Shilpa Vasishta
Jared E. Coe
Daniel A. Burack
Helen Tsai
Emily H. Miller
Margaret E. McCort
David M. Loeb
<p>Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma migration, invasion, and metastasis. Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA. More recently, the laboratory has developed an interest in targeting the metabolic reprogramming associated with metastasis as a way to prevent the outgrowth of distant metastases from disseminated tumor cells.</p>
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<p>Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He serves as the local PI for a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. Finally, as an offshoot of his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents, and young adults with sarcomas.</p>
<p>Dr. Loeb is a leading pediatric oncologist and NIH-funded researcher. He has extensive expertise in sarcoma research and clinical care and is a bone marrow transplantation specialist. Dr. Loeb’s research spans the spectrum from basic and translational studies to clinical trials using novel therapies.</p>
<p>Dr. Loeb's PubMed bibliography can be found here: </p>
<p><a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1fiIspwqfwUE46/bibliography/5…;
<p>David Loeb, MD, PhD, is Chief, Pediatric Hematology, Oncology and Cellular Therapy at Children’s Hospital at Montefiore and Professor, Pediatrics and Professor, Developmental and Molecular Biology at Montefiore Einstein. His clinical work focuses on tumors of connective tissue, such as bone and muscle. He also has expertise in the care of children with other solid tumors. As a member of the bone marrow transplantation team, Dr. Loeb also cares for patients with acute leukemias and has expertise in the application of immunotherapy to childhood cancer.</p><p>Dr. Loeb earned his Bachelor of Arts in biology in 1987 at Johns Hopkins University. In 1993, he received his Doctor of Philosophy in Pathology and, in 1994, his Doctor of Medicine at Columbia University. In 1994, he also began an internship in Pediatrics at the Johns Hopkins University School of Medicine, followed by a residency in 1995 and a fellowship in Pediatric Hematology Oncology at the same institution.</p><p>Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis and has used this model to perform preclinical testing of novel agents that can interfere with this process. One area of focus is the metabolic differences between cancer cells and normal cells, and between metastases and the primary tumor, with the intention of targeting these differences therapeutically. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma and osteosarcoma migration, invasion and metastasis. Dr. Loeb also studies the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA.</p><p>Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He has also directed a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. Stemming from his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents and young adults with sarcomas. Dr. Loeb’s original research, based on his clinical and laboratory studies, has been published in multiple journals and books.</p><p>Dr. Loeb has been a recipient of many awards, including the Director’s Teaching Award in Clinical Science from Sidney Kimmel Comprehensive Cancer Center in 2006, 2010 and 2015, and The Justin Straus Chordoma Research Award in 2009.</p>
Inessa Gendlina
<p>Despite tremendous progress, exact mechanism of hospital transmission of infections remans uncertain. My research interest lies in understanding mechanism of transmisison of <em>Clostridioides difficile</em> in acute care setting. Specifically, I would like to understand spatio-temporal factors involved in <em>Clostridioides difficile</em> acquisition and transmission, and apply process improvement methodology to limit HAI trasnmission. I am also interested in leveraging EMR data and healthcare informatics tools to improve early recognition and management of sepsis. </p>
<p>My clinical infectious diseases interest lies is preventing, treating and managing infections with patients with immune-mediated inflammatory disease (IMID), including patients with primary and secondary immunedeficiencies as well as drug induced immune dysregulation. </p>
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<p style="font-family: Calibri; font-size: medium;">Gendlina I, Held KG, Bartra SS, Gallis BM, Doneanu CE, Goodlett DR, Plano GV, Collins CM. Identification and type III-dependent secretion of the Yersinia pestis insecticidal-like proteins. Mol Microbiol. 2007 Jun;64(5):1214-27. PubMed PMID: 17542916.</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I. Identification and Characterization of a Yersinia pestis insecticidal-like toxin complex. Miami: University of Miami; 2006. 229p</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I, Gutman DM, Thomas V, Collins CM. Urea-dependent signal transduction by the virulence regulator UreR. J Biol Chem. 2002 Oct 4;277(40):37349-58. PubMed PMID: 12147687.</p>
<p style="font-family: Calibri; font-size: medium;">Ames RY, Ting LM, Gendlina I, Kim K, Macian F. The Transcription Factor NFAT1 Participates in the Induction of CD4<sup>+</sup> T Cell Functional Exhaustion during Plasmodium yoelii Infection. Infect Immun. 2017 Sep;85(9)PubMed PMID: 28630062; PubMed Central PMCID: PMC5563568.</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I, Silmon de Monerri N, Kim K. Modification of the Host Epigenome by Parasitic Protists. Springer series on Epigenetics and Human Health. 2017</p>
Barry S. Zingman
<p>Barry S. Zingman, M.D., has been the Medical Director of the AIDS Center at Montefiore since 2003 following his service as Medical Director of the AIDS Center's Center for Positive Living/Infectious Diseases (CPL/ID) Clinic for five years.</p>
<p>Dr. Zingman directs the largest multidisciplinary and multispecialty adult HIV/AIDS treatment and prevention program in New York State. His program’s clinical sites include (1) the Center for Positive Living/I.D. Clinic, for HIV, Hepatitis C, and general Infectious Diseases care; (2) The Oval Center at Montefiore, which provides screening and treatment for sexually transmitted infections, HIV pre- and post-exposure prophylaxis programs, and Hepatitis C care; and (3) other inpatient and outpatient sites at the Moses Division of Montefiore Medical Center. He has been Principal Investigator or Medical Director on over 75 HIV/AIDS-related research protocols and grants. These currently include grants from HRSA, the New York State Department of Health's AIDS Institute, NIH, and industry for multidisciplinary HIV primary care and testing; HIV retention, adherence and viral suppression; studies of broadly-neutralizing therapeutic HIV antibodies; new HIV viral load assays; response to pneumococcal vaccine in HIV+ and HIV- individuals; and studies of other new antiretroviral agents.</p>
<p>Dr. Zingman directs an HIV research team consisting of 6 study coordinators that enrolls over 200 patients per year into research protocols.</p>
<p>Dr. Zingman is Professor of Clinical Medicine at Albert Einstein College of Medicine. He is formerly Chair of the AIDS Institute's Medical Care Criteria Committee (the principal body setting HIV care guidelines in NYS); former Vice-Chair of the NYS AIDS Institute's Quality of Care Advisory Committee; and Chair or Member on numerous other state and national HIV quality and standard of care subcommittees. He is a practicing infectious diseases subspecialist and maintains an active patient panel in the CPL/ID Clinic and the Department of Medicine Faculty Practice.</p>
<p> Dr. Zingman directs the largest multidisciplinary and multispecialty adult HIV/AIDS treatment and prevention program in New York State. His program’s clinical sites include (1) the Center for Positive Living/I.D. Clinic, for HIV, Hepatitis C, and general Infectious Diseases care; (2) The Oval Center at Montefiore, which provides screening and treatment for sexually transmitted infections, HIV pre- and post-exposure prophylaxis programs and Hepatitis C care; and (3) other inpatient and outpatient sites at the Moses Division of Montefiore Medical Center. He has been Principal Investigator or Medical Director on over 75 HIV/AIDS-related research protocols and grants. These currently include grants from HRSA, the New York State Department of Health's AIDS Institute, NIH, and industry for multidisciplinary HIV primary care and testing; HIV retention, adherence and viral suppression; studies of broadly-neutralizing therapeutic HIV antibodies; new HIV viral load assays; response to pneumococcal vaccine in HIV+ and HIV- individuals; and studies of other new antiretroviral agents.</p>
<p>Barry S. Zingman, MD, is Medical Director, AIDS Center and Clinical Director, Infectious Diseases at Montefiore Einstein, and Professor, Medicine at our Albert Einstein College of Medicine. Dr. Zingman cares for people with a wide range of infectious disease conditions including HIV care, HIV prevention (PrEP; PEP), sexually transmitted infections, COVID, MPOX (monkeypox), other viral infections, diabetic foot infections, bone infections, heart and lung infections, post-surgical infections, tuberculosis and many others.</p><p>After completing his Bachelor of Arts in biochemistry at Brandeis University in 1981, Dr. Zingman attended New York University School of Medicine, earning his Doctor of Medicine in 1985. He completed his internship and residency in internal medicine at Boston City Hospital in 1988. Dr. Zingman continued his training at Boston University School of Medicine, completing clinical and research fellowships in infectious diseases in 1991.</p><p>Dr. Zingman’s research focuses on new treatments, vaccines, and other preventive strategies for infectious diseases including HIV, sexually transmitted infections, other viral infections, E coli urinary tract infections and others. He has shared his work through peer-reviewed journals, articles, case reports, book chapters, abstracts, and other media as well as presentations, invited lectures and webinars.</p><p>Dr. Zingman is board certified in Infectious Diseases and Internal Medicine. He is a member of the Infectious Disease Society of America (IDSA) and the HIV Medicine Association of IDSA. In 2017, he was inducted into the Leo M. Davidoff Society for distinguished, caring and committed teaching of medical students.</p>