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Epigenomics
The Epigenomics Shared Facility (ESF) is part of Einstein's Center for Epigenomics and is an Illumina Certified Service Provider (CSPro) laboratory. The ESF's high-throughput molecular technology resources include massively parallel sequencing (MPS) platforms — the Oxford Nanopore MinION, Illumina NextSeq 2000, and Illumina MiSeq — supported by TECAN Freedom EVO® 200 robotics, as well as the BD Rhapsody HT Xpress system from Waters Biosciences (formerly BD Biosciences) for single-cell multi-omic assays.
The ESF supports diverse assays for MPS services to study the epigenome and strives to bring cutting-edge technologies, including quality control and assurance, to benefit the programs of Einstein researchers. The ESF also provides support and services for single-cell assays, expanding its library of multi-omic assays on the BD Rhapsody HT Xpress system (Waters Biosciences) for fragile, rare, and challenging cell types. View the list of available assays.
Data analytical services are provided by Computational Genomics Core (CGC).
Support for single cell analysis include
- Single-Cell Whole Transcriptome (scWTA)-Seq
- Single-Cell ATAC-seq
- scCUT&Tag-seq
- scATAC + mRNA (scWTA)-Seq
Please contact the facility if you are interested in any of the following assays:-BD Rhapsody™ TCR/BCR (VDJ or VDJ CDR3 Assays), intracellular/extracellular CITE-seq single or multi-omic assays alongside scWTA or targeted mRNA expression and protein analyses.
Support for Diverse Assays for bulk samples include
- Directional RNA-seq, Ultra-Low RNA-seq, miRNA-seq
- Exome Capture Enrichment Sequencing (Human/Mouse)
- ChIP-seq
- ATAC-seq
- CUT&RUN-seq
- Enzymatic Methyl-Seq (EM-seq)
Support for long-read sequencing include
- Direct RNA sequencing: transcriptome and epitranscriptome (RNA modifications) analysis using the MinION platform.
Related Shared Facilities
Center Affiliations
Location and Contacts
Epigenomics Price Center/Block Research Pavillion 159
John M. Greally, M.B., Ph.D.
Scientific Director
Shahina B. Maqbool, Ph.D.
Operations Director