glycobiology-intracellular-trafficking

Glycobiology & Intracellular Trafficking 

Investigators in the Department of Cell Biology at Albert Einstein College of Medicine who are interested in glycobiology and intracellular trafficking study the secretory pathway which produces glycoproteins that reside in the endoplasmic reticulum, Golgi, lysosomes, and endosomes; travel to the plasma membrane; or are secreted from the cell. 

The Stanley Lab identifies roles for glycans on key glycoproteins like Notch receptors and receptor tyrosine kinases in cells and mutant mice. The Steidl Lab, using recognition of glycans on proteoglycans, isolates potentially novel subsets of hematopoietic and leukemic cells. While trafficking mechanisms in the cell are a broad focus, the Kielian Lab investigates mechanisms of entry and exit of enveloped RNA viruses that fuse with the plasma membrane, including Dengue and Chikungunya, and the Meier Lab studies transport of RNA-protein complexes across the nuclear envelope and inside the nucleus.

Research Faculty

The Department of Cell Biology faculty below conduct research on glycobiology and intracellular trafficking. If you are interested in collaborating on a research project, please contact the investigators directly for more information. 

Margaret Kielian, Ph.D.

Professor Emerita, Department of Cell Biology

Specific research topics: drug development and experimental therapeutics, membrane trafficking, proteomics and protein biochemistry, and virology 

U. Thomas Meier, Ph.D.

Professor, Department of Cell Biology

Specific research topics: aging, imaging, proteomics and protein biochemistry, and RNA processing/splicing/modification 

Pamela Stanley, Ph.D.

Professor Emerita, Department of Cell Biology

Specific research topics: cancer genetics, development, drug development and experimental therapeutics, glycobiology/glycomics, hematopoiesis, immunology, membrane trafficking, proteomics and protein biochemistry, signal transduction, and stem cells

Ulrich G. Steidl, M.D., Ph.D.

Chair and Professor, Department of Cell Biology; Professor, Departments of Medicine and Oncology; Deputy Director, Montefiore Einstein Comprehensive Cancer Center

Specific research topics: aging, cancer genetics, cancer microenvironment, chromatin biology/gene regulation, drug development and experimental therapeutics, glycobiology/glycomics, hematopoiesis, imaging, immunology, signal transduction, single cell analysis, and stem cells