Proteomics provides an unbiased window on the workings of the cell, and can provide cues to functional protein complexes, biomarkers and potential therapeutic targets.  My research focus has been on analytical chemistry approaches to understand important biological questions. My background spanned experimental biology and embryology and chemistry, which proved important as the sophistication of analytical technologies developed, and translational studies became possible. 

 Link to NIHMS profile:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40412936/?sort=date&direction=ascending

A Hishimoto, H Nomaru, K Ye, A Nishi, J Lim, JT Aguilan, E Nieves, G Kang, R Hogue Angeletti, and N Hiroi. Molecular histochemistry identifies peptidomic organization and reorganization along striatal projection units. Biological Psychiatry (2016) PMID 26520239 

El Bissati K, Suvorova ES, Xiao H, Lucas O, Upadhya R, Ma Y, Hogue AngelettiR, White MW, Weiss LM, Kim K. Toxoplasma gondii Arginine Methyltransferase 1(PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division. MBio. 2016 7. PMC4742710.

Outhiriaradjou Benard, Jihyeon Lim, Pasha Apontes, Xiaohong Jing, Ruth H Angeletti, Yuling Chi.  Impact of high-fat diet on the proteome of mouse liver http://dx.doi.org/10.1016/j.jnutbio.2015.12.012

Nika H, Angeletti RH, Hawke DH. Phosphopeptide Enrichment by Covalent Chromatography After Solid Phase Derivatization of Protein Digests on Reversed Phase Supports. Methods Mol Biol. 2016;1355:31-50. PMID: 26584917

Carvallo L, Lopez L, Che FY, Lim J, Eugenin EA, et al. Buprenorphine Decreases the CCL2–Mediated Chemotactic Response of Monocytes. J Immunol. 2015;194:3246-58. PMC4369415

 Harris TM, Du P, Kawachi N, Belbin TJ, Wang Y, et al. Proteomic analysis of oral cavity squamous cell carcinoma specimens identifies patient outcome-associated proteins. Arch Pathol Lab Med. 2015 Apr;1 3 9(4):494-507  PMC4380852 .

 Nika H, Angeletti RH, Hawke DH. N-terminal protein characterization by mass spectrometry using combined microscale liquid and solid-phase derivatization. J Biomol Tech. 2014, 25:77-86. PMC436438

 Tarassishin L, Lim J, Weatherly DB, Angeletti RH, Lee SC. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. J Proteomics. 2014 Mar 17 ;99:1 52 -68. PMC3977979.

 Lim J, Liu Z, Apontes P, Feng D, Pessin JE, et al. Dual mode action of mangiferin in mouse liver under high fat diet. PLoS One. 2014;9(3):e90137 PMC3943915

 Albrethsen J, Angeletti RH, Horwitz SB, Yang CP. Proteomics of cancer cell lines resistant to microtubule stabilizing agents. Mol Cancer Ther. 2014, 13:2 60-9. PMC3 947109

 Nardelli SC, Che FY, Silmon de Monerri NC, Xiao H, Nieves E, et al. The histone code of Toxoplasm a gondii comprises conserved and unique posttranslational modifications. MBio. 2 01 3 Dec 1 0;4(6):e0092 2 -1 3 PMC3870261

 L Miller, A Menthena, C Chatterjee, P Verdier-Pinard, P Novikoff, SB Horwitz, R Hogue Angeletti (2008) Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer., Biochemistry 47, 7572-7582. PMC2574767

 JM Dybas, CM Madrid-Aliste, FY Che, E Nieves, D Rykunov, R Hogue Angeletti, LM Weiss, K Kim, A Fiser.(2008) Computational Analysis and Experimental Validation of Gene Predictions in Toxoplasma gondii. PLoS ONE 3: e3899 doi:10.1371/journal.pone.0003899, PMC2587701

 C Madrid-Aliste, JM Dybas, R Hogue Angeletti, LM Weiss, K Kim, I Simon and A Fiser. EPIC-DB: a proteomics database for studying Apicomplexan organisms (2009) BMC Genomics 10:38

 LM Weiss, A Fiser, R Hogue Angeletti, K Kim (2009) Toxoplasma gondii Proteomics, Expert Reviews in Mass Spectrometry, 6, 303-313, PMC2741161

WD Zencheck, H Xiao, BJ Nolen, R Hogue Angeletti, TD Pollard, SC Almo (2009) Nucleotide and activator-dependent structural and dynamic changes of Arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry. J Mol Biol 390, 414-427, PMC2983480

H Xiao, P Verdier-Pinard, N Fernandez-Fuentes, B Burd, R Hogue Angeletti, A Fiser, SB Horwitz, GA Orr. (2006) Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A., 103:10166-10173. PMC1502429