<p>Despite tremendous progress, exact mechanism of hospital transmission of infections remans uncertain. My research interest lies in understanding mechanism of transmisison of <em>Clostridioides difficile</em> in acute care setting. Specifically, I would like to understand spatio-temporal factors involved in <em>Clostridioides difficile</em> acquisition and transmission, and apply process improvement methodology to limit HAI trasnmission. I am also interested in leveraging EMR data and healthcare informatics tools to improve early recognition and management of sepsis. </p>
<p>My clinical infectious diseases interest lies is preventing, treating and managing infections with patients with immune-mediated inflammatory disease (IMID), including patients with primary and secondary immunedeficiencies as well as drug induced immune dysregulation. </p>
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<p style="font-family: Calibri; font-size: medium;">Gendlina I, Held KG, Bartra SS, Gallis BM, Doneanu CE, Goodlett DR, Plano GV, Collins CM. Identification and type III-dependent secretion of the Yersinia pestis insecticidal-like proteins. Mol Microbiol. 2007 Jun;64(5):1214-27. PubMed PMID: 17542916.</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I. Identification and Characterization of a Yersinia pestis insecticidal-like toxin complex. Miami: University of Miami; 2006. 229p</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I, Gutman DM, Thomas V, Collins CM. Urea-dependent signal transduction by the virulence regulator UreR. J Biol Chem. 2002 Oct 4;277(40):37349-58. PubMed PMID: 12147687.</p>
<p style="font-family: Calibri; font-size: medium;">Ames RY, Ting LM, Gendlina I, Kim K, Macian F. The Transcription Factor NFAT1 Participates in the Induction of CD4<sup>+</sup> T Cell Functional Exhaustion during Plasmodium yoelii Infection. Infect Immun. 2017 Sep;85(9)PubMed PMID: 28630062; PubMed Central PMCID: PMC5563568.</p>
<p style="font-family: Calibri; font-size: medium;">Gendlina I, Silmon de Monerri N, Kim K. Modification of the Host Epigenome by Parasitic Protists. Springer series on Epigenetics and Human Health. 2017</p>