Sofiya Milman

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First Name

Sofiya

Last Name

Milman

NPI

1265726962

Faculty ID

12865

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Female

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<p>Dr. Sofiya Milman is Professor of Medicine and of Genetics, Interim Vice-Chair for Research in the Department of Medicine, and Director of Human Longevity Studies at Einstein’s Institute for Aging Research. Dr. Milman&rsquo;s research focuses on a unique population of centenarians and their families who are generally free of age-related diseases. Healthy longevity runs in most of these families, suggesting a heritable basis for this phenomenon.&nbsp;Dr. Milman's team conducts translational research focused on the discovery of genomic mechanisms that regulate endocrine and metabolic pathways that protect against common age-related diseases, like diabetes, cardiovascular disease and Alzheimer's.&nbsp;</p>
<p>Many of the discovered longevity genes and phenotypes are related to hormonal pathways. Changes in most hormones are observed throughout the human lifespan, but it remains unknown whether the observed changes cause aging, are associated with age but are not the cause of aging, or are protective for the aging body. Identification of protective endocrine parameters will inform our understanding of the mechanisms of healthy aging and lead to the discovery of interventions that protect from age-related diseases.</p>
<p>A biological pathway that has been repeatedly implicated in aging is the somatotropic axis that involves signaling via growth hormone and insulin-like growth factor-I (IGF-I). &nbsp;Substantial evidence exists that diminished signaling via this pathway delays aging, resulting in longer lifespan and health-span, not only in animal models, but also in humans. In fact, Dr. Milman's research demonstrated that&nbsp;lower IGF-I levels were associated with longer survival and better cognition in humans with exceptional longevity and provided evidence against supplementing older adults with growth hormone in an attempt to delay aging. Dr. Milman's team uses computational approaches to integrade genetic information, such as whole-exome sequencing, with rich phenotype data in families with inherited longevity to understand the genetic and molecular mechanisms that lead to protective effects of low IGF-I.&nbsp;</p>

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<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp; &nbsp; &nbsp;1. Zhang WB, Ye K, Barzilai N,&nbsp;<strong>Milman S</strong>. The antagonistic pleiotropy of insulin-like growth factor 1.&nbsp;<em>Aging Cell&nbsp;</em>2021;&nbsp;</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #231f20; letter-spacing: -0.05pt; background-color: white;">20(9), e13443</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">;&nbsp;</span><span class="id-label"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">PMCID: PMC8441393</span></span><span class="apple-converted-space"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp;</span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span class="docsum-authors"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #212121;">&nbsp; &nbsp; &nbsp;</span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span class="docsum-authors"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #212121;">&nbsp; &nbsp; &nbsp;2. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ,&nbsp;<strong>Milman S</strong>, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report.&nbsp;<em>Ann NY Acad Sci&nbsp;</em>2021</span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;3. Zhang WB, Aleksic S, Gao T, Weiss EF, Demetriou E, Verghese J, Holtzer R, Barzilai N,<strong>&nbsp;Milman S.&nbsp;</strong><a href="https://pubmed.ncbi.nlm.nih.gov/32492897/?from_term=sofiya+milman&amp;f… style="color: black; text-decoration: none;">Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults.</span></a>&nbsp;<em>Cells</em>&nbsp;2020; 9(6):E1368,&nbsp;PMCID:<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7349399/&quot; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">PMC7349399</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;4. Zhang ZD,&nbsp;<strong>Milman S</strong>, Lin J, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LF, Suh Y, Robbins PD, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing.&nbsp;<em>Nat Metab&nbsp;</em>2020; 2(8)663-672.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;5. Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C,&nbsp;<strong>Milman S</strong>, Barzilai N, Wyss-Coray T. Undulating changes in human plasma proteome profiles across the lifespan.&nbsp;<em>Nat Med</em>&nbsp;2019; 25(12):1843-1850;&nbsp;PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7062043/&quot; target="_blank" rel="noopener"><span style="color: black;">PMC7062043</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;6. Gubbi S, Quipildor GF, Barzilai N, Huffman DM,&nbsp;<strong>Milman S</strong>. 40 Years of IGF-1: IGF-1: the Jekyll and Hyde of the aging brain.&nbsp;<em>J Mol Endocrinol&nbsp;</em>2018; 61(1):T171-T185. PMCID: PMC5988994</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;7. Gubbi S, Schwartz E, Crandall JP, Verghese J, Holtzer R, Atzmon G, Braunstein R, Barzilai N,&nbsp;<strong>Milman&nbsp;S</strong>. Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring.&nbsp;<em>Am J Cardiol</em>&nbsp;2017</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; &nbsp;8. Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N,&nbsp;<strong>Milman S</strong>. Compression of Morbidity is Observed Across Cohorts with Exceptional Longevity.&nbsp;<em>J Am Geriatr Soc</em>&nbsp;2016; 64(8):1583-91. PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988893/"><span style="color: black;">PMC4988893</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">&nbsp; &nbsp; 9.</span><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">, Huffman DM, Barzilai N. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research.&nbsp;<em>Cell Metab</em>&nbsp;2016; 23(6):980-9. PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919980/"><span style="color: black;">PMC4919980</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: 'Verdana',sans-serif; mso-fareast-font-family: Verdana; mso-bidi-font-family: Verdana; color: black; mso-themecolor: text1;"><span style="mso-list: Ignore;">&nbsp; &nbsp; 10.<span style="font: 7.0pt 'Times New Roman';">&nbsp;</span></span></span><!--[endif]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">Perice L, Barzilai N, Verghese J, Weiss EF, Holtzer R, Cohen P,&nbsp;<strong>Milman S</strong>. Lower Circulating Insulin-like Growth Factor-I is Associated with Better Cognition in Females with Exceptional Longevity Without Compromise to Muscle Mass and Function.&nbsp;<em>Aging&nbsp;</em>Albany NY) 2016; 8(10): 2414-2424. PMCID:&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115897/"><span style="color: black;">PMC5115897</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: 'Verdana',sans-serif; mso-fareast-font-family: Verdana; mso-bidi-font-family: Verdana; color: black; mso-themecolor: text1;"><span style="mso-list: Ignore;">&nbsp; &nbsp; 11.<span style="font: 7.0pt 'Times New Roman';">&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">, Barzilai N. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.&nbsp;<em>Cold Spring Harb Perspect Med</em>&nbsp;2015 Dec 4. PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691799/"><span style="color: black;">PMC4691799</span></a>&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp; &nbsp; &nbsp;12.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span></span><!--[endif]--><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity.&nbsp;<em>Aging Cell</em>&nbsp;2014; 13(4):769-71</span></p>

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<p style="font-family: 'Times New Roman'; font-size: 12.0pt; margin: 0pt 0pt .0001pt 0pt;"><span style="font-size: 10.0pt; font-family: Arial;">Dr. Preeti Kishore is a Professor in the Division of Endocrinology.&nbsp;</span><span style="font-family: Arial; font-size: 13.3333px;"> She is the site director for the Einstein/Montefiore Endocrinology Fellowship Program at Jacobi Medical Center. As Chief of the Endocrinology Division at Jacobi she is responsible for the clinical endocrine inpatient and outpatient operations at Jacobi and North Central Bronx Hospitals.</span><span style="font-family: Arial; font-size: 13.3333px;"> She actively participates in the teaching of endocrinology fellows, internal medicine residents and Einstein medical students. Her education philosophy is to empower learners to drive their own educational goals/learning. She is interested in the use of diabetes technology to manage low health literacy patients with diabetes. She is also the Director of the Weight Management Program at Jacobi.</span></p>
<p style="font-family: 'Times New Roman'; font-size: 12.0pt; margin: 0pt 0pt .0001pt 0pt;"><span style="font-family: Arial; font-size: 10pt;">Her research interests have been in Type 2 Diabetes Mellitus and the Insulin resistance syndrome. She has investigated the pathogenic role of free fatty acids in various aspects of </span><span style="font-family: Arial; font-size: 13.3333px;">Type 2 Diabetes Mellitus</span><span style="font-family: Arial; font-size: 10pt;">, particularly the role they play in regulating &ldquo;glucose effectiveness&rdquo;. She is also interested in the role of adipose tissue inflammation in the pathogenesis of the metabolic syndrome and insulin resistance. As an extension to her interest in adipose inflammation, she has investigated the role of vitamin D deficiency in Type 2 diabetes and whether it may regulate adipose inflammation/fibrosis. </span></p>
<p style="font-family: 'Times New Roman'; font-size: 12.0pt; margin: 0pt 0pt .0001pt 0pt;"><span style="font-family: Arial; font-size: 10pt;">Dr. Kishore is </span><span style="font-family: Arial; font-size: 13.3333px;">a member of the Leo M Davidoff Society and a</span><span style="font-family: Arial; font-size: 10pt;"> recipient of the prestigious Henry Christian Award of the American Federation of Medical Research. She is also the recipient of several teaching/advising awards.&nbsp;</span></p>

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<p>Esterson YB, Carey M, Boucai L, Goyal A, Raghavan P, Zhang K, Mehta D, Feng D, Wu L, Kehlenbrink S, Koppaka S, Kishore P, Hawkins M.Central Regulation of Glucose Production May Be Impaired in Type 2 Diabetes. Diabetes. 2016 Sep;65(9):2569-79</p>
<p>Kishore P, Boucai L, Zhang K, Li W, Koppaka S, Kehlenbrink S, Schiwek A, Esterson YB, Mehta D, Bursheh S, Su Y, Gutierrez-Juarez R, Muzumdar R, Schwartz GJ, Hawkins M. Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest. 2011 Dec;121(12):4916-20</p>
<p>Kishore P, Li W, Tonelli J, Lee DE, Koppaka S, Zhang K, Lin Y, Kehlenbrink S, Scherer PE, Hawkins M. Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci Transl Med. 2010 Feb 24;2(20):20ra15.</p>

EMR ID

4182

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Meredith A. Hawkins

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First Name

Meredith

Last Name

Hawkins

NPI

1922189356

Faculty ID

1982

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Full Time

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Adult

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Female

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<p>Dr. Meredith Hawkins is Professor of Medicine and Associate Director of the Einstein-Mt. Sinai Regional Diabetes Research Center. She holds the Harold and Muriel Block Chair in Medicine. Dr. Hawkins earned her M.D. degree <em>cum laude</em> from the University of Toronto and a Master of Science in Clinical Research Methods <em>cum laude</em> from the Albert Einstein College of Medicine. She has served as Associate Editor of the <em>American Journal of Physiology</em>, and as Secretary Treasurer of the American Federation of Medical Research. Dr. Hawkins' current research interests include the effects of nutrient deficiency and excess on the pathogenesis of diabetes mellitus, central regulation of glucose metabolism, nutritional regulation of adipose tissue inflammation, and hypoglycemia-associated autonomic failure.</p>
<p>Dr. Hawkins is a Beeson Scholar of the American Federation of Aging Research, and has received research grants from the National Institutes of Health (continually since 1999), the American Diabetes Association, the Juvenile Diabetes Foundation International and the Diabetes Action Foundation International. She is the recipient of numerous honors and awards, including the Junior Physician Scientist Award (2001) and the Outstanding Investigator Award (2012) from the American Federation of Medical Research, the Novartis Young Investigator award in Diabetes Research (2007), and election to the American Society for Clinical Investigation (2012). She recently served on the Congressionally-appointed National Clinical Care Commission.&nbsp;</p>
<p>Dr. Hawkins founded and directs Einstein's Global Diabetes Institute (<a href="/centers/global-health/global-diabetes-institute/">http://www.einstein.yu.edu/centers/global-health/global-diabetes-instit…;, with the goal of building strategic partnerships in medical research and education to combat the burgeoning global diabetes epidemic.</p>

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<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hawkins specializes in diabetes, with a particular emphasis on the dramatic rise of the disease worldwide. She has traveled the globe investigating diabetes since 1996 and is the founding director of the Global Diabetes Institute (GDI) at Einstein, which conducts diabetes education and training for healthcare workers in South and Central America, Eastern Europe, Africa and Asia.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hawkins also studies the role of nutrients and inflammation in the development of prediabetes and diabetes and is currently investigating the impact of vitamin D on the development and management of the disease.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In collaboration with researchers in India, Dr. Hawkins is investigating malnutrition diabetes, a little understood form of the disease that particularly affects the developing world.&nbsp;Dr. Hawkins is one of the organizers of an annual international conference for continuing medical education that alternates between Asia and Africa.&nbsp;Under Dr. Hawkins&rsquo; leadership, the GDI has partnered with faculty at Uganda&rsquo;s leading medical school to improve diabetes care in hospitals and clinics throughout the country. An NIH-funded researcher, Dr. Hawkins has received the Novartis Young Investigator in Diabetes and the Junior Physician Scientist Award of the American Federation of Medical Research.</span></p>

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Selected Publications

<p>Past 3 years:</p>
<ol>
<li>
<p>Carey M, Lontchi-Yimagou E, Mitchell W, Reda S, Zhang K, Kehlenbrink S, Koppaka S, Maginley SR, Aleksic S, Bhansali S, Huffman DM, Hawkins M. Central KATP channels modulate glucose effectiveness in humans and rodents. Diabetes. 2020 Jun;69(6):1140-1148. doi: 10.2337/db19-1256. PMID: 32217610 (Selected as Editor&rsquo;s Choice by Science Translational Medicine, 29 Apr 2020: Vol. 12, Issue 541, eabb5677).</p>
</li>
<li>
<p>Lontchi-Yimagou E, Aleksic S, Hulkower R, Gospin R, Goyal A, Kuo B, Mitchell WG, You JY, Upadhyay L, Carey M, Sandu OA, Gabriely I, Shamoon H, Hawkins M. Plasma epinephrine contributes to the development of experimental hypoglycemic-associated autonomic failure. Journal of Clinical Endocrinology and Metabolism 2020 Nov 1;105(11):dgaa539. doi: 10.1210/clinem/dgaa539.PMID: 32915987</p>
</li>
<li>
<p>Lontchi-Yimagou E, Kang S, Goyal A, You J-Y, Carey M, Rosen E, Kishore P, Hawkins M. Insulin Sensitizing Effects of Vitamin D Mediated through Reduced Adipose Tissue Inflammation and Fibrosis in Humans and Mice. Molecular Metabolism 2020 Dec;42:101095. doi: 10.1016/j.molmet.2020.101095. Epub 2020 Oct 10. PMID: 33045433&nbsp;</p>
</li>
<li>
<p>Brightwell CR, Kulkarni AS, Paredes W, Zhang K, Perkins JB, Gatlin KJ, Custodio M, Farooq H, Zaidi B, Pai R, Buttar RS, Tang Y, Melamed ML, Hostetter TH, Pessin JE, Hawkins M, Fry CS, Abramowitz MK. Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis. JCI Insight. 2021 Dec 22;6(24):e150112. doi: 10.1172/jci.insight.150112. PMID: 34784301</p>
</li>
<li>
<p>Cefalu WT, Andersen DK, Arreaza-Rub&iacute;n G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND; Symposium planning committee, moderators, and speakers. Heterogeneity of Diabetes: &beta;-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 Jan 1;45(1):3-22. doi: 10.2337/dci21-0051. PMID: 34782355</p>
</li>
<li>
<p>Lontchi-Yimagou E, DasGupta R, Kehlenbrink S, Koppaka S, Carey M, Stein DT, Thomas N, Hawkins M. An Atypical form of diabetes in low BMI individuals. Diabetes Care 2022 45(6):1428-1437. doi: 10.2337/dc21-1957. PMID: 35522035 (In the top 5% of all research outputs scored by Altmetric: as of July 13, 2023, the paper has received 8,874 reads and has been picked up by 94 news outlets.)</p>
</li>
<li>
<p>Lontchi-Yimagou E, Anoop S, Kurian ME, Ye K, Kehlenbrink S, Thomas N, Hawkins M. Response to Comment on Lontchi-Yimagou et al. An Atypical Form of Diabetes Among Individuals With Low BMI. Diabetes Care 2022;45:1428-1437. Diabetes Care. 2022 Nov 1;45(11):e159-e160. doi: 10.2337/dci22-0031.PMID: 36318676</p>
</li>
<li>
<p>Herman WH, Schillinger D, Bolen S, Boltri JM, Bullock A, Chong W, Conlin PR, Cook JW, Dokun A, Fukagawa N, Gonzalvo J, Greenlee MC, Hawkins M, Idzik S, Leake E, Linder B, Lopata AM, Schumacher P, Shell D, Strogatz D, Towne J, Tracer H, Wu S. The National Clinical Care Commission Report to Congress: Recommendations to Better Leverage Federal Policies and Programs to Prevent and Control Diabetes. Diabetes Care. 2023 Feb 1;46(2):255-261. doi: 10.2337/dc22-1587. PMID: 36701592</p>
</li>
<li>
<p>Greenlee MC, Bolen S, Chong W, Dokun A, Gonzalvo J, Hawkins M, Herman WH, Leake E, Linder B, Conlin PR. The National Clinical Care Commission Report to Congress: Leveraging Federal Policies and Programs to Improve Diabetes Treatment and Reduce Complications. Diabetes Care. 2023 Feb 1;46(2):e51-e59. doi: 10.2337/dc22-0621. PMID: 36701593</p>
</li>
<li>
<p>Cook J, Hawkins M, Pajvani UB. Liver insulinization as a driver of triglyceride dysmetabolism. Nature Medicine. 2023 (e-publication 17 July 2023)</p>
<p>&nbsp;</p>
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</li>
</ol>

EMR ID

4098

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Eric J. Epstein

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First Name

Eric

Last Name

Epstein

NPI

1558427930

Faculty ID

10762

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Full Time

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Adult

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Male

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<p>Dr. Epstein is an endocrinologist and professor of medicine in the division of endocrinology, who also currently serves as the vice chair of clinical affairs for the department of medicine (DOM).</p>
<p>Since joining the Montefiore Einstein faculty in 2007, Dr. Epstein has proven himself as an innovative, effective, and exceptional department leader. During his tenure as the medical director for the department of medicine faculty practice, from 2011- 2020, and then as vice chair for clinical affairs, he oversaw a year-over-year increase in wRVUs, improvement in the positive contribution margin, and continued growth in the department. Since his promotion to vice chair in 2020, Dr. Epstein has led all aspects of the department&rsquo;s clinical operations.</p>
<p>Dr. Epstein oversees the development of high-quality and cost-effective care while integrating new systems, processes, workflows, and procedures within the DOM faculty practice. While serving as the leader for the DOM clinical advisory council, he also acts as a liaison for DOM leadership and system partners, working with the faculty practice group, care management organization, and digital transformation office to foster program development and improve patient care and access to specialty medicine. Additionally, he has helped forge new programs within the DOM faculty practice, including the comprehensive weight management center and the new Einstein student health practice.</p>
<p>Dr. Epstein is also the course director for the endocrine systems course for Einstein medical students, for which he was inducted into the Leo M. Davidoff society and has garnered two teaching awards: the 2020 Harry Eagle Award and the Samuel M. Rosen outstanding Teacher Award in 2013. Dr. Epstein received his B.S degree from Cornell University and M.D. degree from the University of Chicago Pritzker School of Medicine. Following an internal medicine residency at New York Hospital/Cornell and Memorial Sloan Kettering, he completed fellowship training at the Montefiore Einstein endocrinology, diabetes, and metabolism fellowship training program.</p>

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EMR ID

4699

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Jill P. Crandall

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First Name

Jill

Last Name

Crandall

NPI

1548359896

Faculty ID

4535

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Employment Status

Full Time

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Adult

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Female

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<p>Jill P. Crandall, MD completed her medical training at SUNY Downstate Medical Center and both internal medicine residency and endocrinology fellowship at Columbia Presbyterian Medical Center. Following fellowship, she worked at St. Luke&rsquo;s-Roosevelt Hospital (with Dr. Xavier Pi-Sunyer) and then Mt. Sinai School of Medicine before being recruited to Einstein in 2001.&nbsp;</p>
<p>Dr. Crandall is Professor of Medicine at Albert Einstein College of Medicine, where she is director of the Diabetes Clinical Trials Unit and a principal investigator for several NIH sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership) and the Glycemia Reduction Approaches in Diabetes (GRADE) study.&nbsp; She is Director of the Einstein-Sinai Diabetes Center&rsquo;s Translational Research Core. Her research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk. &nbsp;Dr. Crandall has served on several grant review panels (NIH and ADA) and is active as a journal reviewer, including as Associate Editor of the Journal of Gerontology (2005-2012) and member of the editorial board for the Journal of Diabetes and its Complications.&nbsp;</p>

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Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">An expert in diabetes prevention, Dr. Crandall is director of the Diabetes Clinical Trials Unit at Einstein and Montefiore and a principal investigator for several NIH-sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership), Glycemia Reduction Approaches in Diabetes (GRADE) and the PERL (Preventing Early Renal Loss) study.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Crandall&rsquo;s research focuses on age-related changes in glucose metabolism and the relationship between high blood-sugar levels (hyperglycemia) and cardiovascular risk. She currently serves on the American Diabetes Association&rsquo;s Professional Practice Committee. Dr. Crandall is an attending physician at the Montefiore Medical Center Diabetes Clinic and maintains an active consultative practice in endocrinology.</p>

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Dr. Crandall's clinical focus is on the treatment of type 1 and type 2 diabetes as well as related metabolic disorders.

Research Focus

Dr. Crandall&rsquo;s research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk.

Elsevier Profile

Lab Website Link

Selected Publications

<ol>
<li>Schmidt AM, Hori O, Chen JX, Li JF, <strong>Crandall</strong>, J, Zhang J, Cao R, Yan SD, Brett J, Stern D. Advanced glycation end-products interacting with their endothelial receptor induces expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice.&nbsp; A potential mechanism for the accelerated vasculopathy of diabetes.&nbsp; <em>J Clin Invest</em> 1995;96:1395-403.</li>
<li> Schmidt AM, <strong>Crandall J</strong>, Hori O, Cao R and Lakatta E.&nbsp; Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease.&nbsp; <em>British J Haematology</em> 1996;92:747-50.</li>
<li> Engel S, <strong>Crandall J</strong>, Basch C, Zybert P and Wylie-Rosett J. Computer-assisted nutrition education increases knowledge and self-efficacy of medical students.&nbsp; <em>The Diabetes Educator</em> 1997;23:545-49.</li>
<li> Rauch U, <strong>Crandall J,</strong> Osende J, Fallon J, Cheseboro J, Fuster V, Badimon J.&nbsp; Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus Type 2. <em>Amer J Cardiol</em> 2000;86:246-249.</li>
<li> Osende J, Badimon J, Fuster V, Herson P, Rabito P, Vidhun R, Zaman A, Rodriguez O, Lev E, Rauch U, Helft G, Fallon J, <strong>Crandall J.</strong>&nbsp; Blood thrombogenicity in type 2 diabetes mellitus is associated with glycemic control.&nbsp;&nbsp; <em>J Am Coll Cardiol</em> 38:1307-12, 2001.</li>
<li> Vlassara H, Cai W, <strong>Crandall J</strong>, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield E.&nbsp; Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.&nbsp; <em>PNAS</em> 99:15596-15601, 2002.</li>
<li> Sambola A,Osende J, Hathcock J, Degen M, Nemerson Y, Fuster V, <strong>Crandall J</strong>, Badimon J.&nbsp; Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity.&nbsp; <em>Circulation </em>107:973-77, 2003.</li>
<li> Haffner S, <strong>Crandall J,</strong> Horton E, Barrett-Connor E, Temprosa E, Mather K, Goldberg R, Krakoff J, Ratner R, Orchard T, Fowler S, Marcovina S, for the DPP Research Group. The effect of intensive lifestyle and metformin on inflammation and coagulation in participants with impaired glucose tolerance. <em>Diabetes </em>2005 May; 54(5):1566-1572.</li>
<li><strong> Crandall J</strong>, Schade D, Ma Y,&nbsp; Fujimoto W, Barrett-Connor E, Fowler S, Dagogo-Jack S, Andres R&nbsp; for the DPP Research Group.&nbsp; The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.&nbsp; <em>J Gerontology</em> 2006;61:1075-81.</li>
<li> Walker E, Molitch M, Kramer K, Kahn S, Ma Y, Edelstein S, Smith K, Johnson M, Kitabchi A, <strong>Crandall J</strong>, for the DPP Research Group.&nbsp; Adherence to preventive medication: predictors and outcomes in the Diabetes Prevention Program.&nbsp; <em>Diabetes Care</em> 2006;29:1997-2002.</li>
<li> Cohen HW, <strong>Crandall JP</strong>, Halipern SM, Billett HH. Aspirin resistance associated with HbA1c and obesity in diabetic patients<em>. Journal of Diabetes and its Complications</em> 2008;22:224-228.</li>
<li> Mather K, Goldberg R, Crandall J, Goldstein B, Marcovina S, Edelstein S, Kahn S, Bray G, Funahashi T. for the DPP Research Group. Adiponectin and change in adiponectin predict diabetes outcomes in the DPP.&nbsp; <em>Diabetes</em> 2008;57:980-986.</li>
<li>&nbsp; Perreault L, Barrett-Connor E, <strong>Crandall J</strong>, Carnethon M, Horton E, Marrero D, Dagogo-Jack S, Ma Y, for the DPP Research Group.&nbsp; Sex differences in diabetes risk and the effect of intensive lifestyle modification the DPP.&nbsp; <em>Diabetes Care</em>, 2008;31:1416-21.</li>
<li> Atzmon, G., Pollin, T.I., <strong>Crandall, J</strong>., Tanner, K., Schechter, C.B., Scherer, P.E., Rincon, M., Siegel, G., Katz, M., Lipton, R.B., Shuldiner, A.R., Barzilai, N.&nbsp; Adiponectin levels and genotype: a potential regulator of life-span in humans.&nbsp; <em>J Geron A Biol Sci</em>, 2008; 63:447-53.</li>
<li> Rajpathak SN, Wylie-Rosett J, Kabat G, Gunter M, Rohan TE and <strong>Crandall J</strong>. Biomarkers of body iron stores and risk of developing diabetes. <em>Diabetes Obes Metab</em> 2009; 11(5):472-9.&nbsp; PMID: 19207293</li>
<li> Molitch M, Barrett-Connor E, <strong>Crandall J</strong>, Das S, Goldberg R, Haffner S, Florez H, Knowler W, Orchard T, Ratner R, Temprosa E. Changes in Albumin Excretion in the Diabetes Prevention Program. <em>Diabetes Care</em> &nbsp;32:720-5, 2009.</li>
<li> <strong> Crandall J</strong> , Shamoon H, Cohen HW,&nbsp; Reid&nbsp; M, Gajavelli&nbsp; S, Trandafirescu G, Tabatabaie V and Barzilai N. Post-challenge Hyperglycemia in Older Adults is Associated with Increased Cardiovascular Risk Profile.&nbsp; <em>J Clin Endocrinol Metab</em> 2009; 94(5):1595-601.&nbsp; PMCID: PMC2684470</li>
<li> <strong>Crandall J</strong>, Polsky S, Howard A, Perreault L, Bray G, Barrett-Connor E, Brown J, Whittington T, Foo S, Ma Y, Edelstein S.&nbsp; Alcohol consumption and diabetes risk in the Diabetes Prevention Program.&nbsp; <em>Am J Clin Nutri, </em>2009; 90:595-601.&nbsp; PMCID: PMC2728644</li>
<li> Rajpathak S, <strong>Crandall JP</strong>, Wylie-Rosett J, Kabat TE, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. <em>Biochim Biophys Acta</em>&nbsp; 2009 1790:671-81.</li>
<li> Rajpathak S, Kumbhani D, Alderman M, <strong>Crandall J</strong>, Barzilai N, Ridker P. Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-analysis.&nbsp; <em>Diabetes Care</em> 2009; 32:1924-9.&nbsp; PMCID: PMC2752935</li>
<li> Schechter CB, Barzilai N, <strong>Crandall JP</strong>, AtzmonG. &nbsp;Reduced Cholesteryl Ester Transfer Protein Levels Is Associated with Decreased Blood Pressure. &nbsp;<em>Mayo Clinic Proceedings</em>, 85:522-6, 2010.</li>
<li> Krakoff J, Clark J, <strong>Crandall JP</strong>, Wilson C, Molitch M, Brancati F, Edelstein S, Knowler WC.&nbsp; Effects of metformin and weight loss on serum alanine aminotransferase activity in the Diabetes Prevention Program.&nbsp; <em>Obesity </em>&nbsp;18:1762-7, 2010.</li>
<li> Rajpathak S, Wassertheil-Smoller S, <strong>Crandall J</strong>, Liu S, Ho G.&nbsp; Hepatocyte growth factor and clinical diabetes in postmenopausal women.&nbsp; <em>Diabetes Care</em> 2010;33:2013-15.</li>
<li> Rajpathak S, Liu Y, Ben-David O, Reddy S, Atzmon G, <strong>Crandall J</strong>, Barzilai N.&nbsp; Lifestyle factors among people with exceptional longevity.&nbsp; <em>J Am Geriatr Society</em>, 2011 59(8):1509-12.</li>
<li> Florez H, Ma Y, <strong>Crandall JP</strong>, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC; for the Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21852284">Parental Longevity and Diabetes Risk in the Diabetes Prevention Program.</a>&nbsp; <em>J Gerontol A Biol Sci Med Sci</em>. 2011 Aug 17. &nbsp;PMID:21852284</li>
<li> Kim C, Edelstein SL, <strong>Crandall JP</strong>, Dabelea D, Kitabchi AE, Hamman RF, Montez MG, Perreault L, Foulkes MA, Barrett-Connor E; Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21709591">Menopause and risk of diabetes in the Diabetes Prevention Program.</a>&nbsp; <em>Menopause</em>. 2011 Aug;18(8):857-68. PMID:21709591</li>
<li> Sokol SI, Grushko M, Srinivas VS, <strong>Crandall JP</strong>. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21936883">The relationship between vitamin D deficiency, post challenge hyperglycemia, and endothelial function in healthy older adults.</a> <em>J Diabetes</em>. 2012 Mar;4(1):102-3. PMID:21936883</li>
<li> <strong>Crandall JP</strong>, Trandafirescu G, Oram V, Kishore P, Hawkins M, Reid M, Cohen H, Barzilai N.&nbsp; Pilot study of resveratrol in older adults with impaired glucose tolerance.&nbsp; <em>J Gerontol A Biol Sci Med Sci </em>2012 Dec;67(12):1307-12. &nbsp;PMID:22219517</li>
<li> <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Davis%20NJ%22%5BAuthor%5D">D… NJ</a>, <strong><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Crandall%20JP%22%5BAuthor%5D… JP</a></strong>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gajavelli%20S%22%5BAuthor%5D… S</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Berman%20JW%22%5BAuthor%5D">… JW</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tomuta%20N%22%5BAuthor%5D">T… N</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wylie-Rosett%20J%22%5BAuthor… J</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Katz%20SD%22%5BAuthor%5D">Ka… SD</a>. Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes. <em><a title="Journal of diabetes and its complications." href="http://www.ncbi.nlm.nih.gov/pubmed/22036100">J Diabetes Complications.</a></em> 2011 Nov;25(6):371-6. PMID:22036100.</li>
<li> Tabatabaie V, Atzmon G, Rajpathak SN, Freeman R, Barzilai N, <strong>Crandall J</strong>.&nbsp; Exceptional longevity is associated with decreased reproduction. <em>Aging</em> 2011 Dec; 3(12):1202-5. PMID:22199025</li>
<li> Bray G, Edelstein S, <strong>Crandall JP, </strong>et al. and DPP Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22442396">Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.</a> <em>Diabetes Care</em><em>.</em> 2012 Apr;35(4):731-7 PMID:22442396</li>
<li> Lai JY, Atzmon G, Melamed ML, Hostetter TH, <strong>Crandall JP</strong>, Barzilai N, Bitzer M. Family history of exceptional longevity is associated with lower serum uric acid levels in Ashkenazi Jews.&nbsp; <em><a title="Journal of the American Geriatrics Society." href="http://www.ncbi.nlm.nih.gov/pubmed/22429185">J Am Geriatr Soc.</a></em> 2012 Apr;60(4):745-50. PMID:22429185</li>
<li> Sokol SI, Srinivas V, <strong>Crandall JP</strong>, Kim M, Tellides G, Lebastchi A, Yu Y, Gupta AK, Alderman MH. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23184900">The effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease.</a> <em>Vasc Med</em>. 2012 Dec;17(6):394-404. PMID:23184900.</li>
<li> Esterson YB, Kishore P, Koppaka S, Li W, Zhang K, Tonelli J, Lee DE, Kehlenbrink S, Lawrence S, <strong>Crandall J</strong>, Barzilai N, Hawkins M. &nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/23089338">Fatty Acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.</a>&nbsp; <em>J Gerontol A Biol Sci Med Sci.</em> 2012 Dec;67(12):1321-8. PMID:23089338</li>
<li> <strong>Crandall JP</strong>, Barzilai N.&nbsp; <a href="http://www.ncbi.nlm.nih.gov/pubmed/23520278">Exploring the promise of resveratrol: where do we go from here?</a> <em>Diabetes</em>. 2013 Apr;62(4):1022-3.PMID:23520278.</li>
<li> Genuth S, Backlund JY, Bayless M, Bluemke DA, Cleary PA, <strong>Crandall J</strong>, Lachin JM, Lima JA, Miao C, Turkbey EB. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23520132">Effects of Prior Intensive versus Conventional Therapy and History of Glycemia on Cardiac Function in Type 1 Diabetes in the DCCT/EDIC.</a> <em>Diabetes</em>. 2013 Mar 21. PMID: 23520132</li>
<li> <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Agarwal%20C%5BAuthor%5D&amp;cau… C</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Cohen%20HW%5BAuthor%5D&amp;caut… HW</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Muzumdar%20RH%5BAuthor%5D&amp;c… RH</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Heptulla%20RA%5BAuthor%5D&amp;c… RA</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Renukuntla%20VS%5BAuthor%5D&amp… VS</a>, <strong><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Crandall%20J%5BAuthor%5D&amp;ca… J</a></strong>. Obesity, hyperglycemia and endothelial function in inner city Bronx adolescents: a cross-sectional study<em>.</em><em> <a title="International journal of pediatric endocrinology." href="http://www.ncbi.nlm.nih.gov/pubmed/24164965">Int J Pediatr Endocrinol.</a></em> 2013 Oct 29;2013(1):18. &nbsp;PMID:24164965</li>
<li> Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, <strong>Crandall JP</strong>, Barzilai N, Melamed ML, Atzmon G <a href="http://www.ncbi.nlm.nih.gov/pubmed/24383816">Individuals with Exceptional Longevity Manifest a Delayed Association Between Vitamin D Insufficiency and Cognitive Impairment.</a>&nbsp; <em>J Am Geriatr Soc</em>. 2014 Jan 2. doi: 10.1111/jgs.12601. PMID:24383816</li>
<li> Milman S, Atzmon G, <strong>Crandall J</strong>, Barzilai N. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24350928">Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity.</a> <em>Curr Vasc Pharmacol</em>. 2013 Dec 18. PMID:24350928</li>
<li> Halter JB, Musi N, McFarland Horne F, <strong>Crandall JP</strong>, Goldberg A, Harkless L, Hazzard WR, Huang ES, Kirkman MS, Plutzky J, Schmader KE, Zieman S, High KP. Diabetes and cardiovascular disease in older adults: current status and future directions " <em>Diabetes&nbsp;</em> 2014 63:2578-2589. DOI: 10.2337/db14-0020 PMID: 25060886</li>
<li> Milman S, Atzmon G, Huffman DM, Wan J, <strong>Crandall JP</strong>, Cohen P, Barzilai N. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24618355">Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.</a> <em>Aging Cell</em>. 2014 Aug;13(4):769-71. doi: 10.1111/acel.12213. PMID: 24618355</li>
<li> Knowler WC, Edelstein SL Goldberg RB, Ackermann RT, <strong>Crandall JP</strong>, Florez JC, Fowler SE, Herman WH, Horton ES, Kahn SE, Mather KJ, Nathan DM.&nbsp; <a href="http://www.ncbi.nlm.nih.gov/pubmed/25336746">HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial.</a>&nbsp; <em>Diabetes Care</em>. 2014 Oct 21. pii: DC_140886.PMID: 25336746</li>
<li> Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, <strong>Crandall JP</strong>, Montez MG, Brown JS; Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/25352018">Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study.</a> <em>Int J Urol</em>. 2015Feb;22(2):206-12. doi: 10.1111/iju.12654. PubMed PMID:25352018; PubMed Central PMCID: PMC4387889.</li>
<li> Ayers E, Barzilai N, <strong>Crandall JP</strong>, Milman S, Verghese J. Association of exceptional parental longevity and physical function in aging. <em>Age</em> (Dordr). 2014;36(4):9677. doi: 10.1007/s11357-014-9677-5.PMID: 24997018 [PubMed - in process]</li>
<li> Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van Vliet-Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini SM, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, <strong>Crandall JP</strong>, Barzilai N, Milman S, Ben-Avraham D; LifeLines Cohort Study Group; DCCT/EDIC Research Group, Wolffenbuttel BH, Paterson AD. GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. <em>Diabetologia</em>. 2014 Aug;57(8):1623-34. PMID: 24934506 [PubMed - in process]</li>
<li> Snyder PJ, Ellenberg SS, Cunningham GR, Matsumoto AM, Bhasin S, Barrett-Connor E, Gill TM, Farrar JT, Cella D, Rosen RC, Resnick SM, Swerdloff RS, Cauley JA, Cifelli D, Fluharty L, Pahor M, Ensrud KE, Lewis CE, Molitch ME, <strong>Crandall JP</strong>, Wang C, Budoff MJ, Wenger NK, Mohler ER 3rd, Bild DE, Cook NL, Keaveny TM, Kopperdahl DL, Lee D, Schwartz AV, Storer TW, Ershler WB, Roy CN, Raffel LJ, Romashkan S, Hadley E.The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men. <em>Clin Trials</em>. 2014 Mar 31;11(3):362-375.PMID: 24686158</li>
<li> Hamman R, Horton E, Barrett-Connor E, Bray G, Christohpi C, <strong>Crandall J</strong>, Florez J, Fowler S, Goldberg R, Kahn S, Knowler W, Lachin J, Murphy M, Venditti E.&nbsp; Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcome Study (DPPOS).&nbsp; <em>Diabetes</em> 2015;64:989-98.</li>
<li> Nathan D, Barrett-Connor E, <strong>Crandall JP</strong>, Edelstein S, Goldberg R, Horton ES, Knowler WC, Mather KJ, Orchard TJ, Pi-Sunyer X, Schade D, Temprosa, M for the Diabetes Prevention Program Research Group.&nbsp;Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study.&nbsp;<em>Lancet Diabetes Endocrinol.&nbsp;</em>2015;3(11):866-75.&nbsp; PMCID:PMC4623946</li>
<li> Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Ellenberg SS, Matsumoto AM, Bhasin S, Molitch ME, Farrar JT, Cella D, Barrett-Connor E, Cauley JA, Cifelli D, <strong>Crandall JP</strong>, Ensrud KE, Fluharty L, Gill TM, Lewis CE, Pahor M, Resnick SM, Storer TW, Swerdloff RS, Anton S, Basaria S, Diem S, Tabatabaie V, Hou X, Snyder PJ. Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. <em>J Clin Endocrinol Metab</em>. 2015Mar;100(3):1146-55. doi: 10.1210/jc.2014-3818. PubMed PMID:25548978; PubMed Central PMCID: PMC4333035.</li>
<li> Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, <strong>Crandall JP</strong>, Montez MG, Brown JS; Diabetes Prevention Program Research Group. Long-term prevalence and predictors of urinary incontinence among women in the diabetes Prevention Program Outcome Study. Int J Urol. 2015 Feb;22(2):206-12. doi: 10.1111/iju.12654. PMID: 2535201853.</li>
<li> Cauley JA, Fluharty L, Ellenberg SS, Gill TM, Ensrud KE, Barrett-Connor E,Cifelli D, Cunningham GR, Matsumoto AM, Bhasin S, Pahor M, Farrar JT, Cella D, Rosen RC, Resnick SM, Swerdloff RS, Lewis CE, Molitch ME, <strong>Crandall JP, </strong>Stephens-Shields AJ, Strorer TW, Wang C, Anton S, Basaria S, Diem S, TabatabaieV, Dougar D, Hou X, Snyder PJ. Recruitment and Screening for the Testosterone Trials. <em>J Gerontol A Biol Sci Med Sci</em>. 2015 Sep;70(9):1105-11. PubMed PMID: 25878029.</li>
<li> Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley &nbsp;JA, Gill TM, Barrett-Connor E, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Farrar JT, Cella D, Rosen RC, Pahor M, <strong>Crandall JP</strong>, Molitch ME, Cifelli D, Dougar D, Fluharty L, Resnick SM, Storer TW, Anton S, Basaria S, Diem SJ, Hou X, Mohler ER 3rd, Parsons JK, Wenger NK, Zeldow B, Landis JR, Ellenberg SS; Testosterone Trials Investigators. Effects of Testosterone Treatment in Older Men. <em>N Engl J Med</em>. 2016 Feb 18;374(7):611-24. PubMed PMID:26886521.</li>
<li> Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ,Bray GA, Schade DS, Temprosa MG, White NH, <strong>Crandall JP</strong>; Diabetes Prevention Program Research Group. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. <em>J Clin Endocrinol Metab.</em> 2016 Feb 22:jc20153754. [Epub ahead of print] PubMed PMID: 26900641.</li>
<li> Roshandel D, Klein R, Klein BE, Wolffenbuttel BH, van der Klauw MM, van Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, <strong>Crandall JP,</strong> Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA,Braffett BH; DCCT/EDIC Research Group, Paterson AD. A New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes also Associated with Blood and Skin Glycated Proteins. <em>Diabetes</em>. 2016 Apr 12. pii: db151484. PubMed PMID: 27207532.&nbsp;</li>
<li> Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM, Parsons JK, Gill TM, Molitch ME, Farrar JT, Cella D, Barrett-Connor E, Cauley JA, Cifelli D, <strong>Crandall JP</strong>, Ensrud KE, Gallagher L, Zeldow B, Lewis CE, Pahor M, Swerdloff RS, Hou X, Anton S, Basaria S, Diem SJ, Tabatabaie V, Ellenberg SS, Snyder PJ. Testosterone treatment and sexual function in older men with low testosterone levels. J Clin Endocrinol Metab. 2016 Aug;101(8):3096-104. doi: 10.1210/jc.2016-1645.PMID: 27355400</li>
<li> Barzilai N, <strong>Crandall JP</strong>, Kritchevsky SB, Espeland MA.&nbsp; Metformin as a tool to target aging.&nbsp; Cell Metabolism 2016; 23:1060-5.</li>
</ol>

<p>&nbsp;Books &amp; Chapters</p>
<ol>
<li><strong>Crandall J </strong>and Tuck C.&nbsp; <span style="text-decoration: underline;">Rational In-patient Management of Diabetes </span>&nbsp;&nbsp;Division of Endocrinology, Columbia University College of Physicians and Surgeons. 1994 (1^st edition), 2001 (2^nd edition).</li>
<li><strong></strong> Smith D and <strong>Crandall J</strong>.&nbsp; Exercise training in special populations: Diabetes; in <span style="text-decoration: underline;">Cardiac Rehabilitation in the Twenty-First Century</span>. Wenger, Smith, Ed.&nbsp;&nbsp; Marcel Dekker, Inc. New York 1999.</li>
<li><strong>Crandall J</strong> and Shamoon H.&nbsp; Prevention of Type 2 Diabetes; in <span style="text-decoration: underline;">Therapy for Diabetes Mellitus and Related Disorders</span>, (4th Edition).&nbsp; American Diabetes Association, 2004.</li>
<li><strong>Crandall J</strong> and Barzilai N.&nbsp; Diabetes Mellitus; in <span style="text-decoration: underline;">The Merck Manual of Health and Aging</span>.&nbsp; Merck ResearchLaboratories, New Jersey, 2004.</li>
<li><strong>Crandall J</strong>.&nbsp; Diabetes Mellitus and other disorders of carbohydrate metabolism; in <span style="text-decoration: underline;">The Merck Manual</span> (18^th edition).&nbsp; Merck Research Laboratories, New Jersey, 2006.</li>
<li><strong>Crandall J.</strong> Type 2 Diabetes: Geriatric Considerations; in <span style="text-decoration: underline;">Type 2 Diabetes: Principles and Practice</span> (2^nd edition), Goldstein &amp; Muller-Wielnad, editors. 2007.</li>
<li><strong>Crandall J</strong> and Shamoon H.&nbsp; Diabetes Mellitus; in <span style="text-decoration: underline;">Cecil Textbook of Medicine</span>, Elsevier, (25^th edition) 2015.&nbsp;</li>
</ol>

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4364

Biography

<p>Jill P. Crandall, MD, is Professor and Jacob A. and Jeanne E. Barkey Chair in Medicine and Chief, Division of Endocrinology at Montefiore Einstein. Her clinical focus is on the treatment of types 1 and type 2 diabetes as well as related metabolic disorders.</p><p>In 1975, Dr. Crandall received her Bachelor of Arts in anthropology at State University of New York at Binghamton. She received her Bachelor of Science in health services (physician assistant program) in 1977 at State University of New York at Stony Brook, earning highest school honors. In 1988, she earned her Doctor of Medicine at State University of New York Health Sciences Center at Brooklyn, and began her postgraduate training the same year with an internship and residency at Presbyterian Hospital, completing it in 1991. She continued her post-graduate training at Columbia University College of Physicians and Surgeons, completing her fellowship in endocrinology in 1994.</p><p>Dr. Crandall&rsquo;s research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk. As the director of the Diabetes Clinical Trials Unit (DCTU), Dr. Crandall serves as the principal investigator for several NIH-sponsored clinical trials in the field of diabetes and metabolism. Most notable is her work with the Diabetes Prevention Program Outcome Study, for which she holds several national leadership positions, including Executive Committee membership and Co-Chair of a collaboration with the National Cancer Institute to study the effect of long-term metformin treatment or lifestyle modification on cancer incidence. Her specific interests include the prevention of type 2 diabetes, the treatment of diabetes in older adults and the prevention of diabetes complications. Dr. Crandall is also director of the Translational Research Core of the <a href="https://einsteinmed.edu/centers/diabetes-research">Einstein-Mount Sinai Diabetes Research Center (ESDRC)</a>. She serves on the editorial board for the <em>Journal of Diabetes and Its Complications</em> and reviews submissions to several publications, including <em>Diabetes Care, the Journal of Clinical Endocrinology and Metabolism</em>, and the <em>Annals of Internal Medicine</em>. She is active in the American Diabetes Association and has served on the Professional Practice and Grant Review committees.</p><p>Dr. Crandall has received many recognitions throughout her career, including the Glenn Award for Research in Biological Mechanisms of Aging from the Glenn Foundation for Medical Research, and the William Dock, MD Master Teacher Award in Medicine from SUNY Downstate Medical Center.</p>

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David J. Carruthers

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David

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Carruthers

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1316333628

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16578

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Full Time

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Adult

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Male

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Primary Care

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<p>Dr. Carruthers graduated from New York University School of Medicine, completed internal medicine residency at the University of Texas Southwestern, and completed an endocrinology fellowship at New York University's endocrinology, diabetes, and metabolism program prior to joining faculty at Albert Eistein and Montefiore hospital. He practices general endocrinology, with clinical interests in thyroid and metabolic disorders, including type 2 diabetes mellitus, hyperlipidemia, and weight management.</p>

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124414

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2499

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Noah A. Bloomgarden

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Noah

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Bloomgarden

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1952680795

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14677

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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">Dr. Noah Bloomgarden received his medical degree from New York Medical College.&nbsp;&nbsp;&nbsp;Thereafter he completed his internal medicine residency at Montefiore Medical Center, followed by Endocrine fellowship at Montefiore/Albert Einstein College of Medicine.&nbsp;&nbsp;After fellowship, he was recruited to the neuroendocrine tumor program at the Montefiore Einstein Center for Cancer Care (MECCC) in 2015.&nbsp;&nbsp;&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">Dr. Bloomgarden is Director of the Endocrinology Fellowship Program. He enjoys teaching, both as a lecturer at the Albert Einstein Medical School and invited speaker nationally. &nbsp;He also serves as the endocrinology director of the Comprehensive Family Care Center (CFCC) and director of the endocrine tumor program at MECCC. He directs the multidisciplinary thyroid tumor board and co-leads the neuroendocrine tumor board. &nbsp; &nbsp; &nbsp;Dr. Bloomgarden enjoys managing and teaching all aspects of endocrine disease however his passion is in management of neuroendocrine and endocrine tumors. His research interests focus on endocrine tumors and he has contributed to the writing of many journal articles, abstracts and posters at national endocrine meetings. &nbsp;</p>

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Thyroid Cancer, Neuroendocrine Tumors, Endocrine Tumors, Parathyroid disease, Adrenal Hypertension (Primary Hyperaldosteronism)

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56806

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<p>Noah A. Bloomgarden, MD, is Associate Professor, Endocrinology and Director, Endocrinology Fellowship Program at Montefiore Einstein. He focuses on all aspects of endocrine disease with a special interest in the management of neuroendocrine and endocrine tumors.</p><p>After earning his Doctor of Medicine from New York Medical College, Dr. Bloomgarden completed his internal medicine residency at Montefiore Einstein, followed by an endocrinology fellowship. After completing his fellowship, he was recruited to the neuroendocrine tumor program at the Montefiore Einstein Center for Cancer Care (MECCC) in 2015.</p><p>Dr. Bloomgarden&rsquo;s research focuses on thyroid cancer, neuroendocrine tumors, endocrine tumors, parathyroid disease and adrenal hypertension (primary hyperaldosteronism). He serves as the Endocrinology Director of the Comprehensive Family Care Center (CFCC) and Director of the Endocrine Tumor Program at MECCC. Dr. Bloomgarden also directs the multidisciplinary thyroid tumor board and co-leads the neuroendocrine tumor board. He has been an invited speaker nationally and has contributed to many journal articles, abstracts and posters at national endocrine meetings.</p>

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