Rui Yang

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Full Name
Rui Yang
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Yang_Rui_MD_420x504.jpg
Type
Provider
Faculty
First Name
Rui
Last Name
Yang
NPI
1215280532
Faculty ID
9892
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-orthopaedic-surgery
Gender
Male
Email
ryan@montefiore.org
Phone
718-920-2060
Titles
Type
Academic
Department
Department of Orthopaedic Surgery
Department Link
Rank
Associate Professor
Type
Clinical
Title
Director, Orthopedic Oncology Fellowship
Type
Clinical
Title
Assistant Professor, Orthopedic Surgery
Type
Clinical
Type
Administrative
Locations
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On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87862 40.88032)
Address Line 1
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-240
Location Title
Montefiore Greene Medical Arts Pavilion
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.99671 40.75115)
Address Line 1
435 West 31st Street, Suite 30
City
New York
State
NY
Zip
10001
Location Title
Montefiore Einstein Advanced Care - Manhattan West
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8785732 40.879979)
Address Line 1
Montefiore Medical Center
Address Line 2
Medical Arts Pavilion
Address Line 3
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Beijing Medical University
Education Type Label
Fellowship
Education Institution
Memorial Sloan Kettering Cancer Center
Education Type Label
Residency
Education Institution
University of Texas
Education Type Label
Residency
Education Institution
Peking University People's Hospital
Professional Interests

<p>Dr. Yang earned his medical degree at Beijing Medical University in China followed by an orthopaedic residency at Peking University People&rsquo;s Hospital in Beijing, China.&nbsp; Following his training in China, he came to the United States where he earned a Master&rsquo;s degree in Biological Sciences from Hunter College at the City University of New York. Dr. Yang completed a second orthopaedic surgery residency at the University of Texas, in Houston and then he did a fellowship in Orthopaedic Oncology at Memorial Sloan-Kettering Cancer Center.</p>
<p>Dr. Yang specializes in the diagnosis and treatment of benign and malignant tumors in the musculoskeletal system. A multidisciplinary approach is emphasized in his practice. He performs surgery to remove the tumor fom the limb and pelvis, and rebuild them using techniques tailored for each individual patient. Dr. Yang is also interested in treating metastatic bony lesions originating from other parts of the body.</p>
<p>Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumorigenesis of osteosarcoma and the genetic profile of the tumors as comparison to its normal counterpart tissues.&nbsp; He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, as well as novel strategies to overcome it in collaboration with the pediatric sarcoma teams.</p>
<p>&nbsp;</p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

Diagnosis and treatment of benign and malignant tumors in the musculoskeletal system, including metastatic bony lesions as well as primary tumors.<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumor genesis of osteosarcoma and the genetic profile of the tumors as compared to normal counterpart tissues. He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, in addition to novel strategies to overcome it in collaboration with pediatric sarcoma teams.<quillbot-extension-portal></quillbot-extension-portal>

Selected Publications

<p>1. Peer-reviewed Papers</p>
<p>1) <strong>Yang, R.</strong>, Piperdi, S.,&nbsp; Zhang, Y., Neophytou, N., Zhu, W., Hoang, B.H., Mason, G., Geller, D., Dorfman, H,, Healey, J.H., Phinney, D.G., and Gorlick, R. Transcriptional Profiling Identifies the Signaling Axes of the Insulin Growth Factor and the Transforming Growth Factor-beta as involved in the Pathogenesis of Osteosarcoma. Clin Orthop Relat Res. 2015. PMID: 26463566</p>
<p>2) Nathan, S.S., Huvos, A.G., Casas-Ganem, J.E., <strong>Yang, R.,</strong> Linkov, I., Sowers, R., DiResta, G.R., Gorlick, R., Healey, J.H.&nbsp;Tumour interstitial fluid pressure may regulate angiogenic factors in osteosarcoma <a href="http://www.ncbi.nlm.nih.gov/pubmed/20052438">.</a&gt; Ann Acad Med Singapore. 2009; 38(12):1041-7. PMID: 20052438</p>
<p>3) Li, N., <strong>Yang, R.</strong>, Zhang, W., Dorfman, H., Rao, P., and Gorlick, R. Genetically Transforming Human Mesenchymal Stem Cells to Sarcomas: changes in cellular phenotype and multilineage differentiation potential. Cancer. 2009; 115(20): 4795-806. PMID: 19593798</p>
<p>4) <strong>Yang, R</strong>., Piperdi, S., and Gorlick, R. Activation of the RAF/MEK/ERK pathway mediates apoptosis induced by chelerythrine in osteosarcoma. Clin Cancer Res. 2008;14(20): 6396-404. PMID: 18927278</p>
<p>5) <strong>Yang, R.</strong>, Qin, J., Hoang, B.H., Healey, J.H., and Gorlick, R. Polymorphisms and methylation of the reduced folate carrier in osteosarcoma. Clin Orthop Relat Res 2008;466:2046-51. PMID: 18528741</p>
<p>6) Nathan, S.S., Huvos, A.G., Casas-Ganem, J.E., <strong>Yang, R.</strong>, Linkov, I., Sowers, R., Diresta, G.R., Gorlick, R., and Healey, J.H. Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma. J Orthop Res 2008;26:1-6. PMID: 18473395</p>
<p>7) <strong>Yang, R.</strong>, Li, W.W., Hoang, B.H., Kim, H., Banerjee, D., Kheradpour, A., Healey, J.H., Meyers, P.A., Bertino, J.R., and Gorlick, R. Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer 2008;8:124. PMID: 18452618</p>
<p>8) <strong>Yang, R.</strong>, Kolb, E.A., Qin, J., Chou, A., Sowers, R., Hoang, B., Healey, J.H., Huvos, A.G., Meyers, P.A. and Gorlick, R. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res 2007;13:2557-67. PMID: 17473184</p>
<p>9) <strong>Yang, R.</strong>, Hoang, B.H., Kubo, T., Kawano, H., Chou, A., Sowers, R., Huvos, A.G., Meyers, P.A., Healey, J.H. and Gorlick, R. Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer 2007;121:943-54. PMID: 17410535</p>
<p>10) Laverdiere, C., Hoang, B.H., <strong>Yang, R.</strong>, Sowers, R., Qin, J., Meyers, P.A., Huvos, A.G., Healey, J.H. and Gorlick, R. Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res 2005;11:2561-7. PMID: 15814634</p>
<p>11) Nathan, S.S., DiResta, G.R., Casas-Ganem, J.E., Hoang, B.H., Sowers, R., <strong>Yang, R.</strong>, Huvos, A.G., Gorlick, R. Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma. Clin Cancer Res 2005;11:2389-97. PMID: 15788690</p>
<p>12) Flintoff, W.F., Sadlish, H., Gorlick, R., <strong>Yang, R.</strong>, Williams, F.M. Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas. Biochim Biophys Acta 2004;1690:110-7. PMID: 15469899</p>
<p>13) Hoang, B.H., Kubo, T., Healey, J.H., <strong>Yang, R.</strong>, Nathan, S.S., Kolb, E.A., Mazza, B., Meyers, P.A. and Gorlick, R. Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res 2004;64:2734-9. PMID: 15087387</p>
<p>14) Hoang, B.H., Kubo, T., Healey, J.H., Sowers, R., Mazza, B., <strong>Yang, R.</strong>, Huvos, A.G., Meyers, P.A. and Gorlick, R. Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int J Cancer 2004;109:106-11. PMID: 14735475</p>
<p>15) <strong>Yang, R.</strong>, Sowers, R., Mazza, B., Healey, J.H., Huvos, A., Grier, H., Bernstein, M., Beardsley, G.P., Krailo, M.D., Devidas, M., Bertino, J.R., Meyers, P.A. and Gorlick, R. Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. Clin Cancer Res 2003;9:837-44. PMID: 12576457</p>
<p>&nbsp;</p>
<p>2. Book Chapters</p>
<p align="left">1) Orthopedic Oncology. Editor: Xun, W.P., Feng, C.H. People&rsquo;s Military Medical Publisher.</p>
<p>(ISBN: 7-80157-159-2), 2001.</p>
<p>2) Review of Surgery: A Guiding Book for Medical Students. Section of Orthopedics. Editor: Jiang, B.G. Beijing Medical University Publisher.&nbsp; (ISBN: 7-81034-946-5), 1999.</p>

EMR ID
78569
Biography

<p>Dr. Yang is a fellowship-trained orthopedic surgeon recognized for his multidisciplinary approach to the diagnosis and treatment of benign and malignant tumors in the musculoskeletal system, including metastatic bony lesions as well as primary tumors. He also serves as an Assistant Professor at our Albert Einstein College of Medicine.</p><p>Dr. Yang earned his medical degree at Beijing Medical University in China followed by an orthopedic residency at Peking University People?s Hospital in Beijing, China. Following his training in China, he came to the United States where he earned a master?s degree in biological sciences from Hunter College at the City University of New York. Dr. Yang completed a second orthopedic surgery residency at the University of Texas, in Houston, followed by a fellowship in orthopedic oncology at Memorial Sloan-Kettering Cancer Center.</p><p>Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumor genesis of osteosarcoma and the genetic profile of the tumors as compared to normal counterpart tissues. He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, in addition to novel strategies to overcome it in collaboration with pediatric sarcoma teams.</p>

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Bang H. Hoang

Submitted by Anonymous (not verified) on
Full Name
Bang H. Hoang
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Hoang_Bang_MD_2x.jpg
Type
Provider
Faculty
First Name
Bang
Last Name
Hoang
NPI
1568542629
Faculty ID
14186
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-orthopaedic-surgery
Gender
Male
Email
bahoang@montefiore.org
Phone
718-920-2060
Titles
Type
Academic
Department
Department of Orthopaedic Surgery
Department Link
Rank
Professor
Type
Clinical
Title
Co-Director, Orthopedic Oncology
Tags
me-patientcare-orthopedics-about-team-chiefs
Type
Clinical
Title
Director, Musculoskeletal Oncology Lab
Type
Clinical
Title
Director, Orthopedic Oncology Research
Tags
me-patientcare-orthopedics-about-team
Type
Clinical
Title
Arnold S. and Madaleine Penner Endowed Professorship, Orthopedic Surgery
Type
Clinical
Type
Administrative
Type
Administrative
Title
Arnold S and Madaleine Penner Professor
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87862 40.88032)
Address Line 1
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-240
Location Title
Montefiore Greene Medical Arts Pavilion
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.99671 40.75115)
Address Line 1
435 West 31st Street, Suite 30
City
New York
State
NY
Zip
10001
Location Title
Montefiore Einstein Advanced Care - Manhattan West
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.76802 41.02579)
Address Line 1
122 Maple Avenue
City
White Plains
State
NY
Zip
10601
Location Title
East Post Road Medical Services, PC
Is Primary
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Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8785732 40.879979)
Address Line 1
Montefiore Medical Center
Address Line 2
Medical Arts Pavilion
Address Line 3
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
UCLA School of Medicine
Education Type Label
Fellowship
Education Institution
Case Western Reserve University
Education Type Label
Fellowship
Education Institution
Memorial Sloan Kettering Cancer Center
Education Type Label
Residency
Education Institution
Case Western Reserve University
Professional Interests

<p><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;">Bang Hoang, M.D. is a board-certified orthopeadic surgeon at Montefiore Einstein Health System who specializes in treating patients with bone and soft tissue tumors. Dr. Hoang is a graduate of UCLA David Geffen School of Medicine and completed his residency in orthopaedic surgery at Case Western Reserve University Hospitals. During medical school, he was awarded a Howard Hughes fellowship to receive training at the National Institutes of Health in Bethesda, MD. After residency, he completed a fellowship in orthopaedic oncology at Memorial Sloan-Kettering Cancer Center in New York. Before coming to Montefiore-Einstein, he was Director of the Multidisciplinary Sarcoma Center at the Univ of California, Irvine Healthcare system in Orange County, CA (sarcomas are tumors arising from nerves, blood vessels, fat, muscles, bones, and other connective tissues). He is currently Professor in the Department of Orthopaedic Surgery and holds the Arnold S. and Madaleine Penner Endowed Chair in Orthopaedic Oncology. He is also Co-Director of the Orthopaedic Oncology Division at Montefiore Einstein. His clinical practice is focused on musculoskeletal oncology, and in particular, the treatment of adults and children with benign and malignant bone and soft tissue tumors and metastatic bone disease. He has served on several grant funding and educational committees for the American Academy of Orthopaedic Surgeons and the Orthopaedic Research and Education Foundation. Currently, he serves on the executive board as a committee chair for the Musculoskeletal Tumor Society, the largest association of bone tumor surgeons in the U.S.</span></p>
<p><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;">Besides his clinical practice, Dr. Hoang also heads a research team at Montefiore Einstein that developed genetically engineered and human-derived xenograft models of sarcoma. These models have been used widely by researchers to understand the complex tumor microenvironments of bone and soft tissue sarcomas and to find new therapies which target signaling pathways and mutations in major tumor suppressor genes, such as Rb1 and p53.&nbsp; Currently, he is leading a team at Montefiore Einstein that receives R01 funding from the National Cancer Institute to develop genetically engineered models and bioinformatic pipelines to study the impact of the proteosome degradation pathway in pediatric sarcoma and to develop new treatments for these cancers.</span></span></p>
<p><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">In 2007, the American Orthopaedic Association selected Dr. Hoang for its flagship North American Traveling Fellowship. During the month-long fellowship, he was invited to lecture at several academic institutions in the U.S. and Canada, including Harvard-MGH, Johns Hopkins, Univ of Maryland-Shock Trauma, Rothman, Darmouth, McGill, and Emory, among others. For their work on the pathogenesis of osteosarcoma, Hoang and his colleagues Yi Guo (Albert Einstein), Randall Holcombe (Univ of Vermont), and Xiaolin Zi (UC Irvine), were awarded the</span></span></span> <span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">2011 Kappa Delta Ann Doner Vaughn Award. S</span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">ince 1950, the Kappa Delta Award has been given </span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">by&nbsp;</span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">the American Academy of Orthopedic Surgeons </span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">to recognize clinical research with the highest impact on musculoskeletal diseases. In addition, Hoang's work on the VEGF-Neuropilin axis as a novel therapeutic target for osteosarcoma was also recognized by </span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">the 2011 </span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">Career Development Award from the Orthopaedic Research and Education Foundation</span></span></span><span style="color: #111111; font-family: Barlow, sans-serif; font-size: 16px;"><span style="color: #373a3c; font-family: 'Open Sans', sans-serif; background-color: #fefefe;"><span style="color: #111111; font-family: Barlow, sans-serif; background-color: #ffffff;">.</span></span></span></p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

<p>Bone and soft tissue sarcoma, treatment of benign tumors in adults and children, metastatic bone disease, investigational therapy for bone and soft tissue tumors, pathologic fractures, musculoskeletal tumor surgery, computer-assisted tumor surgery, reconstructive joint surgery using megaprosthesis and allograft tissue, pelvic and sacral tumor surgery</p>

Research Focus

<p>Musculoskeletal cancer, pathophysiology and molecular mechanisms of bone and soft tissue cancers, pediatric bone cancer</p>

Selected Publications

<p><strong>Selected Publication</strong></p>
<p><strong>&nbsp;</strong></p>
<p>1. Chang SC, <strong>Hoang B</strong>, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ, Kozak CA, Reddi AH, Moos M Jr. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J. Biol. Chem. 262, 28227-34 (1994).</p>
<p>2. <strong>Hoang B</strong>, Moos M Jr., Vukicevic S, Luyten FP. Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled Suggest a Role in Skeletal Morphogenesis. J. Biol. Chem. 271: 26131-37 (1996).</p>
<p>3. <strong>Hoang BH</strong>, Thomas JT, Abdul-Karim FW, Correia KM, Conlon RA, Luyten F.P, Ballock RT. Expression Pattern of Two Frizzled-Related Genes, Frzb-1 and Sfrp-1, During Mouse Embryogenesis Suggests a Role for Modulating Action of Wnt Family Members. Dev. Dyn. 212: 364-372 (1998).</p>
<p>4. Kennedy JG, Donahue JP, <strong>Hoang BH</strong>, Boland PJ. Vesicant characteristics of oxapliplatin following antecubital extravasation. Clin Oncol. 15:237-239 (2003).</p>
<p>5. Kennedy JG, Donahue JR, <strong>Hoang BH</strong>, Aydin H, Huvos A, Morris C. Metastatic breast carcinoma to bone disguised by osteopoikiliosis. Skel. Radiol. 32:240-243 (2003).</p>
<p>6. Kennedy JG, Frelinghuysen P, <strong>Hoang BH</strong>. Ewing sarcoma: current concepts in diagnosis and treatment. Curr Opin Pediatr. 15:53-7 (2003).</p>
<p>7. <strong>Hoang BH</strong>, Kubo T, Healey JH, Sowers R, Mazza B, Yang R, Huvos AG, Meyers PA, Gorlick R. Expression of LDL Receptor-Related Protein 5 (LRP5) as a Novel Marker for Disease Progression in High-Grade Osteosarcoma. Int J Cancer. 109:106-11 (2004).</p>
<p>8. Hoang BH, Kubo T, Healey JH, Yang R, Nathan SS, Mazza B, Meyers PA, Gorlick R. Dkk-3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-Beta-Catenin Pathway. Cancer Res. 64:2734-9 (2004).</p>
<p>9. <strong>Hoang BH</strong>, Dyke JP, Koutcher JA, Mizobuchi H, Huvos AG, Mazza B, Meyers PA, Gorlick R, Healey JH. VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI. Clin Orthop Relat Res. 426:32-8 (2004).</p>
<p>10. Laverdiere C, <strong>Hoang BH</strong>, Yang R, Sowers R, Qin J, Meyers PA, Huvos AG, Healey JH, Gorlick R. Messenger RNA Expression Levels of CXCR4 Correlates with Metastatic Behavior and Outcome in Patients with Osteosarcoma. Clin Cancer Res. 11:2561-7 (2005).</p>
<p>11. Nathan SS, DiResta GR, Casas-Ganem EJ, <strong>Hoang BH</strong>, Sowers R, Yang R, Huvos AG. Gorlick R, Healey JH. Elevated Physiological Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma. Clin Cancer Res. 11:2389-97 (2005).</p>
<p>12. Nathan SS, Healey JH, Mellano D, <strong>Hoang B</strong>, Lewis I, Morris CD, Athanasian EA, Boland PJ. Survival in Patients Operated on for Pathologic Fracture: Implications for End-of-Life Orthopedic Care. J Clin Oncol. 23:6072-82 (2005).</p>
<p>13. Zi X, Guo Y, Simoneau AR, Hope C, Holcombe RF, <strong>Hoang BH</strong>. Expression of a secreted Wnt antagonist, Frzb/sFRP-3, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 65:9762-70 (2005).</p>
<p>14. Hammond G, Gu M, Tehranzadeh J, <strong>Hoang BH</strong>. Periprosthetic soft tissue recurrence of chondroblastoma after attempted en-bloc excision from the proximal humerus. Skel Radiol. 35:53-7 (2006).</p>
<p>15. Haydon JB, <strong>Hoang, BH</strong>. Osteosarcoma: Basic Science and Clinical Implications. Orthop Clin North Am. 37:1-7 (2006).</p>
<p>16. Kuphal S, Lodermeyer S, Bataille F, Schuierer M, <strong>Hoang BH</strong>, Bosserhoff AK. Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene. 25:5027-36 (2006).</p>
<p>17. Shibuya TY, Wadhwa A, Nguyen K, Panossian A, Kim S, Wong H, Feinberg S, Damisah EC, Camilon RP, <strong>Hoang B</strong>. Linking of bone morphogenetic protein-2 to resorbable fracture plates for enhancing bone healing. The Lanryngoscope. 115:2232-7 (2006).</p>
<p>18. Yang R, Kolb EA, Qin J, Chou A, Sowers R, <strong>Hoang B</strong>, Healey JH, Huvos AG, Meyers PA, Gorlick R. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res. 13:2557-67 (2007).</p>
<p>19. Keyak JH, Kaneko TS, Skinner HB, <strong>Hoang BH</strong>. The Effect of Simulated Metastatic Lesions on Proximal Femoral Strength. Clin Orthop Relat Res. 459:139-45 (2007).</p>
<p>20. Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, <strong>Hoang BH</strong>. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses Met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res. 25:964-71(2007).</p>
<p>21. Yang R, <strong>Hoang BH</strong>, Kubo T, Kawano H, Chou A, Sowers R, Huvos AG, Meyers PA, Healey JH, Gorlick R. Overexpression of parathyroid hormone type-1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer. 121:943-54 (2007).</p>
<p>22. Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, <strong>Hoang BH</strong>. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 68:3350-60 (2008).</p>
<p>23. Yang R, Li WW, <strong>Hoang BH</strong>, Kim H, Banerjee D, Kheradpour A, Healey JH, Meyers PA, Bertino JR, Gorlick R. Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer. 8:124 (2008).</p>
<p>24. Yang R, Qin J, <strong>Hoang BH</strong>, Healey JH, Gorlick R. Polymorphisms and Methylation of the Reduced Folate Carrier in Osteosarcoma. Clin Orthop Relat Res. 466:2046-2051 (2008).</p>
<p>25. Guo Y, Rubin E, Xie J, Zi X, <strong>Hoang BH</strong>. Dominant Negative LRP5 Decreases Tumorigenicity and Metastasis of Osteosarcoma. Clin Orthop Relat Res. 466:2039-2045 (2008).</p>
<p>26. Wolf JM, Athwal GS, <strong>Hoang B</strong>, Mehta S, Owens BD. Report from the 2007 AOA North American Traveling Fellowship. J Bone Joint Surg Am. 90:1160-4 (2008).</p>
<p>27. Healey JH, <strong>Hoang, BH</strong>. Cancer Biology - Lessons Learned From Sarcoma. Clin Orthop Relat Res. 466:2029-30 (2008).</p>
<p>28. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, <strong>Hoang BH</strong>, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 8:458-68 (2009).</p>
<p>29. Wolf JM, Athwal G, <strong>Hoang BH</strong>, Mehta S, Williams A, Owens BD. Knowledge of Levels of Evidence Criteria in Orthopaedic Residents. Orthopaedics 32:494 (2009).</p>
<p>30. Abdeen A, <strong>Hoang BH</strong>, Athanasian EA, Morris CD, Boland PJ, Healey JH. Allograft-Prosthesis Reconstruction of the Proximal Part of the Humerus. J Bone Joint Surg Am 91:2406-15 (2009).</p>
<p>31. Lee J, <strong>Hoang BH</strong>, Ziogas A, Zell J. Analysis of Prognostic Factors in Ewing Sarcoma Using a Population-Based Cancer Registry. Cancer 116:1964-73 (2010).</p>
<p>32. Rubin EM, Guo Y, Tu K, Xie J, Zi X, <strong>Hoang BH</strong>. Wnt Inhibitory Factor 1 (WIF-1) decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther. 9:731-41 (2010).</p>
<p>33. Yee SD, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, <strong>Hoang BH</strong>, and Zi X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer 9:162 (2010).</p>
<p>34. Kirkpatrick JS, Cornell CN, <strong>Hoang BH</strong>, Hsu W, Watson JT, Watters WC 3rd, Turkelson CM, Wies JL, Anderson S. Bone void fillers. J Am Acad Orthop Surg. 18:576-9 (2010).</p>
<p>35. McQueen P, Ghaffar S,Guo Y,Rubin EM,Zi X,<strong>Hoang BH</strong>. The Wnt signaling pathway: Implications for therapy in osteosarcoma. Expert Rev Anticancer Ther 11: 1223-32 (2011).</p>
<p>36. Lee J, Bhatia N, <strong>Hoang BH</strong>, Ziogas A, Zell J. Analysis of Prognostic Factors in Chordoma Using the California Cancer Registry. J Bone Joint Surg Am 4:356-63. (2012).</p>
<p>37. Eskander R, Randall L, Sakai T, Guo Y, <strong>Hoang B</strong>, Zi X. Flavokawain B, A Novel Naturally Occuring Chalcone, Exhibits Robust Apoptotic Effects and Induces G2/M Arrest of a Uterine Leiomyosarcoma Cell Line. J Obs Gyn Res. 38:1086-94 (2012).</p>
<p>38. Flavokawain B, a Kava Chalcone, Induces Apoptosis in Synovial Sarcoma Cell Lines. Sakai T, Eskander RN, Guo Y, Kim KJ, Mefford J, Hopkins J, Bhatia NN, Zi X, <strong>Hoang BH</strong>. J Orthop Res. 30:1045-50 (2012).</p>
<p>39. Eskander R, Ali S, Lankes H, Dellinger T, <strong>Hoang B</strong>, Ramirez N, Monk B, Walker J, Eisenhauer E, Randall L. Expression patterns of the Wnt pathway inhibitor dickKOPF-3 (Dkk3) and secreted frizzled-related proteins (sFRP) 1 and 4 in endometrial endometrioid adenocarcinoma: A gynecologic oncology group study. Gynecol Oncol 127(1 Suppl):S5 (2012)</p>
<p>40. Lin CH, Guo Y, Ghaffar S, McQueen P, Pourmorady J, Christ A, Rooney K, Ji T, Eskander R, Zi X, <strong>Hoang BH</strong>. Dkk-3, a secreted Wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma. Sarcoma 2013:147541 Epub (2013).</p>
<p>41. Lee J, Vu L, Steinhoff A, <strong>Hoang BH</strong>.Vascular Tumor in Metal-On-Polyethylene Total Hip Arthroplasty Requiring Hemipelvectomy. Orthopaedics 36:e974-7 (2013).</p>
<p>42. Eskander RN, Ji T, Huynh B, Wardeh R, Randall LM, <strong>Hoang B</strong>. Inhibition of Enhancer of Zeste Homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation, migration and invasion in endometrial cancer cell lines. Int J Gyn Cancer 23:997-1005 (2013).</p>
<p>43. Ji T, Lin C, Krill LS, Eskander R, Guo Y, Zi X, <strong>Hoang BH</strong>. Flavokawain B induces Apoptosis and G2/M Cell-Cycle Arrest in Human Osteosarcoma Cells. Mol Cancer 12:55 (2013).</p>
<p>44. Bederman SS, Shah KN, Hassan JM, <strong>Hoang BH</strong>, Kiester PD, Bhatia NN.Surgical techniques for spinopelvic reconstruction following total sacrectomy: a systematic review. Eur Spine J 23:305-319 (2014).</p>
<p>45. Li X, Xu X, Ji T, Liu Z, Gu M, <strong>Hoang BH</strong>, Zi X. Dietary feeding of Flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice. Toxicol Rep 1:2-11 (2014).</p>
<p>46. Ji T, Eskander R, Wang Y, Sun K, <strong>Hoang BH</strong>, Guo W. Can surgical management of bone metastases improve quality of life among women with gynecologic cancer? World J Surg Oncol 12(1):250 (2014).</p>
<p>47. Lin C, Ji T, Chen CF, <strong>Hoang BH</strong>. Wnt Signaling in Osteosarcoma: Current Advances in Osteosarcoma. Adv Exp Med Biol 804: 33-45 (2014).</p>
<p>48. Lopez G, Ji T, <strong>Hoang BH</strong>, Bederman S. Robotic Guidance for En Bloc Sacrectomy: A Case Report. Spine 39:E1398-401 (2014).</p>
<p>49. Yokoyama NN, Shao S, <strong>Hoang BH</strong>, Mercola D, Zi X. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol 2(1):27-44 (2014).</p>
<p>50. Ji T, Guo Y, Kim K, McQueen P, Ghaffar S, Christ A, Lin C, Eskander R, Zi X, <strong>Hoang BH</strong>. Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Mol Cancer 14(1):86 (2015).</p>
<p>51. Eskander RN, Ali S, Dellinger T, Lankes HA, Randall LM, Ramirez NC, Monk BJ, Walker JL, Eisenhauer E, <strong>Hoang BH</strong>. Expression Patterns of the Wnt Pathway Inhibitors Dickkopf3 and Secreted Frizzled-Related Proteins 1 and 4 in Endometrial Endometrioid Adenocarcinoma: An NRG Oncology/Gynecologic Oncology Group Study. Int J Gynecol Cancer. 26(1):125-32 (2016).</p>
<p>52. Yang R, Piperdi S, Zhang Y, Zhu W, Neophytou N, <strong>Hoang BH</strong>, Mason G, Geller D, Dorfman H, Meyers PA, Healey JH, Phinney DG, Gorlick R. Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-&beta; as Involved in the Pathogenesis of Osteosarcoma. Clin Orthop Relat Res. 474(1):178-89 (2016).</p>
<p>53. Koirala P, Roth ME, Gill J, Piperdi S, Chinai JM, Geller DS, <strong>Hoang BH</strong>, Park A, Fremed MA, Zang X, Gorlick R. Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma. Sci Rep. 6:30093 (2016).</p>
<p>54. Koirala P, Roth ME, Gill J, Chinai JM, Ewart MR, Piperdi S, Geller DS, <strong>Hoang BH</strong>, Fatakhova YV, Ghorpade M, Zang X, Gorlick R. HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival. Sci Rep. 6:31154 (2016).</p>
<p>55. Brochin RL; Silver JS; Thornhill BA; Blosser SA; Abraham JA; <strong>Hoang BH</strong>; Yang R; Geller DS. Characterization and Distribution of Vertebral Hemangiomas Including a Novel Geographic Map. Montefiore J Musculoskel Med &amp; Surg 1:26-29 (2016).</p>
<p>56. Geller DS, Morris J, Revskaya E, Kahn M, Zhang W, Piperdi S, Park A, Koirala P, Guzik H, Hall C, <strong>Hoang B</strong>, Yang R, Roth M, Gill J, Gorlick R, Dadachova E. Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R). Nucl Med Biol. 43:812-817 (2016).</p>
<p>57. Horne L, Avilucea FR, Jin H, Barrott JJ, Smith-Fry K, Wang Y, <strong>Hoang BH</strong>, Jones KB. LRP5 Signaling in Osteosarcomagenesis: a Cautionary Tale of Translation from Cell Lines to Tumors. Translational Oncol. 9:438&ndash;444 (2016).</p>
<p>58. Yang Y, Yang R, Roth M, Piperdi S, Zhang W, Dorfman H, Rao PH, Park A, Sandeep T, Rosenblum J, Geller D, <strong>Hoang B</strong>, Gill J, Gorlick R. Genetically Transforming Human Osteoblasts to Sarcoma: Development of an Osteosarcoma Model.&nbsp;Genes &amp; Cancer 8(1-2):484-494 (2017).</p>
<p>59. Morris J, Yang R, <strong>Hoang BH</strong>, Garfein E, Geller DS. Mechanical Analysis of the Vascularized Fibular Graft Prosthetic Composite (VFGPC) for Internal Hemipelvectomy Reconstruction. J Surg Oncol 115(7):864-869 (2017).</p>
<p>60. Jandial DD, Krill LS, Chen L, Wu C, Ke Y, Xie J, <strong>Hoang BH</strong>, Zi X. Induction of G2M arrest by flavokawain A, a kava chalcone, increases the responsiveness of HER2 overexpressing breast cancer cells to Herceptin. Molecules 21:462 (2017).</p>
<p>61. Peterson HM, <strong>Hoang BH</strong>, Geller D, Yang R, Gorlick R, Berger J, Tingling J, Roth M, Gill J, Roblyer. In vivo, non-invasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging. J Biomed Optic 22(12):1-9 (2017).</p>
<p>62. Shaul E, Roth M, Lo Y, Geller DS, <strong>Hoang B</strong>, Yang R, Malkin D, Gorlick R, Gill J. Pediatric Oncologist Willingness to Offer Germline TP53 Testing in Osteosarcoma. Cancer 124(6):1242-1250 (2018).</p>
<p>63. Barris DM, Weiner SB, Dubin RA, Fremed M, Zhang X, Piperdi S, Zhang W, Maqbool S, Gill J, Roth M, <strong>Hoang B</strong>, Geller D, Gorlick R, Weiser DA. Detection of circulating tumor DNA in patients with osteosarcoma. Oncotarget 9(16):12695-12704 (2018).</p>
<p>64. Zhang, Y, Zvi, YS, Batko, B, Zaphiros, N, O&rsquo;Donnell, E, Wang, J, Sato, K, Yang, R, Geller, DS, Koirala, P, Zhang, W, Du, X, Piperdi, S, Liu, Y, Zheng, D, Roth, M, Gill, J, Zhang, J, Ren, T, Gorlick, R, Zi,<strong> Hoang BH</strong>. Down-Regulation of Skp2 Expression Inhibits Invasion and Lung Metastasis in Osteosarcoma. Sci Rep 24;8(1):14294 (2018).</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">65. Levine, NL, Zhang, Y, <strong>Hoang, BH</strong>, Yang, R, Jurkowski, ZH, Roth, ME, Gill, JB, Lo, Y, Eisenberg, RE, Bekarev, M, Gorlick, RG, Geller, DS. LigaSure&trade; Use Decreases Intraoperative Blood Loss Volume and Blood Transfusion Volume in Sarcoma Surgery. <em>J Am Acad Orthop Surg</em>. 2019 Nov 15;27(22):841-847. PMID: 30889038</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">66. Li, X, Pham, V, Tippin, M, Fu, D, Rendon, RZ, Song, L, Uchio, E, <strong>Hoang, BH</strong>; Zi, X. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. <em>Cell Commun Signal.</em> 17:25 (2019). PMID: 30885218</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">67. Miller BJ, Yang R, Geller DS, <strong>Hoang BH</strong>. Epidemiology, Therapeutic Strategies, Outcomes, and Complications of Pathologic Fractures. <em>Instr Course Lect.</em> 68:567-576 (2019). PMID: 32032057</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">68. Karkare S, Allen KJH, Jiao R, Malo ME, Dawicki W, Helal M, Godson DL, Dickinson R, MacDonald-Dickinson V, Yang R, <strong>Hoang B</strong>, Gorlick R, Geller DS, Dadachova E. Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors. <em>Sci Rep</em> 9(1):11476 (2019). PMID: 31391495</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">69. Levine NL, <strong>Hoang BH</strong>, Yang R, Weiser D, Morris J, Gorlick R, Gill JB, Roth ME, Tingling J, Brohl AS, Geller DS. Genomic Analysis Does Not Support &lsquo;Malignant Transformation&rsquo; of Osteoblastoma to Osteosarcoma. <em>JCO Precision Oncology</em> 3 (2019).</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">70. Krill L, Deng W, Eskander R, Mutch D, Zweizig S, <strong>Hoang B</strong>, Ioffe O, Randall L, Lankes H, Miller DS, Birrer M. Overexpression of enhance of Zeste homolog 2 (EZH2) in endometrial carcinoma: An NRG Oncology/Gynecologic Oncology Group Study. <em>Gynecol Oncol</em> 156 (2): 423-429 (2020). PMID: 31843273</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">71. Yang R, Goch A, Murphy D, Wang J, Charubhumi V, Fox J, Sen M, <strong>Hoang B</strong>, Geller D. A Novel Tripod Percutaneous Reconstruction Technique in Periacetabular Lesions Caused by Metastatic Cancer. <em>J Bone Joint Surg Am</em>. 102(7):592-599 (2020). PMID: 32079881</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">72. Wang J, Sato K, O'Donnell E, Singla A, Yaguare S, O Aldahamsheh, Batko B, Borjihan H, Tingling J, Zhang J, Weiser DA, Loeb DM, Gorlick R, Schwartz EL, Yang R, Zi X, Zhao H, Geller DS, <strong>Hoang BH</strong>. Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma. <em>Transl Oncol.</em> 13(10):100809 (2020). PMID: 32623326</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">73. Peterson HM, Tanka A, Geller D, Yang R, Gorlick R, <strong>Hoang BH</strong>, Roblyer D. Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging. <em>J Biomed Optics</em> 25(8): 086002 (2020).</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">74. Singla A, Wang J, Yang R, Geller DS, Loeb DM, <strong>Hoang BH</strong>. Wnt Signaling in Osteosarcoma. <em>Adv Exp Med Biol.</em> 1258:125-139 (2020). PMID: 32767238</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">75. Ugur E, Volaski H, Yang R, <strong>Hoang B</strong>, Levine N, Singh S, Wang J, Geller D. Variability in the Reported Surgical Techniques and Methods for Intercalary Reconstruction Following Tumor Resection. Surg Oncol. 38:101610 (2021). PMID: 34091268</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">76. Zvi Y, Ugur E, Batko B, Gill J, Roth M, Gorlick R, Hall D, Tingling J, Barkauskas DA, Zhang J, Yang R, <strong>Hoang BH</strong>, Geller DS. Prognostic and Therapeutic Utility of Six Cell Surface Receptors in Osteosarcoma. Sarcoma :8324348 (2021). PMID: 33603563</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">77. Wang J, Aldahamsheh O, Ferrena A, Borjihan H, Singla A, Yaguare S, Singh S, Viscarret V, Tingling J, Zi X, Lo Y, Gorlick R, Zheng D, Schwartz EL, Zhao H, Yang R, Geller DS, <strong>Hoang BH</strong>. The Interaction of SKP2 with p27 Enhances the Progression and Stemness of Osteosarcoma. Ann. N.Y. Acad. Sci. 490(1):90-104 (2021). PMID: 33594717</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">78. Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial. Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Investigators, Ghert M, Schneider P, Guyatt G, Thabane L, V&eacute;lez R, O'Shea T, Randall RL, Turcotte R, Wilson D, Wunder JS, Baptista AM, Cheng EY, Doung YC, Ferguson PC, Giglio V, Hayden J, Heels-Ansdell D, Khan SA, Sampath Kumar V, McKay P, Miller B, van de Sande M, Zum&aacute;rraga JP, Bhandari M, et al. JAMA Oncol. 8(3):345-353. (2022). PMID: 34989778</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">79. Gupta P, Zhao H, <strong>Hoang B</strong>, Schwartz EL. Targeting the untargetable: RB1-deficient tumors are vulnerable to Skp2 ubiquitin ligase inhibition. Br J Cancer. 127(6):969-975 (2022). PMID: 3575271</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">80. Yang R, Singh S, Wang J, Fox J, Thornhill B, Sen M, <strong>Hoang B</strong>, Geller D. Percutaneous Screw Stabilization of Non-Periacetabular Pelvic Lesions Caused by Metastatic Cancer and Multiple Myeloma. J Bone Joint Surg Am. 104: 577-85 (2022). PMID: 35139049</p>
<p class="MsoBodyText" style="margin-right: -22.5pt; text-align: justify; tab-stops: 0in;">81. Ferrena A, Wang J, Zhang R, Karadal-Ferrena B, Al-Hardan W, Singh S, Borjihan H, Schwartz EL, Zhao H, Oktay MH, Yang R, Geller DS, <strong>Hoang BH</strong>, Zheng D. SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis. Mol Cancer Ther. 2023 Oct 24. Online ahead of print. PMID: 37871911</p>
<p class="MsoNormal">82. Wang J, Ferrena A, Zhang R, Singh S, Viscarret V, Al-Harden W, Aldahamsheh O, Borjihan H, Singla A, Yaguare S, Tingling J, Zi X, Lo Y, Gorlick R, Schwartz EL, Zhao H, Yang R, Geller DS, Zheng D, <strong>Hoang BH</strong>. Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma. Oncogene. 2024 Feb 14. Online ahead of print. PMID: 38355807</p>
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EMR ID
5774
Biography

<p>Bang H. Hoang, MD, is Arnold S. and Madaleine Penner Endowed Professor, Orthopedic Surgery, Director, Musculoskeletal Oncology Lab, Co-Director, Orthopedic Oncology and Research Director, Orthopedic Surgery at Montefiore Einstein. He specializes in musculoskeletal tumor surgery and is an expert in benign and malignant tumors, metastatic bone disease, pathologic fractures, complex bone and joint reconstruction with large-segment prosthesis and allograft, tumors of the pelvis and sacrum and investigational therapy for bone and soft tissue sarcoma.</p><p>Dr. Hoang received his Doctor of Medicine from UCLA School of Medicine in 1995. During medical school, he was selected by the Howard Hughes Medical Institute to receive training at the National Institutes of Health in Bethesda, Maryland. He completed his orthopedic surgery residency at Case Western Reserve University and an orthopedic oncology fellowship at Memorial Sloan-Kettering Cancer Center in 2003</p><p>Under his leadership, Montefiore Musculoskeletal Oncology Research focuses on the pathophysiology and therapeutic targets of bone and soft tissue sarcoma. Dr. Hoang is active in collaborative research and clinical trials both nationally and internationally, and his work has been published in multiple peer-reviewed articles, book chapters and abstracts. He has been invited as a lecturer or visiting professor at multiple institutions, including the University of California, Columbia, Emory, Harvard, Thomas Jefferson, Johns Hopkins, McGill and Yale</p><p>Dr. Hoang is board certified and is the first orthopedic surgeon in the United States to receive a K08 Career Development Award from the National Cancer Institute for his research in children&rsquo;s bone cancer. In addition, he has received multiple awards, including the AOA-North American Traveling Fellowship, the Kappa Delta Anne Doner Vaughn Award, the OREF Career Development Award, the Orthopedic Research Society NIRA award, Memorial Sloan-Kettering Chairman&rsquo;s Award and US News and World Report Top Doctor. He is a member of the American Orthopedic Association, the American Academy of Orthopedic Surgeons, the Musculoskeletal Tumor Society, the American Association for Cancer Research and the Connective Tissue Oncology Society. He has served on numerous scientific, grant funding, and educational committees for national organizations such as the American Cancer Society, the Orthopedic Research and Education Foundation, the Musculoskeletal Tumor Society, and the American Academy of Orthopedic Surgeons.</p>

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David S. Geller

Submitted by Anonymous (not verified) on
Full Name
David S. Geller
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Geller_David_S_MD_2x.jpg
Type
Provider
Faculty
Expert
First Name
David
Last Name
Geller
NPI
1467437764
Faculty ID
10675
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-orthopaedic-surgery
einstein-dept-pediatrics
Languages
Hebrew
Gender
Male
Email
dgeller@montefiore.org
Phone
718-920-2060
Titles
Type
Academic
Department
Department of Orthopaedic Surgery
Department Link
Rank
Professor
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Hematology-Oncology
Type
Clinical
Title
Co-Director, Orthopedic Oncology
Tags
me-patientcare-cancer-research-therapeutics
me-patientcare-cancer-clinical-aids-malignancies
me-patientcare-orthopedics-about-team-chiefs
Type
Clinical
Title
Vice-Chairman, Strategy and Innovation
Tags
me-patientcare-orthopedics-orthopediconcology
me-patientcare-orthopedics-about-team
Type
Clinical
Title
Associate Director, Musculoskeletal Oncology Lab
Type
Clinical
Title
Professor, Orthopedic Surgery and Pediatrics
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87862 40.88032)
Address Line 1
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2404
Location Title
Montefiore Greene Medical Arts Pavilion
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10467-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.99671 40.75115)
Address Line 1
435 W 31st Street, Suite 30
City
New York
State
NY
Zip
10001
Location Title
MEAC Manhattan West
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8820619 40.879953)
Address Line 1
111 East 210th Street
Address Line 2
Third Floor
City
Bronx
State
NY
Zip
10467
Location Title
Pediatric Oncology - Rosenthal 3
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.7681117 41.0268898)
Address Line 1
122 Maple Avenue
City
White Plains
State
NY
Zip
10601
Location Title
White Plains Hospital Center for Advanced Medicine & Surgery
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8785732 40.879979)
Building
MMC-MAP
Address Line 1
Montefiore Medical Center
Address Line 2
Medical Arts Pavilion
Address Line 3
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Sackler School of Medicine, New York
Education Type Label
Fellowship
Education Institution
Massachusetts General Hospital
Education Type Label
Residency
Education Institution
Montefiore Medical Center
Professional Interests

<p>Dr. Geller is a full-time faculty member of the Orthopaedic Surgery Department at Montefiore Medical Center and serves as the director of the Orthopaedic Oncology Service, managing both pediatric and adult patients.&nbsp; He is the co-director of Orthopaedic Surgery at the Montefiore Medical Center Moses Campus and currently serves as the Quality Improvement Officer for the Montefiore Cancer Committee.&nbsp; His clinical focus involves primary and metastatic bone and soft tissue tumors, with a secondary interest in joint replacement in the setting of extensive bone loss.&nbsp; He has experience in navigation-guided surgery, allograft reconstruction, endoprosthetic reconstruction, and use of custom or patient-tailored reconstructive prostheses.&nbsp; His research interests include expression patterns in osteosarcoma, surgical margins in osteosarcoma, novel drug screening methods and targeted therapy for osteosarcoma using novel therapeutic modalities.&nbsp; He is extensively involved in resident and medical student education.</p>

Specialties
Expert Tags
Areas of Expertise
Musculoskeletal oncology and joint replacement (adult and pediatric)
Limb sparing surgical techniques
Innovative surgical treatments and patient-tailored implants for those who suffer from osteosarcoma and other primary bone tumors
Expert Summary

<p>Dr. Geller is an orthopaedic surgeon specializing in musculoskeletal oncology and joint replacement, and his practice encompasses adult and pediatric patients. Dr. Geller’s research interests include surface receptor expression in osteosarcoma and potential targeted therapies for the treatment of osteosarcoma. He has developed a novel murine xenograft model for osteosarcoma for the evaluation of surgical margins in osseous tumor surgery. His research additionally includes allograft bone reconstruction techniques, resonance frequency changes during joint reconstruction and pain management in the elderly orthopaedic population.</p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

<p>Orthopedic oncology, orthopedic surgery, bone and soft tissue sarcomas, benign bone and soft-tissue tumors, metastatic carcinoma on the bone </p>

Research Focus

<p>Osteosarcoma, with an interest in innovative treatment strategies for both local disease control and metastatic disease; evaluation of expression patterns in osteosarcoma and surgical margins using a xenograft osteosarcoma murine model; the functional role of bone morphogenetic proteins in osteosarcoma surgery; use of intraoperative navigation techniques for tumor surgery; tumorigenesis of osteosarcoma </p>

PubMed.gov URL
Selected Publications

<ul>
<li>Morris J, Dutcher J, <strong>Geller DS</strong>. Revisiting the Orhtopaedic Management of Metastatic Renal Cell Carcinoma: Rationale for a More Aggressive Approach. <em>Current Orthopaedic Practice. </em>2013 Sept/Oct; 24(5):547-551.</li>
<li>Bekarev M, Elsinger EC, Villanueva-Siles E, Borzykowski RM, <strong>Geller DS.</strong> Synovial Sarcoma of the Foot. <em>Journal of Foot and Ankle Surgery</em>. 2013 Jul-Aug; 52(4):513-7. doi: 10.1053</li>
<li>Capogna BM, Lovy A, Blum Y, Kim SJ, Flesen UR, <strong>Geller DS.</strong> Infection Rate Following Total Joint Arthroplasty in the HIV Population. <em>Journal of Arthroplasty</em>. 2013 Sep; 28(8):1254-8. doi: 10.1016</li>
<li>Lall A, Hohn E, Kim M, Gorlick R, Abraham J, <strong>Geller DS</strong>. Comparison of Surface Area Across the Allograft-Host Junction Site Using Conventional and Navigated Osteotomy Technique. <em>Sarcoma</em>. 2012; 2012:197540.&nbsp;</li>
<li>Piperdi S, Austin-Page L, <strong>Geller DS</strong>, Ahluwalia M, Gorlick S, Gill J, Sellers R, Zhang W, Li N, Ching Sohak, Gorlick R. Beta-Catenin Does Not Confer Tumorigenicity when Introduced into Partially Transformed Human Mesenchymal Stem Cells.<em> Sarcoma</em>. 2012. Epub 2012 Oct 18.</li>
<li>Crocco L, Gorlick R,<strong> Geller DS</strong>. Current Practice Management Regarding Thromboembolic Prophylaxis Within the Pediatric Sarcoma Patient Population, <em>Journal of Pediatric Hematology/Oncology</em>.2012 Sep 19. [Epub ahead of print]</li>
<li>&nbsp;Hall GL, Villanueva-Siles E, Borzykowski RM, Gruson KI, Dorfman HD, <strong>Geller</strong> <strong>DS</strong>. Aspergillus osteomyelitis of the proximal humerus: a case report. <em>Skeletal Radiology</em>. 2012 Aug; 41(8):1021-5. Epub 2012 Mar 31.</li>
<li>Sambaziotis C, Plymale M, Lovy A, O&rsquo;Halloran K, McCulloch K, <strong>Geller DS</strong>. Pseudoaneurysm of the Distal Thigh after Manipulation of a Total Knee Arthroplasty. <em>Journal of Arthroplasty</em>. 2012 Aug; 27(7); 1414.</li>
<li>Shakked RJ, <strong>Geller DS</strong>, Gorlick R, Dorfman HD. Mesenchymal chondrosarcoma: Clinicopathologic study of 20 cases. <em>The Archives of Pathology &amp; Laboratory Medicine</em>.&nbsp; 2012 Jan; 136(1):61-75.</li>
<li>Hohn E, Garfein ES, Mehta KJ, <strong>Geller DS. </strong>Quadriceps Tendon Allograft Augmentation after Wide Excision of a Soft Tissue Sarcoma. <em>Current Orthopaedic Practice</em>. 2012 Jan/Feb; 23(1):68-71.</li>
<li>Singh CK, <strong>Geller DS. </strong>The Telescopic Mating Technique for Bulk Allograft Reconstruction. <em>Orthopaedics</em>. 2012 Feb; 35(2):118-124.</li>
<li>Sambaziotis C, Lovy A, Moadel RM, Chamarthy M, Glaser J, Jaini S, Villanueva-Siles E, <strong>Geller DS</strong>. Florine-18 Fluorodeoxyglucose Positron Emission Tomography for Osteochondromas Utilizing a Triple-Time Point Protocol.&nbsp; <em>Open Journal of Medical Imaging</em>. 2011 Dec; 1(2):15-20.</li>
<li>Hassan SE, Bekarev M, Kim MY, Lin J, Piperdi S, Gorlick R, <strong>Geller DS. </strong>Cell Surface Receptor Expression Patterns in Osteosarcoma. <em>Cancer.</em> 2011 Feb 1; 118(3):740-9.</li>
<li>Plymale M, Lovy A, Villanueva-Siles E, <strong>Geller DS.</strong> Isolated intra-articular pseudorheumatoid nodule of the knee.<em> Skeletal Radiology</em>. 2011 Apr; 40(4):463-6.</li>
<li>Green MC, Dorfman HD, Villanueva-Siles E, Gorlick RG, Thornhill BA, Weber RV, <strong>Geller DS. </strong>Aggressively Recurrent Infantile Myofibroma of the Axilla and Shoulder Girdle. A Case Report. <em>Skeletal Radiology</em>.2010 Mar; 40(3):357-61.</li>
<li><strong>Geller DS</strong>, Pope JB, Thornhill BA, Dorfman, HD. Cryptococcal pyarthrosis and sarcoidosis. <em>Skeletal Radiol</em>. 2009 Jul; 38(7):721-7.</li>
<li>Sah A, <strong>Geller DS</strong>, Mankin HJ, Delaney T, Rosenberg A, Wright C, Hornicek FJ. Malignant Transformation of Synovial Chondromatosis of the Shoulder to Chondrosarcoma - A Case Report," <em>Journal of Bone and Joint Surgery. </em>2007 Jun; 89(6):1321-8.</li>
<li><strong>Geller DS</strong>, Hornicek FJ, Mankin HJ, Raskin KA. &ldquo;Soft Tissue Sarcoma Resection Volume Associated with Wound-Healing Complications,&rdquo; <em>Clinical Orthopaedics and Related Research.</em> 2007; 457:182-5.</li>
<li>Ames JA, Abraham JA, <strong>Geller DS</strong>, Goldsmith J, Gebhardt MC.&nbsp; Proximal Tibial Lesion in a Young Adult: Early Diagnosis Allowing Unique Reconstruction.&nbsp; <em>The Orthopaedic Journal at Harvard Medical School.</em> 2006 Aug: 143-7.</li>
<li>Gardner MJ, Yacoubian S, <strong>Geller DS</strong>, Pode M, Mintz D, Helfet&nbsp; DL,&nbsp; Lorich DG. &ldquo;Prediction of Soft-Tissue Injuries in Schatzker II Tibial Plateau Fractures based on Measurements of Plain Radiographs,&rdquo; <em>Journal of Trauma-Injury Infection &amp; Critical Care</em>. 2006; 60(2):319-324.</li>
<li>Steinberg EL, <strong>Geller DS</strong>, Yacoubian SV, Shasha N, Dekel S, Lorich DG. &ldquo;Intramedullary Fixation of Tibial Shaft Fractures Using an Expandable Nail,&rdquo; <em>Journal of Orthopaedic Trauma.&nbsp; </em>2006 May; 20(5):303-9.</li>
<li>Gardner, MJ, Yacoubian S, <strong>Geller DS</strong>, Suk M, Mintz D, Potter H, Helfet DL, Lorich DG. &ldquo; The Incidence of Soft Tissue Injury in Operative Tibial Plateau Fractures,&rdquo; <em>Journal of Orthopaedic Trauma</em>.&nbsp; 2005; 19:79-84.</li>
<li>Lorich DG, Yacoubian SV, <strong>Geller DS</strong>. &ldquo;Intramedullary Fixation of Humeral Shaft Fractures Using an Inflatable Nail,&rdquo; <em>Orthopaedics</em>. 2003 Oct; 26(10):1011-4.</li>
<li>Lorich DG, <strong>Geller DS</strong>, Yacoubian SV, Leo AJ, Helfet DL. &ldquo;An Innovative Mode of Intramedullary Fixation,&rdquo; <em>International Review of Modern Surgery</em>, March 2002.</li>
<li>Westrich GH, <strong>Geller DS</strong>, O&rsquo;Malley MJ, Deland JT, Helfet DL. &ldquo;Anterior Iliac Crest Bone Graft Harvesting Using the Cortico-Cancellous Reamer System,&rdquo; <em>Journal of Orthopaedic Trauma</em>. 2001 Sep-Oct; 15(7):500-6.</li>
</ul>

EMR ID
4324
Biography

<p>David S. Geller is a board-certified orthopedic oncologist who specializes in the treatment of both pediatric and adult patients with bone and soft-tissue tumors. He has been a full-time faculty member at Montefiore since 2006. He is an Associate Professor of Orthopedic Surgery and Pediatrics at our Albert Einstein College of Medicine.</p><p>Dr. Geller is known for his expertise in musculoskeletal tumor surgery, with specific experience in bone and soft-tissue sarcomas, such as osteosarcoma, Ewing's sarcoma, liposarcoma and synovial sarcoma. He has extensive experience in managing patients with metastatic carcinoma of the bone as well. He routinely offers limb-salvage surgery using a wide array of reconstructive tools.</p><p>Dr. Geller earned his medical degree from Tel Aviv University's Sackler School of Medicine and completed an orthopedic surgery residency at Montefiore. He received his fellowship training from the Harvard Combined Orthopedic Oncology Program, which included Massachusetts General Hospital, Boston Children's Hospital, and Beth Israel Deaconess Medical Center.</p><p>Dr. Geller serves as the Associate Director of the Musculoskeletal Oncology Research Laboratory at Montefiore. He leads numerous translational research efforts designed to investigate the pathophysiology and molecular mechanisms of bone and soft tissue cancers. He is interested in improved surgical techniques and novel therapeutic approaches for primary malignant bone tumors. He is actively involved in collaborative clinical trials both nationally and internationally.</p><p>Dr. Geller is an active member of the American Academy of Orthopedic Surgeons, Muskuloskeletal Tumor Society, Connective Tissue Oncology Society, Children's Oncology Group, American Orthopedic Association, and the American Association for Cancer Research.</p>

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