Pediatrics | Montefiore Einstein

Rosy Chhabra

Read more about Rosy Chhabra

Rosy Chhabra

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Faculty

Expert

First Name

Rosy

Last Name

Chhabra

Faculty ID

9777

Patient Type

Adult

Department

einstein-dept-pediatrics

einstein-dept-psychiatry-behavioral-sciences

rosy.chhabra@einsteinmed.edu

Phone

718-696-4070

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Research Associate Professor

Division

Academic General Pediatrics

Type

Academic

Department

Department of Psychiatry and Behavioral Sciences

Department Link

Rank

Research Associate Professor

Sophie Molholm

Read more about Sophie Molholm

Sophie Molholm

https://assets.montefioreeinstein.org/profiles/images/12028-sophie-molholm.jpg

Faculty

Expert

First Name

Sophie

Last Name

Molholm

Faculty ID

12028

Patient Type

Adult

Department

einstein-dept-pediatrics

einstein-dept-neuroscience

einstein-dept-psychiatry-behavioral-sciences

sophie.molholm@einsteinmed.edu

Phone

718-862-1823

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Developmental Medicine

Type

Academic

Department

Dominick P. Purpura Department of Neuroscience

Department Link

Rank

Professor

Tags

einstein-dept-neuroscience

Type

Academic

Department

Department of Psychiatry and Behavioral Sciences

Department Link

Rank

Professor

Type

Administrative

Title

Co-Director, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center

Type

Administrative

Title

Muriel and Harold Block Faculty Scholar in Mental Illness, Department of Pediatrics

Locations

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Van Etten

Room

1C-3C

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Professional Interests

As a Cognitive Neuroscientist, my research centers around understanding the intricacies of the brain and its role in shaping our experiences of the world. My curiosity lies in the fundamental processes that govern how the human brain processes and integrates sensory inputs to influence perception and behavior. This includes studying mechanisms of attention, speech processing, and higher-order cognition related to executive function.
 My work involves characterizing these processes in healthy adults and tracking their developmental course over childhood. Additionally, I am dedicated to translating these findings to gain insights into the neurobiology of developmental and neuropsychiatric disorders, with a special emphasis on autism, schizophrenia, and rare genetic conditions such as 22q11.2 deletion syndrome and Rett syndrome.
 To achieve these research goals, I employ a diverse range of investigative tools. Non-invasive high-density recordings of brain electrical activity, intracranial recordings in patients, psychophysics, and magnetic resonance imaging and computational modeling (through collaborations with Einstein and non-Einstein investigators) are among the primary methods I use. These techniques, often combined with neuropsychological assessments and clinical diagnoses, provide valuable insights into the workings of the brain. 
 One area in which my research has led to significant discoveries is in the field of multisensory integration, demonstrating how the brain combines inputs from different sensory systems, how this process evolves across development, and how impaired multisensory integration contributes to autism.  The latter has led me to additional avenues of research focused on neurooscillatory dysfunction and predictive processing, aimed at further understanding autism.
 I also serve as the Co-Director of the NIH funded the Rose F. Kennedy Intellectual and Developmental Research Center and the Director of its Human Clinical Phenotyping Core, and I co-direct a T32 training program on intellectual and developmental disabilities. Through these programs my colleagues and I aim to provide a rich intellectual and multidisciplinary environment within which research is performed to better the lives of individuals with an IDD.
 My research efforts have been supported by funding from esteemed organizations like NIMH, NSF, Autism Speaks, the Wallace Research Foundation, and private donors. This financial backing allows me to continue making valuable contributions to the field of cognitive neuroscience and further our understanding of the brain and its role in shaping human experience, particularly in the context of developmental and neuropsychiatric disorders.

Research Areas

attention
multisensory integration
sensory and perceptual processing
executive function

Specialties

Pediatrics

Brain Sciences

Expert Tags

Autism

Multisensory Integration

Areas of Expertise

Neuroscience

Expert Summary

Dr. Molholm is a leader in the field of multisensory integration and focuses her research on developmental disorders, with an emphasis on autism, and on rare genetic conditions. She studies how the human brain processes and integrates sensory inputs—sight, sound, and touch—to impact perception and behavior. She also studies higher order processes such as attention and executive function, and how these interact with lower order cortical processes. Using non-invasive techniques, including brainwave electroencephalogram (EEG) recordings and magnetic resonance imaging (MRI), Dr. Molholm examines the link between deficits in information processing and autism, and how these relate to different neurodevelopmental and neuropsychiatric conditions.
Dr. Molholm has received research funding from the National Institutes of Health, the National Science Foundation, the Simons Foundation, and other private foundations. She is a member of numerous organizations, including the Cognitive Neuroscience Society, International Multisensory Research Forum, Society for Neuroscience and the International Society for Autism Research. She is section editor for the European Journal of Neuroscience and has authored or co-authored more than 100 peer-reviewed research studies, review articles, commentaries, and book chapters.

Research Profile

https://einsteinmed.edu/faculty/12028/Sophie-Molholm

CHAM Provider

Off

Professional Title

Ph.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/1e648915-7cb8-4298-b67a-2859fce52…

Selected Publications

<ol>
<li>Gomes, H., Molholm, S., Ritter, W., Kurtzberg, D., Cowan, N., & Vaughan, H. G., Jr.  (2000).  Mismatch negativity in children and adults, and effects of an attended task.  Psychophysiology, 37, 807-816.</li>
<li>Molholm, S., Ritter, W., Murray, M.M., Javitt, D.C., Schroeder, C.E., & Foxe. J.J. (2002).  Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study.  Cognitive Brain Research, 14, 115-129.</li>
<li>Ritter, W., Sussman, E., & Molholm, S., & Foxe, J.J. (2002).  Memory reactivation or reinstatement and the mismatch negativity.  Psychophysiology, 39, 158-165.</li>
<li>Tartter, V.C., Gomes, H., Dubrovsky, B., Molholm, S., & Vala Stewart, R. (2002).  Novel metaphors appear anomalous at least momentarily:  Evidence from N400.  Brain and Language, 80, 488-509.</li>
<li>Molholm, S., Ritter, W., Javitt, D.C., & Foxe, J.J. (2004).  Visual-Auditory Multisensory Object Recognition in Humans:  A High-density Electrophysiological study.  Cerebral Cortex, 14, 452-465.</li>
<li>Molholm, S.,Gomes, H., Lobosco, Deacon, D., & Ritter, W. (2004).  Feature versus gestalt representation of stimuli in the mismatch negativity system of 7-to-9 year old children.  Psychophysiology, 41, 385-393.</li>
<li>Molholm, S., Martinez, A., Ritter, W., Javitt, D.C., & Foxe, J.J. (2005). The neural circuitry of pre-attentive auditory change-detection: An fMRI study of pitch and duration mismatch negativity generators.  Cerebral Cortex, 15, 545-551. </li>
<li>Murray, M. M., Molholm, S., Michel, C.M., Heslenfeld, D.J., Ritter, W., Javitt, D.C., Schroeder, C.E., & Foxe, J.J. (2005).  Grabbing Your Ear: Rapid Auditory-Somatosensory Multisensory Interactions in Low-level Sensory Cortices are not Constrained by Stimulus Alignment.  Cerebral Cortex, 15, 963-974. </li>
<li>Hester, R., Foxe, J.J., Molholm, S., Shpaner, M., & Garavan, H. (2005).  Neural mechanisms involved in error processing:  A comparison of errors made with and without awareness, NeuroImage, 27, 602-608.</li>
<li>Martinez, A., Teder-Sälejärvi, W., Vazquez, M., Molholm, S., Foxe, J.J., Javitt, D.C., Di Russo, F., Worden, M.S., & Hillyard, S.A. (2006). Objects are highlighted by spatial attention.  Journal of Cognitive Neuroscience, 18, 298-310.</li>
<li>Sehatpour, P., Molholm, S., Javitt, J.C., & Foxe, J.J. (2005).  Spatiotemporal Dynamics of Human Object Recognition Processing: An integrated high-density electrical mapping and functional imaging study of "closure" processes.  NeuroImage, 29, 605-618.</li>
<li>Senkowski, D., Molholm, S., Gomez-Ramirez, M., & Foxe, J.J. (2006). Oscillatory beta activity predicts response speed during a multisensory audiovisual reaction time task: A high-density electrical mapping study.  Cerebral Cortex, 16, 1556-1565.</li>
<li>Magno, E, Foxe, J.J., Molholm, S, Robertson, I.H., & Garavan, H (2006).  The anterior cingulate and error avoidance.  Journal of Neuroscience, 26, 4769-4773.</li>
<li>Ritter, W., De Sanctis, P., Molholm, S., Javitt, D.C., & Foxe, J.J. (2006) Preattentively grouped tones do not elicit MMN with respect to each other. Psychophysiology, 43, 423-430.</li>
<li>Saint-Amour, D., De Sanctis, P., Molholm, S., Ritter, W., & Foxe, J.J. (2007). Seeing voices: High-density electrical mapping and source-analysis of the multisensory mismatch negativity evoked during the McGurk illusion. Neuropsychologia, 45, 587-597.</li>
<li>Molholm, S., Sehatpour, P., Mehta, A.D., Shpaner, M., Gomez-Ramirez, M., Ortigue, S., Dyke, J.P., Schwartz, T.H., & Foxe, J.J. (2006).  Audio-visual multisensory integration in superior parietal lobule revealed by human intracranial recordings. Journal of Neurophysiology, 96, 721-729.</li>
<li>Senkowski, D., Gomez-Ramirez, M., Lakatos, P., Wylie, G.R., Molholm, S., Schroeder, C.E., & Foxe, J.J. (2007). Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians. Experimental Brain Research, 177, 184-195</li>
<li>Leavitt, V.M., Molholm, S., Ritter, W., Shpaner, M., Foxe, J.J. (2007).  Auditory processing in schizophrenia during the middle latency period (10-50 milliseconds): High-density electrical mapping and source-analysis reveal subcortical antecedents to early cortical deficits.  Journal of Psychiatry & Neuroscience, 32, 339-353.</li>
<li>Molholm, S., Martinez, A., Shpaner, M., Foxe, J.J. (2007).  Object based attention is multisensory: Co-activation of an object’s representations in ignored sensory modalities.  European Journal of Neuroscience, 26, 499-509.</li>
<li>Ross, L.A., Saint-Amour, D., Leavitt, V.M., Molholm, S., Javitt, D.C., & Foxe, J.J. (2007). Impaired Multisensory Processing in Schizophrenia: Deficits in Visual Enhancement of Speech Comprehension Under Noisy Environmental Conditions. Schizophrenia Research, 97, 173-183.</li>
<li>Moran, R., Reilly, R.B., Molholm, S., & Foxe, J.J. (2008).  Changes in Effective Connectivity of Human Superior Parietal Lobule under Multisensory and Unisensory Stimulation. European Journal of Neuroscience, 9, 2303-2312.</li>
<li>De Sanctis, F., Ritter, W., Molholm, S., Kelly, S.P., & Foxe, J.J. (2008).  Auditory Scene Analysis: The interaction of stimulation rate and frequency separation on preattentive grouping.  European Journal of Neuroscience, 27, 1271-1276.</li>
<li>Sehatpour, P., Molholm, S., Schwartz, T.H., Mahoney, J.R., Mehta, A. D., Javitt, D.C., Stanton, P.K., & Foxe, J.J. (2008).  Long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing, Proceedings of the National Academy of Sciences, 105, 4399-4404.</li>
<li>Barnett, K.J., Foxe, J.J., Molholm, S., Kelly, S.P., Shalgi, S., Mitchell, K.J., & Newell, F.N. (2008). Differences in early sensory-perceptual processing in synesthesia: a visual evoked potentials study.  NeuroImage, 43, 605-13.</li>
<li>Foxe, J.J., Strugstad, E.C., Sehatpour, P., Molholm, S., Pasieka, W., Schroeder, C.E., McCourt, M.E. (2008). Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential: high-density electrical mapping of the "C1" component. Brain Topogr. 21:11-21.</li>
<li>Fiebelkorn I.C., Foxe, J.J., Butler, J.S., Mercier, M.M., Snyder, A.C., Molholm, S. (2011).</li>
<li>Ritter, W., Sussman, E., & Molholm, S.  (2000).  Evidence that the mismatch negativity system works on the basis of objects.  NeuroReport, 11, 61-63.</li>
<li>Molholm, S., Gomes, H., & Ritter, W. (2001).  The detection of constancy amidst change:  A dissociation between preattentive and intentional processing.  Psychophysiology, 38, 969-978.</li>
<li>Fiebelkorn, I.C., Foxe, J.J. & Molholm, S. (2009).  Dual Mechanisms for Object Based Cross-Sensory Transfer of Attention:How Much Do Learned Associations Matter?  Cerebral Cortex. 20: 109-20.</li>
<li>De Sanctis, P., Ritter, W., Molholm, S., Shpaner, M., Javitt, D.C. and Foxe, J.J. (2009).  Right hemisphere advantage for auditory temporal discrimination: High-density electrical mapping of the duration mismatch negativity (MMN).  Frontiers in Integrative Neuroscience, 3:5. Epub 2009 Apr 20.</li>
<li>Fiebelkorn, I.C., Foxe, J. J., Schwartz, T.H., & Molholm, S. (2010). Staying within the lines: the formation of visuospatial boundaries influences multisensory feature integration.  European Journal of Neuroscience, 31, 1737-1743.</li>
<li>Lucan, J., Foxe, J.J., Weisser, V.D., Sathian, K., & Molholm, S. (2010).  Tactile shape discrimination recruits human lateral occipital complex during early perceptual processing. Human Brain Mapping, 31, 1813-21.</li>
<li>Russo, N., Foxe, J.J., Brandwein, A., Altschuler, T., Gomes, H., & Molholm, S. (2010). Multisensory processing in children with autism: high-density electrical mapping of auditory-somatosensory integration.  Autism Research, 3, 253-67.</li>
<li>Brandwein, A., Foxe, J.J., Altshuler, T., Gomes, H., & Molholm, S (2010). Tracking the developmental course of auditory-visual multisensory processing in children: A high-density electrophysiological study.  Cerebral Cortex, 21, 1042-55.</li>
<li>Foxe, J.J., Yeap, Sherlyn, Thakore, J.H., Snyder, A., Kelly, S.P., & Molholm, S. (2010).  The N1 auditory evoked potential component as an endophenotype for schizophrenia: High-density electrical mapping in clinically unaffected first-degree relatives, first-episode and chronic schizophrenia patients.  European Archives of Psychiatry and Clinical Neuroscience, 261, 331-9.</li>
<li>Butler, J.S., Molholm, S., Fiebelkjorn, I.C., Mercier, M.R., Schwartz, T.H., & Foxe, J.J. (2011).  Common or redundant neural circuits for duration processing across audition and touch. Journal of Neuroscience, 31, 3400-6</li>
<li>Banergee, S., Molholm, S, Snyder, A.C., & Foxe, J.J. (2011). Oscillatory alpha-band mechanisms and the deployment of spatial attention to anticipated auditory and visual target locations: Supramodal or sensory-specific control mechanisms? Journal of Neuroscience, 31, 9923-32.</li>
<li>Ross, L., Molholm, S. Blanco, D., Gomez-Ramirez, M, Saint Amour, D., & Foxe, J.J.  (2011). The tuning of multisensory speech perception continues through the late childhood years.  European Journal of Neuroscience,  33, 2329-37.</li>
<li>Fiebelkorn, I.C., Foxe, J.J., Butler, J.S., & Molholm, S. (2011). Auditory Facilitation of Visual-Target Detection Persists Regardless of Retinal Eccentricity and Despite Wide Audiovisual Misalignments. Experimental Brain Research, 213, 167-74.</li>
<li>Ready, Set, Reset: Stimulus-Locked Periodicity in Behavioral Performance Demonstrates the Consequences of Cross-sensory Phase Reset.  Journal of Neuroscience, 31, 9971-81.</li>
<li><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Leavitt%20VM%22%5BAuthor%5D"…, V.M</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Molholm%20S%22%5BAuthor%5D">…, S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gomez-Ramirez%20M%22%5BAutho…, M</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Foxe%20JJ%22%5BAuthor%5D">Fo…, J.J</a>. (2011). "What" and "where" in auditory sensory processing: a high-density electrical mapping study of distinct neural processes underlying sound object recognition and sound localization. <a title="Frontiers in integrative neuroscience." href="http://www.ncbi.nlm.nih.gov/pubmed/21734870">Front Integr Neurosci.</a> 2011;5:23. Epub 2011 Jun 22.</li>
<li>Gomez-Ramirez, M., Kelly, S.P., Molholm, S., Sehatpour, P., Schwartz, T.H., & Foxe, J.J. (2011).  Oscillatory Sensory Selection Mechanisms during Intersensory Attention to Rhythmic Auditory and Visual Inputs: A Human Electro-Corticographic Investigation.  Journal of Neuroscience, 31, 18556-67.</li>
<li>Altschuler, T., Molholm, S, Russo, N., Snyder, A., Brandwein, A.; Blanco, D., & Foxe, J. (2011). Early Electrophysiological Indices Of Illusory Contour Processing Within The Lateral Occipital Complex Are Virtually Impervious To Large-Scale Manipulations Of Illusion Strength.  NeuroImage, 59. 4074-85.</li>
<li>Berko, E.R., Beren, F., Suzuki,M., Alaimo, C., Calder, R.B., Ballaban-Gil, K., Gounder, B., Kampf, K., Kirschen,J., Lemetre, C., Maqbool, S., Momin, Z., Reynolds, D., Russo, N., Shulman, L., Stasiek, E., Tozour,J., Valicenti, R., Wang, S., Abrahams, B., Hargitai, J., Buxbaum, J., Inbar, D., Zhang, Z., Molholm, S., Foxe, J.J., Marion, R.W., Auton, A., Greally, J.M. (2014). Epigenetic dysregulation in autism spectrum disorder associated with advanced maternal age. PLoS Genetics, 10: e1004402.</li>
<li>Ross, L.A., Del Bene, V.A., Molholm, S., Woo, Y.J., Andrade, G.N., Abrahams, B.S., Foxe, J.J. (2017). Common variation in the Autism risk gene CNTNAP2, brain structural connectivity and multisensory speech integration. Brain and Language, July 21, E-pub ahead of print.</li>
<li>Freedman, E.G., Molholm, S., Gray, M.J., Belyusar, D., Foxe, J.J.  (in press).  Saccade adaptation deficits in developmental dyslexia suggest disruption of cerebellar-dependent learning. Journal of Neurodevelopmental Disorders, July 21, E-pub ahead of print.</li>
<li>Cuppini, C., Ursino, M.,  Magosso, E., Ross, L.A., Foxe, J.J., Molholm, S. (in press). A computational analysis of neural mechanisms responsible for the maturation of multisensory speech integration in neurotypical children and those on the Autism Spectrum. Frontiers in Human Neuroscience.</li>
<li>Gomes, H., Duff, M., Ramos, M., Molholm, S., Foxe, J.J., Halperin, J. (2012). Auditory Selective Attention and Processing in Children with Attention-Deficit/Hyperactivity Disorder. Clinical Neurophysiology, 123, 293-302.</li>
<li>Snyder, A., Shpaner, M., Molholm, S. & Foxe, J.J. (2012).  Visual object processing as a function of stimulus energy, retinal eccentricity and Gestalt configuration: a high-density electrical mapping study.  Neuroscience, 221, 1-11.</li>
<li>Butler, J., Foxe, J.J., Fiebelkorn, I.E., Mercier, M., Molholm, S. (2012). Multisensory representation of frequency across audition and touch: High density electrical mapping reveals early sensory-perceptual coupling. Journal of Neuroscience, 32, 15338-44.</li>
<li>Fiebelkorn, I.C., Foxe., J.J., McCourt, M.E., Dumas, K.N., & Molholm, S. (2013). Atypical Category Processing and Hemispheric Asymmetries in High-Functioning Children with Autism: Revealed through High-Density EEG Mapping, Cortex, 49, 1259-67.</li>
<li>Brandwein, A., Foxe, J., Butler, J.,  Russo, N., Altshuler, T., Gomes, H., Molholm, S. (2013). The Development of multisensory integration in high-functioning autism: High-density electrical mapping and psychophysical measures reveal impairments in the processing of audiovisual inputs.  Cerebral Cortex, 23, 1329-41.</li>
<li>Fiebelkorn, I.E., Snyder, A., Mercier, M., Butler, J., Molholm, S., Foxe, J.J. (2013).  Cortical cross-freqeuncy coupling predicts perceptual outcomes.  NeuroImage, 69, 126-137.</li>
<li>Shpaner, M., Molholm, S., Forde, E-J., & Foxe, J.J.(2013). Disambiguating the roles of area V1 and the lateral occipital complex (LOC) in contour integration.  NeuroImage, 69, 146-156.</li>
<li>Mercier, M.M., Foxe, J.J., Fiebelkorn, I.C., Butler, J.S., Schwartz, T.H., Molholm, S. (2013). Auditory-driven phase reset in visual cortex: Human electrocorticography reveals mechanisms of early multisensory integration.  NeuroImage, 79, 19-29.</li>
<li>Frey, H-P, Molholm, S., Lalor, E., Russo, N., Foxe, J.J. (2013).  Atypical cortical representation of peripheral visual space in children with an Autism Spectrum Disorder (ASD).  European Journal of Neuroscience, 38, 2125-38.</li>
<li>Megevand, P., Molholm, S., Nayak, A., & Foxe, J.J.  (2013). Recalibration of the Multisensory Temporal Window of Integration results from changing task demands.  PLOSONE, 8, 8, e71608.</li>
<li>Molholm, S., Mercier, M., Liebenthal, E., Schwartz, T., Ritter, W., Foxe,J.J., De Sanctis, P. (2014).  Mapping Phonemic Processing Zones along Human Perisylvian Cortex: An Electro-Corticographic Investigation. Brain Structure and Function, 219,1369-83.</li>
<li>Frey, H-P, Schmidt, A.M., Murphy, J.W., Molholm, S., Foxe, J.J. (2014). Modulation of early cortical processing during divided attention to non-contiguous locations. European Journal of Neuroscience, 39, 1499-507.</li>
<li>Murphy, J.B., Foxe, J. J., Peters, J.B., Molholm, S. (2014). Susceptibility to distraction in autism spectrum disorder:  Probing the integrity of oscillatory alpha-band suppression mechanisms.  Autism Research, 7, 442-58. </li>
<li><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Andrade%20GN%5BAuthor%5D&ca…, G.N</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Molholm%20S%5BAuthor%5D&cau…, S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Butler%20JS%5BAuthor%5D&cau…, J.S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Brandwein%20AB%5BAuthor%5D&…, A.B</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Walkley%20SU%5BAuthor%5D&ca…, S.U</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Foxe%20JJ%5BAuthor%5D&cauth…, J.J</a>. (2014).  Atypical multisensory integration in Niemann-Pick type C disease - towards potential biomarkers. Orphanet Journal of Rare Diseases, Sept. 20, 9, 149.</li>
<li>Foxe. J.J., Molholm, S., Del Bene, V.A., Frey, H.P., Russo, N.R., & .Ross, L. (2015). Severe Multisensory Speech Integration Deficits in High- Functioning School-Aged Children with an Autism Spectrum Disorder (ASD) and their Resolution during Early Adolescence.  Cerebral Cortex, 25, 298-312.</li>
<li><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Brandwein%20AB%5BAuthor%5D&…, A.B</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Foxe%20JJ%5BAuthor%5D&cauth…, J.J</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Butler%20JS%5BAuthor%5D&cau…, J.S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Frey%20HP%5BAuthor%5D&cauth…, H.P</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Bates%20JC%5BAuthor%5D&caut…, J.C</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Shulman%20LH%5BAuthor%5D&ca…, L.H</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Molholm%20S%5BAuthor%5D&cau…, S</a>. (2015). Neurophysiological indices of atypical auditory processing and multisensory integration are associated with symptom severity in autism.  Journal of Autism and Developmental Disorders, 45, 230-44.</li>
<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Andrade%20GN%5BAuthor%5D&c…, G.N</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Butler%20JS%5BAuthor%5D&ca…, J.S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Mercier%20MR%5BAuthor%5D&c…, M.R</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Molholm%20S%5BAuthor%5D&ca…, S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Foxe%20JJ%5BAuthor%5D&caut…. J,J</a> (2015). Spatio-temporal dynamics of adaptation in the human visual system: a high-density electrical mapping study. European Journal of Neuroscience, 41, 925-39.</li>
<li>Mercier, M.R., Molholm, S., Fiebelkorn, I.C., Butler, J.S., Schwartz, T.,H., Foxe. J.J. (2015).  Neuro-oscillatory phase alignment drives speeded multisensory response times: an electro-corticographic (ECoG) investigation.  Journal of Neuroscience, 35, 8546-57.</li>
<li>Ross, L.A., Del Bene, V.A., Molholm, S., Frey, HP, & Foxe, J.J. (2015).  Sex Differences in Multisensory speech processing in both typically developing children an those on the autism spectrum.  Frontiers in Neuroscience: Child and Neurodevelopmental Psychiatry, 9: 185.</li>
<li>Murphy, J.B., Foxe, J. J., Molholm, S. (2015).  Neuro-oscillatory mechanisms of intersensory selective attention and task switching in school-aged children, adolescents and young adults.  Developmental Science, July 17, E-pub ahead of print.</li>
<li><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Mahoney%20JR%5BAuthor%5D&c…, J.R</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Molholm%20S%5BAuthor%5D&ca…, S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Butler%20JS%5BAuthor%5D&ca…, J.S</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Sehatpour%20P%5BAuthor%5D&…, P</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Gomez-Ramirez%20M%5BAuthor%5D&…, M</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Ritter%20W%5BAuthor%5D&cau…, W</a>., <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Foxe%20JJ%5BAuthor%5D&caut…, J.J</a>. (2015).Keeping in touch with the visual system: spatial alignment and multisensory integration of visual-somatosensory inputs. Frontiers in Psychology, 5: 1068.</li>
<li>Uppal, N., Foxe. J.J., Butler, J.S., Acluche, F., Molholm, S. (2016).The neural dynamics of somatosensory processing and adaptation across childhood: a high-density electrical mapping study. Journal of Neurophysiology, 115,1605-19.</li>
<li>Woo, Y.J., Wang, T., Guadalupe, T., Nebel, R.A., Vino, A., Del Bene, V.A., Molholm, S., Ross, L.A., Zwiers, M.P., Fisher, S.E., Foxe, J.J., Abrahams, B.S. (2016). A Common CYFIP1 Variant at the 15q11.2 Disease Locus Is Associated with Structural Variation at the Language-Related Left Supramarginal Gyrus. PLoS One, 11:e0158036.</li>
<li>Andrade, G.N., Butler, J.S., Peters, G.A., Molholm, S., Foxe, J.J. (2016). Atypical visual and somatosensory adaptation in schizophrenia-spectrum disorders. Transl Psychiatry, 6:e804.</li>
<li>Foxe, J.J., Kelly M. Burke, K.M., Andrade, G.N., Djukic, A, Frey, H-P, Molholm, S. (2016). Automatic cortical representation of auditory pitch changes in Rett Syndrome. Journal of Neurodevelopmental Disorders, 8:34.</li>
<li>Butler, J.S., Molholm, S., Andrade, G.N., Foxe, J.J. (2017).  An Examination of the Neural Unreliability Thesis of Autism.  Cerebral Cortex, 27, 185-200.</li>
<li>Malcolm, B.R., Foxe, J.J., Butler, J.S., Mowrey, W.B., Molholm, S., De Sanctis, P (2017). Long-term test-retest reliability of event-related potential (ERP) recordings during treadmill walking using the mobile brain/body imaging (MoBI) approach.  Brain Research, May 19, E-pub ahead of print.</li>
<li>Ross, L.A., Del Bene, V.A., Molholm, S., Woo, Y.J., Andrade, G.N., Abrahams, B.S., Foxe, J.J. (2017). Common variation in the Autism risk gene CNTNAP2, brain structural connectivity and multisensory speech integration. Brain and Language, 174, 50-60.</li>
<li>Freedman, E.G., Molholm, S., Gray, M.J., Belyusar, D., Foxe, J.J.  (2017).  Saccade adaptation deficits in developmental dyslexia suggest disruption of cerebellar-dependent learning. Journal of Neurodevelopmental Disorders, 9:36.</li>
<li>Cuppini, C., Ursino, M.,  Magosso, E., Ross, L.A., Foxe, J.J., Molholm, S. (2017). A computational analysis of neural mechanisms responsible for the maturation of multisensory speech integration in neurotypical children and those on the Autism Spectrum. Frontiers in Human Neuroscience,11:518.</li>
<li>Malcolm B.R., Foxe J.J., Butler J.S., Molholm S., De Sanctis P. (2018).  Cognitive load reduces the effects of optic flow on gait and electrocortical dynamics during treadmill walking. J Neurophysiol., Aug 1, E-pub ahead of print.</li>
<li>Foxe JJ, Molholm S, Baudouin SJ, Wallace MT. Explorations and perspectives on the neurobiological bases of autism spectrum disorder. Eur J Neurosci. 2018 Mar;47(6):488-496. doi: 10.1111/ejn.13902. PMID: 29575230.</li>
<li> Beker S, Foxe JJ, Molholm S. Ripe for solution: Delayed development of multisensory processing in autism and its remediation. Neurosci Biobehav Rev. 2018 Jan;84:182-192. doi: 10.1016/j.neubiorev.2017.11.008. Epub 2017 Nov 21. PMID: 29162518; PMCID: PMC6389331.</li>
<li>Crosse MJ, Zuk NJ, Di Liberto GM, Nidiffer AR, Molholm S, Lalor EC. Linear Modeling of Neurophysiological Responses to Speech and Other Continuous Stimuli: Methodological Considerations for Applied Research. Front Neurosci. 2021 Nov 22;15:705621. doi: 10.3389/fnins.2021.705621. PMID: 34880719; PMCID: PMC8648261.</li>
<li>Fagiolini M, Patrizi A, LeBlanc J, Jin LW, Maezawa I, Sinnett S, Gray SJ, Molholm S, Foxe JJ, Johnston MV, Naidu S, Blue M, Hossain A, Kadam S, Zhao X, Chang Q, Zhou Z, Zoghbi H. Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl- CpG Binding Protein 2-related Disorders. Neuroscience. 2020 Oct 1;445:190-206. doi: 10.1016/j.neuroscience.2020.04.037. Epub 2020 Apr 29. PMID: 32360592; PMCID: PMC8025698.</li>
<li>Smirnov K, Stroganova T, Molholm S, Sysoeva O. Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies. Int J Mol Sci. 2021 May 18;22(10):5308. doi: 10.3390/ijms22105308. PMID: 34069993; PMCID: PMC8157853.</li>
<li> Schaaf RC, Mailloux Z, Ridgway E, Berruti AS, Dumont RL, Jones EA, Leiby BE, Sancimino C, Yi M, Molholm S. Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions. J Autism Dev Disord. 2022 Sep 27. doi: 10.1007/s10803-022-05763-0. Epub ahead of print. PMID: 36167886</li>
<li>Crosse MJ, Foxe JJ, Tarrit K, Freedman EG, Molholm S. Resolution of impaired multisensory processing in autism and the cost of switching sensory modality. Commun Biol. 2022 Jun 30;5(1):601. doi: 10.1038/s42003-022-03519-1. PMID: 35773473; PMCID: PMC9246932.</li>
<li>Ross LA, Molholm S, Butler JS, Bene VAD, Foxe JJ. Neural correlates of multisensory enhancement in audiovisual narrative speech perception: A fMRI investigation. Neuroimage. 2022 Nov;263:119598. doi: 10.1016/j.neuroimage.2022.119598. Epub 2022 Aug 30. PMID: 36049699.</li>
<li>Constantino JN, Abbacchi AM, Saulnier C, Klaiman C, Mandell DS, Zhang Y, Hawks Z, Bates J, Klin A, Shattuck P, Molholm S, Fitzgerald R, Roux A, Lowe JK, Geschwind DH. Timing of the Diagnosis of Autism in African American Children. Pediatrics. 2020 Sep;146(3):e20193629. doi: 10.1542/peds.2019-3629. PMID: 32839243; PMCID: PMC7461218.</li>
<li>Carbonell AU, Cho CH, Tindi JO, Counts PA, Bates JC, Erdjument-Bromage H, Cvejic S, Iaboni A, Kvint I, Rosensaft J, Banne E, Anagnostou E, Neubert TA, Scherer SW, Molholm S, Jordan BA. Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome. Nat Commun. 2019 Aug 6;10(1):3529. doi: 10.1038/s41467-019-11437-w. PMID: 31388001; PMCID: PMC6684583.</li>
<li>Wakim KM, Freedman EG, Tivarus ME, Christensen Z, Molholm S, Foxe JJ. Effects of Human Immunodeficiency Virus Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance. Neuroscience. 2022 Oct 15;502:77-90. doi: 10.1016/j.neuroscience.2022.08.008. Epub 2022 Aug 11. PMID: 35963584; PMCID: PMC9588737.</li>
<li>Francisco AA, Foxe JJ, Molholm S. Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis. J Neurodev Disord. 2023 Jun 16;15(1):19. doi: 10.1186/s11689-023-09487-9. PMID: 37328766; PMCID: PMC10273715.</li>
<li>Knight EJ, Krakowski AI, Freedman EG, Butler JS, Molholm S, Foxe JJ. Attentional influences on neural processing of biological motion in typically developing children and those on the autism spectrum. Mol Autism. 2022 Jul 18;13(1):33. doi: 10.1186/s13229-022-00512-7. PMID: 35850696; PMCID: PMC9290301.</li>
<li>Beker S, Foxe JJ, Molholm S. Oscillatory entrainment mechanisms and anticipatory predictive processes in children with autism spectrum disorder. J Neurophysiol. 2021 Nov 1;126(5):1783-1798. doi: 10.1152/jn.00329.2021. Epub 2021 Oct 13. PMID: 34644178; PMCID: PMC8794059.</li>
<li>Knight EJ, Freedman EG, Myers EJ, Berruti AS, Oakes LA, Cao CZ, Molholm S, Foxe JJ. Severely Attenuated Visual Feedback Processing in Children on the Autism Spectrum. J Neurosci. 2023 Mar 29;43(13):2424-2438. doi: 10.1523/JNEUROSCI.1192-22.2023. Epub 2023 Mar 1. PMID: 36859306; PMCID: PMC10072299.</li>
<li>Horsthuis DJ, Molholm S, Foxe JJ, Francisco AA. Event-related potential (ERP) evidence of early visual processing differences in cystinosis. bioRxiv [Preprint]. 2023 Apr 2:2023.03.31.535154. doi: 10.1101/2023.03.31.535154. PMID: 37034748; PMCID: PMC10081319.</li>
<li>De Sanctis P, Wagner J, Molholm S, Foxe JJ, Blumen HM, Horsthuis DJ. Neural signature of mobility-related everyday function in older adults at-risk of cognitive impairment. Neurobiol Aging. 2023 Feb;122:1-11. doi: 10.1016/j.neurobiolaging.2022.11.005. Epub 2022 Nov 9. PMID: 36463848; PMCID: PMC10281759.</li>
<li>Francisco AA, Foxe JJ, Horsthuis DJ, Molholm S. Early visual processing and adaptation as markers of disease, not vulnerability: EEG evidence from 22q11.2 deletion syndrome, a population at high risk for schizophrenia. Schizophrenia (Heidelb). 2022 Mar 21;8(1):28. doi: 10.1038/s41537-022-00240-0. PMID: 35314711; PMCID: PMC8938446.</li>
<li>Francisco AA, Foxe JJ, Horsthuis DJ, DeMaio D, Molholm S. Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome. Transl Psychiatry. 2020 Mar 5;10(1):85. doi: 10.1038/s41398-020-0764-3. PMID: 32139692; PMCID: PMC7058163.</li>
<li>Foxe JJ, Knight EJ, Myers EJ, Cao CZ, Molholm S, Freedman EG. The strength of feedback processing is associated with resistance to visual backward masking during Illusory Contour processing in adult humans. Neuroimage. 2022 Oct 1;259:119416. doi: 10.1016/j.neuroimage.2022.119416. Epub 2022 Jun 25. PMID: 35764208; PMCID: PMC9396416.</li>
<li>Berruti AS, Schaaf RC, Jones EA, Ridgway E, Dumont RL, Leiby B, Sancimino C, Yi M, Molholm S. Notes from an epicenter: navigating behavioral clinical trials on autism spectrum disorder amid the COVID-19 pandemic in the Bronx. Trials. 2022 Aug 19;23(1):691. doi: 10.1186/s13063-022-06635-9. PMID: 35986303; PMCID: PMC9389471.</li>
<li>Sysoeva OV, Molholm S, Djukic A, Frey HP, Foxe JJ. Atypical processing of tones and phonemes in Rett Syndrome as biomarkers of disease progression. Transl Psychiatry. 2020 Jun 10;10(1):188. doi: 10.1038/s41398-020-00877-4. PMID: 32522978; PMCID: PMC7287060.</li>
<li>Brima T, Molholm S, Molloy CJ, Sysoeva OV, Nicholas E, Djukic A, Freedman EG, Foxe JJ. Auditory sensory memory span for duration is severely curtailed in females with Rett syndrome. Transl Psychiatry. 2019 Apr 9;9(1):130. doi: 10.1038/s41398-019-0463-0. PMID: 30967526; PMCID: PMC6456588.</li>
<li>Beker S, Foxe JJ, Venticinque J, Bates J, Ridgeway EM, Schaaf RC, Molholm S. Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism. J Neurodev Disord. 2021 Sep 30;13(1):43. doi: 10.1186/s11689-021-09383-0. PMID: 34592931; PMCID: PMC8483424.</li>
<li>Francisco AA, Berruti AS, Kaskel FJ, Foxe JJ, Molholm S. Assessing the integrity of auditory processing and sensory memory in adults with cystinosis (CTNS gene mutations). Orphanet J Rare Dis. 2021 Apr 13;16(1):177. doi: 10.1186/s13023-021-01818-0. PMID: 33849633; PMCID: PMC8045394.</li>
<li>Malcolm BR, Foxe JJ, Joshi S, Verghese J, Mahoney JR, Molholm S, De Sanctis P. Aging-related changes in cortical mechanisms supporting postural control during base of support and optic flow manipulations. Eur J Neurosci. 2021 Dec;54(12):8139-8157. doi: 10.1111/ejn.15004. Epub 2020 Oct 27. PMID: 33047390.</li>
<li>Cotter M, Reisli S, Francisco AA, Wakim KM, Oakes L, Crosse MJ, Foxe JJ, Molholm S. Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder. J Neurodev Disord. 2023 Apr 1;15(1):11. doi: 10.1186/s11689-023-09480-2. PMID: 37005597; PMCID: PMC10068141.</li>
<li>Shaw LH, Freedman EG, Crosse MJ, Nicholas E, Chen AM, Braiman MS, Molholm S, Foxe JJ. Operating in a Multisensory Context: Assessing the Interplay Between Multisensory Reaction Time Facilitation and Inter-sensory Task-switching Effects. Neuroscience. 2020 Jun 1;436:122-135. doi: 10.1016/j.neuroscience.2020.04.013. Epub 2020 Apr 20. PMID: 32325100.</li>
<li>De Sanctis P, Malcolm BR, Mabie PC, Francisco AA, Mowrey WB, Joshi S, Molholm S, Foxe JJ. Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: Deriving EEG-based neuro-markers during a dual-task walking study. Clin Neurophysiol. 2020 May;131(5):1119-1128. doi: 10.1016/j.clinph.2020.01.024. Epub 2020 Feb 21. PMID: 32200093; PMCID: PMC7196176.</li>
<li>Malcolm BR, Foxe JJ, Butler JS, Mowrey WB, Molholm S, De Sanctis P. Long- term test-retest reliability of event-related potential (ERP) recordings during treadmill walking using the mobile brain/body imaging (MoBI) approach. Brain Res. 2019 Aug 1;1716:62-69. doi: 10.1016/j.brainres.2017.05.021. Epub 2017 May 19. PMID: 28532853; PMCID: PMC7209996.</li>
<li>Foxe JJ, Del Bene VA, Ross LA, Ridgway EM, Francisco AA, Molholm S. Multisensory Audiovisual Processing in Children With a Sensory Processing Disorder (II): Speech Integration Under Noisy Environmental Conditions. Front Integr Neurosci. 2020 Jul 14;14:39. doi: 10.3389/fnint.2020.00039. PMID: 32765229; PMCID: PMC7381232.</li>
<li>Malcolm BR, Foxe JJ, Butler JS, Molholm S, De Sanctis P. Cognitive load reduces the effects of optic flow on gait and electrocortical dynamics during treadmill walking. J Neurophysiol. 2018 Nov 1;120(5):2246-2259. doi: 10.1152/jn.00079.2018. Epub 2018 Aug 1. PMID: 30067106; PMCID: PMC6295527.</li>
<li>Francisco AA, Foxe JJ, Berruti A, Horsthuis DJ, Molholm S. Response inhibition and error-monitoring in cystinosis (CTNS gene mutations): Behavioral and electrophysiological evidence of a diverse set of difficulties. bioRxiv [Preprint]. 2023 Apr 2:2023.03.31.535145. doi: 10.1101/2023.03.31.535145. PMID: 37034772; PMCID: PMC10081337.</li>
<li>Francisco AA, Horsthuis DJ, Popiel M, Foxe JJ, Molholm S. Atypical response inhibition and error processing in 22q11.2 Deletion Syndrome and schizophrenia: Towards neuromarkers of disease progression and risk. Neuroimage Clin. 2020;27:102351. doi: 10.1016/j.nicl.2020.102351. Epub 2020 Jul 17. PMID: 32731196; PMCID: PMC7390764.</li>
<li>Francisco AA, Foxe JJ, Horsthuis DJ, Molholm S. Impaired auditory sensory memory in Cystinosis despite typical sensory processing: A high-density electrical mapping study of the mismatch negativity (MMN). Neuroimage Clin. 2020;25:102170. doi: 10.1016/j.nicl.2020.102170. Epub 2020 Jan 11. PMID: 31954986; PMCID: PMC6965721.</li>
<li>Molholm S, Murphy JW, Bates J, Ridgway EM, Foxe JJ. Multisensory Audiovisual Processing in Children With a Sensory Processing Disorder (I): Behavioral and Electrophysiological Indices Under Speeded Response Conditions. Front Integr Neurosci. 2020 Feb 11;14:4. doi: 10.3389/fnint.2020.00004. PMID: 32116583; PMCID: PMC7026671.</li>
<li>Williams ZJ, Schaaf R, Ausderau KK, Baranek GT, Barrett DJ, Cascio CJ, Dumont RL, Eyoh EE, Failla MD, Feldman JI, Foss-Feig JH, Green HL, Green SA, He JL, Kaplan-Kahn EA, Keçeli-Kaysılı B, MacLennan K, Mailloux Z, Marco EJ, Mash LE, McKernan EP, Molholm S, Mostofsky SH, Puts NAJ, Robertson CE, Russo N, Shea N, Sideris J, Sutcliffe JS, Tavassoli T, Wallace MT, Wodka EL, Woynaroski TG. Examining the Latent Structure and Correlates of Sensory Reactivity in Autism: A Multi-site Integrative Data Analysis by the Autism Sensory Research Consortium. Res Sq [Preprint]. 2023 Jan 10:rs.3.rs-2447849. doi: 10.21203/rs.3.rs-2447849/v1. PMID: 36712092; PMCID: PMC9882639.</li>
<li>Reisli S, Molholm S. Pre-attentive representation of prediction certainty in autism: A mismatch negativity (MMN) study. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543878. doi: 10.1101/2023.06.06.543878. PMID: 37333250; PMCID: PMC10274699.</li>
<li>Wakim KM, Foxe JJ, Molholm S. Cued motor processing in autism and typical development: A high-density electrical mapping study of response-locked neural activity in children and adolescents. Eur J Neurosci. 2023 Jun 20. doi: 10.1111/ejn.16063. Epub ahead of print. PMID: 37340622.</li>
</ol>
Review Articles, commentaries, and chapters:   
<ol>
<li>Gomes, H., Molholm, S., Christodoulou, C., Ritter, W., & Cowan, N. (2000).  The development of auditory attention in children.  Frontiers in Bioscience, 5, d108-120.</li>
<li>Molholm, S. & Foxe, J.J. (2005).  Look 'hear', primary auditory cortex is active during lip-reading.  NeuroReport, 16, 123-124.</li>
<li>Schroeder, C.E.,  Molholm, S., Lakatos, P., Ritter, W., and Foxe, J.J. (2004). Human-Simian correspondence in the early cortical processing of multisensory cues. Cognitive Processing, 5, 140-151.</li>
<li>Foxe, J.J. & Molholm, S. (2009). Ten Years at the Multisensory Forum: Musings on the Evolution of a Field.  Brain Topography.  21: 149-54.</li>
<li>Molholm, S. & Foxe, J.J. (2010).  Making sense of multisensory integration.  European Journal of Neuroscience, 31, 1709-12.</li>
<li>Fiebelkorn, I. Foxe, J.J., & Molholm, S. (2012).  Attention and Multisensory Feature Integration. In Barry Stein (Ed.).  Handbook of Multisensory Processing (pp. 383-396). Cambridge, Massachusetts: MIT Press.</li>
<li>Foxe, J.J., Ross, L., & Molholm, S. (2012).  Multisensory Integration Deficits in Schizophrenia.  In Barry Stein (Ed.).  Handbook of Multisensory Processing (pp. 691-706). Cambridge, Massachusetts: MIT Press.</li>
<li>Hahn, N., Foxe, J.J., Molholm, S. (2014). Impairments of multisensory integration and cross-sensory learning as pathways to dyslexia. Neuroscience Biobehavioral Reviews, 47:384-92.</li>
<li>Beker, S., Foxe, J.J., Molholm, S. (2018). Ripe for solution: Delayed development of multisensory processing in autism and its remediation. Neuroscience Biobehavioral Reviews, 84:182-192.</li>
<li>Foxe, J.J., Molholm, S., Baudouin, S.J., Wallace, M.T. (2018).  Explorations and perspectives on the neurobiological bases of autism spectrum disorder.  European Journal of Neuroscience, 47, 488-496.</li>
<li>Rimmele, J.M., Gross, J., Molholm, S., Keitel, A.  Editorial: Brain Oscillations in Human Communication. Front Hum Neurosci., Feb 7;12:39.</li>
</ol>

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David M. Loeb

Read more about David M. Loeb

David M. Loeb

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Provider

Faculty

Expert

First Name

David

Last Name

Loeb

NPI

1841236676

Faculty ID

15556

CMO Specialties

Pediatric Hematology-Oncology

Clinical Terms

Myelodysplastic Syndromes

Ankle Pain

Chronic Lymphocytic Leukemia

Thrombocytopenia

Suicidal Thoughts

Hospital-Associated Pneumonia

Acute Lymphoblastic Leukemia

Hypertensive Emergency

Abnormal Uterine Bleeding

Knee Pain

Chronic Constipation

CMV Infection

Urinary Tract Infection

Acute Respiratory Distress Syndrome

Hydronephrosis

Unresolved or Complicated Grief

Bone Marrow Transplant

Headaches in Children

Diabetic Peripheral Neuropathy

Mucositis

Boil

Headache

Numbness And Tingling

Grief

Lung Nodules

Secondary Adrenal Insufficiency

Fever

Addison's Disease

Opioid Overdose

Clostridium Difficile Colitis

Secondary High Blood Pressure

Painful Urination

Blood In Stool

Embolism And Thrombosis

Acute Pancreatitis

Deep Vein Thrombosis (DVT)

Elevated Blood Pressure

Hemorrhoids

Congenital Hydrocephalus

Disruptive Behavior Disorder

Peripheral Neuropathy

Abdominal Pain

Electrolyte Imbalance

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

einstein-dept-developmental-molecular-biology

Gender

Male

david.loeb@einsteinmed.edu

Phone

718-920-4664

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Pediatric Hematology-Oncology

Type

Academic

Department

Department of Developmental & Molecular Biology

Department Link

Rank

Professor

Type

Clinical

Title

Chief, Division of Pediatric Hematology, Oncology, and Cellular Therapy

Type

Clinical

Title

Director, Sarcoma Program

Type

Clinical

Title

Professor, Pediatrics and Developmental and Molecular Biology

Lisa H. Shulman

Read more about Lisa H. Shulman

Lisa H. Shulman

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Provider

Faculty

Expert

First Name

Lisa

Last Name

Shulman

NPI

1669538500

Faculty ID

6414

CMO Specialties

Developmental Pediatrics

Clinical Terms

Tic Disorders

Autism

Autism Spectrum Disorder

Personality Disorders

Oppositional Defiant Disorder

Central Auditory Processing Disorder

Learning Disabilities

Disruptive Behavior Disorder

Anxiety

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Gender

Female

lshulman@montefiore.org

Phone

718-430-8500

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Developmental Medicine

Type

Clinical

Title

Professor of Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8464 40.85274)

Address Line 1

1225 Morris Park Avenue

City

Bronx

State

Zip

10461-1900

Location Title

CERC/Rose F. Kennedy Center

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Van Etten

Room

1B33

Address Line 1

Albert Einstein College of Medicine

Address Line 3

1225 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Education and Trainings

Education Type Label

Medical Education

Education Institution

University of Pennsylvania

Education Type Label

Fellowship

Education Institution

Montefiore Medical Center

Education Type Label

Residency

Education Institution

The Mt. Sinai Hospital, NY

Professional Interests

Lisa Shulman, M.D., is a leading developmental pediatrician who specializes in diagnosing and treating children with autism spectrum disorders (ASD) and other developmental and learning disabilities.
Dr. Shulman serves as the director of Infant Toddler Services at Montefiore’s Children’s Evaluation and Rehabilitation Center (CERC), which provides family-based diagnostic assessment and treatment services for young children who have or are suspected of having developmental delays. She also directs CERC’s RELATE program, which offers evaluation and treatment for young children with autism and ASD.
Her research interests include early identification of autism, healthcare disparity in autism diagnosis and management, and the use of complementary and alternative medicine in treating autism.
Dr. Shulman recently led a study that characterized the residual learning and cognitive needs of school-aged children whose early ASD diagnosis resolved. The study showed that most children who outgrow their autism diagnosis still struggle with emotional, behavioral or leaning difficulties later in life.

Specialties

Pediatrics

Expert Tags

Neurodevelopmental Pediatrics

Autism

Areas of Expertise

Causes of Autism

Developmental delays associated with Genetic syndromes

General child development

Idiopathic toe-walking

Language regression

Medical issues of children in foster care

Medical perspectives in autism

Parent advocacy for children with disabilities

Expert Summary

Dr. Shulman is a developmental pediatrician and a neurodevelopmental pediatrician with special expertise in autism spectrum disorders (ASD) and learning disabilities. Her research interests include early identification of autism, evidence-based treatments, healthcare disparities in autism diagnosis and management, and complementary and alternative medicine usage in autism.
Dr. Shulman is the Interim Director of the Children’s Evaluation & Rehabilitation Center (CERC) at the Children’s Hospital at Montefiore. She is the Director of Autism Services at the program which follows over 2,000 children with autism from early childhood through adulthood and provides appropriate medical and educational services in a “one-stop shopping” model. She is also the Director of the Infant Preschool Team which provides diagnostic assessment of young children who have or are suspected of having developmental delays. She is the Director of the nationally funded Leadership Education in Neurodevelopmental Disabilities (LEND) training program at the center. Dr. Shulman is on the Autism Executive Committee of the Council on Children with Disabilities of the National American Academy of Pediatrics. She is the Centers for Disease Control Act Early Ambassador Emeritus to New York state.

Research Profile

https://einsteinmed.edu/faculty/6414/Lisa-Shulman

Clinical Profile

https://montefioreeinstein.org/profiles/1669538500/lisa-h-shulman

CHAM Provider

Professional Title

M.D.

Clinical Focus

Early identification of autism spectrum disorder (ASD), long-term management and treatment of ASD, diagnostic clarification of developmental and behavioral issues manifesting in infants and toddlers, early intervention, idiopathic toe-walking

Research Focus

Practice Emphasis: Developmental pediatrics consultation; multidisciplinary diagnostic evaluation, treatment and medical management of young children with developmental delay and/or behavioral issues; particular expertise in the early diagnosis of ASD

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/3cc398e1-c47d-4b3e-8ac2-f92561d3a…

EMR ID

3888

Biography

Lisa Heidi Shulman, MD, is Professor of Pediatrics at Albert Einstein College of Medicine. Since joining the Montefiore team, her clinical focus has been on the early identification and long-term management of children with autism spectrum disorder (ASD), as well as improving access to care for our community, identification and management of early motor delays and toe walking gait. In 1983, Dr. Shulman received a Bachelor of Science in Applied Mathematics/Psychology at Brown University. She then attended the University of Pennsylvania School of Medicine, where she received her Doctor of Medicine in 1987. Dr. Shulman began her postgraduate training in 1987 with a 3-year internship and residency in Pediatrics at Mount Sinai Medical Center. In 1992, she completed a clinical fellowship in Pediatric Neurodevelopment at the Rose F. Kennedy Center, Children’s Evaluation and Rehabilitation Center at Albert Einstein College of Medicine.Aligning with her clinical interests, her research also focuses on other aspects of ASD, including early diagnosis, developmental outcomes in children with an early diagnosis, comorbid medical and developmental problems, parental stress and complementary and alternative medicine usage in ASD. Dr. Shulman is involved in numerous projects involving ASD, including one that began in 2019 that aims to identify the causes of ASD by carrying out genetic testing, phenotyping, and demographic profiles on the parents of children with ASD. Her work has been shared nationally at presentations and lectures and has been published in a number of peer-reviewed journals, books, review articles and abstracts. She is a featured contributor for Einstein’s blog, the Doctor’s Tablet (<a href="https://blogs.einsteinmed.edu/">https://blogs.einsteinmed.edu/</a>) and has produced popular videos demonstrating baby milestones (<a href="https://www.youtube.com/watch?v=pZSjm0drIGM">https://www.youtube.com/wa… 2008 to 2019, Dr. Shulman has been named one of “New York’s Super Doctors: Best Physicians as Chosen by Their Peers.” She served as the Centers for Disease Control Act Early Ambassador to New York State from 2016-2019. Dr. Shulman is board certified by the American Board of Pediatrics in Pediatrics as well as Developmental and Behavioral Pediatrics. She sits on the National Autism Subcommittee of the American Academy of Pediatrics, and is a member of the Society for Developmental and Behavioral Pediatrics, and the International Society for Autism Research.

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Lauren T. Roth

Read more about Lauren T. Roth

Lauren T. Roth

https://assets.montefioreeinstein.org/profiles/images/lauren-roth.jpg

Provider

Faculty

First Name

Lauren

Last Name

Roth

NPI

1710349063

Faculty ID

16220

CMO Specialties

Pediatrics

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Gender

Female

Provider Type

Primary Care

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Assistant Professor

Division

Academic General Pediatrics

Type

Clinical

Title

Attending Physician, Academic General Pediatrics, Children's Hospital at Montefiore

Type

Clinical

Title

Director, Service-Learning Course, Albert Einstein College of Medicine

Type

Clinical

Title

Assistant Professor, Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84544 40.84518)

Address Line 1

1621 Eastchester Road

City

Bronx

State

Zip

10461-2301

Location Title

Montefiore Medical Group-Comprehensive Family Care Center (CFCC)

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Block

Room

107

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Jack and Pearl Resnick Campus

Address Line 3

1300 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Education and Trainings

Education Type Label

Medical Education

Education Institution

Albert Einstein College of Medicine

Education Type Label

Residency

Education Institution

New York Presbyterian Hospital

Professional Interests

Lauren Roth, MD, is an Assistant Professor of Pediatrics at Albert Einstein College of Medicine and an Attending Physician in the Division of Academic General Pediatrics at the Children’s Hospital at Montefiore. Dr. Roth provides pediatric primary care at the Comprehensive Family Care Center (CFCC).
Dr. Roth received her Bachelor of Science in Neuroscience and Behavioral Biology at Emory University. She attended medical school at Albert Einstein College of Medicine where she was inducted into the Alpha Omega Alpha and Gold Humanism Honor Societies. She completed her residency in pediatrics at New York-Presbyterian/Columbia University Medical Center and was awarded the “Super Senior” Resident of the Year Award during her final postgraduate year.
Dr. Roth is board certified in pediatrics. She is a fellow of the American Academy of Pediatrics (AAP) and a member of the Academic Pediatric Association (APA). She serves on multiple local and national committees related to undergraduate and graduate medical education. In 2022, Dr. Roth was appointed as the inaugural Director of Albert Einstein College of Medicine’s 4-year longitudinal Service-Learning Course. She received the Award for Innovation in Medical Student Education (AIMSE) at Einstein in 2022 and the National Board of Medical Examiner’s (NBME) Emerging Innovators Grant in 2023 for her work developing a 360-assessment tool for service-learning. Dr. Roth received the Academic Pediatric Association Early Career Teaching Award at the Pediatric Academic Society 2024 Annual Meeting. She was selected to the 11th Cohort of the Academic Pediatric Association Educational Scholars Program. In 2025, she was inducted into the Leo M. Davidoff Society. Dr. Roth will also receive the 2025 Rising Star – Clinical Practitioner Award from the Albert Einstein College of Medicine Alumni Association.
Dr. Roth has presented and published widely in the field of medical education. Her NCBI Bibliography can be found here: <a href="https://www.ncbi.nlm.nih.gov/myncbi/lauren.roth.1/bibliography/public/&…; target="_blank" rel="noopener noreferrer">https://www.ncbi.nlm.nih.gov/myncbi/lauren.roth.1/bibliography/public/<…;

Specialties

Pediatrics

Areas of Expertise

Pediatric Primary Care

Medical School and Resident Education

LGBTQ+ Youth healthcare

Gender-affirming care for transgender youth

Expert Summary

Dr. Roth, has particular expertise in caring for LGBTQ+ youth, gender-affirming care for transgender youth, and ways to educate pediatric faculty and trainees regarding clinical practice and treatment guidelines for children with gender dysphoria. Her work has been published in a number of peer-reviewed journals and articles.

Research Profile

https://einsteinmed.edu/faculty/16220/Lauren-Roth

Clinical Profile

https://montefioreeinstein.org/profiles/1710349063/lauren-t-roth

CHAM Provider

Professional Title

M.D.

Clinical Focus

Pediatric Primary Care

Research Focus

Medical Education, Innovation in Medical Education, Service-Learning, Social Determinants of Health, Quality Improvement in General Pediatrics<quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/a61dfdb2-5463-4d2f-b37d-2dac1e697…

EMR ID

113092

Biography

Lauren T. Roth, MD, is an attending physician and Assistant Professor, Pediatrics at Montefiore Einstein. Her clinical focus centers on pediatric primary care.After obtaining her Bachelor of Science in neuroscience and behavioral biology from Emory University in 2012, Dr. Roth earned her Doctor of Medicine at Einstein in 2016. She then completed her pediatrics residency at NewYork-Presbyterian/Columbia University Medical Center in 2019.Building on her clinical focus, Dr. Roth’s research focuses on innovation in medical education, service-learning, social determinants of health and quality improvement in general pediatrics. Her work has been published in numerous peer-reviewed journals, and she has given invited presentations nationally and internationally.Dr. Roth is board certified by the American Board of Pediatrics and is a Fellow of the American Academy of Pediatrics. She is a member of the Academic Pediatric Association. In 2015, Dr. Roth was inducted into the Alpha Omega Alpha and Gold Humanism Honor Societies. In 2022, she received the Award for Innovation in Medical Student Education (AIMSE) from Einstein and was appointed as the inaugural Director of Einstein’s new Service-Learning Course.

Visit Type ID

2558

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Jessica Rieder

Read more about Jessica Rieder

Jessica Rieder

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Provider

Faculty

Expert

First Name

Jessica

Last Name

Rieder

NPI

1053496414

Faculty ID

1063

CMO Specialties

Adolescent Medicine

Pediatrics

Clinical Terms

Low Blood Sugar In Diabetes

Acanthosis Nigricans

Gestational Diabetes Diet

Personality Disorders

Altered Mental Status

Seasonal Affective Disorder

Difficulty Swallowing

Anal Pain

Acute Urinary Retention

Herpes Simplex

Headache

Iron Deficiency Anemia

Hepatitis

Ovarian Cysts

Pelvic Inflammatory Disease

Hyperthyroidism

Postoperative Pain

Functional Ovarian Cysts

Abnormal Uterine Bleeding

Shingles

Kidney Infection

Peritonsillar Abscess

Hypertensive Emergency

Suicidal Thoughts

Borderline Personality Disorder

Nutritional Counseling

Myositis

Drug Abuse and Intoxication

Biliary Colic

Anemia

Polycystic Ovary Syndrome

Orthostatic Hypotension

Secondary Adrenal Insufficiency

Chronic Constipation

Scoliosis

Binge Eating Disorder

Abnormal Respirations

Lung Infection

Lower Respiratory Tract Infection

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Gender

Female

jrieder@montefiore.org

Phone

718-920-6781

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Associate Professor

Division

Adolescent Medicine

Type

Clinical

Title

Director of B'N Fit Power Program

Type

Clinical

Title

Attending Physician, Division of Adolescent Medicine, Children's Hospital at Montefiore

Type

Clinical

Title

Director of Impact Course, Albert Einstein College of Medicine

Type

Clinical

Title

Associate Professor of Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Type

Administrative

Title

Director, MD Scholarly Impact and Research Program

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8791698 40.880273)

Room

Address Line 1

Montefiore Medical Center

Address Line 2

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

University of Alberta

Education Type Label

Fellowship

Education Institution

Montefiore Medical Center

Education Type Label

Residency

Education Institution

Montefiore Medical Center

Professional Interests

Jessica Rieder, MD, MS, a board-certified specialist in adolescent medicine, is Associate Professor of Pediatrics at the Albert Einstein College of Medicine of Yeshiva University. She earned her bachelor’s degree in biochemistry and M.D. degree with honors in research from the University of Alberta. She completed her clinical training including pediatric residency, chief residency, and adolescent medicine fellowship at the Children’s Hospital at Montefiore.  She joined the pediatric faculty at Einstein/Montefiore upon completion of her fellowship and subsequently earned a master’s degree in clinical research from the Albert Einstein College of Medicine of Yeshiva University.
Dr. Rieder has been engaged in action-oriented, policy-relevant research which has been informed by the weight management efforts that have been the focus of her career for over a decade. She is the founder and director of the Bronx Nutrition and Fitness Initiative for Teens (B’N Fit), a joint venture between the Children’s Hospital at Montefiore and the Mosholu Montefiore Community Center (MMCC). She has had extensive experience with the development, administration, and evaluation of B’N Fit, which offers comprehensive weight management programming for inner-city youth, ages 12-21 years. She has an interest in the clinical and behavioral management of adolescent obesity as well as clinical care access issues that prevent impoverished adolescents from accessing weight management services. A decade-long partnership with MMCC and more recently with the Montefiore School Health Program has resulted in youth-focused school-based afterschool programming that aims to  more effectively support a population characterized by significant psychosocial stressors, economic crisis, developing autonomy and noncompliance.  Dr. Rieder continues to enjoy partnering with clinical, research, community, advocacy, administrative, technology, and educational collaborators to design initiatives that engage and support youth and families interested in lifestyle programming that promotes long-term health and prevents illness.

Specialties

Pediatrics

Expert Tags

Adolescent Medicine

Obesity

Areas of Expertise

Obesity in Children and Adolescents

Lifestyle and Diet Modifications for Weight Loss

Complications of Obesit

Childhood Obesity Prevention

Expert Summary

Dr. Rieder, is a board-certified specialist in adolescent medicine and the founder and director of the Bronx Nutrition and Fitness Initiative for Teens (B’N Fit) weight management program. Dr. Rieder’s academic interests include adolescent obesity and its complications, in particular, ovarian hyperandrogenism or polycystic ovary syndrome.

Research Profile

https://einsteinmed.edu/faculty/1063/Jessica-Rieder

Clinical Profile

https://montefioreeinstein.org/profiles/1053496414/jessica-rieder

CHAM Provider

Professional Title

M.D.

M.S.

Clinical Focus

Adolescent medicine, adolescent gynecology, adolescent obesity

Research Focus

Adolescent obesity, adolescent gynecology with research interests in weight management program evaluations and polycystic ovarian syndrome

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/fa446ec4-3d5d-4a0f-8eb1-9c28f79e4…

Selected Publications

Link to Complete List of Published Work in My Bibliography.  
 
<a href="http://www.ncbi.nlm.nih.gov/sites/myncbi/1rcYFranZwvAc/bibliography/487… style="background: white; padding: 0in; border: 1pt windowtext; color: #2f4a8b; mso-bidi-font-size: 8.0pt; mso-bidi-font-family: Arial; mso-border-alt: none windowtext 0in;">http://www.ncbi.nlm.nih.gov/sites/myncbi/1rcYFranZwvAc/bibliography/487…;

EMR ID

4076

Biography

Jessica Rieder, MD, a board-certified specialist in adolescent medicine, is Associate Clinical Professor of Pediatrics at Albert Einstein College of Medicine. She is founder and Director of the Bronx Nutrition and Fitness Initiative for Teens (B’N Fit) weight management program, a joint venture between The Children’s Hospital at Montefiore and the Mosholu Montefiore Community Center.Dr. Rieder earned her bachelor’s degree in biochemistry from the University of Alberta in 1990 and her MD degree with honors in research from the same university in 1994. She completed her clinical training, including pediatric residency, chief residency and adolescent medicine fellowship, at The Children’s Hospital at Montefiore. She joined the pediatric faculty at Einstein and Montefiore upon completion of her fellowship in 2001. In 2003 Dr. Rieder earned a master’s degree in clinical research from Albert Einstein College of Medicine.Dr. Rieder’s academic interests include adolescent obesity and its complications, in particular, ovarian hyperandrogenism or polycystic ovary syndrome. As Director of the B’N Fit Program, she oversees a clinical and research team of physicians, a nutritionist, a social worker, and administrative and support staff. Dr. Rieder is funded through the Department of Health and Human Services Health Resources and Services Administration, the New York State Health Foundation and private foundations to conduct short- and long-term effectiveness evaluations of the B’N Fit program.

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Suzette Olu Busola Oyeku

Read more about Suzette Olu Busola Oyeku

Suzette Olu Busola Oyeku

https://assets.montefioreeinstein.org/profiles/images/physphoto/Oyeku_Suzette_420x504.jpg

Provider

Faculty

Expert

First Name

Suzette

Last Name

Oyeku

NPI

1245332345

Faculty ID

10534

CMO Specialties

Clinical Terms

Attention deficit hyperactivity disorder (ADHD)

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Languages

Spanish

Gender

Female

Provider Type

Primary Care

soyeku@montefiore.org

Phone

718-484-5125

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Academic General Pediatrics

Type

Clinical

Title

Chief, Academic General Pediatrics

Type

Clinical

Title

Director, Academic General Pediatrics Fellowship, Children's Hospital at Montefiore

Type

Clinical

Title

Professor, Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Locations

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84544 40.84518)

Address Line 1

1621 Eastchester Road

City

Bronx

State

Zip

10461-2301

Location Title

Montefiore Medical Group-Comprehensive Family Care Center (CFCC)

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.88133 40.88109)

Address Line 1

3444 Kossuth Avenue

City

Bronx

State

Zip

10467-2241

Location Title

Montefiore Medical Group-Family Care Center (FCC)

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8782381 40.8799784)

Room

861

Address Line 1

Montefiore Medical Center

Address Line 3

3411 Wayne Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

New York University School of Medicine

Education Type Label

Fellowship

Education Institution

Childrens Hospital Boston

Education Type Label

Residency

Education Institution

Childrens Hospital Boston

Professional Interests

Dr. Oyeku is Chief of the Division of Academic General Pediatrics at the Children’s Hospital at Montefiore (CHAM). She is also Professor of Pediatrics at the Albert Einstein College of Medicine. Dr. Oyeku manages the clinical, research, advocacy and educational missions of the division in addition to being responsible for faculty and staff development. 
Dr. Oyeku is a general pediatrician with expertise in health services research, implementation science and the use of quality improvement methods to disseminate effective care strategies and improve care and patient outcomes for children with chronic diseases such as sickle cell disease. Dr. Oyeku’s clinical activities are focused on providing pediatric primary care and inpatient care at Children’s Hospital at Montefiore. Dr. Oyeku also has expertise providing specialized care to children and adolescents with sickle cell disease.
Dr. Oyeku’ s research activities are focused on understanding health services utilization patterns and improving the quality of care for children and adolescents with sickle cell disease. Dr. Oyeku also serves as Medical Director for the Health Resources and Services Administration (HRSA) funded Sickle Cell Disease Treatment Demonstration Program National Coordinating Center at the National Institute for Children’s Health Quality (NICHQ). (<a href="https://www.nichq.org/project/sickle-cell-disease-treatment-demonstrati…;)
On a regional and national level, Dr. Oyeku has also served on advisory panels and committees focused on sickle cell disease and improving healthcare quality for children and adolescents. She completed a three year term as the Treasurer for the Academic Pediatrics Association, a professional society representing 2,000 child health providers in the US.
She holds a Bachelor’s of Science degree in Biomedicine from the Sophie Davis School of Biomedical Education at the City College of New York. Dr. Oyeku received her medical degree from the New York University School of Medicine and completed her pediatric residency training at the Boston Combined Residency Program in Pediatrics at Boston Medical Center and Boston Children’s Hospital. Dr. Oyeku also completed fellowship training at the Harvard Pediatric Health Services Research Fellowship program at Boston Children’s Hospital. She received her Master’s degree in Public Health with a concentration in clinical effectiveness at the Harvard School of Public Health.  She is also a graduate of the Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM), a program of Drexel University College of Medicine. Dr. Oyeku is also actively engaged in community education activities and serves as an ordained deacon at Grace Baptist Church in Mount Vernon, NY.

Specialties

Pediatrics

Expert Tags

General Pediatrics

Chronic Disease

Areas of Expertise

Pediatric Primary Care

Children's Vaccinations

Expert Summary

Dr. Oyeku, is a general pediatrician who has expertise in health services research. She has focused her career on improving care and outcomes for children with chronic diseases, such as sickle cell disease. Dr. Oyeku is actively engaged in community education and advocacy.

Research Profile

https://einsteinmed.edu/faculty/10534/Suzette-Oyeku

Clinical Profile

https://montefioreeinstein.org/profiles/1245332345/suzette-olu-busola-oyeku

CHAM Provider

Professional Title

M.D.

M.P.H.

Clinical Focus

Pediatric Medicine<quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/6b72b18a-0c38-4a6c-b27c-960d481b1…

Selected Publications

<a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1tImkp-hZ18Ae/bibliography/45…;
Selected List of Publications below:
1. Grosse SD, Boulet SL, Amendah D, Oyeku SO. Administrative Datasets and Health Services Research on Hemoglobinopathies. American Journal of Preventive Medicine. 2010; 38(4S) S557-S567
2. Raphael JL, Mueller BU. Mueller, Kowalkowski MA, Oyeku SO, Shorter Hospitalization Trends Among Children with Sickle Cell Disease. Pediatr Blood Cancer. 2012 Oct; 59(4):679-84. Epub 2012 Jan 4.
3. Wang Y,Kennedy J, Caggana M, Zimmerman R, Thomas S, Berninger J, Harris K, Green NS, Oyeku S, Hulihan M, Grant AM, Grosse SD. Sickle Cell Disease Incidence among Newborns in New York State by Maternal Race/Ethnicity and Nativity. Genet Med. 2013 Mar; 15(3):222-8.Epub 2012 Sep 27. 
4.  Oyeku SO, Driscoll MC, Cohen HW, Trachtman R, Pashankar F, Mullen C, Giardina PJ, Velazco N, Racine AD, Green NS.  Parental and Other Factors Associated with Hydroxyurea Use for Pediatric Sickle Cell Disease.Pediatr Blood Cancer. 2013 Apr; 60(4):653-8. Epub 2012 Nov 5
5.Wang WC, Oyeku SO, Luo Z, Boulet SL, Miller ST, Casella JF, Fish B, Thompson BW, Grosse SD; for the BABY HUG Investigators. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23999955">Hydroxyurea Is Associated With Lower Costs of Care of Young Children With Sickle Cell Anemia.</a> Pediatrics.2013 Sep 2. [Epub ahead of print]
6.Raphael JL, Oyeku SO. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24319216">Sickle cell disease pain management and the medical home.</a> Hematology Am Soc Hematol Educ Program. 2013; 2013:433-8.
7. Developing a Unified Approach for Sickle Cell Disease. Supplement to American Journal of Preventive Medicine. Guest Editors: Suzette O. Oyeku, Jean L. Raphael, Cynthia H. Cassell and Mary M. Hulihan. Volume 51(1) Supplement 1. July 2016 <a href="https://www.ajpmonline.org/issue/S0749-3797(16)X0014-1?code=amepre-site…;
8. Faro EZ. Wang CJ. Oyeku SO. Quality of Care Indicator Development for Follow-up of Positive Screens for Sickle Cell Disease. American Journal of Preventive Medicine, 2016 Jul; 51(1 Suppl 1):S48-54
9.Frost JR, Cherry RK, Oyeku SO, Faro E, Crosby L, Britto M, Tuchman L, Horn I, Homer C, Jain A. Improving Sickle Cell Transitions of Care Through Health Information Technology. American Journal of Preventive Medicine.  2016 Jul;51(1 Suppl 1): S17-23
10. Homer CJ, Oyeku SO. Sickle Cell Disease: A Roadmap for Getting to Excellence Everywhere. American Journal of Preventive Medicine 2016 Jul;51(1 Suppl 1): S3-4
11. Brown NM,Brown SN, Briggs RD, German M, Belamarich PF, Oyeku SO,  Associations between adverse childhood experiences and ADHD diagnosis and severity. Academic Pediatrics 2017 May - Jun; 17(4):349-355
12.Fuller A, Messito MJ, Mendelsohn AL, Oyeku SO, Gross RS. <a href="https://www.ncbi.nlm.nih.gov/pubmed/29729425">Prenatal Material Hardships and Infant Regulatory Capacity at 10 Months Old in Low-Income Hispanic Mother-Infant Pairs.</a> Acad Pediatr. 2018 Nov-December; 18(8):897-904; Epub 2018 May 2.
13. Crosby, LE, Walton, A, Shook, LM, Ware, RE, Treadwell, M, Saving, KL, Britto, M, Peugh,         J, McTate, E, Oyeku, S, Nwankwo, C, & Brinkman, WB. Development of a Hydroxyurea Decision Aid for Parents of Children with Sickle Cell Anemia. Journal of   Pediatric Hematology/Oncology. 2018 Jul 23. [Epub ahead of print]

EMR ID

4844

Biography

Suzette Oyeku, MD, MPH, is a general pediatrician and health services researcher. She is Associate Division Chief for Academic Affairs within the division of general pediatrics at CHAM. In this capacity, she oversees a broad array of activities, including stewardship of divisional research initiatives and faculty development activities.In addition to general pediatrics, Dr. Oyeku has particular interest in Quality Improvement, sickle cell disease, and faculty development and community education activities.Since 2008, Dr. Oyeku has served as Co-Director of Pediatric Grand Rounds at CHAM.Dr. Oyeku received her MD from NYU School of Medicine and her MPH from the Harvard T.H. Chan School of Public Health. She completed her residency at the Boston Combined Residency Program in Pediatrics, Department of Medicine, Boston Children's Hospital and Department of Pediatrics, Boston Medical Center.She also completed a Harvard Pediatric Health Services Research Fellowship Program at Boston Children's Hospital.Dr. Oyeku was a recipient of the Dean’s Award for Community Service from Harvard Medical School.

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Deepa G. Manwani

Read more about Deepa G. Manwani

Deepa G. Manwani

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Provider

Faculty

Expert

First Name

Deepa

Last Name

Manwani

NPI

1922077544

Faculty ID

11847

CMO Specialties

Pediatric Hematology-Oncology

Cancer

Clinical Terms

Deep Vein Thrombosis (DVT)

Embolism And Thrombosis

Stroke

Hemophilia

Tinea Versicolor

Temporal Lobe Epilepsy

Elevated Blood Pressure

Dilated Cardiomyopathy

Anemia

Viral Infections

Iron Deficiency Anemia

Chills

Weakness

Acute Chest Syndrome

Acute Lymphoblastic Leukemia

Cardiomyopathy

Vitamin D Deficiency

Myelodysplastic Syndromes

Chronic Pain Syndrome

Sickle Cell Trait

Learning Disabilities

Sarcoma

Transient Ischemic Attack

Headaches in Children

Left Ventricular Hypertrophy

Chronic Lymphocytic Leukemia

Aplastic Anemia

Lower Extremity Edema

Secondary High Blood Pressure

Umbilical Hernia

Pulmonary Atresia

Pulmonary Embolism

Intracranial Hemorrhage

Shingles

Leukemia

Arrhythmias

Lower Gastrointestinal Bleeding

Intraventricular Hemorrhage

Congenital Heart Defects

Lymphoma

FAST Stroke Symptoms

Runny Nose

Hypertensive Emergency

Hypoxemia

Sickle Cell Crisis

Reactive Airway Disease

Mononucleosis

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Languages

Hindi

Gender

Female

dmanwani@montefiore.org

Phone

718-741-2342

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Pediatric Hematology-Oncology

Type

Clinical

Title

Director of Hematology, Department of Pediatrics

Type

Clinical

Title

Professor, Department of Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Locations

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84154 40.84612)

Address Line 1

1250 Waters place

City

Bronx

State

Zip

10461-2720

Location Title

Montefiore at 1250 Waters Place

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

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Coordinates

POINT (-73.8791698 40.880273)

Building

Rosenthal Pavilion

Room

312

Address Line 1

Montefiore Medical Center

Address Line 2

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

B.J. Medical College

Education Type Label

Fellowship

Education Institution

Mount Sinai School of Medicine

Education Type Label

Residency

Education Institution

North Shore University Hospital - Manhasset

Education Type Label

Residency

Education Institution

B.J. Medical College

Specialties

Pediatrics

Expert Tags

Sickle Cell Anemia

Areas of Expertise

Sickle cell disease

Expert Summary

Dr. Manwani is a pediatric hematologist who leads the sickle cell team at CHAM. The team offers treatment and support for young children and teens with sickle cell disease and their families, including weekly support groups and an annual Sickle Cell Awareness Day event focused on new research and strategies for living with this disease.

Research Profile

https://einsteinmed.edu/faculty/11847/Deepa-Manwani

Clinical Profile

https://montefioreeinstein.org/profiles/1922077544/deepa-g-manwani

CHAM Provider

Professional Title

M.B.,B.S.

Clinical Focus

Benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis, thrombocytosis, leukocytosis.

Research Focus

Sickle Cell Disease: Novel therapies, Role of adhesion and neutrophils, Alloimmunization, Transition to adult care, Fetal hemoglobin induction, Gut Microbiome, Pain, Chronic Pain, Quality Improvement.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/cf7dba04-ee20-4d51-a71e-08787c60b…

EMR ID

5141

Biography

Deepa Manwani, MD, is Director, Pediatric Hematology at Children?s Hospital at Montefiore, as well as a Professor in the Department of Pediatrics at Albert Einstein College of Medicine. Dr. Manwani?s clinical focus is on benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis and leukocytosis. Dr. Manwani graduated from B.J. Medical College, Poona University, India, in 1991, earning her Doctor of Medicine. She became a Research Assistant at the Children?s Hospital Oakland in 1991 before beginning an internship in Pediatrics at NSUH-Cornell University Med Center in 1993. Following her internship, Dr. Manwani completed a residency in Pediatrics at the same institution. In 1996, she began a fellowship in Pediatrics Hematology/Oncology at Mount Sinai School of Medicine in New York. Dr. Manwani?s research focuses on fetal hemoglobin activating agents, adhesive cellular interactions in vaso-occlusion in sickle cell disease (SCD) and contribution of neutrophils to SCD pathophysiology. She completed the R01 funded Phase 1 study of IVIG in the treatment of SCD vaso-occlusive crises and is currently leading the R01 funded Phase II study. Dr. Manwani is currently participating in studies aimed at increased adherence to hydroxyurea and improved transition to adult care. She is also collaborating with investigators at Case Western Reserve University on an NHLBI R01 funded study to standardize monitoring of cellular adhesion in SCD patients using a novel microfluidic assay. Her contributions have been recognized by the Sickle Cell Thalassemia Patient Network of New York in the form of the Distinguished Service Award in March 2015. Dr. Manwani?s studies have been published nationally in various reviewed journals and books. Dr. Manwani has received many awards, including Castle Connolly Top Doctor in 2016, New York Magazine Best Doctor and New York Metro Area?s Top Doctors in 2017.

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Daphne T. Hsu

Read more about Daphne T. Hsu

Daphne T. Hsu

https://assets.montefioreeinstein.org/profiles/images/physphoto/Hsu_Daphne_MD_420x504-1.jpg

Provider

Faculty

Expert

First Name

Daphne

Last Name

Hsu

NPI

1689653321

Faculty ID

11172

CMO Specialties

Pediatric Cardiology

Adult Congenital Heart Disease

Clinical Terms

Pulmonary Valve Stenosis

Persistent Atrial Fibrillation

Fever

Lightheadedness

Mitral Valve Prolapse

Sick Sinus Syndrome

Heart Disease

Myocardial Ischemia

Aortic Valve Stenosis

Coronary Artery Disease

Coarctation Of The Aorta

Prader-Willi Syndrome

Bacterial Endocarditis

Pneumonia

Polymyalgia Rheumatica

Hypoxemia

Heart Murmur

Left Ventricular Hypertrophy

Tetralogy Of Fallot

Ventricular Septal Defect

Congenital Heart Defects

Vertigo

Ventricular Tachycardia

Anticoagulants

Patent Foramen Ovale

Shortness Of Breath

Pulmonary Hypertension

Palpitations

Chills

Vasovagal Syncope

Bicuspid Aortic Valve

Patent Ductus Arteriosus

Atrioventricular Septal Defect

Atrial Flutter

Mitral Valve Regurgitation

Supraventricular Tachycardia

Right-Sided Heart Failure

Hypoplastic Left Heart Syndrome

Dilated Cardiomyopathy

Hypertensive Emergency

Cardiomyopathy

Shingles

Wolff-Parkinson-White Syndrome

Chest Wall Pain

Premature Ventricular Contractions

Aortic Valve Regurgitation

Heart Failure With Reduced Ejection Fraction

Heart Valve Disease

Pericardial Effusion

Heart Failure

Rheumatic Heart Disease

Transposition Of Great Arteries

Dwarfism

Unconsciousness

Pulmonary Atresia

Employment Status

Per Diem

Patient Type

Pediatric

Department

einstein-dept-pediatrics

einstein-dept-medicine

Gender

Female

dhsu@montefiore.org

Phone

718-741-2538

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Clinical Professor

Division

Pediatric Cardiology

Type

Academic

Department

Department of Medicine

Department Link

Rank

Clinical Professor

Division

Cardiology

Type

Clinical

Title

Professor of Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Title

Chief, Division of Pediatric Cardiology

Type

Administrative

Title

Co-Director of the Pediatric Heart Center

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.76906 41.02342)

Address Line 1

33 Davis Avenue

City

White Plains

State

Zip

10605

Location Title

White Plains Hospital

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8791698 40.880273)

Address Line 1

Montefiore Medical Center

Address Line 2

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467

Location Title

Montefiore Medical Center

Education and Trainings

Education Type Label

Medical Education

Education Institution

Yale University School of Medicine

Education Type Label

Fellowship

Education Institution

Babies Hospital (Columbia)

Education Type Label

Residency

Education Institution

Babies Hospital (Columbia)

Professional Interests

Dr. Hsu’s main research efforts focus on improving outcomes in children and young adults with congenital heart disease and acquired heart diseases of childhood. She has published extensively in the fields of pediatric cardiomyopathy and pediatric heart transplantation. She has conducted outcomes research in drug therapies in the treatmen of pediatric heart failure. She also has a strong interest in the emerging field of adult congenital heart disease. She has served in leadership positions in the American Heart Association, American College of Cardiology, International Society for Heart and Lung Transplantation, American Academy of Pediatrics, American Board of Pediatrics and is a member of the American Pediatric Society.

Research Areas

Outcomes research in congenital and acquired heart disease in children, pediatric heart failure, transplantation and pediatric cardiomyopathies, adult congenital heart disease

Specialties

Pediatrics

Surgery

Expert Tags

Heart Transplant

Areas of Expertise

Children’s heart failure

Pediatric heart transplantation

Genetic heart abnormalities

Cardiomyopathy

Expert Summary

Dr. Hsu is one of the nation's leading experts in children's heart failure and heart transplant. Dr. Hsu brings specialized medical skills, decades of experience-and extraordinary commitment-to the care of children with complex heart disease. She conducts ongoing clinical research and has participated in many US multi-center studies on children's cardiomyopathies, medical and catheter-based therapy for heart disease in children and heart transplant. She is a nationally recongized pediatric cardiologic thought-leader.

Research Profile

https://einsteinmed.edu/faculty/11172/Daphne-Hsu

Clinical Profile

https://montefioreeinstein.org/profiles/1689653321/daphne-t-hsu

CHAM Provider

Off

Professional Title

M.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/f278dfc4-5254-4b7b-be68-e2a509c52…

PubMed.gov URL

EMR ID

4960

Biography

Dr. Daphne Hsu, is one of the nation's leading experts in children's heart failure and heart transplant. Dr. Hsu has treated more than 600 children with heart failure and more than 250 children undergoing heart transplant. Past director of Pediatric Heart Failure at New York-Presbyterian Hospital, Dr. Hsu brings unique specialized medical skills, decades of experience-and extraordinary commitment-to the care of your child with complex heart disease.When your child is being considered for a heart transplant, Dr. Hsu provides expert evaluation. Before, during and after surgery, she manages the full-spectrum, customized medical therapy-and hands-on specialized care-your child needs for successful heart transplant.In addition to managing her busy practice, Dr. Hsu conducts ongoing clinical research and is a nationally recognized pediatric cardiologic thought-leader.Since beginning her career in 1987, Dr. Hsu has participated in many important US multi-center studies on children's cardiomyopathies, medical and catheter-based therapy for heart disease in children and heart transplant. Dr. Hsu served on the end-point and steering committee of the only multi-centered, placebo-controlled trial studying the effect of Carvedilol in pediatric heart failure patients.Past president and board member of the Pediatric Heart Transplant Study Group, Dr. Hsu also sits on the boards of the Pediatric Cardiomyopathy Registry and the Adult Congenital Heart Disease Committee for the American Heart Association. In addition to authoring dozens of peer-reviewed cardiologic studies (link: p. 41), Dr. Hsu reviews pediatric cardiologic-related grants for the Food and Drug Administration and the National Institutes of Health and is a member of the Sub Board of Pediatric Cardiology of the American Board of Pediatrics.Dr. Hsu was drawn to pediatric cardiology early in her career. "I like being able to care for the sickest children," she explains. Children with heart failure "have a terrible disease," says Dr. Hsu. "You have to figure out what it is. You have to treat it quickly. And you have to do it well-and then you can follow them for the rest of their lives." Lasting relationships with her patients-and their families-are for Dr. Hsu among the most rewarding aspects her work. "You can share with the family the joy of this child who is doing so beautifully because you know where they've come from."

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Betsy Herold

Read more about Betsy Herold

Betsy Herold

https://assets.montefioreeinstein.org/profiles/images/physphoto/Herold_Betsey_MD_420x504.jpg

Provider

Faculty

Expert

First Name

Betsy

Last Name

Herold

NPI

1619938206

Faculty ID

10991

CMO Specialties

Pediatric Infectious Disease

Clinical Terms

Low Blood Pressure

Upper Gastrointestinal Bleeding

CMV Infection

Ankylosing Spondylitis

Benign Bone Tumor

Familial Dysautonomia

Pulmonary Hypertension

Streptococcal Meningitis

Congenital Heart Defects

Hodgkin Lymphoma

Kidney Disease

Heart Valve Disease

Hospital-Associated Pneumonia

Interstitial Lung Disease

Spontaneous Bacterial Peritonitis

Pleural Empyema

Bone Marrow Transplant

Liver Transplant

Bacterial Meningitis

Gastrointestinal Bleeding

Bacterial Endocarditis

Acute Lymphoblastic Leukemia

Guillain-Barre Syndrome

Patent Ductus Arteriosus

Sarcoma

Vancomycin-Resistant Enterococci

Gastroenteritis (Stomach Flu)

Malabsorption Syndrome

Lennox-Gastaut Syndrome

Sacroiliac Joint Pain

Lung Nodules

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

einstein-dept-microbiology-immunology

einstein-dept-obstetrics-gynecology-womens-health

Gender

Female

betsy.herold@einsteinmed.edu

Phone

718-839-7460

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Professor

Division

Pediatric Infectious Disease

Type

Academic

Department

Department of Microbiology & Immunology

Department Link

Rank

Professor

Type

Academic

Department

Department of Obstetrics & Gynecology and Women's Health

Department Link

Rank

Professor

Type

Clinical

Title

Chief, Division of Pediatric Infectious Disease

Type

Clinical

Title

Harold and Muriel Block Chair in Pediatrics

Type

Clinical

Title

Vice Chair, Research

Type

Clinical

Title

Director, Translational Prevention Research Center, Children's Hospital at Montefiore

Type

Clinical

Title

Professor of Pediatrics, Albert Einstein College of Medicine

Type

Administrative

Title

Harold and Muriel Block Chair in Pediatrics

Type

Administrative

Title

Vice Chair for Research, Department of Pediatrics

Type

Administrative

Title

Chief, Division of Pediatric Infectious Diseases, Department of Pediatrics

Type

Administrative

Title

Director, Translational Prevention Research Center

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8459022 40.8504961)

Building

Van Etten

Room

6A04A

Address Line 1

Albert Einstein College of Medicine

Address Line 3

1225 Morris Park Avenue

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Education and Trainings

Education Type Label

Medical Education

Education Institution

University of Pennsylvania School of Dental Med

Education Type Label

Fellowship

Education Institution

Northwestern University/ Children's Memorial Hosp.

Education Type Label

Residency

Education Institution

Northwestern University/ Children's Memorial Hosp.

Professional Interests

Betsy Herold, M.D. directs a basic and translational research program, which focuses on virus host interactions. Projects in the lab include studies designed to identify the cellular signaling pathways that herpes simplex viruses (HSV) usurp to promote viral entry and infection. The lab uncovered a previously unappreciated paradigm associated with activation of phospholipid scramblases, which are known to catalyze the movement of phosphatidylserine lipids between the inner and outer leaflet of the plasma membrane. Surprisingly, they found that the exofacial movement of phospholipids is associated with concomitant translocation of intracellular proteins, including the master kinase Akt to the outside, where Akt becomes phosphorylated to activate an “outside-inside” signaling cascade that promotes viral entry. This pathway is also usurped by SARS-CoV-2 and is important for cellular processes including apoptosis. In collaboration with the Almo lab, they have engineered cell impermeable kinase inhibitors. These compounds block viral entry and prevent induction of apoptosis by select TNF ligands.
 Serendipitously, in studying this signaling pathway, the lab identified a novel candidate vaccine for the prevention and treatment of HSV infections. Most efforts to develop a vaccine have focused on neutralizing antibodies that target HSV glycoprotein D (gD), but all of these have failed in clinical trials. Instead, the lab (in collaboration with the Jacobs lab), engineered a virus completely deleted in gD. Glycoprotein D is required for viral entry and cell-to-cell spread, thus the deletion virus (DgD-2) is restricted a single cycle and will not spread. This candidate vaccine elicits T cell responses and high titer, polyfunctional antibodies that protect through antibody-dependent cell mediated cytotoxicity (ADCC). The vaccine prevents the establishment of latency in mice and is significantly more protective in multiple small animal models than prior vaccines that have failed in clinical trials. The lab has subsequently isolated monoclonal antibodies (mAbs) that have this protective ADCC activity and both the vaccine and the mAbs are being advanced for preclinical development. Studies to understand why this vaccine elicits ADCC-mediating antibodies whereas gD vaccines and primary HSV infection only elicit neutralizing antibodies led to the identification of a key role for TNFRSF14 (aka HVEM) in generating and mediating ADCC responses. HVEM is an immune cell surface protein that functions in signal transduction pathways that regulate inflammatory or inhibitory immune responses but its role in shaping the B cell repertoire and in providing a second signal for ADCC had not been previously described and has implications for vaccine development and oncolytic therapies. 
 The third major area of basic research involves defining the molecular mechanisms underlying the HIV-HSV syndemic. Epidemiological studies have consistently demonstrated that being HSV seropositive is associated with an increased risk for HIV acquisition, replication, higher plasma viral loads and more frequent episodes of HIV reactivation. Using primary cells from patients and HIV latently infected cell lines, the lab has identified several mechanisms by which HSV promotes HIV latency reversal and replication including upregulation of the noncoding RNA, Malat1, and downregulation of IL-32. Defining these pathways may lead to identification of new strategies to “shock and kill” or “block and lock” HIV.
 Clinical studies include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and othersStudies with vaginal microbicides have resulted in the expnasion of studies to focus on soluble mucosal immunity in the genital tract. We found that .female genital tract secretions collected from healthy women provide variable, but significant protection against both HSV and HIV. Mechanistic studies suggest that this endogenous activity is mediated by defensins and other antimicrobial peptides. This endogenous activity may serve as a biomarker of a "healthy mucosal immune environment" and thus provide a surrogate marker to evaluate the safety of vaginal microbicides. In addition, identification of the mediators that contribute to this endogenous activity could lead to development of new strategies to boost this host defense and help protect against infection. These studies are being conducted in collaboration with the proteomics core facility at AECOM. Additionally, we are testing the hypothesis that HSV triggers changes in the mucosal environment, which allow it to escape cervical secretion defenses, enhance its own infectivity and facilitate HIV co-infection. Our preliminary observations support the paradigm that HSV disrupts the epithelial barrier by targeting tight junction and adherens junction proteins, and interferes with host defenses by triggering an inflammatory response and a loss in protective proteins such as SLPI. These changes could facilitate both its own infectivity and enhance HIV co-infection. 
Results obtained from this bench research are critical to the laboratory's translational studies. The focus of the Translational Microbicide Research Program is to identify optimal combinations of topical microbicides that are safe and target different steps in HIV life cycle, thus reducing the risks of drug resistance and providing greater protection than could be achieved with a single agent, and also target HSV infection. Candidate combinations are evaluated using a multi-tiered approach for anti-viral activity and safety using human cervical cultures, as well as primary T cells and macrophages, in the presence of cervicovaginal secretions and seminal plasma. Leading combinations are then evaluated in human explant cultures (cervical, vaginal) and in murine genital models and a new cotton rat model for anti-viral activity and for the impact on mucosal immunity. If results of these pre-clinical studies suggest that candidate microbicides are safe and effective, the drugs are advanced for regulatory testing, and undergo evaluation in Phase I clinical studies. 
Clinical research interests also include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and other related infectious complications.

Research Areas

Herpes simplex virus (HSV) infection; synergy between HSV and HIV; microbicide development; genital tract mucosal immunity

Specialties

Infectious Diseases

Pediatrics

Expert Tags

Herpes Simplex Viruses

Vaccines & Antivirals

COVID-19

Areas of Expertise

Antibiotic resistance

Antimicrobial resistance

Community-acquired MRSA (Methicillin-resistant Staphylococcus aureus)

HSV (herpes simplex virus)

Transplant infectious diseases

Expert Summary

<div>Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens. </div>
<div>  </div>
<div>Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.  </div>
<div>Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.  </div>
<div>Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.</div>

Research Profile

https://einsteinmed.edu/faculty/10991/Betsy-Herold

Clinical Profile

https://montefioreeinstein.org/profiles/1619938206/betsy-herold

CHAM Provider

Professional Title

M.D.

Clinical Focus

Pediatric Infectious Diseases.

Research Focus

Prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/45c11fb5-c8c7-49c5-964e-4481260f4…

EMR ID

4968

Biography

Betsy Herold, MD, is Chief of the Division of Pediatric Infectious Diseases and Vice Chair for Research at Children's Hospital at Montefiore. Dr. Herold is also a Professor of Pediatrics, Microbiology & Immunology, and Obstetrics & Gynecology and Women's Health at our Albert Einstein College of Medicine. She specializes in pediatric infectious diseases. Dr. Herold received her Bachelor of Arts in Biology in 1978 from Brown University and went on to receive her Doctor of Medicine from the University of Pennsylvania Medical School in 1982. Dr. Herold completed an internship and residency in pediatrics at Children's Memorial Hospital, where she became a Chief Resident in 1985. She then began a fellowship in research at Hagedorn Research Laboratory in Gentofte, Denmark. In 1987, Dr. Herold began a fellowship in pediatric infectious diseases at Children's Memorial Hospital, followed by a Research Associate/Postdoctoral Virology Fellowship in the Department of Microbiology and Immunology at Northwestern University in Chicago. Dr. Herold's clinical research focuses on the prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients. Dr. Herold has also been involved in research in Kawasaki disease and the emergence of methicillin-resistant staphylococcus aureus (MRSA) in the community. Dr. Herold directs a basic and translational research program on the prevention of herpes simplex virus (HSV) and HIV infections through the development of vaccines and novel antivirals. The current major focus of her lab is on a novel, paradigm-shifting, single-cycle vaccine to prevent HSV-1 and HSV-2. She has been continuously funded by the NIH since 1989. Dr. Herold has over 150 peer reviewed publications in peer-reviewed journals and has presented her work internationally. In 2012, Dr. Herold received the Clinical Science Faculty Mentor Award from the Albert Einstein College of Medicine. She has also been awarded the Henry and Jacob Lowenberg Prize in Pediatrics and the Pediatric Infectious Disease Young Investigator Award. Dr. Herold is board certified by the American Board of Pediatrics in Pediatrics and in Pediatric Infectious Diseases.

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