Andreas Linkermann

Andreas Linkermann, M.D.

Area of research

  • Kidney Transplantation, Acute Kidney Injury, Cell Death Mechanisms (necroptosis, pyroptosis, ferroptosis)

Email

Location

  • Univ Hospital Carl Gustav Technical University Dresden Fetscherstr. 74 Dresden, Saxony, Germany, SN 01309

Professional Interests

We are a team of clinician-scientists (nephrologists and transplant physicians), biotechnologists, biochemists and molecular biologists. Our primary interest is to inhibit clinically relelevant necrotic type cell death pathways and the inflammatory response (immunogenicity) associated with necrosis (necroinflammation). Pathways of regulated necrosis are necroptosis, ferroptosis and pyroptosis.

Selected Publications

1.     von Mässenhausen, A., Zamora Gonzalez, N., Maremonti, F., Belavgeni, A., Tonnus, W., Meyer, C., Beer, K., Hannani, M.T., Lau, A., Peitzsch, M., Hoppenz, P., Locke, S., Chavakis, T., Kramann, R., Muruve, D.A., Hugo, C., Bornstein, S.R. and Linkermann, A. (2022) Dexamethasone Sensitizes to Ferroptosis by Glucocorticoid Receptor-induced Dipeptidase-1 expression and Glutathione Depletion. Science Advances –Feb 4;8(5):eabl8920

2.     Mishima, E., Ito, J., Wu, Z., Nakamura, T., Wahida, A., Doll, S., Tonnus, W., Nepachalovich, P., Eggenhofer, E., Aldrovandi, M., Henkelmann, B., Yamada, K.-I., Wanninger, J., Zilka, O., Sato, E., Feederle, R., Hass, D., Maida, A., Mourao, A.S.D., Linkermann, A., Geissler, E.K., Nakagawa, K., Abe, T., Fedorova, M., Proneth, B., Pratt, D.A. and Conrad, M. (2022) A non-canonical vitamin K cycle is a potent ferroptosis suppressor Nature –Aug;608(7924):778-783

3.     Tonnus, W.*, Meyer, C.*, C. Steinebach, A. Belavgeni, A. von Mässenhausen, N. Zamora Gonzalez, F. Maremonti, F. Gembardt, N. Himmerkus, M. Latk, S. Locke, J. Marschner, W. Li, S. Short, S. Doll, I. Ingold, B. Proneth, C. Daniel, N. Kabgani, R. Kramann, S. Motika, P. Hergenrother, S. R. Bornstein, C. Hugo, J. U. Becker, K. Amann, H.-J. Anders, D. Kreisel, D. Pratt, M. Gütschow, M. Conrad and Linkermann, A.. (2021). Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury, Nature Communications, Jul 20;12(1):4402 *shared first authors

4.     Belavgeni, A. *, Bornstein, S.R. *, von Mässenhausen, A., Tonnus, W., Stumpf, J., Meyer, C., Othmar, E., Latk, M., Kanczkowski, W., Kroiss, M., Hantel, C., Hugo, C., Fassnacht, M., Ziegler, C.G., Schally, A.V., Krone, N.P.  and Linkermann, A. (2019) Exquisite Sensitivity of Adrenocortical Carcinomas to Induction of Ferroptosis Proceedings of the National Academy of Science (PNAS) – Oct 29;116(44):22269-22274

5.     Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wie, J., Gu, S., Gao, F., Zhu, N., Yin, X., Cheng, Q., Zhang, P., Dai, W., Chen, J., Yang, F., Yang, H.-T., Linkermann, A.*, Gu, W.*, Min J. and Wang, F.* (2019) Ferroptosis as a novel target for protection against cardiomyopathy Proceedings of the National Academy of Science (PNAS) – Feb 12;116(7):2672-2680. *shared corresponding authors

6.     Gong Y.-N., Guy C., Olauson H., Becker J.U., Yang M., Fitzgerald P., Linkermann A.* and Green D.R.* (2017): ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell Apr 6;169(2):286-300, *Corresponding authors

7.     Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S. (2014) Synchronized renal tubular cell death involves ferroptosis. Proceedings of the National Academy of Science (PNAS) 25;111(47):16836-41

8.      Linkermann, A., Bräsen J.H., Darding, M., Jin, M.K., Sanz, A.B., Heller, J.-O., De Zen, F., Weinlich, R., Ortiz, A., Walczak, H., Weinberg, J.M., Green, D.R., Kunzendorf, U., Krautwald, S. (2013). Two Independent Pathways of Regulated Necrosis Mediate Ischemia-Reperfusion Injury, Proceedings of the National Academy of Science (PNAS) 16;110(29):12024-9.

9.     Linkermann, A., Heller, J.-O., Prokai, A., Weinberg, J.M., De Zen, F., Himmerkus, N., Szabo, A.J., Bräsen, J.H., Kunzendorf, U., Krautwald, S. (2013). Osmotic Nephrosis and Contrast-Induced Acute Kidney Injury are prevented by the RIP1-kinase Inhibitor Necrostatin-1 in Mice. Journal of the American Society of Nephrology (JASN) Nov 24(10):1545-57.

10.  Linkermann, A., Bräsen, J.H., Himmerkus, N., Liu, S., Huber, T.B., Kunzendorf, U., Krautwald, S. (2011). RIP1-mediated necroptosis essentially contributes to renal ischemia/reperfusion injury. Kidney International 81, 751-761.