Dr. Xie’s research focuses on developing statistical methods for modeling missing data due to detection limits in longitudinal study. He also works on generalized linear mixed models with measurement errors and detection limits, both of which are common in lab assays. His other research interests include genomic data analysis, epidemiological methods, survival analysis, and statistical computing.

He has been working on data analysis on HIV and HPV in a large longitudinal cohort: the Women’s Interagency HIV Study (WIHS). He is also the lead biostatistician in analyzing the patients on placebo in a lupus study, a disease that affects millions of people worldwide and is very heterogeneous.

Xie, X., Xue, X., Gange, S., Strickler, H., Kim, M., and WIHS HPV Study Group. Estimation and inference on correlations between biomarkers with repeated measures and left-censoring due to minimum detection levels. Statistics in Medicine 2012; 31:2275-2289.

Xie, X., Xue, X., Strickler, H. Generalized linear mixed model for binary outcomes when covariates are subject to measurement errors and detection limits. Statistics in Medicine 2018, 37:119-136.

Xie, X., Strickler, H., Xue, X. Additive hazard regression models: application to the natural history of Human Papillomavirus. Computational and Mathematical Methods in Medicine 2013; Article ID 796270.

Xue, X.,Xie, X., et al. Testing the proportional hazards assumption in case-cohort analysis. BMC Medical Research Methodology 2013; 13:88.

Xue, X., Xie, X., Strickler, H. A censored quantile regression approach for the analysis of time to event data. Statistical Methods in Medical Research 2016; pii: 0962280216648724.

Kuniholm, MH, Xie, X., Anastos, K., Xue, X., Reimers, L., French, AL, Gange, SJ, Kassaye, SG, Kovacs, A., Wang, T., Aouizerat, BE, Strickler, HD. Human leucocyte antigen class I and II imputation in a multiracial population. International Journal of Immunogenetics 2016; 43:369-375.

Keller, M., Burk, R., Xie, X., et al. Risk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection. Journal of the American Medical Association 2012; 308:362-369.

Kalunian, K., Kim, M., Xie, X., Baskaran, A., Daly, R., Merrill, J. Impact of Standard of Care (SOC) treatments and disease variables on outcomes in Systemic Lupus Erythematosus (SLE) trials: analysis from the Lupus Foundation of America Combined Data Analysis Initiative (LFA CDAI). European Journal of Rheumatology 2016; 3:13-19.