Proteomics (LMAP)

The Proteomics Facility, supported by the Laboratory for Macromolecular Analysis and Proteomics (LMAP), provides Einstein researchers with a comprehensive mass spectrometry resource for analysis of proteins, peptides and other selected families of biomolecules. Expert staff scientists are available to help plan and execute a successful proteomics based analysis. They also assist in data analysis, including statistics and data visualization.

Services

Protein-related studies:

Identification and quantification of purified proteins and/or complex proteomes (label-free, SILAC, isobaric tagging)

Determination of protein-protein interactions and protein-nucleic acid interactions

Computational determination of regulated protein pathways, complexes and other networks

dentification and quantification of protein post-translational modifications

Mapping of protein and proteome localization in the cell, in particular chromatin complexes

High throughput analysis (100s samples per day) of histone post-translational modifications

Determination of protein synthesis rate (turnover) as complementary quantitative dimension of protein abundance

Preliminary data analysis, including time-series statistics and assistance in biomarker selection

Other biomolecules:

Spatial localization of molecules by imaging (in situ) mass spectrometry

Confirmation of synthetic and recombinant molecules

High-resolution analysis of metabolites, drugs, peptides and other small molecules

Targeted assays and pharmacokinetics