Proteostasis of Aging Core Alterations in proteostasis have been described in multiple age-related disorders and are also tightly linked to additional mechanisms of aging such as molecular damage, cellular response to stress, metabolism, inflammation and stem cell functioning. Genetic interventions in invertebrates and in mammals, now support beneficial effects in life- and health-span of modulating components of the intracellular pathways responsible for proteostasis maintenance, chaperones and the proteolytic systems. Translation of these findings into humans requires: 1) characterization of changes in proteostasis in old organisms; 2) understanding the molecular mechanisms behind proteostasis loss in aging and 3) extensive testing of the effect of chemical and natural compounds on the proteostasis machinery and their future development into drugs. The Proteostasis of Aging Core (PAC) was created in response to these needs of the aging research community and, during its ten years in operation, has been providing reliable and highly validated services, state-of-the art methodology, expertise and cutting-edge knowledge related to proteostasis to internal and external E-NSC members and aging research groups worldwide Services Access the Services Assays: Autophagy profiling, LC3-II flux, Protein turnover, Electron microscopy and morphometry, Lysosomal functions, Enzymes assays Reagents and Samples: Autophagy antibody panel, Autophagy reporters, Lysosomal markers Consulting: Autophagy methods and assays and Drug developments and design Related Shared Facilities no-related-facilities Center Affiliations Nathan Shock Center of ExcellencePaul F. Glenn Center for the Biology of Human Aging Selected Publications no-publications Location and Contacts Proteostasis of Aging Core Golding 701 Ana Maria Cuervo, MD, PhDScientific Director718-430-8975ana-maria.cuervo@einsteinmed.eduAntonio DiazTechnician718-430-2091antonio.diazcarretero@einsteinmed.edu
