Shipra Gupta

Submitted by Anonymous (not verified) on
Full Name
Shipra Gupta
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Gupta_Shipra_MD_2x.jpg
Type
Provider
Faculty
First Name
Shipra
Last Name
Gupta
NPI
1073744421
Faculty ID
19561
Employment Status
Full Time
Patient Type
Pediatric
Gender
Female
Email
shipgupta@montefiore.org
Phone
718-741-2470
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845 40.85026)
Address Line 1
1825 Eastchester Road
City
Bronx
State
NY
Zip
10467-2404
Location Title
Montefiore Weiler Hospital
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Fellowship
Education Institution
Detroit Medical Center
Education Type Label
Residency
Education Institution
Detroit Medical Center
CHAM Provider
On
Professional Title
M.B.,B.S.
EMR ID
202428
Biography

<p>Shipra Gupta, MD, FAAP, is an attending physician at the Children&rsquo;s Hospital at Montefiore Einstein and Assistant Professor, Pediatrics at our Albert Einstein College of Medicine. Her clinical focus is in the diagnosis and treatment of infections in children as well as recurrent bacterial infections.</p><p>After completing her medical education at Ganesh Shankar Vidyarthi Memorial Medical College in Kanpur, India, Dr. Gupta came to the United States for postgraduate training at Children&rsquo;s Hospital of Michigan. She completed her pediatrics residency in 2012, was Chief Resident until 2013, then completed a three-year fellowship in pediatric infectious diseases in 2016.</p><p>Dr. Gupta&rsquo;s research focuses on the prevention of infections in both inpatient and outpatient settings. She has shared her work through peer-reviewed journals, book chapters, review articles, abstracts, and national and international presentations. She also has served as an ad hoc reviewer for <em>Global Pediatric Health Journal, West Virginia Medical Journal</em> and <em>Clinical Pediatrics</em>.</p><p>Dr. Gupta is board certified in Pediatrics and Pediatric Infectious Diseases by the American Board of Pediatrics. She is a member of the American Academy of Pediatrics, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society and the Society for Healthcare Epidemiology of America.</p>

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Julia A. Piwoz

Submitted by Anonymous (not verified) on
Full Name
Julia A. Piwoz
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/5488be90-d6d5-11ee-a78d-911a4304bee1.jpg
Type
Provider
Faculty
First Name
Julia
Last Name
Piwoz
NPI
1285601682
Faculty ID
18121
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Female
Email
jpiwoz@montefiore.org
Phone
718-741-2470
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Associate Professor
Division
Pediatric Infectious Disease
Type
Clinical
Title
Director, Antimicrobial Stewardship
Type
Clinical
Title
Associate Professor of Pediatrics, Albert Einstein College of Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87811 40.87956)
Address Line 1
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467-2509
Location Title
Montefiore At 3411 Wayne Avenue
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Hahnemann University School of Medicine
Education Type Label
Fellowship
Education Institution
Icahn School of Medicine at Mount Sinai
Education Type Label
Residency
Education Institution
Icahn School of Medicine at Mount Sinai
CHAM Provider
On
Professional Title
M.D.
EMR ID
192641
Biography

<p>Julia Piwoz, MD, is Director, Pediatric Antimicrobial Stewardship and Medical Director, Congenital Cytomegalovirus (CMV) Infectious Diseases Specialty Care Center at the Children&rsquo;s Hospital at Montefiore Einstein and Associate Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Piwoz&rsquo;s clinical focus includes congenital infections, including CMV, as well as both inpatient and outpatient antimicrobial stewardship.
</p><p>After earning her Doctor of Medicine from Hahnemann University School of Medicine in 1991, Dr. Piwoz completed her pediatric residency at the Mount Sinai School of Medicine in 1994. She remained at this institution to complete a pediatric infectious diseases fellowship in 1996, followed by a postdoctoral research associateship in HIV virology in 1997. </p><p>Dr. Piwoz&rsquo;s research is focused on the evaluation and long-term study of infants with congenitally acquired CMV infection. She serves on the New York State CMV Working Group and is the site principal investigator for the National Institute of Child Health and Human Development-funded PROACTIVE Study. Dr. Piwoz developed
and passed landmark legislation for perinatal HIV testing that served as the basis for a significant decline in transmission of HIV from mother to child. She also helped develop a World AIDS Day program for local teens that became a large annual event. Dr. Piwoz has been principal investigator on several research projects and her work has been published in numerous peer-reviewed journals, review articles and abstracts. She has also shared her work through national and international presentations. </p><p>Dr. Piwoz is board certified in General Pediatrics by the American Board of Pediatrics with a subspecialty certification in Pediatric Infectious Diseases. She is a Diplomate of the National Board of Medical Examiners and is a member of several professional organizations, including the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society and the American Academy of Pediatrics, among others. Dr. Piwoz has received many accolades for her work. For multiple years, she has been named in Castle Connolly&rsquo;s &ldquo;Top Doctors&rdquo; and &ldquo;New York Metro Area&rsquo;s Top Doctors&rdquo;. She has also been named in New York Magazine&rsquo;s &ldquo;Top Doctors&rdquo;, 201 Magazine&rsquo;s &ldquo;Top Doctor: Infectious Diseases&rdquo; and Inside Jersey Magazine&rsquo;s
&ldquo;Top Doctors for Children&rdquo;, among others.
</p>

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Marguerite M. Mayers

Submitted by Anonymous (not verified) on
Full Name
Marguerite M. Mayers
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Mayers_Marguerite_MD_420x504.jpg
Type
Provider
Faculty
First Name
Marguerite
Last Name
Mayers
NPI
1003972944
Faculty ID
5279
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Female
Provider Type
Primary Care
Email
mmayers@montefiore.org
Phone
718-920-2273
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Academic General Pediatrics
Type
Clinical
Title
Director, Pediatric Infectious Disease Ambulatory Clinic, Children's Hospital at Montefiore
Type
Clinical
Title
Professor, Pediatrics, Albert Einstein College of Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88133 40.88109)
Address Line 1
3444 Kossuth Avenue
City
Bronx
State
NY
Zip
10467-2241
Location Title
Montefiore Medical Group-Family Care Center (FCC)
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8811763 40.8814305)
Building
Brown Zone
Address Line 1
Montefiore Medical Center
Address Line 3
3444 Kossuth Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Pediatric Medicine<quillbot-extension-portal></quillbot-extension-portal>

EMR ID
3396
Biography

<p>Dr. Mayers has been a Bronx pediatrician for many years. In 2011 she was recognized as one of New York City&rsquo;s best primary care doctors by <em>New York Magazine</em> and one of the premier infectious diseases specialist by <em>New York Times Magazine</em>. She counts as her greatest achievement the relationships that she has developed with the children of the Bronx and their families, in some instances over two generations.</p>

Visit Type ID
2558
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Nathan Litman

Submitted by Anonymous (not verified) on
Full Name
Nathan Litman
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Litman_Nathan_MD_420x504.jpg
Type
Provider
Faculty
First Name
Nathan
Last Name
Litman
NPI
1225114168
Faculty ID
4593
Employment Status
part-time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Male
Provider Type
Primary Care
Email
nlitman@montefiore.org
Phone
718-741-2470
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Infectious Disease
Type
Clinical
Title
Vice Chair Department of Pediatrics Children’s Hospital at Montefiore
Type
Clinical
Title
Professor Pediatrics
Type
Administrative
Title
Vice Chair for Clinical Affairs, Department of Pediatrics
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
CHAM Provider
Off
Professional Title
M.D.
EMR ID
19563
Biography

<p>Nathan Litman, MD, FAAP, FIDSA, FPIDS, is Vice Chair, Pediatrics at the Children&rsquo;s Hospital at Montefiore and Professor, Pediatrics at Montefiore Einstein. His clinical focus centers on general pediatric infectious diseases.</p><p>After earning his Bachelor of Science in chemistry from Brooklyn College in 1967, Dr. Litman obtained his Doctor of Medicine from Einstein in 1971. He completed his straight pediatric internship, pediatric residency, and Chief Pediatric Residency at Montefiore Medical Center. He served for 2 years as Lieutenant Commander in the US Public Health Service. He returned to Montefiore to complete a two-year Infectious Disease Fellowship in 1978.</p><p>Dr. Litman&rsquo;s research has been published in multiple peer-reviewed journals, books, chapters, review articles and abstracts, including the <em>New England Journal of Medicine, The Journal of Pediatrics, Principles and Practice of Infectious Diseases</em> and many more. Dr. Litman has served as a reviewer for <em>Medical Letter, Journal of Perinatology</em>, the <em>Pediatric Infectious Diseases Journal</em>, the <em>Journal of Pediatrics, Journal of National Medical Association</em> and the <em>Journal of the American Medical Association</em>. He has also served on many committees such as the Advisory Committee on AIDS and the Advisory Committee on Health Curriculum, and is currently a member of the Pediatric Research Day Committee at Children&rsquo;s Hospital at Montefiore.</p><p>Dr. Litman is board certified in Pediatrics and Pediatric Infectious Diseases by the American Board of Pediatrics. He has received many awards and honors including the Teaching Excellence Award in Recognition of Outstanding Teaching in the Division of Infectious Diseases from Montefiore Einstein in 2014, Appreciation for Dedication, Support, and Commitment to Pediatric Hospital Medicine from the Children&rsquo;s Hospital at Montefiore in 2013, the Peer to Peer Excellence in Medicine Award from Bronx County Medical Society in 2008 and the William Obrinsky Award Outstanding Medical Student Teaching Award in Pediatrics from the Children&rsquo;s Hospital at Montefiore in 2004</p>

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Betsy Herold

Submitted by Anonymous (not verified) on
Full Name
Betsy Herold
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Herold_Betsey_MD_420x504.jpg
Type
Provider
Faculty
Expert
First Name
Betsy
Last Name
Herold
NPI
1619938206
Faculty ID
10991
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
einstein-dept-microbiology-immunology
einstein-dept-obstetrics-gynecology-womens-health
Gender
Female
Email
betsy.herold@einsteinmed.edu
Phone
718-839-7460
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Infectious Disease
Type
Academic
Department
Department of Microbiology & Immunology
Department Link
Rank
Professor
Type
Academic
Department
Department of Obstetrics & Gynecology and Women's Health
Department Link
Rank
Professor
Type
Clinical
Title
Chief, Division of Pediatric Infectious Disease
Type
Clinical
Title
Harold and Muriel Block Chair in Pediatrics
Type
Clinical
Title
Vice Chair, Research
Type
Clinical
Title
Director, Translational Prevention Research Center, Children's Hospital at Montefiore
Type
Clinical
Title
Professor of Pediatrics, Albert Einstein College of Medicine
Type
Administrative
Title
Harold and Muriel Block Chair in Pediatrics
Type
Administrative
Title
Vice Chair for Research, Department of Pediatrics
Type
Administrative
Title
Chief, Division of Pediatric Infectious Diseases, Department of Pediatrics
Type
Administrative
Title
Director, Translational Prevention Research Center
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Van Etten
Room
6A04A
Address Line 1
Albert Einstein College of Medicine
Address Line 3
1225 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Pennsylvania School of Dental Med
Education Type Label
Fellowship
Education Institution
Northwestern University/ Children's Memorial Hosp.
Education Type Label
Residency
Education Institution
Northwestern University/ Children's Memorial Hosp.
Professional Interests

<p><strong>Betsy Herold, M.D.</strong> directs a basic and translational research program, which focuses on virus host interactions. Projects in the lab include studies designed to identify the cellular signaling pathways that herpes simplex viruses (HSV) usurp to promote viral entry and infection. The lab uncovered a previously unappreciated paradigm associated with activation of phospholipid scramblases, which are known to catalyze the movement of phosphatidylserine lipids between the inner and outer leaflet of the plasma membrane. Surprisingly, they found that the exofacial movement of phospholipids is associated with concomitant translocation of intracellular proteins, including the master kinase Akt to the outside, where Akt becomes phosphorylated to activate an &ldquo;outside-inside&rdquo; signaling cascade that promotes viral entry. This pathway is also usurped by SARS-CoV-2 and is important for cellular processes including apoptosis. In collaboration with the Almo lab, they have engineered cell impermeable kinase inhibitors. These compounds block viral entry and prevent induction of apoptosis by select TNF ligands.</p>
<p> Serendipitously, in studying this signaling pathway, the lab identified a novel candidate vaccine for the prevention and treatment of HSV infections.  Most efforts to develop a vaccine have focused on neutralizing antibodies that target HSV glycoprotein D (gD), but all of these have failed in clinical trials. Instead, the lab (in collaboration with the Jacobs lab), engineered a virus completely deleted in gD. Glycoprotein D is required for viral entry and cell-to-cell spread, thus the deletion virus (DgD-2) is restricted a single cycle and will not spread. This candidate vaccine elicits T cell responses and high titer, polyfunctional antibodies that protect through antibody-dependent cell mediated cytotoxicity (ADCC). The vaccine prevents the establishment of latency in mice and is significantly more protective in multiple small animal models than prior vaccines that have failed in clinical trials. The lab has subsequently isolated monoclonal antibodies (mAbs) that have this protective ADCC activity and both the vaccine and the mAbs are being advanced for preclinical development.  Studies to understand why this vaccine elicits ADCC-mediating antibodies whereas gD vaccines and primary HSV infection only elicit neutralizing antibodies led to the identification of a key role for TNFRSF14 (aka HVEM) in generating and mediating ADCC responses. HVEM is an immune cell surface protein that functions in signal transduction pathways that regulate inflammatory or inhibitory immune responses but its role in shaping the B cell repertoire and in providing a second signal for ADCC had not been previously described and has implications for vaccine development and oncolytic therapies. </p>
<p> The third major area of basic research involves defining the molecular mechanisms underlying the HIV-HSV syndemic. Epidemiological studies have consistently demonstrated that being HSV seropositive is associated with an increased risk for HIV acquisition, replication, higher plasma viral loads and more frequent episodes of HIV reactivation.  Using primary cells from patients and HIV latently infected cell lines, the lab has identified several mechanisms by which HSV promotes HIV latency reversal and replication including upregulation of the noncoding RNA, <em>Malat1</em>, and downregulation of IL-32. Defining these pathways may lead to identification of new strategies to &ldquo;shock and kill&rdquo; or &ldquo;block and lock&rdquo; HIV.</p>
<p> Clinical studies include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and others</p><p>Studies with vaginal microbicides have resulted in the expnasion of studies to focus on soluble mucosal immunity in the genital tract. We found that .female genital tract secretions collected from healthy women provide variable, but significant protection against both HSV and HIV. Mechanistic studies suggest that this endogenous activity is mediated by defensins and other antimicrobial peptides. This endogenous activity may serve as a biomarker of a "healthy mucosal immune environment" and thus provide a surrogate marker to evaluate the safety of vaginal microbicides. In addition, identification of the mediators that contribute to this endogenous activity could lead to development of new strategies to boost this host defense and help protect against infection. These studies are being conducted in collaboration with the proteomics core facility at AECOM. Additionally, we are testing the hypothesis that HSV triggers changes in the mucosal environment, which allow it to escape cervical secretion defenses, enhance its own infectivity and facilitate HIV co-infection. Our preliminary observations support the paradigm that HSV disrupts the epithelial barrier by targeting tight junction and adherens junction proteins, and interferes with host defenses by triggering an inflammatory response and a loss in protective proteins such as SLPI. These changes could facilitate both its own infectivity and enhance HIV co-infection.<br /><br /></p>
<p>Results obtained from this bench research are critical to the laboratory's translational studies. The focus of the Translational Microbicide Research Program is to identify optimal combinations of topical microbicides that are safe and target different steps in HIV life cycle, thus reducing the risks of drug resistance and providing greater protection than could be achieved with a single agent, and also target HSV infection. Candidate combinations are evaluated using a multi-tiered approach for anti-viral activity and safety using human cervical cultures, as well as primary T cells and macrophages, in the presence of cervicovaginal secretions and seminal plasma. Leading combinations are then evaluated in human explant cultures (cervical, vaginal) and in murine genital models and a new cotton rat model for anti-viral activity and for the impact on mucosal immunity. If results of these pre-clinical studies suggest that candidate microbicides are safe and effective, the drugs are advanced for regulatory testing, and undergo evaluation in Phase I clinical studies.<br /><br /></p>
<p>Clinical research interests also include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and other related infectious complications.<br /><br /></p>

Research Areas
Herpes simplex virus (HSV) infection; synergy between HSV and HIV; microbicide development; genital tract mucosal immunity
Areas of Expertise
Antibiotic resistance
Antimicrobial resistance
Community-acquired MRSA (Methicillin-resistant Staphylococcus aureus)
HSV (herpes simplex virus)
Transplant infectious diseases
Expert Summary

<div>Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.&nbsp;</div>
<div><span style="white-space: pre;"> </span>&nbsp;</div>
<div>Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.&nbsp;<br /><br /></div>
<div>Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.&nbsp;<br /><br /></div>
<div>Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.</div>

CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Pediatric Infectious Diseases.

Research Focus

Prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients.

EMR ID
4968
Biography

<p>Betsy Herold, MD, is Chief of the Division of Pediatric Infectious Diseases and Vice Chair for Research at Children's Hospital at Montefiore. Dr. Herold is also a Professor of Pediatrics, Microbiology &amp; Immunology, and Obstetrics &amp; Gynecology and Women's Health at our Albert Einstein College of Medicine. She specializes in pediatric infectious diseases. </p><p>Dr. Herold received her Bachelor of Arts in Biology in 1978 from Brown University and went on to receive her Doctor of Medicine from the University of Pennsylvania Medical School in 1982. Dr. Herold completed an internship and residency in pediatrics at Children's Memorial Hospital, where she became a Chief Resident in 1985. She then began a fellowship in research at Hagedorn Research Laboratory in Gentofte, Denmark. In 1987, Dr. Herold began a fellowship in pediatric infectious diseases at Children's Memorial Hospital, followed by a Research Associate/Postdoctoral Virology Fellowship in the Department of Microbiology and Immunology at Northwestern University in Chicago. </p><p>Dr. Herold's clinical research focuses on the prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients. Dr. Herold has also been involved in research in Kawasaki disease and the emergence of methicillin-resistant staphylococcus aureus (MRSA) in the community. Dr. Herold directs a basic and translational research program on the prevention of herpes simplex virus (HSV) and HIV infections through the development of vaccines and novel antivirals. The current major focus of her lab is on a novel, paradigm-shifting, single-cycle vaccine to prevent HSV-1 and HSV-2. She has been continuously funded by the NIH since 1989. Dr. Herold has over 150 peer reviewed publications in peer-reviewed journals and has presented her work internationally. </p><p>In 2012, Dr. Herold received the Clinical Science Faculty Mentor Award from the Albert Einstein College of Medicine. She has also been awarded the Henry and Jacob Lowenberg Prize in Pediatrics and the Pediatric Infectious Disease Young Investigator Award. Dr. Herold is board certified by the American Board of Pediatrics in Pediatrics and in Pediatric Infectious Diseases. </p>

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David L. Goldman

Submitted by Anonymous (not verified) on
Full Name
David L. Goldman
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Goldman_David_MD_2x.jpg
Type
Provider
Faculty
First Name
David
Last Name
Goldman
NPI
1730245671
Faculty ID
5923
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
einstein-dept-microbiology-immunology
Gender
Male
Email
dagoldma@montefiore.org
Phone
718-741-2450
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Associate Professor
Division
Pediatric Infectious Disease
Type
Academic
Department
Department of Microbiology & Immunology
Department Link
Rank
Associate Professor
Type
Clinical
Title
Fellowship Director Pediatric Infectious Diseases
Type
Clinical
Title
Associate Professor of Pediatrics
Type
Clinical
Title
Associate Professor of Microbiology and Infectious Diseases
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Jefferson Medical College
Education Type Label
Fellowship
Education Institution
Albert Einstein College of Medicine
Education Type Label
Residency
Education Institution
Albert Einstein College of Medicine
Professional Interests

<p>The medical community has long recognized fungi as important allergens for patients with asthma. Interestingly, fungal sensitization is more common in children and has been linked to severe asthma resulting in death. The accepted paradigm is that fungal sensitization occurs as a result of recurrent, transient environmental exposures. Yet, increasing evidence suggests that fungi may interact with people in unrecognized ways to promote asthma. My lab is interested in understanding the role of subclinical fungal infections in asthma and their potential contribution to the high prevalence of asthma in urban areas.<br /><br /></p>
<p><em>Cryptococcus neoformans</em> is an encapsulated fungus that is well suited to serve as co-factor in urban asthma. <em>C. neoformans</em> colonizes pigeon droppings and is endemic to urban areas. Once inhaled, this fungus causes persistent, subclinical infections. We have demonstrated that the majority of Bronx children older than 2 years have serologic evidence of cryptococcal infection. Cryptococcal infection induces TH2 inflammation in animal models. In a rat model, we have shown that cryptococcal pulmonary infection acts a co-factor to enhance allergic inflammation to allergen challenge and promotes airway hyper-responsiveness, both hallmark features of asthma. Pulmonary cryptococcosis also induces chitinase expression, which has recently been implicated as an essential mediator of allergic inflammation.<br /><br /></p>
<p>To study this phenomenon, we have established collaborations with Pulmonary Medicine, Critical Care and Emergency Medicine at the Children&Atilde;&cent;&acirc;&sbquo;&not;&acirc;&bdquo;&cent;s Hospital of Montefiore. These collaborations provide access to the large number of children with asthma in the Bronx. Current studies underway include a characterization of chitinase expression among asthmatics and a comparison of cryptococcal infection prevalence among asthmatics and non-asthmatics. Animal experimentation directed at understanding the mechanisms and variables related to fungal induced asthma are also underway.<br /><br /></p>
<p>In addition to fungal studies, my lab is interested in anthrax pathogenesis. <em>Bacillus anthracis</em> is widely recognized as a potential agent of bioterrorism as evidenced by the 2001 anthrax attack. The toxins of <em>B. anthracis</em> are essential to virulence. In collaborations with Drs. Arturo Casadevall and Jurgen Brojatsch, we have studied the mechanisms by which <em>Bacillus anthracis</em> toxins contribute to host death. We have identified a previously unrecognized protease in human serum that inactivates the protective antigen component of lethal toxin <em>in vitro</em>. The precise protease and its role in the host response and susceptibility to anthrax remain to be determined. We have also identified a potential role for platelet activating factor (PAF) in mediating the lethal effects of toxin, including the alterations in vascular permeability which is characteristic of anthrax. Together, these observations may have important implications in developing new approaches to the treatment of anthrax.</p>

Research Areas
Fungal pathogenesis; Cryptococcus neoformans; asthma; anthrax
CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Dr. Goldman has a special interest in fungal infections in children, including hospital and community acquired mycoses.

Research Focus

Dr. Goldman has two primary research interests: the contribution of fungi to the development of asthma in children and the pathogenesis of C. difficile infection in children

Selected Publications

<div id="pmid_19708853" class="rprt">
<div class="rprtNum">&nbsp;</div>
<br />&nbsp;</div>
<p>1.&nbsp; Fungal sensitization in childhood persistent asthma is associated with disease severity.&nbsp; Vicencio AG, Santiago MT, Tsirilakis K, Stone A, Worgall S, Foley EA, Bush D, Goldman DL.&nbsp; Pediatr Pulmonol. 2013 Feb 8. doi: 10.1002/ppul.22779. [Epub ahead of print]</p>
<p>&nbsp;</p>
<p>2.&nbsp; Increased chitinase expression and fungal-specific antibodies in the bronchoalveolar lavage fluid of asthmatic children.&nbsp; Goldman DL, Li X, Tsirilakis K, Andrade C, Casadevall A, Vicencio AG.&nbsp; Clin Exp Allergy. 2012 Apr;42(4):523-30. doi: 10.1111/j.1365-2222.2011.03886.x. Epub 2011 Oct 10.</p>
<p>&nbsp;</p>
<p>3.&nbsp; CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization?&nbsp; Vicencio AG, Chupp GL, Tsirilakis K, He X, Kessel A, Nandalike K, Veler H, Kipperman S, Young MC, Goldman DL.</p>
<p>Pediatrics. 2010 Oct;126(4):e982-5. doi: 10.1542/peds.2010-0321. Epub 2010 Sep 6.</p>
<p>&nbsp;</p>
<p>4.&nbsp; Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.Muehlbauer SM, Lima H Jr, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J.&nbsp; Am J Pathol. 2010 Aug;177(2):735-43. doi: 10.2353/ajpath.2010.090828. Epub 2010 Jul 1. Erratum in: Am J Pathol. 2010 Oct;177(4):2145.</p>
<p>&nbsp;</p>

EMR ID
4147
Biography

<p>David L. Goldman, MD, is Fellowship Director, Pediatric Infectious Diseases; Associate Professor, Pediatrics, and Associate Professor, Microbiology and Infectious Diseases at Montefiore Einstein. He has a special interest in fungal infections in children, including hospital and community acquired mycoses.</p><p>After earning his Bachelor of Arts from Brandeis University in 1983, Dr. Goldman attended Jefferson Medical College, earning his Doctor of Medicine in 1987. He began his postdoctoral education at St. Vincent&rsquo;s Hospital. Yale University, New York Medical College, completing a yearlong internship before coming to Einstein&rsquo;s Jacobi Medical Center, where he completed a residency in pediatrics in 1991, a fellowship in academic pediatrics in 1992 and a fellowship in pediatric infectious diseases in 1996.</p><p>Dr. Goldman has two primary research interests: the contribution of fungi to the development of asthma in children and the pathogenesis of C. difficile infection in children. He has shared his work through conferences, symposia, books, peer-reviewed journals, review articles, abstracts and poster presentations. He has also been an ad hoc reviewer for several journals including <em>Infection and Immunity, Microbes and Infection</em>, and <em>Medical Mycology</em>.</p><p>Dr. Goldman is board certified in pediatrics and pediatric infectious diseases. He is a member of the American Society of Microbiology, the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society.</p>

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Marc D. Foca

Submitted by Anonymous (not verified) on
Full Name
Marc D. Foca
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/9b717240-3e81-11ed-b478-7f7f2b3c3759.jpg
Type
Provider
Faculty
First Name
Marc
Last Name
Foca
NPI
1881660512
Faculty ID
16522
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Male
Email
mfoca@montefiore.org
Phone
718-741-2470
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Infectious Disease
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Rutgers New Jersey Medical School
Education Type Label
Fellowship
Education Institution
Columbia Presbyterian Medical Center
Education Type Label
Residency
Education Institution
Columbia Presbyterian Medical Center
CHAM Provider
On
Professional Title
M.D.
EMR ID
62237
Biography

<p><span>Marc D. Foca, MD, is Attending Physician, Pediatric Infectious Diseases at Children&rsquo;s Hospital at Montefiore and Associate Professor of Pediatrics at our Albert Einstein College of Medicine. His clinical focus is on transplant infectious diseases.</span></p><p><span>In 1986, Dr. Foca received his Bachelor of Arts degree at Johns Hopkins University. He then attended Rutgers New Jersey Medical School, where he received his Doctor of Medicine in 1995. Dr. Foca began his postgraduate training in 1995 with a three-year internship and residency at Babies and Children&rsquo;s Hospital at Columbia Presbyterian Medical Center. He then completed a fellowship in pediatric infectious diseases at Columbia University in 2001. </span></p><p><span>His research focuses on the clinical aspects of immunosuppressed pediatric patients,</span><span>including those with HIV and organ transplants. Dr. Foca&rsquo;s work has been shared at national invited lectures and international expert panels and published in a number of peer-reviewed journals, books and abstracts.</span></p><p>Dr. Foca has been named one of Castle Connolly&rsquo;s Top Doctors in pediatric infectious diseases from 2014 to 2020. He is board certified in pediatric infectious diseases and a member of numerous professional societies, including the Pediatric Infectious Diseases Society and the American Society of Transplantation.</p>

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Brenda I. Anosike

Submitted by Anonymous (not verified) on
Full Name
Brenda I. Anosike
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/70ea9750-c7c1-11eb-bfe4-df29db1b362a.jpg
Type
Provider
Faculty
First Name
Brenda
Last Name
Anosike
NPI
1851518609
Faculty ID
16590
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Female
Email
banosike@montefiore.org
Phone
718-741-2470
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Assistant Professor
Division
Pediatric Infectious Disease
Type
Clinical
Title
Director, Diagnostic Stewardship
Type
Clinical
Title
Assistant Professor of Pediatrics
Type
Clinical
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
State University of NY at Stony Brook School of Medicine
Education Type Label
Fellowship
Education Institution
Boston Children's Hospital
Education Type Label
Residency
Education Institution
Brown University Memorial Hospital
CHAM Provider
On
Professional Title
M.D.
M.P.H.
Clinical Focus

Clinical focus is on the treatment of various infectious diseases in healthy children, adolescents and young adults as well as those with complex medical conditions and the immunocompromised.

Research Focus

Research focuses on antimicrobial management of orbital cellulitis and/or sub periosteal abscesses, global health, clinical outcomes of COVID therapeutics in children, antimicrobial stewardship tools, and immunocompromised care

EMR ID
123744
Biography

<p>Brenda I. Anosike, MD, MPH, is Director, Pediatric Antimicrobial Stewardship at Children&rsquo;s Hospital at Montefiore and Assistant Professor, Pediatrics at Montefiore-Einstein. Dr. Anosike&rsquo;s clinical focus is on the treatment of various infectious diseases in healthy children, adolescents and young adults as well as those with complex medical conditions and the immunocompromised. She is co-lead for the pediatric COVID-19 monoclonal antibody program, antimicrobial/diagnostic stewardship program and global health.</p><p>After completing her Bachelor of Arts in 2002 at Brown University, Dr. Anosike attended Stony Brook University School of Medicine, earning her Doctor of Medicine in 2006. She pursued postdoctoral training with a residency and internship at Brown University, Hasbro Pediatric Residency Program, completing it in 2009. From 2017 to 2020, she undertook a clinical research fellowship in pediatric infectious diseases with Boston Children&rsquo;s Hospital. In 2020, she also completed her Master of Public Health in clinical effectiveness with the Harvard T. H. Chan School of Public Health.</p><p>Dr. Anosike&rsquo;s research focuses on antimicrobial management of orbital cellulitis and/or subperiosteal abscesses, global health, clinical outcomes of COVID therapeutics in children, antimicrobial stewardship tools, and immunocompromised care. Her work has been shared through peer-reviewed journals, abstracts and review articles.</p><p>Dr. Anosike is board certified and is a member of several professional societies including the American Academy of Pediatrics, the Pediatric Infectious Diseases Society and the Infectious Diseases Society of North America.</p>

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