNAS USA. 2014;111:15250-5.
55) MicroRNA-directed gene delivery selectively targets VSMCs to prevent restenosis.
Santulli G.
Journal of Clinical Investigation. 2014;online-only.
54) Diabetes Ask1ng for trouble: Terminating microRNA biogenesis in ER stress.
Ferracin M, Gautheret D, Hubé F, Mani SA, Mattick JS, Ørom UA, Santulli G, Slotkin RK, et al.
Non-Coding RNA. 2015;1:87-93.
Ferracin M, Gautheret D, Hubé F, Mani S, Mattick J, Ørom UA, Santulli G, Slotkin RK, Szweykowska-Kulinska Z, Taube JH, et al.
Non-Coding RNA. 2015;1:87-93.
52) An interview with Gaetano Santulli.
Nguyen FT, Patel C, Santulli G.
JCI Impact 2014; September Issue:p10. Editor’s picks.
51) A selective microRNA-based strategy inhibits restenosis while preserving endothelial function.
Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, et al.
Journal of Clinical Investigation. 2014;124:4102-4114 (with Editorial Commentary).
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
50) Functional role of miRNA in cardiac resynchronization therapy.
Sardu C, Marfella R, Santulli G, Paolisso G.
Pharmacogenomics. 2014;15:1159-1168.
49) Chest pain, panic disorder and coronary artery disease: A systematic review.
Fonseca Soares-Filho GL, Arias-Carrión O, Santulli G, Silva AC, Machado S, et al.
CNS Neurol Disord Drug Targets. 2014;13:992-1001.
48) CaMKII protects MKP-1 from proteasome degradation in endothelial cells.
Ciccarelli M, Rusciano M, Sorriento D, Basilicata MF, Santulli G, Campiglia P, et al.
Cell Signal. 2014;26:2167-74.
47) Trafficking GRK2: Cellular and metabolic consequences of GRK2 subcellular localization.
Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G.
Transl Med @ UniSa. 2014;10: 3–7.
Sardu C, Marfella R, Santulli G.
J Card Transl Res. 2014;7:362-368.
45) Atrial fibrillation and MicroRNAs.
Santulli G, Iaccarino G, De Luca N, Trimarco B, Condorelli G.
Frontiers in Physiology. 2014;24;5:15.
Sardu C, Carreras G, Katsanos S, Kamperidis V, Pace MC, Passavanti MB, Fava I, Paolisso P, Pieretti G, Francesco Nicoletti GF, Santulli G, Paolisso G, Marfella R.
BMC Card Disord. 2014;14:176.
43) Adrenal signaling in heart failure: Something more than a distant ship's smoke on the horizon.
Santulli G.
Hypertension. 2014;63:215-6.
42) Angiopoietin-like proteins: A comprehensive look.
Santulli G.
Frontiers in Endocrinology. 2014;2;5:4.
41) Tailoring mTOR-based therapy: molecular evidence and clinical challenges.
Santulli G, et al.
Pharmacogenomics. 2013;14:1517-26.
40) Myocardial perfusion imaging study of CO2-induced panic attack.
Soares-Filho GLF, Machado S, Arias-Carrión O, Santulli G, Mesquita CT, et al.
American Journal of Cardiology. 2013;113:384-8.
39) Imaging atrial arrhythmic intracellular calcium in intact heart.
Xie W, Santulli G, Guo X, Gao M, et al.
J Mol Cell Cardiol (JMCC). 2013;64:120-3.
Santulli G, Ciccarelli M, Trimarco B, Iaccarino G.
Frontiers in Physiology. 2013;4:209.
Santulli G, Trimarco B, Iaccarino G.
High Blood Press & Cardiovasc Prev. 2013;20:5-12. (with Editorial commentary).
36) The essential role of β2-adrenergic receptor in glucose homeostasis.
Santulli G, Iaccarino G.
PLoS One. 2013;e-pages.
Santulli G, Iaccarino G.
Immun Ageing. 2013;15;10:10.
34) Epidemiology of cardiovascular disease in the 21st century: Updated numbers and updated facts.
Santulli G.
JCvD. 2013;1:1-2.
33) Angiogenesis in chronic obstructive pulmonary disease: A translational appraisal.
Matarese A, Santulli G.
Nature Prec. 2012; doi: 10.1038/npre.2012.7112.1.
Santulli G, D’ascia SL, D’ascia C.
Can J Cardiol. 2012;28:245.e17–245.e18.
31) The impact of left ventricular size on response to cardiac resynchronization therapy.
Santulli G, D’ascia S, D’ascia C.
Am Heart J. 2012;163:e11.
30) CaMK4 gene deletion induces hypertension.
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, et al.
JAHA. 2012;1:e001081.
29) Coronary heart disease risk factors and mortality.
Santulli G.
Journal of the American Medical Association - JAMA. 2012;307:1137.
28) Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G.
Hypertension. 2012;60:129-136.
Santulli G, Chiariello M, D’Ascia C, D’Ascia S.
Nature Prec. 2012; https://www.nature.com/articles/npre.2012.7137.1
doi: 10.1038/npre.2012.7137.1
26) Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus.
Santulli G.
Neurology. 2012;78:840.
25) Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy.
Santulli G, D’Ascia C.
Heart. 2012;98:517.
24) Age-related impairment in insulin release: the essential role of Beta2 Adrenergic Receptor.
Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, et al.
Diabetes. 2012;61:692-701.
23) Atrial function in patients undergoing CRT.
Santulli G, D’Ascia SL, Marino V, D’Ascia C.
JACC Imaging. 2012;5:124-125.
22) Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.
Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, et al.
Cell Signal. 2012;24:468-475.
21) Angiogenesis in chronic obstructive pulmonary disease.
Matarese A, Santulli G.
Transl Med @ UniSa. 2012;3:49–56.
20) G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.
Santulli G, Campanile A, Spinelli L, Assante di Panzillo E, Ciccarelli M, et al.
Am J Cardiol. 2011;107:1125-1130.
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, et al.
J Transl Med. 2011;9:7.
D’Ascia S, D’Ascia C, Marino V, Chiariello M, Santulli G.
Int J Clinical Practice. 2011;69:1149-1155.
17) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Perino A, Ghigo A*, Ferrero E*, Morello F*, Santulli G, Baillie GS, et al.
Molecular Cell. 2011;42:84-95.
Ciccarelli M, Sorriento D, Santulli G, Zhou R, Eckhart A, Peppel K, Koch WJ, et al.
British Journal of Pharmacology. 2011;162:712-721.
Sorriento D*, Santulli G* (*co-First Authorship), Fusco A, Anastasio A, et al.
Hypertension. 2010;56:696-704.
14) The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events.
Galasso G, Santulli G, Piscione F, De Rosa R, Piccolo R, Cassese S, et al.
BMC Cardiovasc Dis. 2010;10:41.
13) Advanced algorithms can lead to electrocardiographic misinterpretations.
D’Ascia S, Santulli G, Liguori V, Marino V, Chiariello M, et al.
International Journal of Cardiology. 2010;141:e34-e36.
12) In vivo properties of the proangiogenic peptide QK.
Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, et al.
J Transl Med. 2009;7:41.
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, et al.
Molecular Cancer. 2009;8:97.
Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P, et al.
Cardiovasc Res. 2009;84:407-415.
Oriente F., Iovino S., Cassese A., Romano C., Miele C., Troncone G., Balletta M., Perfetti A., Santulli G., Iaccarino G., et al.
Diabetologia. 2009;52:2642-2652.
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, et al.
PNAS. 2008;195:17818-17823.
7) Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients.
Izzo R, Cipolletta E, Ciccarelli M, Campanile A, Santulli G, Palumbo G, et al.
Clinical and Translational Science. 2008;1:215-220.
6) Endothelial Alpha-1 Adrenergic Receptors Regulate Neo-angiogenesis.
Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervèro P, et al.
British J Pharmacol. 2008;153:936-946.
Lanni F, Santulli G, Izzo R, Rubattu S, Zanda B, Volpe M, et al.
J Hypertension. 2007;25:551-556.
4) Endothelial β2 adrenergic signaling to AKT: Role of Gi and SRC.
Ciccarelli M, Cipolletta E, Santulli G, et al.
Cell Signal. 2007;19:1949-1955.
3) G Protein-Coupled Receptor Kinases and Hypertension: A Review of Disease Mechanisms
Iaccarino G, Campanile A, Santulli G, Zuppieri F, Koch WJ.
High Blood Pressure & Cardiovascular Prevention. 2006;13(4):151-158.
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, et al.
Circulation Research. 2005;97:1182-1189.
1) AKT Participates in Endothelial Dysfunction in Hypertension.
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, et al.
Circulation. 2004;109:2587-2593.
BOOKS and BOOK CHAPTERS |
-Books:
-INFLUENCE OF LIFESTYLE FACTORS IN THE MANAGEMENT OF DIABETES MELLITUS. Apple Books - Frontiers Media. Editors: Gaetano Santulli, Celestino Sardu, Nunzia D’Onofrio (2023) ISBN: 978-2-8325-3345-1; DOI 10.3389/978-2-8325-3345-1.
-TRANSLATIONAL ASPECTS OF CARDIOVASCULAR BIOLOGY: FROM BENCH TO BEDSIDE. Hardcover Book, eds. MDPI. Editor: Gaetano Santulli (2023) ISBN: 978-3-0365-7575-9.
-METHODS AND APPLICATIONS IN CLINICAL AND TRANSLATIONAL PHYSIOLOGY: eds. Frontiers. Editors: Claudio De Lucia, Christina Maria Pabelick, Yih-Kuen Jan, Gaetano Santulli, Pierre Denise (2023) ISBN: 9782832520437.
-CARDIOVASCULAR DISEASE: FROM MOLECULAR MECHANISMS TO CLINICAL THERAPIES. eds. MDPI. Editor: Gaetano Santulli (2021).
-MITOCHONDRIAL REMODELING AND DYNAMIC INTER-ORGANELLAR CONTACTS IN CARDIOVASCULAR PHYSIOPATHOLOGY. eds. Frontiers. Editors: Gaetano Santulli, Giovanni Monaco, Valentina Parra, Giampaolo Morciano (2021).
-CARDIOVASCULAR DISEASE AND DIABETES: A JOURNEY FORM BENCH TO BEDSIDE. eds. Frontiers. Editor: Gaetano Santulli (2019).
-MITOCHONDRIAL DYNAMICS IN CARDIOVASCULAR MEDICINE. Hardcover Book (646 pages) – eds. Springer-Nature. Editor: Gaetano Santulli (2017).
-DIET AND METABOLIC DYSFUNCTON. Hardcover Book – eds. MDPI, Basel, Switzerland. Adapted from the Special Issue published in Nutrients. Editor: Gaetano Santulli (2017).
-microRNA: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE. Hardcover Book – 3 volumes, eds. Springer Editor: Gaetano Santulli (2016).
-ADRENAL GLANDS: FROM PATHOPHYSIOLOGY TO CLINICAL PRACTICE. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2015).
-ANGIOGENESIS: INSIGHTS FROM A SYSTEMATIC OVERVIEW. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2013).
-Book chapters:
-Gaetano Santulli, et al. microRNAs in diabetes. In “MicroRNA: From Bench to Bedside”. Editor: Dr. J. Xiao; eds. Elsevier (2022).
-Gaetano Santulli, Daniel Lewis, Andrew Marks, and Joachim Frank. Ryanodine receptor structure and function in health and disease. In “Membrane-bound Macromolecular Protein Complexes: Structure and Function”. Editors: Dr. J. Robin Harris and E. Boekema; eds. Springer-Nature (2018).
-Daniela Sorriento, Gaetano Santulli, et al. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium/Calmodulin Dependent Transcription Factors. In “Calcium Signaling in Human Health and Diseases”. Editor: F. Moccia, eds. MDPI (2018).
-Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, and Gaetano Santulli (Corresponding Author). New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling. In “Heart Failure: From Research to Clinical Practice”. Editor: Shaidul Islam (Karolinska Institutet), eds. Springer-Nature (2017).
-Michele Ciccarelli, Daniela Sorriento, Enrico Coscioni, Guido Iaccarino, Gaetano Santulli (Corresponding Author). Adrenergic Receptors. In “Endocrinology of the heart in health and disease”. Editors: JC. Schisler, CH. Lang, MS. Willis, eds. Elsevier (2016).
-Gaetano Santulli, (Corresponding Author) et al. Essential roles of intracellular calcium release channels in muscle, brain and metabolism. In “50th Anniversary of Calcium Channel Research: Biomedical Perspectives”. eds. Bentham Science, Potomac, MD, USA (2015).
-Gaetano Santulli. The adrenergic system in cardiovascular metabolism and aging. In “The cardiovascular adrenergic system”. Hardcover Book, Editor: A. Lymperopoulos, eds. Springer (2018).
-Gaetano Santulli. Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging. In “Pathophysiology and Pharmacotherapy of Cardiovascular Disease”. Editor: G. Jagadeesh, eds. Springer (2015).