Gil Atzmon

Gil Atzmon, Ph.D.

Area of research

  • My research focus is on the role of epigenetics in diseases, aging and longevity.

Email

Phone

Location

  • Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Golding Building 502B Bronx, NY 10461

Professional Interests

Dr. Gil Atzmon is currently an Associate Professor in the Division of Endocrinology, Departments of Medicine and Genetics at Albert Einstein College of Medicine, New York, USA. He is also a member of the Institute for Aging Research (IAR) and the Diabetes Research and Training Center (DRTC) at Albert Einstein College of Medicine. A graduate in Population Genetics from Hebrew University, he completed his fellowship in Human Genetics at Albert Einstein College of Medicine where he then joined as a faculty and rose to the rank of Associate Professor. As Associate Professor of Medicine at Einstein, Dr. Atzmon's focus is in a new and challenging field involving the role of epigenetics in diseases, aging and longevity. Dr. Atzmon's work has provided the foundation for the genetic approaches of the Institute of Aging. The foremost focus of Dr. Atzmon's research career has been the understanding of the association of the whole genome to disease, performance, health and longevity. Dr. Atzmon has international collaborated with scientists and researchers across the world. He had more than 150 scientific publications in leading scientific journals. He was invited to present his work in numerous international scientific conferences and meetings. He has been an expert reviewer for many leading scientific journals on genetics and genomics. He is also on the editorial board of couple of journals including the International Journal of Case Report and Images, Genes, Frontiers in Medicine: longevity and healthy aging, Ageing Research Reviews.

Selected Publications

  1. Gutman D, Lidzbarsky G, Milman S, Gao T, Sin-Chan P, Gonzaga-Jauregui C, Regeneron Genetics Center, Deelen J, Shuldiner AR, Barzilai N, Atzmon G. Similar Burden of Pathogenic Coding Variants in Exceptionally Long-Lived Individuals and Individuals without Exceptional Longevity. Aging Cell. 2020

  2.  

     Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020, 12(12):11185-11199.

  3.  

    Giller A, Andrawus M, Gutman D, Atzmon G. Pregnancy as a model for aging. Ageing Res Rev. 2020.

  4.  

     Amir Y, Insler M, Giller A, Gutman D, Atzmon G. Senescence and Longevity of Sea Urchins. Genes (Basel). 2020 11(5);E573.

  5.  

    Andrawus M, Sharvit L, Shekhidem HA, Roichman A, Cohen HY, Atzmon G. The effects of environmental stressors on candidate aging associated genes. Exp Gerontol. 2020 137;110952.

  6.  

    Rozanov L, Ravichandran M, Grigolon G, Zanellati MC, Mansfeld J, Zarse K, Barzilai N, Atzmon G, Fischer F, Ristow M. Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A. Redox Biol. 2020 32;101448.

  7.  

    Falah G, Giller A, Gutman D, Atzmon G. Breaking the Glass Ceiling. Gerontology. 2020 26;1-6.

  8.  

    Gutman D, Rivkin E, Fadida A, Sharvit L, Hermush V, Rubin E, Kirshner D, Sabin I, Dwolatzky T, Atzmon G. Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity. Int J Mol Sci. 2020 21(2); 615.

  9.  

    Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 179(6);1424-1435.

  10.  

    Gurinovich A, Andersen SL, Puca A, Atzmon G, Barzilai N, Sebastiani P. Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. J Gerontol A Biol Sci Med Sci. 2019 74(Supplement_1); S45-S51.

  11.  

    Adelson RP, Renton AE, Li W, Barzilai N, Atzmon G, Goate AM, Davies P, Freudenberg-Hua Y. Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance. Sci Rep. 2019 9(1);16156.

  12.  

    Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 10(1);3669.

  13.  

    Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G. Telomeres and Longevity" A Cause or an Effect? Int J Mol Sci. 2019;20(13) 3233.

  14.  

    Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ. Correction" Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2019 May 30;15(5) e1008190.

  15.  

    Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Córdova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, García-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jørgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara- Hernandez JM, Martínez-Hernández A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C; Broad Genomics Platform, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberón X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusié-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 570(7759); 71-76.

  16.  

    Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY, Zelaya I, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau G, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Luðvigsson P, Sæmundsen E, Thorarensen Ó, Atzmon G, Barzilai N, Wagner M, Moessner R, Ophoff R, Pato CN, Pato MT, Knowles JA, Roffman JL, Smoller JW, Buckner RL, Willsey AJ, Tischfield JA, Heiman GA, Stefansson H, Stefansson K, Posthuma D, Cox NJ, Pauls DL, Freimer NB, Neale BM, Davis LK, Paschou P, Coppola G, Mathews CA, Scharf JM; Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group. Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. Am J Psychiatry. 2019 176(3); 217-227.

  17.  

    Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster" an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019 35(17);3046-3054.

  18.  

    Gielen M, Hageman GJ, Antoniou EE, Nordfjall K, Mangino M, Balasubramanyam M, de Meyer T, Hendricks AE, Giltay EJ, Hunt SC, Nettleton JA, Salpea KD, Diaz VA, Farzaneh-Far R, Atzmon G, Harris SE, Hou L, Gilley D, Hovatta I, Kark JD, Nassar H, Kurz DJ, Mather KA, Willeit P, Zheng YL, Pavanello S, Demerath EW, Rode L, Bunout D, Steptoe A, Boardman L, Marti A, Needham B, Zheng W, Ramsey-Goldman R, Pellatt AJ, Kaprio J, Hofmann JN, Gieger C, Paolisso G, Hjelmborg JBH, Mirabello L, Seeman T, Wong J, van der Harst P, Broer L, Kronenberg F, Kollerits B, Strandberg T, Eisenberg DTA, Duggan C, Verhoeven JE, Schaakxs R, Zannolli R, Dos Reis RMR, Charchar FJ, Tomaszewski M, Mons U, Demuth I, Iglesias Molli AE, Cheng G, Krasnienkov D, D'Antono B, Kasielski M, McDonnell BJ, Ebstein RP, Sundquist K, Pare G, Chong M, Zeegers MP; TELOMAAS group. Body mass index is negatively associated with telomere length" a collaborative cross-sectional meta-analysis of 87 observational studies. Am J Clin Nutr. 2018 108(3);453-475.

  19.  

    Udler MS, Kim J, von Grotthuss M, Bonàs-Guarch S, Cole JB, Chiou J; Christopher D. Anderson on behalf of METASTROKE and the ISGC, Boehnke M, Laakso M, Atzmon G, Glaser B, Mercader JM, Gaulton K, Flannick J, Getz G, Florez JC. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes" A soft clustering analysis. PLoS Med. 2018 15(9); e1002654.

  20.  

    Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2019 74(1); 44-51. 

  21. Sathyan S, Barzilai N, Atzmon G, Milman S, Ayers E, Verghese J. Genetic Insights Into Frailty" Association of 9p21-23 Locus With Frailty. Front Med (Lausanne). 2018 5105. 
  22. Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2018 14(5);           e1007329.

  23. Lidzbarsky G, Gutman D, Shekhidem HA, Sharvit L, Atzmon G. Genomic Instabilities, Cellular Senescence, and Aging” In Vitro, In Vivo and Aging-Like Human Syndromes”. Front Med (Lausanne). 2018 5;104.

  24.  

    Lencz T, Yu J, Palmer C, Carmi S, Ben-Avraham D, Barzilai N, Bressman S, Darvasi A, Cho JH, Clark LN, Gümüş ZH, Joseph V, Klein R, Lipkin S, Offit K, Ostrer H, Ozelius LJ, Peter I, Atzmon G, Pe'er I. High-depth whole genome sequencing of an Ashkenazi Jewish reference panel enhancing sensitivity, accuracy, and imputation. Hum Genet. 2018 137(4); 343-355.

  25. Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe'er I, Ioannou Y, McGovern DPB, Yue Z, Schadt EE, Cho JH, Peter I. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med. 2018 10(423).
  26. Lencz T, Yu J, Palmer C, Carmi S, Ben-Avraham D, Barzilai N, Bressman S, Darvasi A, Cho JH, Clark LN, Gümüş ZH, Joseph V, Klein R, Lipkin S, Offit K, Ostrer H, Ozelius LJ, Peter I, Atzmon G, Pe'er I. High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation. Hum Genet. 2018 137(4):343-355.
  27. Sathyan S, Barzilai N, Atzmon G, Milman S, Ayers E, Verghese J. Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty. Front Med (Lausanne). 2018 5:105.
  28. Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2018.
  29. Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet. 2018 14(5):e1007329
  30. Goo J, Manning AK, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee SY, Lincoln SE, Trubetskoy V, DePristso M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zolllner S, Curran JE, Peralta J, Akolkar B, Bell G, Burtt NP, Cox NJ, Florez JC, Hanis C, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis G, Blangero J. Evaluating the Contribution of Rare Variants to Type 2 Diabetes and Related Traits using Pedigrees. Proceedings of the National Academy of Sciences of the United States 2018 115(2):379-384.
  31. Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data 2017 4:170179.
  32. Gubbi S, Schwartz E, Crandall J, Verghese J, Holtzer R, Atzmon G, Braunstein R, Barzilai N, #Milman S. Parental longevity is associated with protection from cardiovascular disease independent of lifestyle. American Journal of Cardiology, 2017 120(12), 2170-2175.
  33. Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2017.
  34. Sathyan S, Barzilai N, Atzmon G, #Milman S, Ayers E, Verghese J. Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population. Neurobiology of Aging. 2017 58:238.e1-238.
  35. Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JRB, Rayner NW, Robertson NR,  Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SBR, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T,  Lindstrom J, Brandslund I, Christensen C, Surdulescu GL, Lakka TA, Doney ASF, Nilsson P, Wareham NJ, Langenberg C, Varga TV, Franks PW, Rolandsson O, Rosengren AH, Farook VS, Thameem F, Puppala S, Kumar S, Lehman DM, Jenkinson CP, Curran JE, Hale DE, Fowler SP, Arya R, DeFronzo RA, Abboud HE, Syvänen AC, Hicks PJ, Palmer  ND, Ng MCY, Bowden DW, Freedman BI, Esko T, Mägi R, Milani L, Mihailov E, Metspalu A, Narisu N, Kinnunen L, Bonnycastle LL, Swift A, Pasko D, Wood AR, Fadista J, Pollin TI, Barzilai N, Atzmon G, Glaser B, Thorand B, Strauch K, Peters A, Roden M, Müller-Nurasyid M, Liang L, Kriebel J, Illig T, Grallert H, Gieger C, Meisinger C, Lannfelt L, Musani SK, Griswold M, Taylor HA Jr, et al.. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017, 66(7):2019-2032.  
  36. Raz Y, Guerrero-Ros I, Maier A, Slagboom PE, Atzmon G, Barzilai N, Macian F.J Gerontol A Biol Sci Med Sci. 2017 72(9):1201-1206
  37. Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. J Gerontol A Biol Sci Med Sci, 2017 72(11):1453-1464.
  38. Ben-Avraham D, Karasik D , Verghese J, Lunetta KL, Smith JA , Eicher JA, Vered R, Deelen J , Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R , Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SLR , Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G , Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging, 2017 9(1), 209-246.
  39. Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X,  Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A;  BIOS Consortium., Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, et. al.. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016 48(12), 1462-1472.
  40. Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T,  Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D,  Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R,  Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S,   Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K,   Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan  S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise  AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH.  A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 151(4):710-723.
  41. Waldman YY, Biddanda A, Dubrovsky M, Campbell CL, Oddoux C, Friedman E, Atzmon G, Halperin E, Ostrer H, Keinan A. The genetic history of Cochin Jews from India. HUGE 2016.
  42. Freudenberg-Hua Y, Wentian L, Vacic V, Abhyankar AV, Cortes V, Ben-Avraham D, Barzilai N, Koppel J, Greenwald B,  Germer S, Darnell RB, Freudenberg J, Atzmon G, Davies P. Increased Burden of Rare Protein Truncating Variants in Alzheimer’s Disease Patients Compared to Centenarian Controls. Human Molecular Genetics 2016.
  43. Ryu S, Atzmon G, Barzilai N, Raghavachari N, Suh Y. Genetic landscape of APOE in human longevity revealed by high-throughput sequencing. Mech Ageing Dev. 2016, 155:7-9.
  44. Roshandel D, Klein R, Klein BEK, Wolffenbuttel BHR, Atzmon G, Ben-Avraham D, Crandall JP, Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA, Braffett BH, DCCT/EDIC Research Group, Paterson AD. A Locus Associated with Skin Intrinsic Fluorescence in Type 1 Diabetes.Diabetes 2016.
  45. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, […272 co-  authors…], Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Min Kang H, Boehnke M, Altshuler D, McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016.
  46. Waldman YY, Biddanda A, Davidson NR, Billing-Ross P, Dubrovsky M, Campbell CL, Oddoux C, Friedman E, Atzmon G, Halperin E, Ostrer H, Keinan A. The genetics of Bene Israel from India reveals both substantial Jewish and Indian ancestry. PLoS One 2016 11(3):e0152056.
  47. Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou W, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu Y, Ittermann T, Lahousse L, Liewald DC, Liu Y, Rivadeneira F, Rotter J, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. GWAS Analysis of Hand Grip and Lower Body Strength in Older Adults in the CHARGE Consortium. Aging cell 2016.
  48. Marzec M, Hawkes CP, Eletto D, Boyle S, R osenfeld R, Hwa V, Wit JM, Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen OB, Have CT, Yeap BB, Flicker L, Atzmon G, Barzilai N, Grimberg A, Argon Y. A human variant of GRP94 that supports IGF production inefficiently. Endocrinology 2016157(5):1914-28.
  49. Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, Fontanillas P, Thuillier D, Yengo L, Below JE, Tam CHT, Wu Y, T2D-GENES Consortium, Abecasis G, Altshuler D, Bell GI, Blangero J, Burtt NP, Duggirala R, Florez JC, Hanis CL, Seielstad M, Atzmon G, Chan JCN, Ma RCW, Froguel P, Wilson JG, Bharadwaj D, Dupuis J, Meigs JB, Cho YS, Park T, Kooner JS, Chambers JC, Saleheen D, Kadowaki T, Tai ES, Mohlke KL, Cox NJ, Ferrer J, Zeggini E, Kato N, Teo YY, Boehnke M, McCarthy MI, Morris MP. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics 2016.
  50. Baskovich B, Hiraki S, Upadhyay K, Meyer P, Carmi S, Barzilai N, Darvasi A, Ozelius L, Peter I, Cho JH, Atzmon G, Clark L, Yu J, Lencz T, Pe'er I, Ostrer H, Oddoux C. Expanded genetic screening panel for the Ashkenazi Jewish population. Genet Med. 2015 18(5):522-8.
  51. Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, Kim SK. Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLoS Genet. 2015 11(12).
  52. Han J, Atzmon G, Barzilai N, Suh Y. Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews. Transl Res. 2015 165(4):480-1.
  53. Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. British Journal of Cancer. 2015 112, 313–318.
  54. Govindaraju D, Atzmon G, Barzilai N. Genetics, lifestyle and longevity: Lessons from centenarians. Applied & Translational Genomics. 2015 4:23–32.
  55. Deluty JA, Atzmon G, Crandall J, Barzilai N, Milman Sofiya. The influence of gender on inheritance of exceptional longevity. Aging, 7(6), 2015,
  56. Kato K, Zweig R, Schechter CB, Barzilai Nir, Atzmon G. Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians. Aging & Mental Health, 2015.
  57. Govindaraju D, Atzmon G, Barzilai N. Genetics, lifestyle and longevity: Lessons from centenarians. Applied & Translational Genomics, 4, 23-32, 2015.
  58. Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. BJC, 112(2): 313-318, 2015.
  59. Han J, Atzmon G, Barzilai N, Suh Y. Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews. Translational Research, 65 (4), 480-481, 2015.
  60. Gutman D, Sharvit L and Atzmon G. Possible Mechanisms for Telomere Length Maintenance in Extremely Old People. Hereditary Genet, 3, e11, 2014.
  61. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI. on behalf of T2D-GENES; Boehnke M. on behalf of GoT2D; Altshuler D. on behalf of SIGMA T2D, Tuomileheto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL. Age-related clonal hematopoiesis associated with adverse outcomes. NEJM, 371 (26), 2488-2498, 2014.
  62. Gershoni M, Toiw Y, Ovadia O, Levin L, Shani N, Dadon S, Atzmon G, Wainstein J, Tsur A, Nijtmans L, Glaser B, Mishmar D. Interfering with nucleus-mitochondrial co-evolution disrupts OXPHOS complex I integrity and alters risk to type 2 diabetes mellitus. GBE, 6(10):2665-80, 2014.
  63. Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB; GoT2D Consortium; NHGRI JHS/FHS Allelic Spectrum Project; SIGMA T2D Consortium; T2D-GENES Consortium, Rosen ED, Altshuler D; GoT2D Consortium. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. PNAS. 111(36):13127-32, 2014.
  64. Zidan J, Ben-Avraham D, Carmi S, Maray  T, Friedman E, Atzmon G. Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck. EJHG, 2014.
  65. Carmi S, Hui KY, Kochav E, Liu X, [….] Ostrer H, Atzmon G, Clark LN, Lencz T, Pe’er I. Whole genome sequencing of an Ashkenazi Jewish reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nature Communication. 5:4835, 2014.
  66. Eny KM, Lutgers HL, Maynard J, Klein B, Lee KE, Atzmon G., Monnier VM, van Vliet – Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini MS, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D, LifeLines Cohort Study, DCCT/EDIC Research Group, Wolffenbuttel BHR, Paterson AD. GWAS identifies the N-acetyltransferase 2 (NAT2) acetylator status tag SNP to be a major locus for skin fluorescence. Diabetologia. 57(8):1623-34, 2014.
  67. Freudenberg-Hua Y, Freudenberg J, Vacic V, Abhyankar A, Emde AK, Ben-Avraham D, Barzilai N, Oschwald D, Christen E, Koppel J, Greenwald B, Darnell RB, Germer S, Atzmon G, Davies P. Disease Variants in Genomes of 44 Centenarians. MGGM, 2(5):438-50, 2014.
  68. Friedman E, Moran DS, Ben-Avraham D, Yanovich R, Atzmon G. Novel candidate genes putatively involved in stress fracture predisposition detected by whole Exome sequencing. Genetics Research, 96:e004, 2014.
  69. Vacic V, Ozelius LJ, Clark LN, Bar-Shira A,  Gana-Weisz M, Gurevich T, Gusev A, Kedmi M, Kenny EE, Liu X, Mejia-Santana H, Mirelman A, Raymond D, Saunders-Pullman R, Desnick RJ, Atzmon G, Burns ER, Ostrer H, Hakonarson H, Bergman A, Barzilai N, Darvasi A, Peter I, Guha S, Lencz T, Giladi N, Marder K,  Pe’er I, Bressman SB, Orr-Urtreger A. Genome-wide mapping of identical-by-descent segments in an Ashkenazi Parkinson disease cohort identifies associated haplotypes. Human Molecular Genetics. 23(17):4693-702, 2014.
  70. Bashiri A, Heo HJ, Mazor M, Budagov T, Einstein FH,  Atzmon G. Pregnancy Complicated by Obesity Induces Global Dysregulation in Visceral and Subcutaneous Fat. Molecular Genetics and Genomics. 289(4):695-705, 2014.
  71. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity. Aging Cell, 13(4):769-71, 2014.
  72. Flannick J, Thorleifsson G, Beer NL, Jacobs SBR, Grarup N, Mahajan A, Fuchsberger C, Atzmon G, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nature genetics, 46(4):357-63, 2014.
  73. Atzmon G, Chang ALS, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. Journal of Investigative Dermatology, 134(3):651-7, 2014.
  74. Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, Crandall JP, Barzilai N, Melamed ML, Atzmon G. Individuals with Exceptional Longevity Manifest a Delayed Association between Vitamin D Insufficiency and Cognitive Impairment. J Am Geriatr Soc. 62(1):153-8, 2014.
  75. The SIGMA Type 2 Diabetes Consortium; Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C [….]; T2D-GENES Consortium, Flannick J, Fontanillas P, Morris A, Teslovich TM, Burtt NP, Atzmon G, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature, 506(7486):97-101, 2014.
  76. Barzilai N, Atzmon G. Annual Review of Gerontology and Geriatrics, 34 (1): 171-188, 2014.
  77. Milman S, Atzmon G, Crandall J, Barzilai N. Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity. Curr Vasc Pharmacol. 12(5):690-7, 2014.
  78. Botigué LR, Henn BM, Gravel S, Maples BK, Gignoux CR, Corona E, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD. Gene flow from North Africa contributes to differential human genetic diversity in southern Europe. PNAS, 110(29):11791-6, 2013.
  79. Kato K, Zweig R, Schechter CB, Verghese J, Barzilai N, Atzmon G. Personality, Self-Rated Health, and Cognition in Centenarians: Do Personality and Self-Rated Health Relate to Cognitive Function in Advanced Age?. Aging, 5(3):183-91, 2013.
  80. Axelrad MD, Atzmon G. Epigenomic of Aging. Hereditary Genetics, 2013.
  81. Axelrad MD, Budagov T, Atzmon G. Telomere length and telomerase activity; a yin and yang of cell senescence. J Vis Exp, (75). 2013.
  82. Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. Growth Hormone Receptor (GHR) Exon 3 Polymorphism Status Detection by Dual-Enzyme-Linked Immunosorbent Assay (ELISA). JCEM, 98(1): E77-E81, 2013.
  83. Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mechanisms of Ageing and Dev. 134(10):478-85, 2013.
  84. Huffman DM, Augenlicht LH. , Zhang X, Lofrese JJ, Atzmon G, Chamberl JP. Mantzoros CS. Abdominal obesity, independently from caloric intake, accounts for the development of intestinal tumors in Apc1638N/+ female mice. Cancer Prevention Research, 6(3):177-87, 2013.
  85. Mirina A, Atzmon G, Ye K, Bergman A. Gene Size Matters. PLoS One, 7(11):e49093, 2012.
  86. Ben-Avraham D, Muzumdar RH, Atzmon G. Epigenetic-genome wide association (EWAS) methylation in aging and longevity. Epigenomics, 4(5):503-9, 2012.
  87. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JHJ, Campisi J, Vijg J, Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC genomics, 13(1):353, 2012.
  88. Campbell CL, Palamara PF, Dubrovsky M, Botigué LR, Fellous M, Atzmon G, Oddoux C, Pearlman A, Hao L, Henn BM, Burns E, Bustamante CD, Comas D, Friedman E, Pe'er I, Ostrer H. North African Jewish and non-Jewish populations form distinctive, orthogonal clusters. PNAS, 109(34):13865-70, 2012.  
  89. Kato K, Zweig R, Barzilai N, Atzmon G. Positive Attitude Towards Life and Emotional Expression as Personality Phenotypes for Centenarians. Aging, 4(5):359-67, 2012.
  90. Broer L, Demerath EW, Garcia ME, Homuth G, Kaplan RC, Lunetta KL, Tanaka T, Tranah GJ, Walter S, Arnold AM, Atzmon G, Harris TB, Hoffmann W, Karasik D, Kiel DP, Kocher T, Launer LJ, Lohman KK, Rotter JI, Tiemeier H, Uitterlinden AG, Wallaschofski H, Bandinelli S, Dörr M, Ferrucci L, Franceschini N, Gudnason V, Hofman A, Liu Y, Murabito JM, Newman AB, Oostra BA, Psaty BM, Smith AV, van Duijn CM. Association of heat shock proteins with all-cause mortality. Age (Dordr). 35(4):1367-76, 2012.
  91. Huffman DM, Deelen J, Ye K, Bergman A, Slagboom EP, Barzilai N, Atzmon G. Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: The case of the MTP gene. J Gerontol A Biol Sci Med Sci. 67(11):1153-60, 2012.
  92. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell, 11(3):475-81, 2012.
  93. Atzmon G, Lai JYC, Melamed ML, Hostetter TH, Crandall JP, Barzilai N, Bitzer M. Family History of Exceptional Longevity is associated with lower serum uric acid levels. JAGS, 60(4):745-50, 2012. 
  94. Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Meng Ng S, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi  N, Gregersen PK, Hakonarson H, Jones MR, McGovern DPB, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer  L, Katz S, Desnick RJ, Cho JH, Peter I. A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci. PLoS Genetics, 8(3):e1002559, 2012.
  95. Tabatabaie V, Atzmon G, Rajpathak SN, Freeman R, Barzilai N, Crandall J. Exceptional longevity is associated with decreased reproduction. Aging, 3(12):1202-5, 2011.
  96. Hansen BC, Shamekh R, Budagov T, Linden E, Pessin J,  Atzmon G. The rhesus monkey: a nonhuman primate model for T2DM associated gene screening. J Diabetes Metab, 2:150. 2011.  
  97. Velez C, Palamara PF, Guevara-Aguirre J, Hao L, Karafet T, Guevara-Aguirre M, Pearlman A, Oddoux C, Hammer M, Burns E, Pe'er I, Atzmon G, Ostrer H. The Impact of Converso Jews on the Genomes of Modern Latin Americans. Human genetics, 131(2):251-63, 2012.
  98. Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, et al. A Genome-Wide Association Study of Ageing. Neurobiology of Aging, 32(11): 2109.e15-e28, 2011.
  99. Rajpathak SN, Liu J, Ben-David O, Reddy S, Atzmon G, Crandall J, Barzilai N. Lifestyle Factors among People with Exceptional longevity. JAGS, 59(8):1509-12, 2011.
  100. Moorjani P, Patterson N, Hirschhorn JN, Hao L, Atzmon G, Burns E, Keinan A, Osterer H, Price A, Reich D. The history of African gene flow into Southern Europeans, Levantines and Jews. PLoS Genet 7(4): e1001373, 2011.
  101. Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D and Bergman A. The promise of human genetics in preventing ageing-related disease. JCEM, 95(10):4493-500. Erratum in: JCEM. 2011;96(6):1908, 2010.
  102. Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Gundewar S, Yong Ji S, Lefer DJ. Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice. ATVB. 30(10):1940-8, 2010.
  103. Einstein FH, Huffman DM, Fishman S, Jerschow E, Heo HJ, Atzmon G, Barzilai N, Muzumdar RH. Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance. J Gerontol A Biol Sci Med Sci. 65(8):800-8, 2010.
  104. Thompson RF, Atzmon G, Liang HQ, Lowes C, Greally JM, Barzilai N. Tissue-specific dysregulation of DNA methylation in aging. Aging cell, 9(4):506-18, 2010.
  105. Cai G, Atzmon G, Naj A, Beecham GW, Barzilai N, Haines JL, Sano M, Pericak-Vance M, Buxbaum JD. Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease. Neurobiology of Aging, 33(2):416-417.e3, 2012.
  106. Atzmon G, Hao L,  Pe'er I, Velez C, Pearlman A, Palamara P, Morrow B, Friedman E, Oddoux C, Burns E, Ostrer H. Abraham’s Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry. AJHG, 86(6):850–9, 2010.
  107. Schechter CB, Barzilai N, Crandall JP, Atzmon G. Reduced Cholesteryl Ester Transfer Protein Levels Is Associated with Decreased Blood Pressure. Mayo Clinic Proceeding, 85(6):522-6, 2010.
  108. Neuman RJ, Wasson J, Atzmon G, Sun L, Barzilai N, Blech I, Glaser B, Permutt MA.Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in Genetically Homogenous Versus Heterogeneous Populations. PLoS One, 26;5(3):e9903, 2010.
  109. Atzmon G, Cho M,Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, and Suh Y. Evolution in Health and Medicine Sackler Colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. PNAS, 107(1):1710-1717, 2010.
  110. Sebastiani P, Montano M, Puca A, Timofeev N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SEJ, Anderson S, Hartley S, Sedgewick A, Arai Yasumichi, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Steinberg MH,  Hirose N, Atzmon G, Ruvkun G, Baldwin CT & Perls TT. RNA Editing Genes Associated with Extreme Old Age in Humans and Lifespan in C. elegans. PLoS One, 4 (12): e8210, 2009.
  111. Atzmon G, Barzilai N, Surks MI, Gabriely l. Genetic Predisposition to Elevated Serum Thyrotropin is Associated with Exceptional Longevity. JCEM, 94(12):4768-75, 2009.
  112. Pawlikowska L, Hu Donglei, Huntsman S, Sung A, Chu C, Chen J, Reiner A, Atzmon G, Barzilai N, Psaty B, Hsueh W-C, Cummings S, Browner W, Kwok P-Y, Ziv E. Association of common genetic variation in the IGF1 signaling pathway with human lifespan. Aging cell, 8(4):460-72, 2009.
  113. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. PLoS one, 4(7):e6334, 2009.
  114. Walston JD, Matteini AM, Nievergelt C, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Russell PT, Atzmon G, Lange EM, Reiner AP. Inflammation and Stress-Related Candidate Genes, Plasmainterleukin-6 Levels, and Longevity In Older Adults. Experimental Gerontology, 44(5):350-5, 2009.
  115. Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I. Extreme Longevity is Associated with Increased Serum Thyrotropin. JCEM, 94(4):1251-4, 2009.
  116. Shlush LI, Atzmon G, Weisshof R, Behar D, Yudkovsky G, Barzilai N, Skorecki K.  Ashkenazi Jewish Centenarians do not Demonstrate Enrichment in Mitochondrial Haplogroup J. PLoS One. 3(10):e3425, 2008.
  117. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith SW, Barzilai N.Visceral Adipose Tissue Modulates Mammalian Longevity. Aging Cell. 7(3):438-40, 2008.
  118. Einstein FH, Bauman J, Fishman S, Thompson R, Atzmon G, Barzilai N, Muzumdar RH. Enhanced Activation of ‘Nutrient-Sensing pathway’ with Age Contributes to the Insulin Resistance and Inflammatory State. FASEB. 22(10):3450-7, 2008.
  119. Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, Shuldiner AR, Barzilai N. Adiponectin levels and genotype: A potential regulator of life-span in humans. J Gerontol A Biol Sci Med Sci. 63(5):447-53, 2008.
  120. Atzmon G, Blum S, Feldman M, Cahaner A, Lavi U, Hillel J. QTLs detected in a multigenerational resource chicken population. Journal of Heredity. 99(5):528-38, 2008.
  121. Suh Y, Atzmon G, Cho M, Hwang D, Liu B, Leahy D, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. PNAS. 105(9):3438-42, 2008.
  122. Einstein FH, Fishman S, Muzumdar R, Yang X, Atzmon G, Barzilai N. Accretion of Visceral Fat and Hepatic Insulin Resistance in Pregnant Rats. Am J Physiol Endocrinol Metab. 294(2):E451-5, 2008.
  123. Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G. Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion 7(4):267-72, 2007.
  124. Atzmon G, Blum S, Feldman M, Lavi U, Hillel J. Detection of agriculturally important QTLs in chickens and identification of the best genotyping strategy. Cytogenet Genome Res 117:327–337, 2007.
  125. Fishman S, Muzumdar R, Atzmon G, Ma X, Barzilai N. Resistance to Leptin Action is the Major Determinant of Hepatic Triglycerides Accumulation in vivo. FASEB 21(1):53-60, 2007.
  126. Atzmon G, Rincon M, Schechter C, Shuldiner A, Lipton R, Bergman A, Barzilai N: Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biology 4(4):e113, 2006.
  127. Atzmon G, Ronin YI, Korol A, Yonash N, Cheng H and Hillel J. QTLs associated with growth traits and abdominal fat weight and their interactions with gender and hatch in commercial meat-type chickens. Animal Genetics 37:352–358, 2006.
  128. Lahav T, Atzmon G, Blum S, Ben-Ari G, Weigend S, Cahaner A, Lavi U, Hillel J. Marker Assisted Selection Based On Multi-Trait Economic Index In Chicken: Experimental Results And Simulation. Animal Genetics 37: 482–488, 2006.
  129. Muzumdar R, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. Central and Opposing effects of IGF-1 and IGFBP-3 on systemic insulin action. Diabetes 55:2788-96, 2006.
  130. Terry DF, Diego FW, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL,  Wilcox MA, Farrer LA, Perls TT, Barzilai N, Baldwin CT, Asea A, Serum Heat Shock Protein 70 Level as a Biomarker of Exceptional Longevity. Mechanisms of Aging and Dev. 127(11):862-8, 2006.
  131. Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB, A Genotype of Exceptional Longevity is Associated with Preservation of Cognitive Function. Neurology 26;67(12):2170-5, 2006.
  132. Bergman A, Atzmon G, Ye K, Barzilai N: Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Computational Biology, 3(8):e170, 2007.
  133. Muzumdar RH, Ma X, Yang X, Atzmon G, Barzilai N: Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging. Neurobiol Aging, 27:9:1308-1314, 2006.
  134. Atzmon G, Einstein FH, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N: Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54:672-678, 2005.
  135. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC: Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96:412-418, 2005.
  136. Atzmon G, Rincon M, Rabizadeh P, Barzilai N: Biological evidence for inheritance of exceptional longevity. Mech Ageing Dev 126:341-345, 2005.
  137. Rincon M, Muzumdar R, Atzmon G, Barzilai N: The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech Ageing Dev 125:397-403, 2004.
  138. Muzumdar R, Ma X, Atzmon G, Vuguin P, Yang X, Barzilai N: Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. Diabetes 53:441-446, 2004.
  139. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N: Clinical phenotype of families with longevity. JAGS 52:274-277, 2004.
  140. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR: Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290:2030-40, 2003.
  141. Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N: Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J 17:1130-1132, 2003.
  142. Ma X, Muzmudar R, Gabriely I, Atzmon G, Barzilai N. Does the brain lead the metabolic decline in aging?: Lessons from animal models and human centenarians. Clinical Neuroscience Research.  2(5-6): 269-362, 2003.
  143. Atzmon G, Yang XM, Muzumdar R, Ma XH, Gabriely I, Barzilai N: Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res 34:622-628, 2002.
  144. Atzmon G, Gabriely I, Greiner W, Davidson D, Schechter C, Barzilai N: Plasma HDL levels highly correlate with cognitive function in exceptional longevity. J Gerontol A Biol Sci Med Sci 57:M712-715, 2002.
  145. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N: Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51:2951-2958, 2002.
  146. Atzmon G, Cassuto D, Lavi U, Cahaner A, Zeitlin G, Hillel J: DNA markers and crossbreeding scheme as means to select sires for heterosis in egg production of chickens. Anim Genet, 33:132-9, 2002.
  147. Atzmon G, Van Oss H, Cxosnek H: PCR-amplification of tomato yellow leaf curl virus (TYLCV) DNA from squashes of plants and whitefly vectors: application to the study of TYLCV acquisition and transmission. European Journal of Plant Pathology 104:189-194, 1998.